A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Filters
Tools enabling the elucidation of molecular pathways active in human disease: application to Hepatitis C virus infection
2005
BMC Bioinformatics
Preserved Fulltext
This integrated data set in turn enabled simple analyses to yield hypotheses related to the response to Hepatitis C viral infection. ...
We applied these techniques to extract, from genomic expression data from Hepatitis C virus-infected liver tissue, potentially useful hypotheses related to the onset of this disease. ...
and Babylaksmi Muthusamy for their help in providing the HPRD interactions in a machine-readable format. ...
doi:10.1186/1471-2105-6-154
pmid:15967031
pmcid:PMC1181626
fatcat:bnh4jkkpjbaixaixm67r4eowbu
The Clinical Application of MicroRNAs in Infectious Disease
2017
Frontiers in Immunology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Elucidating the roles miRNAs in host response to infectious disease is inherently interesting at it provides a tool for identifying key genes and pathways that must be activated, enhanced, repressed, or ...
Viruses such as enterovirus, CMV, human papilloma virus, hepatitis B virus (HBV), and HCV, manipulate the expression of specific cellular miRNAs to inhibit translation of proinflammatory proteins (16, ...
doi:10.3389/fimmu.2017.01182
pmid:28993774
pmcid:PMC5622146
fatcat:l5cvmbeyhfgbpoenizvkeyv2fm
Accelerating Next-Generation Vaccine Development for Global Disease Prevention
2013
Science
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
However, past strategies for vaccine development are unlikely to succeed in the future against major global diseases such as AIDS, TB, and malaria. ...
Vaccines are among the greatest successes in the history of public health. ...
Acknowledgments The authors acknowledge the assistance of Sandi Glass, Lisa Gieber, Olga Shmaidenko, Michelle Dees and Bill Hayes in the preparation of this manuscript. ...
doi:10.1126/science.1232910
pmid:23723240
pmcid:PMC4026248
fatcat:ltxjup67qnhwpccmdwggyom7ee
Zebrafish as a disease model for studying human hepatocellular carcinoma
2015
World Journal of Gastroenterology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Multiple risk factors are highly correlated with HCC, including infection with the hepatitis B or C viruses, alcohol abuse, aflatoxin exposure, and metabolic diseases. ...
This review will focus on illustrative examples involving the application of zebrafish models to the study of human liver disease and HCC, through transgenesis, genome editing technology, xenografts, drug ...
Hepatocellular carcinoma (HCC) formation results from multiple risk factors, including hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, alcohol, Aflatoxin, and metabolic diseases. ...
doi:10.3748/wjg.v21.i42.12042
pmid:26576090
pmcid:PMC4641123
fatcat:zqawvobzdvdrnhkeioirt5ndvq
Engineering DNA vaccines against infectious diseases
2018
Acta Biomaterialia
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Despite improvement, to the extent of our knowledge, there are currently no regulatory body-approved DNA vaccines for human use (four vaccines approved for animal use). ...
This article discusses engineering DNA vaccines against infectious diseases while discussing advantages and disadvantages of each, with an emphasis on applications of these DNA vaccines. ...
Enabling the ability to engineer optimized delivery systems is the objective in elucidating such SARs. ...
doi:10.1016/j.actbio.2018.08.033
pmid:30172933
pmcid:PMC7105045
fatcat:7ebi4sokgnchfp2keuaokpcr2q
Pharmacogenomics of Viral Diseases
[chapter]
2013
Omics for Personalized Medicine
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Viral diseases are leading cause of deaths worldwide as WHO report suggests that hepatitis A virus (HAV) infects more than 80 % of the population of many developing countries. ...
The discovery of human genome project has opened new vistas to understand the behaviors of genetic makeup in development and progression of diseases and treatment in various viral diseases. ...
Acknowledgments Authors are thankful to Prof. Kamlesh K Pant, head of the department Pharmacology and Therapeutics for their proper guidance and Capt. ...
doi:10.1007/978-81-322-1184-6_28
fatcat:ckjlgcqotbgxvefhdawjuhjwjq
Metabolomics in infectious diseases and drug discovery
2021
Molecular Omics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
Metabolomics has emerged as an invaluable tool that can be used along with genomics, transcriptomics and proteomics to understand host-pathogen interactions at small-molecule levels. ...
Metabolomics has been used to study... ...
Application of metabolomics to hepatitis C Hepatitis C virus (HCV) is a leading cause of infection that can develop into chronic disease in 70% of infected individuals (WHO, 2018). ...
doi:10.1039/d1mo00017a
pmid:34125125
pmcid:PMC8202295
fatcat:vgk3y4uoebdenpcdtkkq4x3v5e
Liver Disease: Induction, Progression, Immunological Mechanisms, and Therapeutic Interventions
2021
International Journal of Molecular Sciences
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
We also discuss a variety of pathologies that lead to liver cirrhosis, such as alcoholic liver disease and chronic hepatitis B virus (HBV). ...
This review summarizes the complex immunological activities in different liver diseases, and how failure to maintain liver homeostasis leads to progressive fibrotic tissue development. ...
Chronic Hepatitis C Chronic hepatitis C virus (HCV) is a blood-borne infection that is transmitted through blood, commonly caused by the exchange of needles or accidental puncture by infected glass or ...
doi:10.3390/ijms22136777
pmid:34202537
pmcid:PMC8267746
fatcat:zwfy7vsgajgvhdlaf3hatbde24
The Antiviral Activities of Artemisinin and Artesunate
2008
Clinical Infectious Diseases
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Analysis of the complete profile of the pharmacological activities and molecular modes of action of artemisinin and artesunate and their performance in clinical trials will further elucidate the full antimicrobial ...
of the Herpesviridae family (e.g., herpes simplex virus type 1 and Epstein-Barr virus), hepatitis B virus, hepatitis C virus, and bovine viral diarrhea virus. ...
Bayerische Forschungsstiftung (576/03), the HHV-6 Foundation, and the Deutsche Forschungsgemeinschaft (Ma 1289/4-1). Potential conflicts of interest. All authors: no conflicts. ...
doi:10.1086/591195
pmid:18699744
fatcat:z7j3rdcnvffl3lwwz7ffqcjk3q
Proteomics and integrative omic approaches for understanding host–pathogen interactions and infectious diseases
2017
Molecular Systems Biology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is application/pdf.
Organisms are constantly exposed to microbial pathogens in their environments. When a pathogen meets its host, a series of intricate intracellular interactions shape the outcome of the infection. ...
, and metabolomics, to obtain a systems-level understanding of infectious diseases. ...
To date, in the context of infectious disease, this technique has been applied primarily to individual pathogen proteins, such as the hepatitis C virus pore protein p7 (Konijnenberg et al, 2015) , and ...
doi:10.15252/msb.20167062
pmid:28348067
pmcid:PMC5371729
fatcat:nqw2a5yf25hfdhllm2mfnkl6by
Proteomics Tracing the Footsteps of Infectious Disease
2017
Molecular & Cellular Proteomics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf.
Every year, a major cause of human disease and death worldwide is infection with the various pathogens-viruses, bacteria, fungi, and protozoa-that are intrinsic to our ecosystem. ...
In efforts to control the prevalence of infectious disease and develop improved therapies, the scientific community has focused on building a molecular picture of pathogen infection and spread. ...
candidate host factors, particularly during replication of RNA viruses, such as norovirus (50) , poliovirus (51), dengue virus (52, 53) , and hepatitis C virus (54) . ...
doi:10.1074/mcp.o116.066001
pmid:28163258
pmcid:PMC5393401
fatcat:gj7rwjhpvbcyplexkysnofxbkq
Glycosaminoglycan-Protein Interactions and Their Roles in Human Disease
2021
Frontiers in Molecular Biosciences
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2021; you can also visit the original URL.
The file type is application/pdf.
This review focuses on aspects of the molecular basis and mechanisms of GAG-protein interactions involved in human disease. ...
The breakthrough in analytical tools and approaches during the last two decades has facilitated a greater understanding of the importance of GAG-protein interactions and their roles in human diseases. ...
ACKNOWLEDGMENTS The authors would like to thank Xiaojun Sun for proofreading the manuscript. ...
doi:10.3389/fmolb.2021.639666
pmid:33768117
pmcid:PMC7985165
fatcat:ysoqvfvt2na3hp54l6ddgyfxpy
Single Cell Metabolomics: A Future Tool to Unmask Cellular Heterogeneity and Virus-Host Interaction in Context of Emerging Viral Diseases
2020
Frontiers in Microbiology
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
The potential of SCM has already been exploited to resolve several biological conundrums. Thus SCM is knocking at the door of virus-host interface. ...
The potential hotspots of viral emergence often remain neglected and the information related to them is insufficient, particularly for emerging viruses. ...
Although RNA viruses like rhinovirus, hepatitis C virus and several emerging arboviruses such as Zika virus, Dengu virus, Chikungunya virus etc. modulate host metabolic pathways in a little different manner ...
doi:10.3389/fmicb.2020.01152
pmid:32582094
pmcid:PMC7286130
fatcat:a2k5smwjgvhlflsvpfg6vh7tmu
Montpellier Infectious Diseases (MID), 2nd annual meeting (2012)
2013
Infection, Genetics and Evolution
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf.
Acknowledgments: The organizing committee of the MID' 2nd annual meeting thank the Languedoc Roussillon local authorites (Région LR), Universities of Montpellier and national research institutions, Biocampus ...
Montpellier, Idenix pharmaceuticals, Dominique Dutscher, StarLab, Biohit, Oxeltis, Copyshop and Elsevier-MEEGID for their support and/or sponsoring of this meeting. ...
, herpes simplex virus, cytomegalovirus, varicella zoster virus, hepatitis B and C viruses and influenza viruses. ...
doi:10.1016/j.meegid.2013.01.019
pmid:23416259
fatcat:kfby4apqhbhv3dyxrqck7dak5e
Nanotechnology Applications of Flavonoids for Viral Diseases
2021
Pharmaceutics
Preserved Fulltext
A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2022; you can also visit the original URL.
The file type is application/pdf.
Despite their abundance in plants, which are a part of human diet, flavonoids have the problem of low bioavailability. ...
Various attempts are in progress to increase the bioavailability of flavonoids, one of the promising fields being nanotechnology. ...
We acknowledge the help of Shereen Basiouni preparing a part of Figure 3 of this article. ...
doi:10.3390/pharmaceutics13111895
pmid:34834309
pmcid:PMC8625292
fatcat:5sqztvhtyrebhjnyy2wbfmbize
« Previous
Showing results 1 — 15 out of 6,225 results