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The inhibitory effects of human-derived Bifidobacterium longum BB536 on harmful intestinal bacteria were examined by co-cultivation of BB536 with each one of the following eight bacterial strains: Escherichia coli, Klebsiella pneumoniae, Clostridium clostridiiforme, C. perfringens, Bacteroides distasonis, B. fragilis, B. thetaiotaomicron and B. vulgatus. In comparison with the results of mono-cultivation, BB536 inhibited both the growth of these putrefactive bacteria and their production ofdoi:10.12938/bifidus1982.14.2_59 fatcat:gs6nnhzimna4dopizjlaigutyy
more »... nia, and decreased the pH of the culture medium by producing lactic and acetic acids. Enzymatic assays showed that in BB536 the sorts of the enzymes involved in ammonia production (urease and amino acid deaminases) were rather few and their activities were weaker than observed in the harmful bacteria, whereas the activities of enzymes involved in ammonia assimilation (glutamine synthetase, glutamate synthase and glutamate dehydrogenase) were much higher in BB536 than in the putrefactive bacteria.
The inhibitory effects of seven human-derived Bifidobacterium strains on pathogenic Escherichia coli serotype O-lll were examined in co-cultivation. All of the Bifidobacterium strains tested inhibited the growth of E. coli and limited the increase in the ammonia concentration in the co-cultures. Also, in each instance, the pH of the culture medium decreased due to their production of acetic and lactic acids. From the results of pH-controlled fermentation, the growth inhibition of E. coli wasdoi:10.12938/bifidus1996.15.17 fatcat:vfmzviswhbefrmd6f2hmvszccu
more »... ributed mainly to the decrease in the pH of the culture medium. The possibility that some unidentified inhibitory substances derived from Bifidobacterium strains were present was little thought. In mono-cultures of Bifidobacterium strains, the ammonia concentration in the culture medium decreased to a level below that initially present in the medium prior to inoculation. Enzymatic assays showed that the activity of an enzyme involved in ammonia production (L-asparagine deaminase) was much weaker in each of the Bifidobacterium strains than in E. coli, whereas the activities of enzymes involved in ammonia assimilation (glutamine synthetase, glutamate synthase and glutamate dehydrogenase) were much higher in bifidobacteria. The decrease in the ammonia concentration in the co-culture appears to be related not only to the number of colonyforming units of bifidobacteria but also to the differences among the bacteria examined in enzymatic activities which are concerned with utilization and production of ammonia.
His27 is not used in the formation of these unusual residues, and, from our experiment, the bactericidal activity of the antibiotic produced by JCM7638 seemed comparable to the one of nisin from NCD0497 (Araya ...doi:10.2323/jgam.38.271 fatcat:4yggiig2yngdlho5kn7buekr54
Annual Report of the Society of Plant Protection of North Japan
The imbalanced redox status in lung has been widely implicated in idiopathic pulmonary fibrosis (IPF) pathogenesis. To regulate redox status, hydrogen peroxide must be adequately reduced to water by glutathione peroxidases (GPx). Among GPx isoforms, GPx4 is a unique antioxidant enzyme that can directly reduce phospholipid hydroperoxide. Increased lipid peroxidation products have been demonstrated in IPF lungs, suggesting the participation of imbalanced lipid peroxidation in IPF pathogenesis,doi:10.4049/jimmunol.1801232 pmid:31534007 fatcat:eckh2nscdzaxjm5iuwrwv4a5ia
more »... ch can be modulated by GPx4. In this study, we sought to examine the involvement of GPx4-modulated lipid peroxidation in regulating TGF-β-induced myofibroblast differentiation. Bleomycin-induced lung fibrosis development in mouse models with genetic manipulation of GPx4 were examined. Immunohistochemical evaluations for GPx4 and lipid peroxidation were performed in IPF lung tissues. Immunohistochemical evaluations showed reduced GPx4 expression levels accompanied by increased 4-hydroxy-2-nonenal in fibroblastic focus in IPF lungs. TGF-β-induced myofibroblast differentiation was enhanced by GPx4 knockdown with concomitantly enhanced lipid peroxidation and SMAD2/SMAD3 signaling. Heterozygous GPx4-deficient mice showed enhancement of bleomycin-induced lung fibrosis, which was attenuated in GPx4-transgenic mice in association with lipid peroxidation and SMAD signaling. Regulating lipid peroxidation by Trolox showed efficient attenuation of bleomycin-induced lung fibrosis development. These findings suggest that increased lipid peroxidation resulting from reduced GPx4 expression levels may be causally associated with lung fibrosis development through enhanced TGF-β signaling linked to myofibroblast accumulation of fibroblastic focus formation during IPF pathogenesis. It is likely that regulating lipid peroxidation caused by reduced GPx4 can be a promising target for an antifibrotic modality of treatment for IPF.
Ayrıca, bu eser iki projeyi bir araya getirilerek oluşturulmuştur. ... Bu kitap da Race'in üç-yönlü tipolojisinin otuz yıl içinde kullanımı, eleştirileri ve alternatifleri üzerine yürütülen tartışmaları bir araya getiren derleme bir eserdir. ... Burada, Moyaert bu konuda önemli bir yere sahip Tomoko Masuzawa'nin eserinden 8 bahsetmemiş olsa da post-sömürgeci yaklaşımları öne sürmesi önemlidir. ...doi:10.17335/sakaifd.467931 fatcat:h6vopflxsvd77dlinecvndyuwe
The New Japanese Woman
Thanks also are due to Azuma Emiko and Yamaguchi Tomoko. ... To Arai Noriko, Araya Shigehiko, Arima Hideko, Asaoka Kunio, Egami Wataru, Eto Fumio, Fujita Keisuke, Haga Tōru, Hama Yuki, Hayashi Hirotchika, Ibi Takashi, Ikegami Hiroko, Inoue Ken, Inoue Shōichi, Inoue ...doi:10.1515/9780822384762-002 fatcat:qtvbfo5mlrbbzm7ltdy2bgep3u
., Araya, A., Kurita, K., Tanaka, S., Iwata, T. and Sasaki, S. , 2009, MELOS Planetary people , 18, 84-88. Komatsu, G. , 2008, GIS Jour. Tokyo Geogr. Soc. Japan , 117, 401-411. ... Miura 8 , Yuichiro Cho 9 , Kazuhisa Goto 1 , Hiroki Senshu 1 , Koji Wada 1 , Ko Ishibashi 1 , Tomoko Arai 1 , Masanori Kobayashi 1 , Sohsuke Ohno 1 and Mars rover study group 1.5 3397 km 6.42 10 ...doi:10.5575/geosoc.2012.0016 fatcat:fywroukmmvb27m6j2zes4ixime
Tomoko Takahashi bir hurda düzenleyicisidir. Galerilerde, okullarda, ofislerde, polis karakollarında ve tenis kortlarında kurulumlar gerçekleştirir. ... Nesneleri ve enkazları, iki gerçekliği birbirine bağlayan kendi kendini küçümseyen çalışmalara bir araya getirirler. ...doi:10.7816/idil-10-78-02 fatcat:ciafutgbdrgefbqs72lgaxakt4
DECIGO (DECI-hertz interferometer Gravitational wave Observatory) is the future Japanese space gravitational wave antenna with observation band around 0.1 Hz. It aims at detecting gravitational waves from various kinds of sources, with sufficient sensitivity to establish the gravitational wave astronomy. In the pre-conceptual design, DECIGO is formed by three drag-free spacecraft, 1000 km apart from one another. The relative displacements between proof masses housed in these spacecraft aredoi:10.1088/1742-6596/154/1/012040 fatcat:k5wdfvpsfrbsbguzmdckphhviu
more »... red by Fabry-Perot interferometers. We plan to launch DECIGO in 2024 after research and development phase, including two milestone missions (DECIGO pathfinder and Pre-DECIGO) for verification of required technologies.
Those studies showed a specific increase in the growth rate with respect to light intensity (Araya et al., 2014; Nguyen et al., 2019; McClure et al., 2019) . ... Carotenoid productivity in volumetric unit corresponds to the product • , where stands for intracellular carotenoid content (mg carotenoids/g biomass) (Araya et al., 2014) . ...doi:10.14716/ijtech.v11i5.4331 fatcat:yfp6vjsribhurnfmxo2kswj5xu
Araya-Kojima et al. (1) reported the inhibition of ammonia production by fecal putrefactive bacteria when BB536 was co-cultured with them in vitro. ... Bifidobacterium longum BB536 Administration on the Intestinal Environment, Defecation Frequency and Fecal Characteristics of Human Volunteers Tomohiro OGATA,1 Teiichi NAKAMURA,1 Katsue ANJITSU,1 Tomoko ...doi:10.12938/bifidus1996.16.53 fatcat:tuouebiglnftvci7cgn47tqj7a
thermal diffusion. 3507-Pos 3508-Pos Board B236 Using Nanofluidic Channels to Probe the Dynamics of Rad51-DNA Filaments Louise Helena Fornander 1 , Fredrik Persson 2 , Joachim Fritzsche 1 , Joshua Araya ... Dresden, Germany, 1 2 3512 - 3512 Pos Board B240 Construction and Characterization of Cy3-or Cy5-Conjugated Hairpin Pyrrole/Imidazole Polyamides Binding to DNA in the Nucleosome Yong-Woon Han 1 , Tomoko ...doi:10.1016/j.bpj.2013.11.3830 fatcat:s3zulgebojhupo5stnytecmivy
Journal of the Japanese Society of Agricultural Machinery
any objects moving through air, the characteristics of the scatter pattern of grain vary in accordance with the air temperature and pressure (Nakayama, 1998), and the shape and/or weight of the grain (Araya ...doi:10.11357/jsam1937.65.4_77 fatcat:5zfxad7wxvgdlkn3bnjicydigi
Araya, T. Chan-Ard, T. Hikida, J. Nabhitabhata, and S. Panha are also acknowledged for their help in field trips. We thank S. ... Saidapur, Wichase Khonsue, Tomoko Tanaka-Ueno and Guan-Fu Wu, page 489-495. for the reader's convenience, the corrections appear as follows; page 495, Received date 11 January, 2004 (correct) 11 January ...doi:10.2108/zsj.22.489 pmid:15846058 fatcat:vgbaojfp55bu5p4ufub6645m24
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