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Sodium Thiosulfate acts as an H2S mimetic to prevent intimal hyperplasia via inhibition of tubulin polymerization [article]

Diane Macabrey, Alban Longchamp, Michael Macarthur, Martine Lambelet, Severine Urfer, Jean-Marc Corpataux, Sebastien Deglise, Florent ALLAGNAT
2021 bioRxiv   pre-print
Interpretation: STS, a drug used for the treatment of cyanide poisoning and calciphylaxis, protects against IH in a mouse model of arterial restenosis and in human vein segments.  ...  Intimal hyperplasia (IH) remains a major limitation in the long-term success of any type of revascularization.  ...  Right panel Quantitative assessment of Collagen III immunofluorescent staining. Data are scatter plots of 5 different veins with mean±SEM.  ... 
doi:10.1101/2021.09.09.459573 fatcat:c6nhg3c6ireezp7vxjgndcuari

An antioxidant approach directed to non-healing wounds activation - A case report study

Juan Francisco Jiménez-García, Gabriel Aguilera-Manrique, Laura Parra-Anguita, Joan Enric Torra-Bou, Irene Villegas-Tripiana, Francisco Pedro García-Fernández
2021 Clinical Case Reports and Reviews  
Conflicts of interest: The authors declare no conflict of interest.  ...  The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.  ...  This method allows the simultaneous assessment of key parameters that indicate the progression towards healing.  ... 
doi:10.15761/ccrr.1000499 fatcat:nfd3qxmfmna5fjmcwalraqnt6q

The Strategy to Prevent and Regress the Vascular Calcification in Dialysis Patients

Nai-Ching Chen, Chih-Yang Hsu, Chien-Liang Chen
2017 BioMed Research International  
, intravenous labile iron, and positive calcium and phosphate balance), correction of high and low bone turnover, and restoration of anticalcification factor balance such as correction of vitamin D and  ...  The role of bone antiresorption therapy such as bisphosphonates and denosumab in vascular calcification in high-bone-turnover disease remains unclear.  ...  Despite its weaknesses as a biomarker, PTH represents perhaps the best current option for noninvasive assessment of bone turnover.  ... 
doi:10.1155/2017/9035193 pmid:28286773 pmcid:PMC5329685 fatcat:aem7bwdwxvdpbh5e65hlkp3jjy

Longitudinal changes in bone and mineral metabolism after cessation of cinacalcet in dialysis patients with secondary hyperparathyroidism

Irene Ruderman, Edward R. Smith, Nigel D. Toussaint, Tim D. Hewitson, Stephen G. Holt
2018 BMC Nephrology  
Over the 12-month period, there were two fractures, five cardiovascular events, one episode of calciphylaxis, and one parathyroidectomy, with a mortality rate of 19% (n = 13).  ...  Changes to reimbursement of cinacalcet in Australia provided an opportunity to assess effects of medication cessation on biochemical and clinical outcomes in dialysis patients, including changes to novel  ...  Acknowledgements The authors acknowledge the help of Connie Karschimkus in collecting study samples over the trial period.  ... 
doi:10.1186/s12882-018-0910-9 pmid:29764395 pmcid:PMC5952622 fatcat:c2pc2vljrffrzbbq3i33wd7nya

An approach to the diagnosis and treatment of cryofibrinogenemia

Tshering D Amdo, James A Welker
2004 American Journal of Medicine  
Diagnostic criteria are outlined, and therapies are assessed critically. This information should help clinicians in establishing a diagnosis of cryofibrinogenemia and initiating treatment.  ...  In this review, the classification, pathophysiology, and clinical presentation of cryofibrinogenemia are described, based on case reports and prospective observational data.  ...  Cryofibrinogens can be quantitated in two ways.  ... 
doi:10.1016/j.amjmed.2003.09.033 pmid:14984819 fatcat:wfxbr7hf45dcnkkc3s4uyx3pq4

Cardiovascular Pathology

2017 Modern Pathology  
AR expression in TNBCs using 1% and 10% cutoff was 41% and 28% respectively of all TNBCs. CK5/6 expression was seen in 122 of 228 (54%), 106 of 228 (46%) TNBCs.  ...  The percentage and intensity of both markers were evaluated by two pathologists independently.  ...  None of the amputation patients had a clinical presentation suggestive of calciphylaxis.  ... 
doi:10.1038/modpathol.2016.244 pmid:28134891 fatcat:5mssizt6orb57m2w4yr6xx5ywq

Dermatopathology

2016 Laboratory Investigation  
diagnosis of calciphylaxis.  ...  Fetuin-B staining was positive in 63% (5/8) of calciphylaxis cases and 33% (5/15) of non-calciphylaxis cases (p=0.17).  ... 
doi:10.1038/labinvest.2016.6 pmid:26813168 fatcat:bam5xm6jjbe3bn2kgxtzrgy5vq

Vascular calcification in chronic kidney disease: Pathogenesis and clinical implication

Sinee Disthabanchong
2012 World Journal of Nephrology  
of calcification inhibitors play important roles in promoting the development of VC.  ...  risk factors on the development of VC.  ...  As a result, the possibility of accurate assessment of changes of calcification burden, especially over a short period of time, may be limited.  ... 
doi:10.5527/wjn.v1.i2.43 pmid:24175241 pmcid:PMC3782198 fatcat:depkyihfdzherjbwcrpgguuuo4

Osteogenic regulation of vascular calcification: an early perspective

Radhika Vattikuti, Dwight A. Towler
2004 American Journal of Physiology. Endocrinology and Metabolism  
A minimum of four histoanatomic variants-atherosclerotic (fibrotic) calcification, cardiac valve calcification, medial artery calcification, and vascular calciphylaxis-arise in response to metabolic, mechanical  ...  and extent of calcific vasculopathy.  ...  However, only intact OPN was assayed (92) , and no quantitative assessment of OPN phosphorylation in vascular or circulating forms induced by PTH has yet been performed.  ... 
doi:10.1152/ajpendo.00552.2003 pmid:15102615 fatcat:o5l2ahdvlbfw5ihfmf6boswvim

SNF472, a novel inhibitor of vascular calcification, could be administered during hemodialysis to attain potentially therapeutic phytate levels

Joan Perelló, M. Gómez, M. D. Ferrer, N. Y. Rodríguez, C. Salcedo, J. M. Buades, M. M. Pérez, J. V. Torregrosa, E. Martín, F. Maduell
2018 JN. Journal of Nephrology (Milano. 1992)  
SNF472 (the hexasodium salt of phytate) is being developed for the treatment of calciphylaxis and CVC in HD patients.  ...  Methods Dialyzability was assessed in vitro using online-hemodiafiltration and high-flux HD systems in blood and saline. SNF472 was infused for 20 min and quantified at different time points.  ...  Government of Spain) grants.  ... 
doi:10.1007/s40620-018-0471-9 pmid:29350348 pmcid:PMC5829128 fatcat:idat2zjsmzflbjil2tcsfcrlu4

The Skin as a critical window in unveiling the pathophysiologic principles of COVID-19

Cynthia Magro, Gerard Nuovo, Justin Mulvey, Jeffrey Laurence, Joanna Harp, A. Neil Crowson
2021 Clinics in Dermatology  
In this contribution, we review an array of cutaneous manifestations of COVID-19 that provide an opportunity to study critical pathophysiologic mechanisms that underlie all clinical facets of COVID-19,  ...  A variety of skin eruptions have been described in the setting of SARS-CoV-2 infection and more recently, after COVID-19 vaccination.  ...  classic features of calciphylaxis.  ... 
doi:10.1016/j.clindermatol.2021.07.001 pmid:34920833 pmcid:PMC8298003 fatcat:kfmnrezvibcobctj5bjm3aqvja

Cilostazol attenuates intimal hyperplasia in a mouse model of chronic kidney disease

Wiwat Chancharoenthana, Asada Leelahavanichkul, Sujittra Taratummarat, Jutamas Wongphom, Khajohn Tiranathanagul, Somchai Eiam-Ong, Jun Yu
2017 PLoS ONE  
We demonstrated a proof of concept of the effectiveness of cilostazol in attenuating IH in a Chr I/R mouse model, a CKD model with predominantly indirect-vascular-injury-induced IH.  ...  The diameters of aorta and renal function were unchanged by cilostazol.  ...  Histology and assessment of intimal hyperplasia The vascular cross-sections of aorta (3 μm thickness) were stained with H&E and PAS, then quantitatively analyzed in ten sections per mouse, starting from  ... 
doi:10.1371/journal.pone.0187872 pmid:29206849 pmcid:PMC5716535 fatcat:5tziypri75funa3qzlmcolndiy

Poster Presentations

2021 Nephrology (Carlton. Print)  
Methods and Material: A case of rhabdomyolysis-associated AKI in the setting of statin therapy is described here.  ...  Objectives: A case of statin-induced rhabdomyolysis is presented here, highlighting the pathophysiology and complications of this condition.  ...  This study is supported by National Research Council of Thailand (6/2562).  ... 
doi:10.1111/nep.13944 fatcat:2rir6wey7vgrzlqzilykfpnw2i

Bisphosphonates in Chronic Kidney Disease; Balancing Potential Benefits and Adverse Effects on Bone and Soft Tissue

N. D. Toussaint, G. J. Elder, P. G. Kerr
2009 American Society of Nephrology. Clinical Journal  
The authors review the potential benefits and risks associated with bisphosphonate use for bone protection in CKD, and assess their effect on vascular calcification and atherosclerosis.  ...  Some experimental and clinical studies have also suggested that bisphosphonates may reduce progression of extra-osseous calcification and inhibit the development of atherosclerosis.  ...  sensitivity or specificity except toward the extremes.  ... 
doi:10.2215/cjn.02550508 pmid:18987295 fatcat:xoblvea3sfactnur5upcqqubgu

Calcification of Aortic Smooth Muscle Cells Isolated From Spontaneously Hypertensive Rats

Kouta Kanemaru, Kazuhiko Seya, Izumi Miki, Shigeru Motomura, Ken-Ichi Furukawa
2008 Journal of Pharmacological Sciences  
The gene expressions of calcificationregulating proteins including msh homeobox homolog 2, Osterix (a master transcription factor for osteogenesis), and alkaline phosphatase (ALP) (a marker of vascular  ...  normotensive rats and spontaneously hypertensive rats (SHR), a typical rat model of hypertension.  ...  Acknowledgments This work was supported in part by a Grant-in-Aid from the Ministry of Education, Science, Sports, and Culture of Japan to Dr. Ken-Ichi Furukawa. Financial support to Dr.  ... 
doi:10.1254/jphs.fp0072013 pmid:18270471 fatcat:vhafp24blfclblkolpwcbgvulq
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