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Tractometry-based Anomaly Detection for Single-subject White Matter Analysis [article]

Maxime Chamberland, Sila Genc, Erika P. Raven, Greg D. Parker, Adam Cunningham, Joanne Doherty, Marianne van den Bree, Chantal M. W. Tax, Derek K. Jones
2020 arXiv   pre-print
Deep autoencoders have shown great potential to detect anomalies in neuroimaging data.  ...  There is an urgent need for a paradigm shift from group-wise comparisons to individual diagnosis in diffusion MRI (dMRI) to enable the analysis of rare cases and clinically-heterogeneous groups.  ...  Maxime Descoteaux and Jean-Christophe Houde (Sherbrooke Connectivity Imaging Lab) for their helpful discussions and code sharing.  ... 
arXiv:2005.11082v2 fatcat:ov5h5lcvyjfsjd5gur2hhdym5q

Detecting microstructural deviations in individuals with deep diffusion MRI tractometry [article]

Maxime Chamberland, Sila Genc, Chantal M.W. Tax, Dmitri Shastin, Kristin Koller, Erika P. Raven, Greg D. Parker, Khalid Hamandi, William P. Gray, Derek K. Jones
2021 medRxiv   pre-print
To this end, Detect was developed to advance dMRI-based Tractometry towards single-subject analysis.  ...  along brain white matter pathways in the individual.  ...  University) for recruiting the CNV patients.  ... 
doi:10.1101/2021.02.23.21252011 fatcat:h3a5uvtrirasxilafc562pneuu

Recognition of white matter bundles using local and global streamline-based registration and clustering

Eleftherios Garyfallidis, Marc-Alexandre Côté, Francois Rheault, Jasmeen Sidhu, Janice Hau, Laurent Petit, David Fortin, Stephen Cunanne, Maxime Descoteaux
2018 NeuroImage  
Having automated tools that can extract white matter bundles for tract-based studies of large numbers of people is of great interest for neuroscience and neurosurgical planning.  ...  Thus, RecoBundles can be a valuable method for exploring tractograms and facilitating tractometry studies.  ...  Acknowledgments We are grateful to the Établissement Nouveau Chercheur FQNRT program, the University-Industry NSERC CREATE Medical Image Analysis program, the Samuel de Champlain France-Québec program,  ... 
doi:10.1016/j.neuroimage.2017.07.015 pmid:28712994 fatcat:bpspukam5zeuxe6yu5ca3cqcmy

Quantification of apparent axon density and orientation dispersion in the white matter of youth born with congenital heart disease

Kaitlyn Easson, Charles V. Rohlicek, Jean-Christophe Houde, Guillaume Gilbert, Christine Saint-Martin, Kimberly Fontes, Annette Majnemer, Ariane Marelli, Pia Wintermark, Maxime Descoteaux, Marie Brossard-Racine
2019 NeuroImage  
White matter alterations have previously been demonstrated in adolescents born with congenital heart disease (CHD) using diffusion tensor imaging (DTI).  ...  matter, as a complement to classic DTI measures.  ...  Acknowledgements First and foremost, we would like to thank the participants and their families for their participation in this study.  ... 
doi:10.1016/j.neuroimage.2019.116255 pmid:31605826 fatcat:kvvg7ohsgzeubkojvwa6fgjekq

Detecting Corticospinal Tract Impairment in Tumor Patients With Fiber Density and Tensor-Based Metrics

Lucius S. Fekonja, Ziqian Wang, Dogu B. Aydogan, Timo Roine, Melina Engelhardt, Felix R. Dreyer, Peter Vajkoczy, Thomas Picht
2021 Frontiers in Oncology  
The bihemispheric along-tract analysis provides an approach to detect subject-specific structural changes in healthy and pathological WM.  ...  The delineation of the healthy-pathological white matter (WM) interface area, for which diffusion magnetic resonance imaging (dMRI) has shown promising potential, may improve treatment outcome.  ...  Investigating white matter fibre density and morphology using fixel-based analysis.  ... 
doi:10.3389/fonc.2020.622358 pmid:33585250 pmcid:PMC7873606 fatcat:gdradh3wkzbfdbfvwctbyzirsq

Altered white matter microstructure in 22q11.2 deletion syndrome: a multisite diffusion tensor imaging study

Julio E. Villalón-Reina, Kenia Martínez, Xiaoping Qu, Christopher R. K. Ching, Talia M. Nir, Deydeep Kothapalli, Conor Corbin, Daqiang Sun, Amy Lin, Jennifer K. Forsyth, Leila Kushan, Ariana Vajdi (+40 others)
2019 Molecular Psychiatry  
Prior single-site diffusion magnetic resonance imaging (dMRI) studies have reported altered white matter (WM) microstructure in 22q11DS, but small samples and variable methods have led to contradictory  ...  These show the JHU-ICBM atlas white matter ROIs that passed multiple comparisons correction after meta-analysis.  ...  WM: Average of all white matter JHU-ICBM ROIsFig. 3 Results from the local nonparametric ANCOVA analysis comparing 22q11DS subjects with psychotic disorder (N = 35) vs those with no lifetime history of  ... 
doi:10.1038/s41380-019-0450-0 pmid:31358905 pmcid:PMC6986984 fatcat:vdlunkrqw5alhee7u5rv72ylxa