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DNA aptamer technology for personalized medicine

Hang Xing, Kevin Hwang, Ji Li, Seyed-Fakhreddin Torabi, Yi Lu
2014 Current Opinion in Chemical Engineering  
Examples include design of aptamers in combination with DNA nanostructures, nanomaterials, or microfluidic devices as diagnostic probes or therapeutic agents for cancers and other diseases.  ...  This review highlights recent progress in developing DNA aptamers for personalized medicine, with more focus on in vivo studies for potential clinical applications.  ...  Acknowledgments We thank the US National Institute of Health (ES016865) and the National Science Foundation (DMR-0117792, CTS-0120978 and DMI-0328162) for financial support.  ... 
doi:10.1016/j.coche.2014.01.007 pmid:24791224 pmcid:PMC4001932 fatcat:mtbhfw2ypff43c74bpzaauy2jy

ABC of clinical haematology: The future of haematology, molecular biology, and gene therapy

A. K Fielding, S. Ager, S. J Russell
1997 BMJ (Clinical Research Edition)  
The major advances in scientific thought and technological development that have already changed the practice of modern haematology are likely to affect both laboratory diagnosis and treatment in the future  ...  not yet resulted in improved treatment.  ...  them to integrate directly into haemopoietic cells In vivo Ex vivo and in vivo gene transfer strategies.  ... 
doi:10.1136/bmj.314.7091.1396 pmid:9161316 pmcid:PMC2126638 fatcat:bqubibyrcjcqnazm55isa4hg7e

Can Bacteriocins Curb the Emergence of Antibiotic Resistant Pathogenic Bacteria in the Globe?

Shyamapada Mandal
2018 Current Trends in Biomedical Engineering & Biosciences  
The latest DNA typing technologies allow timely genome wide scans [7] . Hence, medical applications for better diseases' diagnosis, treatment, and prevention" are rapidly developing.  ...  The use of DNA sequencing in the investigation of infectious disease outbreaks, including Ebola virus, drug-resistant strains of Staphylococcus aureas and Klebsiellapneumoniae, as well as diagnosis of  ... 
doi:10.19080/ctbeb.2018.17.555964 fatcat:rt5cma4e7vdjbelsbwehw5x6gi

Genomic profiling and directed ex vivo drug analysis of an unclassifiable myelodysplastic/myeloproliferative neoplasm progressing into acute myeloid leukemia

Axel Hyrenius-Wittsten, Helena Sturesson, Mahtab Bidgoli, Tord Jonson, Mats Ehinger, Henrik Lilljebjörn, Stefan Scheding, Anna K. Andersson
2016 Genes, Chromosomes and Cancer  
We found that that the patient´s AML cells were sensitive towards inhibition of MEK ex vivo, suggesting a potential clinical benefit of this treatment.  ...  treatment modalities for the patient using US Food and Drug administration (FDA) approved compounds.  ... 
doi:10.1002/gcc.22384 pmid:27240832 fatcat:agl2gwlmljbq5kg2sls3u634ka

P11.08 Systematic drug repurposing for faster cures of pediatric cancer identifies that Digoxin prolongs survival in a PDOX model of group 4 medulloblastoma

L. Huang, S. G. Injac, H. Zhao, Q. Lin, M. Kogiso, C. Man, X. Li, C. Lau, S. T. C. Wong
2017 Neuro-Oncology  
Considering the high rate of recurrence of these tumors and the limited impact on disease control of the following treatments, BRAF V600E detection is essential for a new therapeutic approach of poor responsive  ...  diseases.  ...  vitro and in vivo.  ... 
doi:10.1093/neuonc/nox036.352 fatcat:zgjrlypkczefnb6gc5fny5yzha

Image Guided Biodistribution of Drugs and Drug Delivery

Hong Ding, Fang Wu
2012 Theranostics  
for chemotherapeutic reagents or DNA delivery.  ...  The application of these new materials and techniques with combined properties of diagnosis and therapy can benefit the development of targeted drug delivery system and modern personalized medicine This  ...  The achievements in theranostics will encourage not only the quick diagnosis on disease but also facilitate the treatment strategy from generalized medicine towards personalized regimen.  ... 
doi:10.7150/thno.5321 pmid:23227120 pmcid:PMC3516835 fatcat:znpexqffwrb4tcl2n675s5rg5m

At the Heart of Genome Editing and Cardiovascular Diseases

Reyna Hernandez-Benitez, Maria Llanos Martinez-Martinez, Jeronimo Lajara, Pierre Magistretti, Nuria Montserrat, Juan Carlos Izpisua Belmonte
2018 Circulation Research  
, but more importantly, may represent tools for CVD early diagnosis, patient stratification, and treatment.  ...  Use of these genetic tools has greatly enhanced our mechanistic understanding of the CV system and CVD, but the number of studies attempting to use these technologies towards the treatment of CV disorders  ... 
doi:10.1161/circresaha.118.312676 pmid:29976689 fatcat:ltv2akbecfamxckccbrefmjf2m

Nanoneuromedicine for management of neurodegenerative disorder

Nitin Dwivedi, Jigna Shah, Vijay Mishra, Murtaza Tambuwala, Prashant Kesharwani
2019 Journal of Drug Delivery Science and Technology  
Single walled carbon nanohorns (CNHs) are graphene-based tubules having 25 nm diameter and 4050 nm length. In medical field, their potential uses are in drug delivery, diagnosis, and clinical tests.  ...  Nanotechnological approaches involve various nano-sized carrier systems and other devices, which stimulate the action of therapeutic agents on molecular level and revolutionized the treatment and diagnosis  ...  In the case of QD and NTs, repeated in-vivo toxicity limited their future use at the level of in vitro diagnosis.  ... 
doi:10.1016/j.jddst.2018.12.021 fatcat:x4tvgumam5edzkpafw2x7rejgu

Nanoscience in diagnostics: A short review

GA Menezes, PS Menez, C Meneze
2011 Internet Journal of Medical Update  
This brief review tries to reiterate the most contemporary developments in the field of applied nanoscience, particularly in their relevance in diagnosis of various diseases and discuss their future prospects  ...  The use of nanoscience may open new vistas of improving the effectiveness and efficiency of medical diagnosis and therapeutics, so called nanomedicine.  ...  Nanotechnology is already starting to have an impact on the diagnosis, treatment and prevention of disease, especially by enabling early disease detection and diagnosis, as well as precise and effective  ... 
doi:10.4314/ijmu.v6i1.63971 fatcat:mknw5ffixrhp3gqqjkuemsbdqq

Genetic heterogeneity and clonal evolution in neuroblastoma

J Mora, N-K V Cheung, W L Gerald
2001 British Journal of Cancer  
In this report we use 1p allelic analysis and DNA ploidy to evaluate clonal heterogeneity and clonal selection in vivo.  ...  Standard treatment consisted of surgical resection for patients with local-regional disease (stages 1, 2 and 3) and the use of N6 or N7 multimodality protocols for patients with stage 4 disease as previously  ...  more sensitive to cytotoxic treatments than 1p-intact ones. Differential proliferative rates may explain their different chemosensitivity.  ... 
doi:10.1054/bjoc.2001.1849 pmid:11461074 pmcid:PMC2364052 fatcat:mhr57mbijffanjxbjbcj5og7ha

Current Advances in the Application of Raman Spectroscopy for Molecular Diagnosis of Cervical Cancer

Inês Raquel Martins Ramos, Alison Malkin, Fiona Mary Lyng
2015 BioMed Research International  
In addition to the diagnostic potential, promising results for HPV detection and monitoring treatment response suggest more than just a diagnosis prospective.  ...  This review summarizes the key research in the area and the evidence compiled is very encouraging for ongoing and further research.  ...  The identification and further understanding of these changes would allow improved diagnosis and treatments, as well as overall management and disease survival.  ... 
doi:10.1155/2015/561242 pmid:26180802 pmcid:PMC4477184 fatcat:o3m55boemjcz3i4lzywvqugjui

Application of aptamers in diagnostics, drug-delivery and imaging

Chetan Chandola, Sheetal Kalme, Marco G Casteleijn, Arto Urtti, Muniasamy Neerathilingam
2016 Journal of Biosciences  
In this review we will discuss about the latest developments in using aptamers in diagnostics, drug delivery and imaging.  ...  Hence, we discuss their use in targeted delivery in conjugation with siRNAs, nanoparticles, liposomes, drugs and antibodies.  ...  Acknowledgement We would like to acknowledge contribution of Lakshmi Narayanan Gopalan for preparation of a figure in the article.  ... 
doi:10.1007/s12038-016-9632-y pmid:27581942 fatcat:2camhhefgjayxhacai4sm3hqvq

Functionalized Nanomaterials as Tailored Theranostic Agents in Brain Imaging

Ramar Thangam, Ramasamy Paulmurugan, Heemin Kang
2021 Nanomaterials  
Moreover, the beneficial aspects of nano-theranostics of nanoparticles are their multifunctional systems proportioned towards personalized disease management via comprising diagnostic and therapeutic abilities  ...  Functionalized nanomaterials of various categories are essential for developing cancer nano-theranostics for brain diseases; however, some limitations exist in their effectiveness and clinical translation  ...  It plays a prominent role in disease diagnosis and therapeutic monitoring outcomes in vivo [27] .  ... 
doi:10.3390/nano12010018 fatcat:fv5qlpduibgulphmdacc3qwvmq

Potential applications of peptide nucleic acid in biomedical domain

Kshitij RB Singh, Parikipandla Sridevi, Ravindra Pratap Singh
2020 Engineering Reports  
Hence, to date, many methods utilizing PNA for diagnosis and treatment of various diseases namely cancer, AIDS, human papillomavirus, and so on, have been designed and developed.  ...  They are being used widely in polymerase chain reaction modulation/mutation, fluorescent in-situ hybridization, and in microarray as a probe; they are also utilized in many in-vitro and in-vivo assays  ...  PROPERTIES Properties of PNAs offer vast applications in the field of biomedical research, including diagnosis using in vivo imaging and biosensors; in therapeutics used for antisense and antigene therapies  ... 
doi:10.1002/eng2.12238 pmid:32838227 pmcid:PMC7404446 fatcat:bqkvmvkvlbc3ze6v2mg54wcxky

Nanotechnology in diagnostics and therapeutics for gastrointestinal disorders

Hamed Laroui, Poonam Rakhya, Bo Xiao, Emilie Viennois, Didier Merlin
2013 Digestive and Liver Disease  
This review describes the state of the art in nanoparticle and nanodevice applications for medical diagnosis and disease treatment.  ...  during treatment, and reducing treatment expenses.  ...  Such techniques can potentially be used to adjust dosage towards treatment optimization. smart phones) and provides a customized and real time diagnosis on a disease blood markers.  ... 
doi:10.1016/j.dld.2013.03.019 pmid:23660079 pmcid:PMC3970315 fatcat:wexlcqlosvhcxns6avnwynexfa
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