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A systematic review and meta-analysis of topoisomerase inhibition in pre-clinical glioma models

Toni Rose Jue, Emily S. Sena, Malcolm R. Macleod, Kerrie L. McDonald, Theodore C. Hirst
2018 OncoTarget  
Malignant glioma is a devastating disease affecting both adults and children with limited treatment strategies. Pre-clinical animal studies are critical to the development and planning of novel treatment designs for human clinical trials. Topoisomerases has been a target of interest in the treatment of high grade gliomas, such as glioblastoma, in the past years. Here we assess pre-clinical glioma literature with the aim to identify predictive variables that favour treatment outcomes from
more » ... merase inhibition. Data was extracted from 90 experimental comparisons, this was divided based on available survival (n = 61) and tumor volume (n = 29) data. The meta-analysis revealed that the overall effect of topoisomerase inhibition prolonged survival by a factor of 1.33 (95% CI: 1.23-1.43) and reduced tumor growth by a factor of 3.21 (95% CI: 1.99-5.88), with considerable between-study heterogeneity. Multivariable meta-regression identified glioma model, type of control, route of drug administration and drug of choice to be predictive of improved survival outcome. Publication bias assessment by contour-enhanced funnel plots, Egger's regression test and trim and fill analysis showed evidence of publication bias in all studies. This study identified multiple study design factors that should be taken into consideration to improve the translation of pre-clinical investigation of topoisomerase inhibition into clinical use. www.impactjournals.com/oncotarget/
doi:10.18632/oncotarget.24334 pmid:29541421 pmcid:PMC5834287 fatcat:fbwhfhlkj5gf3p6sbkz3b3ut64

Data Sharing Challenges and Recommendations for Human Biorepositories: A Systematic Literature Review

Jitendra Jonnagaddala, Toni Rose Jue, Pradeep Ray, Amir Talaei-Khoei
2014 The International Technology Management Review  
Biorepositories collect biospecimens like blood and tissue from the p atients along with associated clinical and pathological data. Medical research tends to require sharing of biospecimens and associated data at a large scale across multiple biorepositories. The objective of this review is to identify issues faced and recommendations made in sharing biospecimens data. Our review identified that significant amount of work has been done in the past and biorepositories can take advantage of this work by working collectively.
doi:10.2991/itmr.2014.4.2.1 fatcat:prwmcw5eojcrhkvtqgfv5eyz7a

Improving the dictionary lookup approach for disease normalization using enhanced dictionary and query expansion

Jitendra Jonnagaddala, Toni Rose Jue, Nai-Wen Chang, Hong-Jie Dai
2016 Database: The Journal of Biological Databases and Curation  
., Jue,T.R., Chang,N.-W. and Dai,H.-J. Improving the dictionary lookup approach for disease normalization using enhanced dictionary and query expansion.  ... 
doi:10.1093/database/baw112 pmid:27504009 pmcid:PMC4976299 fatcat:bproo6ouo5hjlgmukudmhvo6ay

Cytotoxic lanthanum oxide nanoparticles sensitize glioblastoma cells to radiation therapy and temozolomide: an in vitro rationale for translational studies

Victor M. Lu, Toni Rose Jue, Kerrie L. McDonald
2020 Scientific Reports  
Glioblastoma (GBM) is a malignant brain tumour with a dismal prognosis, despite best treatment by surgical resection, radiation therapy (RT) and chemotherapy with temozolomide (TMZ). Nanoparticle (NP) therapy is an emerging consideration due to the ability of NPs to be formulated and cross the blood brain barrier. Lanthanum oxide (La2O3) NPs are therapeutically advantageous due to the unique chemical properties of lanthanum making it cytotoxic to cancers, and able to enhance existing
more » ... treatments. However, La2O3 NPs have yet to be thoroughly investigated in brain tumors. We show that these NPs can reach the brain after venous injection, penetrate into GBM cells via endocytosis, dissociate to be cytotoxic, and enhance the therapeutic effects of RT and TMZ. The mechanisms of cell death by La2O3 NPs were found to be multifaceted. Increasing NP concentration was correlated to increased intrinsic and extrinsic apoptosis pathway markers in a radical oxygen species (ROS)-dependent manner, as well as involving direct DNA damage and autophagic pathways within GBM patient-derived cell lines. NP interactions to sensitize GBM to RT and TMZ were shown to involve these pathways by enhancing ROS and apoptotic mechanisms. We therefore demonstrate the therapeutic potential of La2O3 NPs to treat GBM cells in vitro, and encourage translational exploration in the future.
doi:10.1038/s41598-020-75372-3 pmid:33097778 fatcat:5igzyp765be3dpf2u3pfhn3ova

Veliparib in combination with radiotherapy for the treatment of MGMT unmethylated glioblastoma

Toni Rose Jue, Kyoko Nozue, Ashleigh J. Lester, Swapna Joshi, Lisette B. W. Schroder, Shane P. Whittaker, Sheri Nixdorf, Robert W. Rapkins, Mustafa Khasraw, Kerrie L. McDonald
2017 Journal of Translational Medicine  
Significance determined by student t-test where ***(p < 0.001); **(p < 0.01); *(p < 0.05) Jue et al.  ...  Sensitivity to PARP inhibitors is mediated by mutations in the BRCA1 and two genes, which result in the defective function of the homologous recombination (HR) Jue et al.  ... 
doi:10.1186/s12967-017-1164-1 pmid:28314386 pmcid:PMC5356284 fatcat:4pjgttxzarf5bp7etnraadom5i

A case study of a long-term glioblastoma survivor with unmethylated MGMT and hypermutated genotype

Toni Rose Jue, Lauren R. Olafson, Anna H. Siddell, Robert W. Rapkins, Benedict Ng, Julia X.M. Yin, Victor M. Lu, Sylvia A. Chung, Shane P. Whittaker, Matthew Davies, Jacob M. Fairhall, Elizabeth J. Hovey (+1 others)
2019 Molecular Case Studies  
Inherent intraand intertumoral heterogeneity has made treatment challenging (Jue and McDonald 2016) . Selection of better therapies based on the genomics of each particular tumor is needed.  ... 
doi:10.1101/mcs.a003251 pmid:31160353 pmcid:PMC6549560 fatcat:aulfbqgxpnee5o2oe72icc24xe

MET network in PubMed: a text-mined network visualization and curation system

Hong-Jie Dai, Chu-Hsien Su, Po-Ting Lai, Ming-Siang Huang, Jitendra Jonnagaddala, Toni Rose Jue, Shruti Rao, Hui-Jou Chou, Marija Milacic, Onkar Singh, Shabbir Syed-Abdul, Wen-Lian Hsu
2016 Database: The Journal of Biological Databases and Curation  
T. et al. MET network in PubMed: a text-mined network visualization and curation system. Abstract Metastasis is the dissemination of a cancer/tumor from one organ to another, and it is the most dangerous stage during cancer progression, causing more than 90% of cancer deaths. Improving the understanding of the complicated cellular mechanisms underlying metastasis requires investigations of the signaling pathways. To this end, we developed a METastasis (MET) network visualization and curation
more » ... l to assist metastasis researchers retrieve network information of interest while browsing through the large volume of studies in PubMed. MET can recognize relations among genes, cancers, tissues and organs of metastasis mentioned in the literature through text-mining techniques, and then produce a visualization of all mined relations in a metastasis network. To facilitate the curation process, MET is developed as a browser extension that allows curators to review and edit concepts and relations related to metastasis directly in PubMed. PubMed users can also view the metastatic networks integrated from the large collection of research papers directly through MET. For the BioCreative 2015 interactive track (IAT), a curation task was proposed to curate metastatic networks among PubMed abstracts. Six curators participated in the proposed task and a post-IAT task, curating 963 unique metastatic relations from 174 PubMed abstracts using MET.
doi:10.1093/database/baw090 pmid:27242035 pmcid:PMC4885604 fatcat:ezti4idx6ngktmesrtu5slzywa

Page 67 of Everybody's Magazine Vol. 44, Issue 3 [page]

1921 Everybody's Magazine  
The ten¬ derness which his tone had brought to her eyes was obscured by the anger that rose at his words. “You haven’t caught up!” “I make as much as you.”  ...  This steal¬ ing of glances was in itself a new thing for Jue, whose look used to be direct and SBlJe-mindcd. It was due entirely to Temy’s deplorable frivolity.  ... 

Page 557 of National Union Catalog Vol. 50, Issue [page]

1963 National Union Catalog  
F234.A3S866 917.55296044 66-25636 Somerville, Rose M Family insights through the short story; a guide for teachers and workshop leaders ;by, Rose M. Somerville.  ...  Spink -109 $ cutta, 73124 F-62983 Spink . ame pro- 35-7864 jue... The National Union Catalog Somerville, Christopher C see Bramall, Eric.  ... 

Page 751 of Linguistics and Language Behavior Abstracts: LLBA Vol. 28, Issue 2 [page]

1994 Linguistics and Language Behavior Abstracts: LLBA  
J., 9402882 Worner, Regina, 9403838 Wouters, Annelies, 9403326 Woiniewicz, Wladyslaw, 94r01512 Wrenn, Phyllis, 9402707 Wright, Susan Hyde, 9403804 Wright, Tony, 9402400 ba Heide Spruck, 9402401, Wu, i,  ...  9402220 Williams, Roberta, 94r010 Williams, Sian Rhiannon, 94101505 Williamson, Sherrie Ellen, 9403847 Willis, Dave, 9402399, 94101506, 94101507 Wilmet, Marc, 94r01508 Wilson, Andrew, 9403276 Wilson, jue  ... 

Nouvelles Observations Sur Le Développement D'un Semis DeStemonitis Oblonga

M. Casimir Roumeguère
1873 Bulletin de la Société Botanique de France  
(Toni<Hl'C, 5 février 187J.)  ...  -Péridiums ohovales, de conlem· jaunâtre, rosés à la basr~, montrant le commencl'lliPtll d'un stipe également rosé ct transparent, fistuleux (ce stipe n'est encore que le prolongement du péridium, la matière  ... 
doi:10.1080/00378941.1873.10827681 fatcat:cfhcmxtcgjcexpg3ebcjdheene

Page 104 of The New Jersey Law Journal Vol. 70, Issue 13 [page]

1947 The New Jersey Law Journal  
Many communities still look upon law-preparation as country-boy Tony did. Tony said | goodbye and went up to the city one Monday morning to study | |law.  ...  “Why Tony,” said the minister, “we understood that you were going away to! study law and be a lawyer.’ | “Yes, so I did,” answered Tony, “but I don’t like it and I’m sorry I learned it.”  ... 

Sur Les Canaux Oléifères Des Composées

M. Ph. Van Tieghem
1871 Bulletin de la Société Botanique de France  
Nous étions toni à l'liPnrt· dan'i la racine, r'p~t-it-din· an-dPsso11s df' la limiiP ~npf'rlicif.  ...  Cha<JUe faisceau foliah·e, en émergeant, demeure enveloppé dans la membrane protectrice qui sc replie tout autour de lui pour lui former une gaine indh·i<luelle.  ... 
doi:10.1080/00378941.1871.10825375 fatcat:r2myu65jvzhc7fz2hswf5j523a

Note sur quelques plantes de la Flore atlantique

MM. J.-A. Battandier, L. Trabut
1905 Bulletin de la Société Botanique de France  
E. liasse '.Heprintt'd l"rom the, lJullctin of" ll11.> Ton·y l1otallim/ CIHI1. \ni.\.\\", Il" 12, dt":ceml1. 18!)8, l'· n:l2).  ...  T11èques cylinùri<Jues, rt~nl'ermant un grant! nombre de spores. Spores ovulaires, unisept(·es. pm·J'ois simples, entourées d'un halo, longues de l:l-1 :; :-;ur ü !  ... 
doi:10.1080/00378941.1905.10829187 fatcat:ru44rpsrvbchxan5elfn6qfk7e
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