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Tools enabling the elucidation of molecular pathways active in human disease: application to Hepatitis C virus infection

David J Reiss, Iliana Avila-Campillo, Vesteinn Thorsson, Benno Schwikowski, Timothy Galitski
2005 BMC Bioinformatics  
This integrated data set in turn enabled simple analyses to yield hypotheses related to the response to Hepatitis C viral infection.  ...  We applied these techniques to extract, from genomic expression data from Hepatitis C virus-infected liver tissue, potentially useful hypotheses related to the onset of this disease.  ...  and Babylaksmi Muthusamy for their help in providing the HPRD interactions in a machine-readable format.  ... 
doi:10.1186/1471-2105-6-154 pmid:15967031 pmcid:PMC1181626 fatcat:bnh4jkkpjbaixaixm67r4eowbu

The Clinical Application of MicroRNAs in Infectious Disease

Ruth E. Drury, Daniel O'Connor, Andrew J. Pollard
2017 Frontiers in Immunology  
Elucidating the roles miRNAs in host response to infectious disease is inherently interesting at it provides a tool for identifying key genes and pathways that must be activated, enhanced, repressed, or  ...  Viruses such as enterovirus, CMV, human papilloma virus, hepatitis B virus (HBV), and HCV, manipulate the expression of specific cellular miRNAs to inhibit translation of proinflammatory proteins (16,  ... 
doi:10.3389/fimmu.2017.01182 pmid:28993774 pmcid:PMC5622146 fatcat:l5cvmbeyhfgbpoenizvkeyv2fm

Accelerating Next-Generation Vaccine Development for Global Disease Prevention

W. C. Koff, D. R. Burton, P. R. Johnson, B. D. Walker, C. R. King, G. J. Nabel, R. Ahmed, M. K. Bhan, S. A. Plotkin
2013 Science  
However, past strategies for vaccine development are unlikely to succeed in the future against major global diseases such as AIDS, TB, and malaria.  ...  Vaccines are among the greatest successes in the history of public health.  ...  Acknowledgments The authors acknowledge the assistance of Sandi Glass, Lisa Gieber, Olga Shmaidenko, Michelle Dees and Bill Hayes in the preparation of this manuscript.  ... 
doi:10.1126/science.1232910 pmid:23723240 pmcid:PMC4026248 fatcat:ltxjup67qnhwpccmdwggyom7ee

Zebrafish as a disease model for studying human hepatocellular carcinoma

Jeng-Wei Lu
2015 World Journal of Gastroenterology  
Multiple risk factors are highly correlated with HCC, including infection with the hepatitis B or C viruses, alcohol abuse, aflatoxin exposure, and metabolic diseases.  ...  This review will focus on illustrative examples involving the application of zebrafish models to the study of human liver disease and HCC, through transgenesis, genome editing technology, xenografts, drug  ...  Hepatocellular carcinoma (HCC) formation results from multiple risk factors, including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, alcohol, Aflatoxin, and metabolic diseases.  ... 
doi:10.3748/wjg.v21.i42.12042 pmid:26576090 pmcid:PMC4641123 fatcat:zqawvobzdvdrnhkeioirt5ndvq

Engineering DNA vaccines against infectious diseases

Jihui Lee, Shreedevi Arun Kumar, Yong Yu Jhan, Corey J. Bishop
2018 Acta Biomaterialia  
Despite improvement, to the extent of our knowledge, there are currently no regulatory body-approved DNA vaccines for human use (four vaccines approved for animal use).  ...  This article discusses engineering DNA vaccines against infectious diseases while discussing advantages and disadvantages of each, with an emphasis on applications of these DNA vaccines.  ...  Enabling the ability to engineer optimized delivery systems is the objective in elucidating such SARs.  ... 
doi:10.1016/j.actbio.2018.08.033 pmid:30172933 pmcid:PMC7105045 fatcat:7ebi4sokgnchfp2keuaokpcr2q

Pharmacogenomics of Viral Diseases [chapter]

Shailendra Dwivedi, Suraj Singh Yadav, Manish Kumar Singh, Shailja Shukla, Sanjay Khattri, Kamlesh Kumar Pant
2013 Omics for Personalized Medicine  
Viral diseases are leading cause of deaths worldwide as WHO report suggests that hepatitis A virus (HAV) infects more than 80 % of the population of many developing countries.  ...  The discovery of human genome project has opened new vistas to understand the behaviors of genetic makeup in development and progression of diseases and treatment in various viral diseases.  ...  Acknowledgments Authors are thankful to Prof. Kamlesh K Pant, head of the department Pharmacology and Therapeutics for their proper guidance and Capt.  ... 
doi:10.1007/978-81-322-1184-6_28 fatcat:ckjlgcqotbgxvefhdawjuhjwjq

Metabolomics in infectious diseases and drug discovery

Paraskevi Tounta, Yi Liu, Ashleigh Cheyne, Gérald Larrouy-Maumus
2021 Molecular Omics  
Metabolomics has emerged as an invaluable tool that can be used along with genomics, transcriptomics and proteomics to understand host-pathogen interactions at small-molecule levels.  ...  Metabolomics has been used to study...  ...  Application of metabolomics to hepatitis C Hepatitis C virus (HCV) is a leading cause of infection that can develop into chronic disease in 70% of infected individuals (WHO, 2018).  ... 
doi:10.1039/d1mo00017a pmid:34125125 pmcid:PMC8202295 fatcat:vgk3y4uoebdenpcdtkkq4x3v5e

Liver Disease: Induction, Progression, Immunological Mechanisms, and Therapeutic Interventions

Sarah Y. Neshat, Victor M. Quiroz, Yuanjia Wang, Sebastian Tamayo, Joshua C. Doloff
2021 International Journal of Molecular Sciences  
We also discuss a variety of pathologies that lead to liver cirrhosis, such as alcoholic liver disease and chronic hepatitis B virus (HBV).  ...  This review summarizes the complex immunological activities in different liver diseases, and how failure to maintain liver homeostasis leads to progressive fibrotic tissue development.  ...  Chronic Hepatitis C Chronic hepatitis C virus (HCV) is a blood-borne infection that is transmitted through blood, commonly caused by the exchange of needles or accidental puncture by infected glass or  ... 
doi:10.3390/ijms22136777 pmid:34202537 pmcid:PMC8267746 fatcat:zwfy7vsgajgvhdlaf3hatbde24

The Antiviral Activities of Artemisinin and Artesunate

Thomas Efferth, Marta R. Romero, Dana G. Wolf, Thomas Stamminger, Jose J. G. Marin, Manfred Marschall
2008 Clinical Infectious Diseases  
Analysis of the complete profile of the pharmacological activities and molecular modes of action of artemisinin and artesunate and their performance in clinical trials will further elucidate the full antimicrobial  ...  of the Herpesviridae family (e.g., herpes simplex virus type 1 and Epstein-Barr virus), hepatitis B virus, hepatitis C virus, and bovine viral diarrhea virus.  ...  Bayerische Forschungsstiftung (576/03), the HHV-6 Foundation, and the Deutsche Forschungsgemeinschaft (Ma 1289/4-1). Potential conflicts of interest. All authors: no conflicts.  ... 
doi:10.1086/591195 pmid:18699744 fatcat:z7j3rdcnvffl3lwwz7ffqcjk3q

Proteomics and integrative omic approaches for understanding host–pathogen interactions and infectious diseases

Pierre M Jean Beltran, Joel D Federspiel, Xinlei Sheng, Ileana M Cristea
2017 Molecular Systems Biology  
Organisms are constantly exposed to microbial pathogens in their environments. When a pathogen meets its host, a series of intricate intracellular interactions shape the outcome of the infection.  ...  , and metabolomics, to obtain a systems-level understanding of infectious diseases.  ...  To date, in the context of infectious disease, this technique has been applied primarily to individual pathogen proteins, such as the hepatitis C virus pore protein p7 (Konijnenberg et al, 2015) , and  ... 
doi:10.15252/msb.20167062 pmid:28348067 pmcid:PMC5371729 fatcat:nqw2a5yf25hfdhllm2mfnkl6by

Proteomics Tracing the Footsteps of Infectious Disease

Todd M. Greco, Ileana M. Cristea
2017 Molecular & Cellular Proteomics  
Every year, a major cause of human disease and death worldwide is infection with the various pathogens-viruses, bacteria, fungi, and protozoa-that are intrinsic to our ecosystem.  ...  In efforts to control the prevalence of infectious disease and develop improved therapies, the scientific community has focused on building a molecular picture of pathogen infection and spread.  ...  candidate host factors, particularly during replication of RNA viruses, such as norovirus (50) , poliovirus (51), dengue virus (52, 53) , and hepatitis C virus (54) .  ... 
doi:10.1074/mcp.o116.066001 pmid:28163258 pmcid:PMC5393401 fatcat:gj7rwjhpvbcyplexkysnofxbkq

Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease

Deling Shi, Anran Sheng, Lianli Chi
2021 Frontiers in Molecular Biosciences  
This review focuses on aspects of the molecular basis and mechanisms of GAG-protein interactions involved in human disease.  ...  The breakthrough in analytical tools and approaches during the last two decades has facilitated a greater understanding of the importance of GAG-protein interactions and their roles in human diseases.  ...  ACKNOWLEDGMENTS The authors would like to thank Xiaojun Sun for proofreading the manuscript.  ... 
doi:10.3389/fmolb.2021.639666 pmid:33768117 pmcid:PMC7985165 fatcat:ysoqvfvt2na3hp54l6ddgyfxpy

Single Cell Metabolomics: A Future Tool to Unmask Cellular Heterogeneity and Virus-Host Interaction in Context of Emerging Viral Diseases

Rajesh Kumar, Mayukh Ghosh, Sandeep Kumar, Minakshi Prasad
2020 Frontiers in Microbiology  
The potential of SCM has already been exploited to resolve several biological conundrums. Thus SCM is knocking at the door of virus-host interface.  ...  The potential hotspots of viral emergence often remain neglected and the information related to them is insufficient, particularly for emerging viruses.  ...  Although RNA viruses like rhinovirus, hepatitis C virus and several emerging arboviruses such as Zika virus, Dengu virus, Chikungunya virus etc. modulate host metabolic pathways in a little different manner  ... 
doi:10.3389/fmicb.2020.01152 pmid:32582094 pmcid:PMC7286130 fatcat:a2k5smwjgvhlflsvpfg6vh7tmu

Montpellier Infectious Diseases (MID), 2nd annual meeting (2012)

Patrick Bastien, Catherine Braun-Breton, Nathalie Chazal, Christian Devaux, Vincent Foulongne, Marie Frank, Jean-François Hernandez, Laurent Kremer, Maryse Lebrun, Vincent Le Moing, Jean-Paul Leonetti, Corinne Lionne (+1 others)
2013 Infection, Genetics and Evolution  
Acknowledgments: The organizing committee of the MID' 2nd annual meeting thank the Languedoc Roussillon local authorites (Région LR), Universities of Montpellier and national research institutions, Biocampus  ...  Montpellier, Idenix pharmaceuticals, Dominique Dutscher, StarLab, Biohit, Oxeltis, Copyshop and Elsevier-MEEGID for their support and/or sponsoring of this meeting.  ...  , herpes simplex virus, cytomegalovirus, varicella zoster virus, hepatitis B and C viruses and influenza viruses.  ... 
doi:10.1016/j.meegid.2013.01.019 pmid:23416259 fatcat:kfby4apqhbhv3dyxrqck7dak5e

Nanotechnology Applications of Flavonoids for Viral Diseases

Khoshnur Jannat, Alok K. Paul, Tohmina A. Bondhon, Anamul Hasan, Muhammad Nawaz, Rownak Jahan, Tooba Mahboob, Veeranoot Nissapatorn, Polrat Wilairatana, Maria de Lourdes Pereira, Mohammed Rahmatullah
2021 Pharmaceutics  
Despite their abundance in plants, which are a part of human diet, flavonoids have the problem of low bioavailability.  ...  Various attempts are in progress to increase the bioavailability of flavonoids, one of the promising fields being nanotechnology.  ...  We acknowledge the help of Shereen Basiouni preparing a part of Figure 3 of this article.  ... 
doi:10.3390/pharmaceutics13111895 pmid:34834309 pmcid:PMC8625292 fatcat:5sqztvhtyrebhjnyy2wbfmbize
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