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Quantitative mapping of the brain's structural connectivity using diffusion MRI tractography: a review [article]

Fan Zhang, Alessandro Daducci, Yong He, Simona Schiavi, Caio Seguin, Robert Smith, Chun-Hung Yeh, Tengda Zhao, Lauren J. O'Donnell
2021 arXiv   pre-print
Diffusion magnetic resonance imaging (dMRI) tractography is an advanced imaging technique that enables in vivo mapping of the brain's white matter connections at macro scale.  ...  Over the last two decades, the study of brain connectivity using dMRI tractography has played a prominent role in the neuroimaging research landscape.  ...  FZ and LJO acknowledge funding provided by the following National Institutes of Health (NIH) grants: P41EB015902, P41EB015898, R01MH074794, R01MH125860, P41EB028741 and R01MH119222.  ... 
arXiv:2104.11644v1 fatcat:l3ixpcwu7jb7zcqo2sm5pswmja

IX Congresso Sindem: Italian Association for the study of Dementia linked to the Italian Neurological Society (SIN)

Vincenzo Bonavita, Alessandro Padovani, Amalia Bruni, Leonardo Pantoni, Carlo Caltagirone, Lucilla Parnetti, Francesca Clerici, Daniela Perani, Monica Di Luca, Sandro Sorbi, Gianluigi Forloni, Francesco Tagliavini (+6 others)
2014 Journal of Alzheimer's Disease  
Conclusions: Structural MRI is able to detect longitudinal changes in patients with FTD clinical syndromes and AD.  ...  Objective: To investigate grey (GM) and white matter (WM) volume contraction in patients with frontotemporal lobar degeneration (FTD) syndromes and Alzheimer's disease (AD) using tensor based morphometry  ...  Methods: We studied the brain macroscopic appearance and the possible damage of GM microstructure in 3 patients with PCA and in 3 patients with AD.  ... 
doi:10.3233/jad-149999 pmid:24916691 fatcat:tujmogibkjbxzocjjokjx2w6ua

Magnetic resonance imaging for the diagnosis of Parkinson's disease

Beatrice Heim, Florian Krismer, Roberto De Marzi, Klaus Seppi
2017 Journal of neural transmission  
This review aims to summarize research findings regarding the value of the different MRI techniques, including advanced sequences at high-and ultra-high-field MRI and modern image analysis algorithms,  ...  The differential diagnosis of parkinsonian syndromes is considered one of the most challenging in neurology and error rates in the clinical diagnosis can be high even at specialized centres.  ...  reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.  ... 
doi:10.1007/s00702-017-1717-8 pmid:28378231 pmcid:PMC5514207 fatcat:mijrauiwbvdw3cepks7qfj2e24

17th Quadrennial Meeting of the World Society for Stereotactic and Functional Neurosurgery. Berlin, Germany, June 26-29, 2017: Abstracts

2017 Stereotactic and Functional Neurosurgery  
The results of this study are a step towards precisely understanding the dysfunction of cognitive control in OCD and delineating specific regions in the brain that are implicated in OCD.  ...  We simulated VTAs for each lead in subject's related MRI space based on chronic stimulation parameters obtained from a chart review and associated with BFMDRS/TWSTRS improvement.  ...  This study highlights the role of unique structural changes in TN and structural brain imaging towards a more objective definition of neuropathic pain disorders.  ... 
doi:10.1159/000478281 pmid:28641280 fatcat:ivcbjloukfgiriry65t37fccm4

Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

Harald Hampel, Nicola Toschi, Claudio Babiloni, Filippo Baldacci, Keith L. Black, Arun L.W. Bokde, René S. Bun, Francesco Cacciola, Enrica Cavedo, Patrizia A. Chiesa, Olivier Colliot, Cristina-Maria Coman (+32 others)
2018 Journal of Alzheimer's Disease  
The Precision Neurology development process implements systems theory with system biology and neurophysiology in a parallel, bidirectional research path: a combined hypothesis-driven investigation of systems  ...  dysfunction within distinct molecular, cellular and large-scale neural network systems in both animal models as well as through tests for the usefulness of these candidate dynamic systems biomarkers in  ...  Deficits in cholinergic transmission play a major role for deficits in memory and attention in patients with dementia.  ... 
doi:10.3233/jad-179932 pmid:29562524 pmcid:PMC6008221 fatcat:j3u6gkzfqbg47kv4o2hpkjadn4

American Association of Neuropathologists, Inc. Abstracts of the 87thAnnual Meeting June 23–26, 2011 Seattle, WA

2011 Journal of Neuropathology and Experimental Neurology  
Hippocampal sclerosis (HS-Aging) is a relatively prevalent disease of brain aging with strong impact on cognition.  ...  From these groups, we examined cortical and hippocampal  ...  An MRI of the brain showed diffuse meningeal enhancement around the cervical cord and brainstem, and a second MRI showed multifocal dural based, leptomeningeal and cranial nerve enhancement.  ... 
doi:10.1097/nen.0b013e3182227917 fatcat:gtigoq4ag5d7joowcbdsnysmda

Heavy Metal-Induced Cerebral Small Vessel Disease: Insights into Molecular Mechanisms and Possible Reversal Strategies

Jayant Patwa, Swaran Jeet Singh Flora
2020 International Journal of Molecular Sciences  
In this review, we discuss the possible implication of heavy metals/metalloid exposure in CSVD and its associated disorders based on in-vitro, preclinical, and clinical evidences.  ...  In conclusion, heavy metals in small vessels are strongly associated with the development as well as the progression of CSVD.  ...  and round-shaped) in cortical and sub-cortical brain regions.  ... 
doi:10.3390/ijms21113862 pmid:32485831 fatcat:wkdhrqnq6zb6xfokijj3dls7xy

ePresentation Sessions

2018 European Journal of Neurology  
Using whole-brain tract-based spatial statistics (TBSS) diffusion tensor imaging (DTI) we aim to explore the potential association between brain microstructural damage and ECAS scores.  ...  Conclusion: Results point towards an early microstructural degeneration of brain areas, with significant relationships between DTI metrics and ALS-specific and non-specific ECAS scores.  ...  to predict in patients with diffuse axonal injury (DAI) after traumatic brain injury (TBI).  ... 
doi:10.1111/ene.13700 fatcat:xk5co6xixzbs3n7wnhc5xjkpv4

Sleep: The Tip of the Iceberg in the Bidirectional Link Between Alzheimer's Disease and Epilepsy

Anna B. Szabo, Benjamin Cretin, Fleur Gérard, Jonathan Curot, Emmanuel J. Barbeau, Jérémie Pariente, Lionel Dahan, Luc Valton
2022 Frontiers in Neurology  
An overwhelming majority of data suggests not only a higher prevalence of epilepsy in Alzheimer's disease compared to healthy aging, but also that AD patients with a comorbid epileptic syndrome, even subclinical  ...  The observation that a pathophysiological link might exist between Alzheimer's disease (AD) and epilepsy dates back to the identification of the first cases of the pathology itself and is now strongly  ...  However, once the macro-and microstructural damages reach a level where compensation is no longer possible, the disease seems to progress at an excessive speed, as is the case for AD patients with EA (  ... 
doi:10.3389/fneur.2022.836292 pmid:35481265 pmcid:PMC9035794 fatcat:22wz7czkxbddzmkflfuir6xf5i

Saturday, December 5, 2009�Poster Session 1�1:00 p.m.-8:00 p.m

2009 Epilepsia  
The exact anti-epileptic drug combination type was reviewed for all patients with femoral neck measurements taken. (N=152) and for all patients with lumbar spine measurments taken (N-148) .  ...  The drug group combination information was looked at in both normal femoral neck and lumbar spine measurement groups and with abnormal femoral neck and lumbar spine bone loss groups.  ...  DTI interrogates white matter integrity and measures the amplitude (diffusivity) and directionality (anisotropy) of diffusional motion.  ... 
doi:10.1111/j.1528-1167.2009.02377_1.x pmid:19817824 fatcat:75g2b4qnwrbrnpmcvebgz24dvq

ACNP 58th Annual Meeting: Poster Session III

2019 Neuropsychopharmacology  
All subjects participated in a magnetic resonance imaging (MRI) study and one [11C]PBR28 PET scan with arterial blood sampling to measure the metabolite-corrected parent input function. [11C]PBR28 binds  ...  In addition, based on the findings, we present the optimal strategies of treatment for AD.  ...  Structural brain measurements included cortical thickness, local cortical gyrification, and cortical and subcortical volumes in 47 brain regions. Gyrification is an index of deepness of sulci.  ... 
doi:10.1038/s41386-019-0547-9 pmid:31801974 pmcid:PMC6957926 fatcat:dd7d43ysfvc5bbbstfl73szya4

Abstracts From the 2008 International Stroke Conference

2008 Stroke  
In this post-hoc analysis we hypothesized that earlier treatment and exclusion of patients with high probability of poor outcome (massive hemorrhage volumes, substantial intraventricular hemorrhage [IVH  ...  of ICH patients may benefit from hemostatic therapy with rFVIIa.  ...  Control patients with no stroke or TIA were matched (3:1) on age, gender and region. Patients with 12 months of data prior to the index event were included.  ... 
doi:10.1161/strokeaha.107.100001 fatcat:77qgaaljhbdvdia4xmfzhuv6ie

Final Program, Fortieth Annual Meeting International Neuropsychological Society February 15–18, 2012 Montréal, Québec, Canada

2012 Journal of the International Neuropsychological Society  
The symposium is geared towards students with a focus on the unique challenges faced by junior investigators.  ...  In this symposium a panel of neuropsychologists will provide direction and insights towards developing a program of sustained externally funded research.  ...  MRI measures of total brain T2 lesion volume in improved, stable and worsened patients did not show any significant differences.  ... 
doi:10.1017/s1355617712000537 fatcat:4p2fkgxxzna3vcf3uxxgac6rsi

ACNP 55th Annual Meeting: Poster Session III

2016 Neuropsychopharmacology  
evaluation of these two radioligands in a healthy rhesus monkey brain.  ...  Both 11C-PS13 and 11C-MC1 showed good uptake in monkey brain (peak concentrations of 3-5 SUV) and washed out relatively quickly (demonstrating that the binding was reversible, as expected).  ...  Methods: Demonstrating that diffusion tensor imaging (DTI) tractography could be used to guide trans-synaptic activation of a deep brain target such as BA25 with cortical TMS required two separate MRI  ... 
doi:10.1038/npp.2016.242 fatcat:4efd43swjbboranfrcs3pp32h4

Final Program Forty Second Annual Meeting International Neuropsychological Society February 12–15, 2014 Seattle, Washington, USA

2014 Journal of the International Neuropsychological Society  
Also addressed will be "macro" issues germane to clinical trial design such as consideration of the state of existing knowledge and the challenges of specifying the active ingredients in the complex, learning-based  ...  what masking is and list at least methods of achieving optimal masking in a behavioral clinical trial; (3) Describe at least 3 phases of research that may be needed along the trajectory toward clinical  ...  Mean diffusivity (MD) and fractional anisotropy (FA) were obtained via DTI acquired at 3T to measure microstructural abnormalities in orbitofrontal white matter.  ... 
doi:10.1017/s1355617714000381 pmid:24666775 fatcat:6bwv7b2wjjez3beb3z5bryms6i
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