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Tractography in the presence of multiple sclerosis lesions

Ilona Lipp, Greg D. Parker, Emma C. Tallantyre, Alex Goodall, Steluta Grama, Eleonora Patitucci, Phoebe Heveron, Valentina Tomassini, Derek K. Jones
2019 NeuroImage  
Accurate anatomical localisation of specific white matter tracts and the quantification of their tract-specific microstructural damage in conditions such as multiple sclerosis (MS) can contribute to a  ...  a high prevalence of lesions.  ...  Acknowledgements The study was funded by a research grant of the MS Society UK.  ... 
doi:10.1016/j.neuroimage.2019.116471 pmid:31877372 pmcid:PMC7613131 fatcat:h3zxzrco5vhhtevbu672s3pjiq

Tractography in the presence of white matter lesions in multiple sclerosis [article]

Ilona Lipp, Greg D Parker, Emma Tallantyre, Alex Goodall, Steluta Grama, Eleonora Patitucci, Phoebe Heveron, Valentina Tomassini, Derek Jones
2019 bioRxiv   pre-print
Accurate anatomical localisation of specific white matter tracts and the quantification of their tract-specific microstructural damage in multiple sclerosis (MS) can contribute to a better understanding  ...  of lesions.  ...  The study was funded by a research grant of the MS Society UK. DKJ is supported by a Wellcome Trust Investigator Award (096646/Z/11/Z) and a Wellcome Trust Strategic Award (104943/Z/14/Z).  ... 
doi:10.1101/559708 fatcat:wxoapenumzgixkhbyy3gdi2apq

White matter tract-specific quantitative analysis in multiple sclerosis: Comparison of optic radiation reconstruction techniques

Chenyu Wang, Alexander Klistorner, Linda Ly, Michael H. Barnett, Kristen C. Maitland
2018 PLoS ONE  
However, diffusionbased tractography approaches, which are typically used for OR segmentation are confounded by the presence of focal white matter lesions.  ...  The posterior visual pathway is commonly affected by multiple sclerosis (MS) pathology that results in measurable clinical and electrophysiological impairment.  ...  Additionally, in conditions characterised by localised brain pathology, fibre-based tractography permits separation of the OR into 'lesional' and 'non-lesional' fibres, as defined by the presence or absence  ... 
doi:10.1371/journal.pone.0191131 pmid:29342192 pmcid:PMC5771610 fatcat:hvxzbshi7bdmjokqdoandaw4se

Diffusion tensor imaging in assessment of demyelinating diseases of central nervous system

Arindam Mukherjee, Umesh Chandra Garga
2020 International Journal of Research in Medical Sciences  
Conventional MR plays an important role in detection of demyelinating lesions.  ...  DTI is an important tool in assessment of anisotropy in affected and apparently normal region of brain. 3D Tractography maps are useful in showing white matter fibre loss.  ...  14 Among different phenotype of Multiple Sclerosis, we found the mean FA value at lesion core in patients of CIS was 0.336, in patients of RRMS FA value at lesion core was 0.289 (Figure 1 ), in patients  ... 
doi:10.18203/2320-6012.ijrms20202556 fatcat:4qfcjfyqbzagldzutsldi6nk3q

Validating atlas-based lesion disconnectomics in multiple sclerosis: a retrospective multi-centric study [article]

Veronica Ravano, Michaela Andelova, Mario Joao Fartaria, Mazen Fouad A-Wali Mahdi, Benedicte Marechal, Reto Meuli, Tomas Uher, Jan Krasensky, Manuela Vaneckova, Dana Horakova, Tobias Kober, Jonas Richiardi
2021 medRxiv   pre-print
extracted from individual tractography and explore its clinical utility for reducing the gap between radiological findings and clinical symptoms in multiple sclerosis.  ...  First, tracking algorithms are known to be sensitive to the presence of white matter lesions and therefore leading to interpretation pitfalls and poor inter-subject comparability in clinical applications  ...  Acknowledgments We thank Frank Yeh, author of the tractography atlas and developer of DSI Studio, for the fruitful discussion and his advice on the reconstruction and tracking algorithms used.  ... 
doi:10.1101/2021.05.03.21256161 fatcat:uqbphsjxfvglxcoz5fy6iz67pe

Diffusion tensor tractography-based group mapping of the pyramidal tract in relapsing-remitting multiple sclerosis patients

F Lin, C Yu, T Jiang, K Li, P Chan
2007 American Journal of Neuroradiology  
Our study sought to use diffusion tensor tractography-based group mapping to investigate the presence of abnormal diffusion in the normal-appearing pyramidal tract (PYT) of RRMS and its possible mechanism  ...  Many studies have reported abnormal changes in relapsing-remitting multiple sclerosis (RRMS) by histogram and region-of-interest-based methods by using diffusion tenor imaging.  ...  Acknowledgments The authors are very grateful to the anonymous reviewers for their significant and constructive comments and suggestions, which greatly improved the article.  ... 
pmid:17296994 pmcid:PMC7977424 fatcat:jae4o2m2cnck3gkoeqq3noaq34

A combined post-mortem magnetic resonance imaging and quantitative histological study of multiple sclerosis pathology

James Kolasinski, Charlotte J. Stagg, Steven A. Chance, Gabriele C. DeLuca, Margaret M. Esiri, Eun-Hyuk Chang, Jacqueline A. Palace, Jennifer A. McNab, Mark Jenkinson, Karla L. Miller, Heidi Johansen-Berg
2012 Brain  
These data demonstrate for the first time the relevance of functional anatomical connectivity to the spread of multiple sclerosis pathology in a 'tract-specific' pattern.  ...  In this study, we used the complementary approaches of whole brain post-mortem magnetic resonance imaging and quantitative histology to assess patterns of multiple sclerosis pathology.  ...  The authors acknowledge the support of the UK Multiple Sclerosis Brain Bank for supplying tissue samples and clinical information presented in this study.  ... 
doi:10.1093/brain/aws242 pmid:23065787 pmcid:PMC3470716 fatcat:25v7hvayx5go3km7yaalc6ndai

Sensory-motor network topology in multiple sclerosis: Structural connectivity analysis accounting for intrinsic density discrepancy

Simona Schiavi, Maria Petracca, Matteo Battocchio, Mohamed M El Mendili, Swetha Paduri, Lazar Fleysher, Matilde Inglese, Alessandro Daducci
2020 Human Brain Mapping  
We found that topology differences identified with standard tractography in MS seem to be mainly driven by density, which, in turn, is strongly influenced by the presence of lesions.  ...  Graph theory and network modelling have been previously applied to characterize motor network structural topology in multiple sclerosis (MS).  ...  influenced by the presence of lesions.  ... 
doi:10.1002/hbm.24989 pmid:32412678 pmcid:PMC7336144 fatcat:ruetsg64nncapnhcylulglolx4

Just pretty pictures? What diffusion tractography can add in clinical neuroscience

Heidi Johansen-Berg, Timothy EJ Behrens
2006 Current Opinion in Neurology  
comparisons of specific white matter pathways in disease; second, evidence from tractography for the presence of qualitatively different pathways in congenital disorders or following recovery; third,  ...  Purpose of review-Diffusion tractography uses non-invasive brain imaging data to trace fibre bundles in the human brain in vivo.  ...  Acknowledgments We are grateful to The Wellcome Trust (HJB) and Medical Research Council (TEJB) for funding and to Derek Jones for useful discussion.  ... 
doi:10.1097/01.wco.0000236618.82086.01 pmid:16914977 pmcid:PMC3119814 fatcat:snvopu55bfgilfb3wg5yiypu5u

Advanced neuroimaging in Balo's concentric sclerosis: MRI, MRS, DTI, and ASL perfusion imaging over 1 year

Crystal Jing Jing Yeo, George J. Hutton, Steve H. Fung
2018 Radiology Case Reports  
similar to that in multiple sclerosis (MS) lesions [2] .  ...  Advanced neuroimaging has proven helpful for early diagnosis, classification, prognostication, and monitoring of progression in multiple sclerosis, but has not been fully explored in BCS.  ...  Graph of relative ADC over time shows relatively reduced diffusion in the periphery compared to the central part of the lesion.  ... 
doi:10.1016/j.radcr.2018.04.010 pmid:30228838 pmcid:PMC6137900 fatcat:kjteqnvxxzgx7cwjjtbs4dxz3e

Long-range connections are more severely damaged and relevant for cognition in multiple sclerosis

2019 Brain  
Our results showed that the structural network had a reduced efficiency and integrity in multiple sclerosis relative to healthy controls (both P < 0.05).  ...  From the Amsterdam multiple sclerosis cohort, 133 patients (age = 54.2 ± 9.6) with long-standing multiple sclerosis and 48 healthy controls (age = 50.8 ± 7.0) with neuropsychological testing and MRI were  ...  The results of tractography algorithms may be affected by the presence of white matter lesions. To assure the credibility of the tractography findings, we performed additional analyses.  ... 
doi:10.1093/brain/awz355 pmid:31730165 pmcid:PMC6938033 fatcat:fztce4h35ffzfkexdabh7losiq

The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients

Amgad Droby, Vinzenz Fleischer, Marco Carnini, Hilga Zimmermann, Volker Siffrin, Joachim Gawehn, Michael Erb, Andreas Hildebrandt, Bernhard Baier, Frauke Zipp
2015 NeuroImage: Clinical  
Here, this damaging effect, reflected by changes in diffusivity measures, was detected in vivo in multiple sclerosis patients in early stages of the disease, thus demonstrating the influence of a focal  ...  immune attack on more distant networks, and emphasizing the pathophysiological role of Wallerian degeneration in multiple sclerosis.  ...  Acknowledgements None of the authors report any conflicts of interest relevant to this work.  ... 
doi:10.1016/j.nicl.2015.03.003 pmid:26106534 pmcid:PMC4473264 fatcat:izzurcmspjapdlxvudzn6cn3wm

Gadolinium-Enhancing Lesions Lead to Decreases in White Matter Tract Fractional Anisotropy in Multiple Sclerosis

Gloria C. Chiang, Soniya Pinto, Joseph P. Comunale, Susan A. Gauthier
2015 Journal of Neuroimaging  
Purpose-Although MRI identification of new lesions forms the basis for monitoring disease progression in multiple sclerosis patients, how lesion activity relates to longitudinal white matter changes in  ...  Methods-Thirty patients with relapsing-remitting multiple sclerosis were included in this study -13 had enhancing lesions at baseline and 17 did not.  ...  Grant Support: The work was supported in part by the NIH National Center for Advancing Translational Sciences/CTSC grant (UL1 TR000457-06)  ... 
doi:10.1111/jon.12309 pmid:26458494 pmcid:PMC4833697 fatcat:ofmnomykwnfthiqakxkptjp5pm

Transcallosal and Corticospinal White Matter Disease and Its Association With Motor Impairment in Multiple Sclerosis

Keejin Yoon, Derek B. Archer, Margareta A. Clarke, Seth A. Smith, Ipek Oguz, Gary Cutter, Junzhong Xu, Francesca Bagnato
2022 Frontiers in Neurology  
probabilistic tractography, white matter tract templates can improve the assessment of regional axonal injury and its association with disability of people with multiple sclerosis (pwMS).MethodsParametric  ...  IVF in several TC tracts was associated with the Expanded Disability Status Scale score (p ≤ 0.047), while regional and overall lesion burden correlated with the Timed 25-Foot Walking Test (p ≤ 0.049).  ...  We thank all the VUIIS MRI technicians for their assistance with scanning, Ms. Nikita Thomas and Kehaunani Hubbard for assistance with scheduling, and Ms. Nikita Thomas and Dr.  ... 
doi:10.3389/fneur.2022.811315 pmid:35785345 pmcid:PMC9240189 fatcat:pwlbtsndgbdmxmma2fiq2wb5sm

Tract-specific white matter correlates of fatigue and cognitive impairment in benign multiple sclerosis

Maxim Bester, Mariana Lazar, Maria Petracca, James S. Babb, Joseph Herbert, Robert I. Grossman, Matilde Inglese
2013 Journal of the Neurological Sciences  
Background-Although benign multiple sclerosis (BMS) is traditionally defined by the presence of mild motor involvement decades after disease onset, symptoms of fatigue and cognitive impairment are very  ...  Deficits in processing speed and attention were associated with the T2 lesion volume of the AT tracts (p<0.01 for all).  ...  Introduction The benign form of Multiple Sclerosis (BMS) is classically defined by minimal disease progression and motor disability decades after the clinical onset (1) .  ... 
doi:10.1016/j.jns.2013.04.005 pmid:23643443 pmcid:PMC4651179 fatcat:r3jpeyggbvglnexwgh5hormhqe
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