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Kartagener's Syndrome and Rheumatoid Arthritis

Satoshi Takasaki, Shu Yamakage, Sachiko Fukase, Toshiyuki Takahashi
2014 Internal medicine (Tokyo. 1992)  
We herein present the case of a 47-year-old woman with rheumatoid arthritis (RA) complicated by Kartagener's syndrome (KS). Although her RA disease activity score (DAS28-CRP) decreased following the administration of periodontitis treatment and etanercept, she did not achieve symptom relief or DAS28-CRP remission. After undergoing surgery for chronic sinusitis, her articular symptoms improved and the DAS28-CRP declined to the level of remission. Patients with KS may develop respiratory
more » ... s due to an impaired defense mechanism against microbes in the airway. Therefore, in patients with RA complicated by KS, comprehensive management of infection, including surgical therapy for sinusitis, is needed to reduce the RA disease activity.
doi:10.2169/internalmedicine.53.1262 pmid:24492699 fatcat:h2m7ujol6bhezix7fn3ftexfvq

Basic indexes and Aluthge transformation for 2 by 2 matrices

Toshiyuki Takasaki
2008 Mathematical Inequalities & Applications  
BASIC INDEXES AND ALUTHGE TRANSFORMATION FOR 2 BY 2 MATRICES TOSHIYUKI TAKASAKI Abstract.  ... 
doi:10.7153/mia-11-51 fatcat:gvl6bms5snaazpz5us2bokxegm

Biodegradation of phenylmercuric acetate by organomercury-resistant Penicillium sp. MR-2

Toshiyuki TEZUKA, Yoshiyuki TAKASAKI
1988 Agricultural and Biological Chemistry  
doi:10.1271/bbb1961.52.3183 fatcat:owhpexxa6baurly2grgyvspsye

Supporting multilingual discussion for collaborative translation

Noriyuki Ishida, Donghui Lin, Toshiyuki Takasaki, Toru Ishida
2012 2012 International Conference on Collaboration Technologies and Systems (CTS)  
In recent years, collaborative translation has become more and more important for translation volunteers to share knowledge among different languages, among which Wikipedia translation activity is a typical example. During the collaborative translation processes, users with different mother tongues always conduct frequent discussions about certain words or expressions to understand the content of original article and to decide the correct translation. To support such kind of multilingual
more » ... ions, we propose an approach to embedding a serviceoriented multilingual infrastructure with discussion functions in collaborative translation systems, where discussions can be automatically translated into different languages with machine translators, dictionaries, and so on. Moreover, we propose a Meta Translation Algorithm to adapt the features of discussions for collaborative translation, where discussion articles always consist of expressions in different languages. Further, we implement the proposed approach on LiquidThreads, a BBS on Wikipedia, and apply it for multilingual discussion for Wikipedia translation to verify the effectiveness of this research.
doi:10.1109/cts.2012.6261055 dblp:conf/cts/IshidaLTI12 fatcat:fudub6v44jhptn57jhi6xrnowu

Taste Impairment and Compliance Improvement of Branched-Chain Amino Acids in Patients with Liver Cirrhosis

Atsushi Naganuma, Department of Gastroenterology, Takasaki General Medical Center, National Hospital Organization, Gunma, Japan, Satoru Kakizaki, Takashi Hoshino, Toshiyuki Tanaka, Tetsushi Ogawa, Tomoki Araki, Shuya Sawada, Satomi Adachi, Yusuke Ogawa, Toyoshi Sasaki, Ken Sato (+14 others)
2018 OBM Hepatology and Gastroenterology  
This study was approved by the Institutional Review Board of Takasaki General Medical Center (Takasaki, Japan).  ...  These chronic liver disease patients were diagnosed in Takasaki General Medical Center.  ... 
doi:10.21926/obm.hg.1804011 fatcat:65xlomvusnfjnhi5x4nqqkgt2i

Fine Structure and Morphogenesis of Borna Disease Virus

Takehiro Kohno, Toshiyuki Goto, Tomohiko Takasaki, Chizuko Morita, Takaaki Nakaya, Kazuyoshi Ikuta, Ichiro Kurane, Kouichi Sano, Masuyo Nakai
1999 Journal of Virology  
Borna disease virus (BDV), a negative nonsegmented single-stranded RNA virus, has not been fully characterized morphologically. Here we present what is to our knowledge the first data on the fine ultrastructure and morphogenesis of BDV. The supernatant of MDCK cells persistently infected with BDV treated with n-butyrate contained many virus-like particles and more BDV-specific RNA than that of untreated samples. The particles were spherical, enveloped, and approximately 130 nm in diameter; had
more » ... pikes 7 nm in length; and reacted with BDV p40 antibody. A thin nucleocapsid, 4 nm in width, was present peripherally in contrast to the thick nucleocapsid of hemagglutinating virus of Japan. The BDV particles reproduced by budding on the cell surface.
doi:10.1128/jvi.73.1.760-766.1999 fatcat:khpzo3erobhipgtwqpv2dpq7ba

Human detection of cultural differences in pictogram interpretations

Heeryon Cho, Toru Ishida, Naomi Yamashita, Tomoko Koda, Toshiyuki Takasaki
2009 Proceeding of the 2009 international workshop on Intercultural collaboration - IWIC '09  
. † † Tomoko Koda, Department of Information Science and Technology, Osaka Institute of Technology, Osaka 573-0196, Japan. koda@is.oit.ac.jp † † † Toshiyuki Takasaki, Kyoto R&D Center, NPO Pangaea, Kyoto  ... 
doi:10.1145/1499224.1499250 fatcat:yk2jxkqryrbnhiwvhiwhk74fvq

Field and Weather Monitoring with Youths as Sensors for Agricultural Decision Support

Takashi Togami, Seishi Ninomiya, Kyosuke Yamamoto, Yumiko Mori, Toshiyuki Takasaki, Yasukazu Okano, Ryoichi Ikeda, Akane Takezaki, Takaharu Kameoka
2012 Agricultural Information Research  
In Vietnam, proper and continual agricultural engineering guidance for local farmers is required to improve rice cultivation and conserve environment, yet there are issues in the low literacy rate of adults and information dissemination. In order to resolve the issues, the YMC-Viet project, based on the Youth Mediated Communication (YMC) model in which youths mediate communication between local farmers and agricultural experts in remote locations, was proposed. It is inadequate only to
more » ... lly extract problems from farmers and provide guidance. Advice can be further optimized by providing local quantitative data to agricultural experts. Accordingly, information collection to accurately comprehend local environmental conditions and the rice growth situation is indispensable. However, there is no weather station in the target area and environmental information is severely lacking. In addition, the number of agricultural experts in the area is extremely low and gaining an understanding of the field situation is almost impossible. In this research, therefore, we devised a method to regularly collect environmental and field situation information, by having youths working as weather and field sensors, and utilizing the collected data for agricultural decisions supported by agricultural experts in remote locations, and its efficacy was verified. Then, we created a cultivation knowledge resource and applied it as a contrivance for youths to adequately inform agricultural experts about field growth situations based on collected information. As a result of the experiment, it was revealed that youths met more than 85 percent of the requirements of temperature and humidity measurement and weather observation. Additionally, the data collected and the records showed higher potential by agricultural experts for utilizing the data in agricultural decision support. Moreover, it was confirmed that sometimes youths functioned as disorder and defect detectors. Thus, the efficacy of youths as sensors in terms of collecting information for agricultural support was verified.
doi:10.3173/air.21.65 fatcat:gwuge5m3szhqhpl37kgrxvvxli

A metabolism-based approach to elucidating the mechanism of liver dysfunction induced by troglitazone

Yasushi YOSHIGAE, Toshiyuki WATANABE, Kumiko KOYAMA, Wataru TAKASAKI, Sunao MANABE, Toshihiko IKEDA
2001 Drug Metabolism and Pharmacokinetics  
Yasushi YOSHIGAE', Toshiyuki WATANABE2, Kumiko KOYAMA', Wataru TAKASAKI', Sunao MANABEZ and Toshihiko IKEDA' 1, Pharmacokinetics and Drug Delivery Research Laboratories, Sankyo Co., Ltd., 2-58, Hiromachi  ... 
doi:10.2133/dmpk.16.supplement_140 fatcat:dsm2fmowf5hthnu4j2tmphdyyq

Ⅰ-3. Radioactivity related survey in fish inhabiting lakes
Ⅰ-3. 湖沼に棲息する魚類における放射能関連調査

KAZUYOSHI TAKASAKI, TOSHIHIRO WADA, ATSUSHI TOMIYA, DAIGO MORISHITA, TOSHIYUKI SATO, GYO KAWATA, SHUNJI SUZUKI
2017 Nippon Suisan Gakkaishi  
Radioactivity related survey in sh inhabiting lakes KAZUYOSHI TAKASAKI, 1 TOSHIHIRO WADA, 2 ATSUSHI TOMIYA, 3a DAIGO MORISHITA, 1b TOSHIYUKI SATO, 1 GYO KAWATA 1 AND SHUNJI SUZUKI 1b 1 Fukushima  ... 
doi:10.2331/suisan.wa2446-4 fatcat:wshajcwdnjal7eedkgzufxouq4

Macrophage Infiltration into the Glomeruli in Lipoprotein Glomerulopathy

Satoshi Takasaki, Kunihiko Maeda, Kensuke Joh, Shu Yamakage, Sachiko Fukase, Toshiyuki Takahashi, Masayuki Suzuki, Akira Matsunaga, Takao Saito
2015 Case Reports in Nephrology and Dialysis  
Karger AG, Basel www.karger.com/cnd Takasaki et al.: Macrophage Infiltration into the Glomeruli in Lipoprotein Glomerulopathy Fig. 1.  ...  Karger AG, Basel www.karger.com/cnd Takasaki et al.: Macrophage Infiltration into the Glomeruli in Lipoprotein Glomerulopathy Fig. 2. Electron microscopic findings of the first biopsy.  ... 
doi:10.1159/000441715 pmid:26955632 pmcid:PMC4777904 fatcat:su4kbd7pgzdx5omagwwpprjxa4

GaAs0.5Sb0.5 Layers Grown on (111)B InP Substrates by MBE
InP(111)B基板上へのGaAs0.5Sb0.5層の分子線エピタキシャル成長

Toshiyuki HIGASHINO, Yuichi KAWAMURA, Atsushi KONDO, Masato FUJIMOTO, Hideki TAKASAKI, Naohisa INOUE
2001 Shinku  
doi:10.3131/jvsj.44.183 fatcat:3asqk5qksjb35lgf36ha3saf4m

Activation of Rheb, but not of mTORC1, impairs spine synapse morphogenesis in tuberous sclerosis complex

Shin Yasuda, Hiroko Sugiura, Shutaro Katsurabayashi, Tadayuki Shimada, Hidekazu Tanaka, Kotaro Takasaki, Katsunori Iwasaki, Toshiyuki Kobayashi, Okio Hino, Kanato Yamagata
2014 Scientific Reports  
Mutations in the Tsc1 or Tsc2 genes cause tuberous sclerosis complex (TSC). Tsc1 and Tsc2 proteins form a complex that inhibits mammalian target of rapamycin complex 1 (mTORC1) signalling through Rheb-GTPase. We found that Tsc2 1/2 neurons showed impaired spine synapse formation, which was resistant to an mTORC1 inhibitor. Knockdown of mTOR also failed to restore these abnormalities, suggesting mTORC may not participate in impaired spinogenesis in Tsc2 1/2 neurons. To address whether Rheb
more » ... tion impairs spine synapse formation, we expressed active and inactive forms of Rheb in WT and Tsc2 1/2 neurons, respectively. Expression of active Rheb abolished dendritic spine formation in WT neurons, whereas inactive Rheb restored spine synapse formation in Tsc2 1/2 neurons. Moreover, inactivation of Rheb with farnesyl transferase inhibitors recovered spine synapse morphogenesis in Tsc2 1/2 neurons. In conclusion, dendritic spine abnormalities in TSC neurons may be caused through activation of Rheb, but not through of mTORC1. I n the mammalian brain, dendritic spines make most excitatory synapses. During development, synapse formation and elimination are accompanied by changes in dendritic spine number and morphology, allowing the establishment and remodelling of neuronal circuits. Structural plasticity of dendritic spines is tightly correlated with synaptic function and plasticity; even subtle changes in dendritic spines may have marked effects on synaptic plasticity. In particular, a large number of brain disorders, including developmental disorders are accompanied by disease-related changes in dendritic spine density and/or morphology. Tuberous sclerosis complex (TSC) is a systemic genetic disease that causes the growth of hamartomas in the brain and other organs 1 . The neurological symptoms of TSC include mental retardation, intractable epilepsy, and autism 1 . TSC results from inactivating mutations in either Tsc1 2 or Tsc2 3 , which encode hamartin and tuberin, respectively. Hamartin and tuberin form a complex that exhibits guanosine triphosphatase (GTPase)-activating protein (GAP) activity toward Rheb, a Ras-like small G-protein 4-6 . Inactivating mutations in Tsc1 or Tsc2 result in the accumulation of the GTP-bound form of Rheb, which activates mammalian target of rapamycin complex 1 (mTORC1) 7 . The mTOR is a serine/threonine protein kinase that stimulates translation initiation processes involving both eIF4E/4E-binding protein (4EBP) and p70S6 kinase/ribosomal S6 protein. Mouse models that harbor a mutation in the Tsc1 or Tsc2 genes have been extensively investigated to clarify the mechanisms of the pathogenesis of TSC. Several lines of evidence suggest that these TSC model mice exhibit impairments in dendritic spine formation 8 , long-term depression and cognitive behaviors 9 , suggesting that activation of mTORC1 in TSC neurons may cause memory disturbance probably through dendritic spine abnormalities. However, the mTOR signaling has been demonstrated to be activated during learning and is required for spatial memory formation 10 . This controversy may suggest that another mechanism other than the mTOR signaling could be involved in memory impairment in TSC. In the present study, we first confirmed that dendritic spine formation was abrogated and also excitatory spine synapses were drastically reduced in cultured rat Tsc2 1/2 neurons. This observation was consistent with the finding that filopodia-like protrusions were increased in Tsc2 1/2 rat brain. We treated cultured Tsc2 1/2 neurons with rapamycin, a specific mTORC1 inhibitor; however, it did not restore spine morphology but rather elongated dendritic protrusions. Knockdown of mTOR did not restore spine synapse formation either, suggesting that the mTORC pathway may not participate in spine synapse morphogenesis. We therefore focused on Rheb upstream OPEN SUBJECT AREAS: MOLECULAR NEUROSCIENCE DISEASES
doi:10.1038/srep05155 pmid:24889507 pmcid:PMC4042127 fatcat:wuudzyul3vafvbjxb5syx6nkwu

Ⅰ-4. The current status of radioactive contamination of fish in river
Ⅰ-4. 河川に棲息する魚類における放射能汚染の現状

DAIGO MORISHITA, TOSHIHIRO WADA, KAZUYOSHI TAKASAKI, TOSHIYUKI SATO, GYO KAWATA, SHUNJI SUZUKI
2017 Nippon Suisan Gakkaishi  
図 1 地域のカテゴリー概略図 Nippon Suisan Gakkaishi 83(5), 806 (2017) シンポジウム記録 福島の淡水域における放射能汚染と魚類に及ぼす影響これまでとこれから  4. 河川に棲息する魚類における 放射能汚染の現状 森下大悟, 1a 和田敏裕, 2 鷹o和義, 1 佐藤利幸, 1 川田 暁, 1 鈴木俊二 1a 1 福島県内水面水産試験場, 2 福島大学環境放射能研究所  4. The current status of radioactive contamination ofˆsh in river DAIGO MORISHITA, 1a TOSHIHIRO
doi:10.2331/suisan.wa2446-5 fatcat:jbof7idkmzbsfgce5xfuhi7abu

通信技術を用いた野生動物の位置探索システムの開発
Development of wild animal tracking systems with communication technology

Ikuo MISUMI, Rie NAGATO, Toshiyuki TAKASAKI, Emiko MORISHITA, Hiroyoshi HIGUCHI, Ken SASAKI, Ikutaro KOBAYASHI, Hiroshi HOSAKA, Kiyoshi ITAO
2002 Micromechatronics  
A8 wid animal tracking systems , positiQning systems with GPS and PHS techno 互 ogie 蠢 have advantages against conven 魔onal technologies in terms of accuracy etc ! On the other side , these When devices systems require more power consu 皿 ption and this results in a device weight increase. attached to anilnals , the weight of them 8hould be hlnited. Therefore, in designing a tracking system ,
doi:10.20805/micromechatronics.46.3_1 fatcat:zfol4nu63ne67kywyuhs5mwk5a
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