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Mining the literature for genes associated with placenta-mediated maternal diseases

Laritza M Rodriguez, Stephanie M Morrison, Kathleen Greenberg, Dina Demner Fushman
2018 AMIA Annual Symposium Proceedings  
To facilitate automatic extraction of information about placenta-mediated disorders from the literature, we manually annotated genes and proteins, the associated diseases, and the functions and processes  ...  involved in the development and function of placenta in a collection of PubMed/MEDLINE abstracts.  ...  Our long-term goal is to extract genes, gene pathways, biomarkers, and related events from the human placenta literature to create a specialized human placenta gene repository and to identify pathways  ... 
pmid:29854219 pmcid:PMC5977710 fatcat:j5ry7inw5zejtpamvt3qzceqgu

Differential Gene Expression Analysis of Placentas with Increased Vascular Resistance and Pre-Eclampsia Using Whole-Genome Microarrays

M. Centlow, C. Wingren, C. Borrebaeck, M. J. Brownstein, S. R. Hansson
2011 Journal of Pregnancy  
In the preeclamptic group compared to notch only, there was increased expression of genes related to chemotaxis and the NF-kappa B pathway and decreased expression of genes related to antigen processing  ...  and presentation, such as human leukocyte antigen B.  ...  Pro-inflammatory genes may drive the placenta towards PE, and protective genes may have the opposite effect.  ... 
doi:10.1155/2011/472354 pmid:21490790 pmcid:PMC3066560 fatcat:xmr6zw3kw5cwxbkl7tv6mxtkry

Cancer During Pregnancy: The Role of Vascular Toxicity in Chemotherapy-Induced Placental Toxicity

Hadas Bar-Joseph, Fedro Alessandro Peccatori, Tal Goshen-Lago, Fulvia Milena Cribiù, Giovanna Scarfone, Irit Miller, Luba Nemerovsky, Mattan Levi, Ruth Shalgi, Irit Ben-Aharon
2020 Cancers  
efficiency, and modulation in vascular-related pathways of treated placenta proteomics.  ...  The immunohistochemistry of the EPI-treated human placentae showed enhanced proliferation and apoptosis as compared with matched chemo-naïve placentae, as well as reduced neovascularization (CD34).  ...  The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.  ... 
doi:10.3390/cancers12051277 pmid:32443608 pmcid:PMC7281110 fatcat:luuje533mvbctduehqgposuv24

GEneSTATION 1.0: a synthetic resource of diverse evolutionary and functional genomic data for studying the evolution of pregnancy-associated tissues and phenotypes

Mara Kim, Brian A. Cooper, Rohit Venkat, Julie B. Phillips, Haley R. Eidem, Jibril Hirbo, Sashank Nutakki, Scott M. Williams, Louis J. Muglia, J. Anthony Capra, Kenneth Petren, Patrick Abbot (+2 others)
2015 Nucleic Acids Research  
phenotypes and to accelerate the translation of discoveries from model organisms to humans.  ...  For every human gene, GEneSTATION contains diverse evolutionary (e.g. gene age, population genetic and molecular evolutionary statistics), organismal (e.g. tissuespecific gene and protein expression, differential  ...  ACKNOWLEDGEMENTS We are grateful to the investigators of the March of Dimes Prematurity Research Center Ohio Collaborative, the March of Dimes leadership and boards of external reviewers, as well as to  ... 
doi:10.1093/nar/gkv1137 pmid:26567549 pmcid:PMC4702823 fatcat:73jbmb7qfzbghp2da5zrr6xpze

Evidence by molecular profiling for a placental origin of infantile hemangioma

C. M. Barnes, S. Huang, A. Kaipainen, D. Sanoudou, E. J. Chen, G. S. Eichler, Y. Guo, Y. Yu, D. E. Ingber, J. B. Mulliken, A. H. Beggs, J. Folkman (+1 others)
2005 Proceedings of the National Academy of Sciences of the United States of America  
We show here that the transcriptomes of human placenta and infantile hemangioma are sufficiently similar to suggest a placental origin for this tumor, expanding on recent immunophenotypical studies that  ...  The transcriptomes of placenta, hemangioma, and eight normal and diseased tissues were compared by hierarchical and nonhierarchical clustering analysis of >7,800 genes.  ...  Our data strongly support the hypothesis that hemangiomas are related to placenta in terms of the molecular portrait. But how could placental cells physically reach the fetus?  ... 
doi:10.1073/pnas.0509579102 pmid:16365311 pmcid:PMC1323205 fatcat:nf75robgp5fkro2jwfdxx55pee

Epigenetic Dysregulation of Trophoblastic Gene Expression in Gestational Trophoblastic Disease

Zoltan Szabolcsi, Amanda Demeter, Peter Kiraly, Andrea Balogh, Melissa L. Wilson, Jennifer R. King, Szabolcs Hetey, Zsolt Gelencser, Koji Matsuo, Beata Hargitai, Paulette Mhawech-Fauceglia, Petronella Hupuczi (+5 others)
2021 Biomedicines  
DNA methylation principally influences the gene expression of villous trophoblast differentiation-related or predominantly placenta-expressed genes in moles and choriocarcinoma cells.  ...  Here, we analyzed genome-wide DNA methylation and transcriptome data to reveal the epigenetic basis of disease pathways that may lead to benign or malignant GTDs.  ...  Acknowledgments: We thank Judit Baunoch, Diana Csala, Zsofia Feher, Nikolett Szenasi (Hungarian Academy of Sciences), Andras Matolcsy, Ilona Kovalszky, Dorottya Csernus-Horvath, Katalin Karaszi, (Semmelweis  ... 
doi:10.3390/biomedicines9121935 pmid:34944751 pmcid:PMC8698431 fatcat:ortzvl2vkze7ph6ndfscfb3nca

Gestational diabetes mellitus alters apoptotic and inflammatory gene expression of trophobasts from human term placenta

Thomas R. Magee, Michael G. Ross, Lauren Wedekind, Mina Desai, Siri Kjos, Louiza Belkacemi
2014 Journal of diabetes and its complications  
We hypothesize that reduced apoptosis in GDM placentas is caused by dysregulation of apoptosis related genes from death receptors or mitochondrial pathway or both to enhance placental growth in GDM pregnancies  ...  to non-diabetic Control placentas.  ...  In support of our hypothesis elevated circulating concentration of inflammatory cytokines and inflammation-related genes were observed in GDM placentas. 3 However, the exact pathophysiological relevance  ... 
doi:10.1016/j.jdiacomp.2014.03.010 pmid:24768206 pmcid:PMC4166519 fatcat:lv4s5mw4yvgj7bnfmi64xoooau

The levels of hypoxia-regulated microRNAs in plasma of pregnant women with fetal growth restriction

J.-F. Mouillet, T. Chu, C.A. Hubel, D.M. Nelson, W.T. Parks, Y. Sadovsky
2010 Placenta  
As expected, pregnancy was associated with increased plasma levels of several placenta-specific miRNAs, compared to non-pregnant controls.  ...  MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression at the posttranscriptional level.  ...  Larger, highthroughput analyses of plasma miRNAs are needed prior to application of these and similar discoveries to clinical care. Fig. 1.  ... 
doi:10.1016/j.placenta.2010.07.001 pmid:20667590 pmcid:PMC3204658 fatcat:j4mt4t5dqba7bjy2tqqczuvel4

The Expression of T-Helper Associated Transcription Factors and Cytokine Genes in Pre-Eclampsia

Behrouz Gharesi-Fard, Fatemeh Mobasher-Nejad, Fatemeh Nasri
2016 Iranian journal of immunology : IJI  
To investigate differences in the levels of transcription factors and cytokine gene expression of Th1/Th2/Th17/Treg subsets within decidual and chorionic layers of placentas from 15 PE-afflicted and 15  ...  Our results shed more light on the contribution of Th1/Th2/Th17/Treg balance within placenta in the fate of a normal pregnancy.  ...  After the PCR reaction completed, the data were automatically analyzed by the instrument software and the copy number of the target genes and internal control genes in the samples were calculated.  ... 
pmid:27999241 fatcat:sf2rqfbo2bgw5b3lu7o2eluejm

Usutu Virus Infects Human Placental Explants and Induces Congenital Defects in Mice

Hélène Martin, Jonathan Barthelemy, Yamileth Chin, Mathilde Bergamelli, Nathalie Moinard, Géraldine Cartron, Yann Tanguy Le Gac, Cécile E. Malnou, Yannick Simonin
2022 Viruses  
To evaluate the ability of USUV to replicate in the placenta and gain access to the fetus, we combined the use of several trophoblast model cell lines, ex vivo human placental explant cultures from first  ...  are closely related to USUV.  ...  We greatly thank the whole ViNeDys team, for their numerous suggestions and discussions which facilitated the progress of this work, and Daniel Gonzalez-Dunia for critical reading of the manuscript.  ... 
doi:10.3390/v14081619 pmid:35893684 pmcid:PMC9330037 fatcat:amo6zvblgbconf7yppco2fhaam

Minor Histocompatibility Antigens Are Expressed in Syncytiotrophoblast and Trophoblast Debris

Olivia J. Holland, Caitlin Linscheid, Herbert C. Hodes, Traci L. Nauser, Melissa Gilliam, Peter Stone, Larry W. Chamley, Margaret G. Petroff
2012 American Journal of Pathology  
We mapped the expression of four mHAgs (human mHAg 1, pumilio domain-containing protein KIAA0020, B-cell lymphoma 2-related protein A1, and ribosomal protein S4, Y linked) in the placenta.  ...  The finding of mHAgs in the placenta and in trophoblast debris provides the first direct evidence that fetal antigens are present in debris shed from the human placenta.  ...  the Center for Women's Health (Overland Park, KS); the University of Chicago Department of Obstetrics and Gynecology; the Epsom Day Unit, Greenlane Clinical Centre (Auckland, New Zealand); and the Auckland  ... 
doi:10.1016/j.ajpath.2011.09.021 pmid:22079431 pmcid:PMC3338347 fatcat:ctpexdt5gbeivcljett2spqpgi

Comparative analysis of mouse and human placentae across gestation reveals species-specific regulators of placental development

Francesca Soncin, Marwa Khater, Cuong To, Donald Pizzo, Omar Farah, Anna Wakeland, Kanaga Arul Nambi Rajan, Katharine K. Nelson, Ching-Wen Chang, Matteo Moretto-Zita, David R. Natale, Louise C. Laurent (+1 others)
2018 Development  
Genomewide expression profiling of mouse and human placentae revealed clusters of genes with distinct co-expression patterns across gestation.  ...  An increasing body of evidence points to significant spatio-temporal differences in early placental development between mouse and human, but a detailed comparison of placentae in these two species is missing  ...  to the human placenta.  ... 
doi:10.1242/dev.156273 pmid:29361559 fatcat:rrlgzog5jje3bndkgvas7s35nq

DNA Microarrays: a Powerful Genomic Tool for Biomedical and Clinical Research

Victor Trevino, Francesco Falciani, Hugo A. Barrera-Saldaña
2007 Molecular Medicine  
School for additional laboratory training; Albert Sasson for critical reading of the manuscript and the offices of the Dean of his school and of the President of his University for support.  ...  ACKNOWLEDGMENTS HABS thanks the Staff of the Microarray Technology EMBO-INER Advanced Practical Course for enjoyable course lessons, materials and results; Peter Davies, Nancy and Greg Shipley of UT Medical  ...  To identify genes specific for human placenta, we used a two-color microarray.  ... 
doi:10.2119/2006-00107.trevino pmid:17660860 pmcid:PMC1933257 fatcat:5wd6d6w67bapfl33lkcbisuu3a

In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta

Maria Pernemalm, AnnSofi Sandberg, Yafeng Zhu, Jorrit Boekel, Davide Tamburro, Jochen M Schwenk, Albin Björk, Marie Wahren-Herlenius, Hanna Åmark, Claes-Göran Östenson, Magnus Westgren, Janne Lehtiö
2019 eLife  
the mother and the newborn as well as changes related to pregnancy.  ...  between mother and fetus across the placenta.  ...  We then expanded the criteria and searched for FDA-approved drug targets, cancer-related proteins and possible tissue leakage proteins, all classified according to the Human Protein Atlas (HPA) (Uhle  ... 
doi:10.7554/elife.41608 pmid:30958262 pmcid:PMC6519984 fatcat:pjfvf2voh5gylll2plt54zzzda

An imaging workflow for characterizing phenotypical change in large histological mouse model datasets

Kishore Mosaliganti, Tony Pan, Randall Ridgway, Richard Sharp, Lee Cooper, Alex Gulacy, Ashish Sharma, Okan Irfanoglu, Raghu Machiraju, Tahsin Kurc, Alain de Bruin, Pamela Wenzel (+3 others)
2008 Journal of Biomedical Informatics  
The specific application is a study of the morphological change in a mouse placenta induced by knocking out the retinoblastoma gene.  ...  Motivation: This paper presents a workflow designed to quantitatively characterize the 3D structural attributes of macroscopic tissue specimens acquired at a micron level resolution using light microscopy  ...  Acknowledgments This work was supported in part by funding from the National Institutes of Health NIBIB BISTI P20-EB000591, and The National Science Foundation (Grants CNS-0615155 and CNS-0509326).  ... 
doi:10.1016/j.jbi.2008.03.013 pmid:18502696 pmcid:PMC2657595 fatcat:manfzwyk5vag3kjhy7ykpgntei
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