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Inhibitory Effects of Bifidobacterium longum BB536 on Harmful Intestinal Bacteria

Tomoko ARAYA-KOJIMA, Tomoko YAESHIMA, Norio ISHIBASHI, Seiichi SHIMAMURA, Hirotoshi HAYASAWA
1995 Bifidobacteria and Microflora  
The inhibitory effects of human-derived Bifidobacterium longum BB536 on harmful intestinal bacteria were examined by co-cultivation of BB536 with each one of the following eight bacterial strains: Escherichia coli, Klebsiella pneumoniae, Clostridium clostridiiforme, C. perfringens, Bacteroides distasonis, B. fragilis, B. thetaiotaomicron and B. vulgatus. In comparison with the results of mono-cultivation, BB536 inhibited both the growth of these putrefactive bacteria and their production of
more » ... nia, and decreased the pH of the culture medium by producing lactic and acetic acids. Enzymatic assays showed that in BB536 the sorts of the enzymes involved in ammonia production (urease and amino acid deaminases) were rather few and their activities were weaker than observed in the harmful bacteria, whereas the activities of enzymes involved in ammonia assimilation (glutamine synthetase, glutamate synthase and glutamate dehydrogenase) were much higher in BB536 than in the putrefactive bacteria.
doi:10.12938/bifidus1982.14.2_59 fatcat:gs6nnhzimna4dopizjlaigutyy

Inhibitory Effects of Human-Derived Bifidobacterium on Pathogenic Escherichia coli Serotype O-111

Tomoko ARAYA-KOJIMA, Tomoko YAESHIMA, Norio ISHIBASHI, Seiichi SHIMAMURA, Hirotoshi HAYASAWA
1996 Bioscience and Microflora  
The inhibitory effects of seven human-derived Bifidobacterium strains on pathogenic Escherichia coli serotype O-lll were examined in co-cultivation. All of the Bifidobacterium strains tested inhibited the growth of E. coli and limited the increase in the ammonia concentration in the co-cultures. Also, in each instance, the pH of the culture medium decreased due to their production of acetic and lactic acids. From the results of pH-controlled fermentation, the growth inhibition of E. coli was
more » ... ributed mainly to the decrease in the pH of the culture medium. The possibility that some unidentified inhibitory substances derived from Bifidobacterium strains were present was little thought. In mono-cultures of Bifidobacterium strains, the ammonia concentration in the culture medium decreased to a level below that initially present in the medium prior to inoculation. Enzymatic assays showed that the activity of an enzyme involved in ammonia production (L-asparagine deaminase) was much weaker in each of the Bifidobacterium strains than in E. coli, whereas the activities of enzymes involved in ammonia assimilation (glutamine synthetase, glutamate synthase and glutamate dehydrogenase) were much higher in bifidobacteria. The decrease in the ammonia concentration in the co-culture appears to be related not only to the number of colonyforming units of bifidobacteria but also to the differences among the bacteria examined in enzymatic activities which are concerned with utilization and production of ammonia.
doi:10.12938/bifidus1996.15.17 fatcat:vfmzviswhbefrmd6f2hmvszccu

Genetic evidence that Lactococcus lactis JCM7638 produces a mutated form of nisin

TOMOKO ARAYA, NORIO ISHIBASHI, SEIICHI SHIMAMURA
1992 Journal of General and Applied Microbiology  
His27 is not used in the formation of these unusual residues, and, from our experiment, the bactericidal activity of the antibiotic produced by JCM7638 seemed comparable to the one of nisin from NCD0497 (Araya  ... 
doi:10.2323/jgam.38.271 fatcat:4yggiig2yngdlho5kn7buekr54

The Life Cycle of Small Brown Planthopper, Laodelphax striatellus FALLEN, in Aomori Prefecture
青森県におけるヒメトビウンカの周年経過

Tomoko MURAI, Masao FUJITA, Nobuo ABE, Etsumu ARAYA, Toshiyuki KIMURA, Takehiko FUJIMURA
1984 Annual Report of the Society of Plant Protection of North Japan  
doi:10.11455/kitanihon1966.1984.79 fatcat:d4xz4ndflrdonfrp6oumgy5q3q

Involvement of GPx4-Regulated Lipid Peroxidation in Idiopathic Pulmonary Fibrosis Pathogenesis

Kazuya Tsubouchi, Jun Araya, Masahiro Yoshida, Taro Sakamoto, Tomoko Koumura, Shunsuke Minagawa, Hiromichi Hara, Yusuke Hosaka, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Yusuke Kurita (+16 others)
2019 Journal of Immunology  
The imbalanced redox status in lung has been widely implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis. To regulate redox status, hydrogen peroxide must be adequately reduced to water by glutathione peroxidases (GPx). Among GPx isoforms, GPx4 is a unique antioxidant enzyme that can directly reduce phospholipid hydroperoxide. Increased lipid peroxidation products have been demonstrated in IPF lungs, suggesting the participation of imbalanced lipid peroxidation in IPF pathogenesis,
more » ... ch can be modulated by GPx4. In this study, we sought to examine the involvement of GPx4-modulated lipid peroxidation in regulating TGF-β-induced myofibroblast differentiation. Bleomycin-induced lung fibrosis development in mouse models with genetic manipulation of GPx4 were examined. Immunohistochemical evaluations for GPx4 and lipid peroxidation were performed in IPF lung tissues. Immunohistochemical evaluations showed reduced GPx4 expression levels accompanied by increased 4-hydroxy-2-nonenal in fibroblastic focus in IPF lungs. TGF-β-induced myofibroblast differentiation was enhanced by GPx4 knockdown with concomitantly enhanced lipid peroxidation and SMAD2/SMAD3 signaling. Heterozygous GPx4-deficient mice showed enhancement of bleomycin-induced lung fibrosis, which was attenuated in GPx4-transgenic mice in association with lipid peroxidation and SMAD signaling. Regulating lipid peroxidation by Trolox showed efficient attenuation of bleomycin-induced lung fibrosis development. These findings suggest that increased lipid peroxidation resulting from reduced GPx4 expression levels may be causally associated with lung fibrosis development through enhanced TGF-β signaling linked to myofibroblast accumulation of fibroblastic focus formation during IPF pathogenesis. It is likely that regulating lipid peroxidation caused by reduced GPx4 can be a promising target for an antifibrotic modality of treatment for IPF.
doi:10.4049/jimmunol.1801232 pmid:31534007 fatcat:eckh2nscdzaxjm5iuwrwv4a5ia

Twenty-First Century Theologies of Religions: Retrospection and Future Prospects

Esra AKAY DAĞ
2018 Sakarya Üniversitesi İlahiyat Fakültesi Dergisi  
Ayrıca, bu eser iki projeyi bir araya getirilerek oluşturulmuştur.  ...  Bu kitap da Race'in üç-yönlü tipolojisinin otuz yıl içinde kullanımı, eleştirileri ve alternatifleri üzerine yürütülen tartışmaları bir araya getiren derleme bir eserdir.  ...  Burada, Moyaert bu konuda önemli bir yere sahip Tomoko Masuzawa'nin eserinden 8 bahsetmemiş olsa da post-sömürgeci yaklaşımları öne sürmesi önemlidir.  ... 
doi:10.17335/sakaifd.467931 fatcat:h6vopflxsvd77dlinecvndyuwe

Acknowledgments [chapter]

2020 The New Japanese Woman  
Thanks also are due to Azuma Emiko and Yamaguchi Tomoko.  ...  To Arai Noriko, Araya Shigehiko, Arima Hideko, Asaoka Kunio, Egami Wataru, Eto Fumio, Fujita Keisuke, Haga Tōru, Hama Yuki, Hayashi Hirotchika, Ibi Takashi, Ikegami Hiroko, Inoue Ken, Inoue Shōichi, Inoue  ... 
doi:10.1515/9780822384762-002 fatcat:qtvbfo5mlrbbzm7ltdy2bgep3u

A proposal for rover geological exploration on Mars
ローバによる火星地質調査計画

Noriyuki Namiki, Goro Komatsu, Tomohiro Usui, Seiji Sugita, Hideaki Miyamoto, Takashi Kubota, Genya Ishigami, Hirohide Demura, Tatsuaki Okada, Yayoi N. Miura, Yuichiro Cho, Kazuhisa Goto (+7 others)
2012 Chishitsugaku zasshi  
., Araya, A., Kurita, K., Tanaka, S., Iwata, T. and Sasaki, S. , 2009, MELOS Planetary people , 18, 84-88. Komatsu, G. , 2008, GIS Jour. Tokyo Geogr. Soc. Japan , 117, 401-411.  ...  Miura 8 , Yuichiro Cho 9 , Kazuhisa Goto 1 , Hiroki Senshu 1 , Koji Wada 1 , Ko Ishibashi 1 , Tomoko Arai 1 , Masanori Kobayashi 1 , Sohsuke Ohno 1 and Mars rover study group 1.5 3397 km 6.42 10  ... 
doi:10.5575/geosoc.2012.0016 fatcat:fywroukmmvb27m6j2zes4ixime

TRANSFORMING OBJECTS INTO ART WORKS BY METHOD ACCUMULATION IN ARTv

2021 Idil Sanat ve Dil Dergisi  
Tomoko Takahashi bir hurda düzenleyicisidir. Galerilerde, okullarda, ofislerde, polis karakollarında ve tenis kortlarında kurulumlar gerçekleştirir.  ...  Nesneleri ve enkazları, iki gerçekliği birbirine bağlayan kendi kendini küçümseyen çalışmalara bir araya getirirler.  ... 
doi:10.7816/idil-10-78-02 fatcat:ciafutgbdrgefbqs72lgaxakt4

DECIGO: The Japanese space gravitational wave antenna

Shuichi Sato, Seiji Kawamura, Masaki Ando, Takashi Nakamura, Kimio Tsubono, Akito Araya, Ikkoh Funaki, Kunihito Ioka, Nobuyuki Kanda, Shigenori Moriwaki, Mitsuru Musha, Kazuhiro Nakazawa (+124 others)
2009 Journal of Physics, Conference Series  
DECIGO (DECI-hertz interferometer Gravitational wave Observatory) is the future Japanese space gravitational wave antenna with observation band around 0.1 Hz. It aims at detecting gravitational waves from various kinds of sources, with sufficient sensitivity to establish the gravitational wave astronomy. In the pre-conceptual design, DECIGO is formed by three drag-free spacecraft, 1000 km apart from one another. The relative displacements between proof masses housed in these spacecraft are
more » ... red by Fabry-Perot interferometers. We plan to launch DECIGO in 2024 after research and development phase, including two milestone missions (DECIGO pathfinder and Pre-DECIGO) for verification of required technologies.
doi:10.1088/1742-6596/154/1/012040 fatcat:k5wdfvpsfrbsbguzmdckphhviu

The Effects of Solvents and Solid-to-Solvent Ratios on Ultrasound-Assisted Extraction of Carotenoids from Chlorella vulgaris

Dianursanti Dianursanti, Aisyah Siregar, Yoshiaki Maeda, Tomoko Yoshino, Tsuyoshi Tanaka
2020 International Journal of Technology  
Those studies showed a specific increase in the growth rate with respect to light intensity (Araya et al., 2014; Nguyen et al., 2019; McClure et al., 2019) .  ...  Carotenoid productivity in volumetric unit corresponds to the product • , where stands for intracellular carotenoid content (mg carotenoids/g biomass) (Araya et al., 2014) .  ... 
doi:10.14716/ijtech.v11i5.4331 fatcat:yfp6vjsribhurnfmxo2kswj5xu

Effect of Bifidobacterium longum BB536 Administration on the Intestinal Environment, Defecation Frequency and Fecal Characteristics of Human Volunteers

Tomohiro OGATA, Teiichi NAKAMURA, Katsue ANJITSU, Tomoko YAESHIMA, Sachiko TAKAHASHI, Yasuo FUKUWATARI, Norio ISHIBASHI, Hirotoshi HAYASAWA, Tomohiko FUJISAWA, Hisakazu IINO
1997 Bioscience and Microflora  
Araya-Kojima et al. (1) reported the inhibition of ammonia production by fecal putrefactive bacteria when BB536 was co-cultured with them in vitro.  ...  Bifidobacterium longum BB536 Administration on the Intestinal Environment, Defecation Frequency and Fecal Characteristics of Human Volunteers Tomohiro OGATA,1 Teiichi NAKAMURA,1 Katsue ANJITSU,1 Tomoko  ... 
doi:10.12938/bifidus1996.16.53 fatcat:tuouebiglnftvci7cgn47tqj7a

Using Nanofluidic Channels to Probe the Dynamics of Rad51-DNA Filaments

Louise Helena Fornander, Fredrik Persson, Joachim Fritzsche, Joshua Araya, Philip Nevin, Penny Beuning, Mauro Modesti, Karolin Frykholm, Fredrik Westerlund
2014 Biophysical Journal  
thermal diffusion. 3507-Pos 3508-Pos Board B236 Using Nanofluidic Channels to Probe the Dynamics of Rad51-DNA Filaments Louise Helena Fornander 1 , Fredrik Persson 2 , Joachim Fritzsche 1 , Joshua Araya  ...  Dresden, Germany, 1 2 3512 - 3512 Pos Board B240 Construction and Characterization of Cy3-or Cy5-Conjugated Hairpin Pyrrole/Imidazole Polyamides Binding to DNA in the Nucleosome Yong-Woon Han 1 , Tomoko  ... 
doi:10.1016/j.bpj.2013.11.3830 fatcat:s3zulgebojhupo5stnytecmivy

Regulating the Winnowing Fan to Accommodate Changes in the Grain Feed Rate
穀粒流量の変化に基づくプレートファンの速度制御に関する研究

Masami MATSUI, Eiji INOUE, Tomoko KUWANO, Ken MORI
2003 Journal of the Japanese Society of Agricultural Machinery  
any objects moving through air, the characteristics of the scatter pattern of grain vary in accordance with the air temperature and pressure (Nakayama, 1998), and the shape and/or weight of the grain (Araya  ... 
doi:10.11357/jsam1937.65.4_77 fatcat:5zfxad7wxvgdlkn3bnjicydigi

Taxonomic Relationships within the Pan-Oriental Narrow-mouth Toad Microhyla ornata as Revealed by mtDNA Analysis (Amphibia, Anura, Microhylidae)

Masafumi Matsui, Hiroharu Ito, Tomohiko Shimada, Hidetoshi Ota, Srinivas K. Saidapur, Wichase Khonsue, Tomoko Tanaka-Ueno, Guan-Fu Wu
2005 Zoological Science  
Araya, T. Chan-Ard, T. Hikida, J. Nabhitabhata, and S. Panha are also acknowledged for their help in field trips. We thank S.  ...  Saidapur, Wichase Khonsue, Tomoko Tanaka-Ueno and Guan-Fu Wu, page 489-495. for the reader's convenience, the corrections appear as follows; page 495, Received date 11 January, 2004 (correct) 11 January  ... 
doi:10.2108/zsj.22.489 pmid:15846058 fatcat:vgbaojfp55bu5p4ufub6645m24
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