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Compositional and Morphological Comparison among Three Coeval Violins Made by Giuseppe Guarneri "del Gesù" in 1734

Giacomo Fiocco, Sebastian Gonzalez, Claudia Invernizzi, Tommaso Rovetta, Michela Albano, Piercarlo Dondi, Maurizio Licchelli, Fabio Antonacci, Marco Malagodi
2021 Coatings  
In the present work, we had the opportunity to study the coating systems of three different coeval violins, namely "Spagnoletti", "Stauffer", and "Principe Doria", made by Giuseppe Guarneri "del Gesù"  ...  These are decisive peculiarities that help to better understand the artisanship of Guarneri "del Gesù".  ...  period of historical violin making, hundreds of musical instruments were made in the workshops of the most important luthiers based in Cremona (Italy), namely Antonio Stradivari, Nicola Amati, Giuseppe Guarneri  ... 
doi:10.3390/coatings11080884 fatcat:zfkytp3byrg7noilzwb6sxua5u

Estimating Leaf Area Index (LAI) in Vineyards Using the PocketLAI Smart-App

Francesca Orlando, Ermes Movedi, Davide Coduto, Simone Parisi, Lucio Brancadoro, Valentina Pagani, Tommaso Guarneri, Roberto Confalonieri
2016 Sensors  
Estimating leaf area index (LAI) of Vitis vinifera using indirect methods involves some critical issues, related to its discontinuous and non-homogeneous canopy. This study evaluates the smart app PocketLAI and hemispherical photography in vineyards against destructive LAI measurements. Data were collected during six surveys in an experimental site characterized by a high level of heterogeneity among plants, allowing us to explore a wide range of LAI values. During the last survey, the
more » ... ty to combine remote sensing data and in-situ PocketLAI estimates (smart scouting) was evaluated. Results showed a good agreement between PocketLAI data and direct measurements, especially for LAI ranging from 0.13 to 1.41 (R 2 = 0.94, RRMSE = 17.27%), whereas the accuracy decreased when an outlying value (vineyard LAI = 2.84) was included (R 2 = 0.77, RRMSE = 43.00%), due to the saturation effect in case of very dense canopies arising from lack of green pruning. The hemispherical photography showed very high values of R 2 , even in presence of the outlying value (R 2 = 0.94), although it showed a marked and quite constant overestimation error (RRMSE = 99.46%), suggesting the need to introduce a correction factor specific for vineyards. During the smart scouting, PocketLAI showed its reliability to monitor the spatial-temporal variability of vine vigor in cordon-trained systems, and showed a potential for a wide range of applications, also in combination with remote sensing.
doi:10.3390/s16122004 pmid:27898028 pmcid:PMC5190985 fatcat:joleqcdaejdynjx5ygzfsxyk2a

Dataset of immune responses induced in swine by an inactivated Porcine Circovirus 2b vaccine

Flavia Guarneri, Enrico Tommaso Tresoldi, Giuseppe Sarli, Maria Beatrice Boniotti, Davide Lelli, Ilaria Barbieri, Barbara Bacci, Giulia D'Annunzio, Massimo Amadori
2021 Data in Brief  
: Conceptualization, Methodology, Supervision, Writing-Original draft preparation, Project administration, Funding acquisition; Flavia Guarneri: Investigation, Data Curation, Methodology, Visualization  ...  , Formal analysis; Enrico Tommaso Tresoldi: Investigation, Resources; Giuseppe Sarli: Methodology, Investigation, Project administration; Maria Beatrice Boniotti: Investigation; Davide Lelli: Investigation  ... 
doi:10.1016/j.dib.2021.106906 pmid:33997189 pmcid:PMC8100898 fatcat:dcj3mzlf4bevxdwo2taqtdwame

Immune characterization of breast cancer metastases: prognostic implications

Maria Vittoria Dieci, Vassilena Tsvetkova, Enrico Orvieto, Federico Piacentini, Guido Ficarra, Gaia Griguolo, Federica Miglietta, Tommaso Giarratano, Claudia Omarini, Serena Bonaguro, Rocco Cappellesso, Camillo Aliberti (+6 others)
2018 Breast Cancer Research  
Tumor-infiltrating lymphocytes (TILs) evaluated in primary breast cancer (BC) convey prognostic information. Limited data in the metastatic setting are available. Methods: Secondary lesions from 94 BC patients, 43 triple-negative (TN) and 51 HER2-positive, were evaluated for TILs and expression of CD8, FOXP3, and PD-L1 by immunohistochemistry. Results: TILs levels on metastasis were generally low (median 5%) and did not differ between TN and HER2+ tumors. Younger patients showed significantly
more » ... wer TILs (p = 0.002). In HER2+ patients, TILs were higher in lung metastases as compared to other sites (p = 0.038). TILs composition was different across metastatic sites: skin metastases presented higher FOXP3 (p = 0.002) and lower CD8/FOXP3 ratio (p = 0.032). Patients treated for metastatic BC prior to biopsy had lower CD8 (overall: p = 0.005, HER2+: p = 0.011, TN: p = 0.075). In TN patients, median overall survival (OS) was 11.8 and 62.9 months for patients with low and high TILs, respectively (HR 0.29, 95%CI 0.11-0.76, log-rank p = 0.008). CD8/FOXP3 ratio was also prognostic in TN patients (median OS 8.0, 13.2, and 54.0 months in 1st, 2nd and 3th tertile, log-rank p = 0.019). Both TILs and CD8/FOXP3 ratio were independent factors at multivariate analysis. Counterintuitively, in HER2+ BC, low TILs tumors showed better prognosis (median OS 53.7 vs 39.9 months in TILs low and TILs high, not statistically significant). Conclusions: Our findings indicate the relevance of TILs as prognostic biomarker for TNBC even in the advanced setting and provide novel hypothesis-generating data on potential sources of immune heterogeneity of metastatic BC.
doi:10.1186/s13058-018-1003-1 pmid:29929548 pmcid:PMC6013851 fatcat:3epycp4bdfb4nm4wmrh6yt7hay

A high-resolution, integrated system for rice yield forecasting at district level

Valentina Pagani, Tommaso Guarneri, Lorenzo Busetto, Luigi Ranghetti, Mirco Boschetti, Ermes Movedi, Manuel Campos-Taberner, Francisco Javier Garcia-Haro, Dimitrios Katsantonis, Dimitris Stavrakoudis, Elisabetta Ricciardelli, Filomena Romano (+5 others)
2018 Agricultural Systems  
25 To meet the growing demand from public and private stakeholders for early yield estimates, a high-26 resolution (2 km × 2 km) rice yield forecasting system based on the integration between the WARM 27 model and remote sensing (RS) technologies was developed. RS was used to identify rice-cropped 28 area and to derive spatially distributed sowing dates, as well as for the dynamic assimilation of RS-29 derived leaf area index (LAI) data within the crop model. The systemtested for the main
more » ... an 30 rice production districts in Italy, Greece and Spainperformed satisfactorily: more than 66% of inter-31 annual yield variability was explained in six out of eight combinations of ecotype × district, with a 32 maximum of 89% of variability explained for Tropical Japonica cultivars in the Vercelli district 33 (Italy). In seven out of eight cases, the assimilation of RS-derived LAI allowed improving the 34 forecasting capability, with minor differences due to the assimilation technology used (updating or 35 recalibration). In particular, RS allowed reducing the uncertainty by capturing factors not properly 36 reproduced by the simulation model (given the uncertainty due to large-area simulations). As an 37 example, the season 2003 in the Serres (Greece) district was characterized by severe blast epidemics, 38 whose effect on canopy vigor was captured by RS-derived LAI products. The systemextending the 39 one used for rice within the EC-JRC-MARS forecasting systemwas pre-operationally used in 2015 40 and 2016 to provide early yield estimates to private companies and institutional stakeholders within 41 the EU-FP7 ERMES project. 42 43 Keywords 44 Assimilation; blast disease; Oryza sativa L.; remote sensing; WARM model. 45 46 as the need of defining selling strategies or planning milling operations (Everingham et al., 2002), the 52 interest of public institutions deals with the need of regulating agricultural markets and mitigating 53 volatility of prices in case of speculative actions on food commodities (e.g., OECD and FAO, 2011; 54 Kogan et al., 2013). Simple forecasting systemsbased, e.g., on agroclimatic indicators (Balaghi et 55 al., 2012)demonstrated their usefulness under conditions characterized by large year-to-year 56 fluctuations in yields and when those fluctuations are driven by one or two key factors. Other 57 approaches are more complex, relying on remote sensing (Mkhabela et al., 2005; Wang et al., 2010; 58 Duveiller et al., 2013; Son et al., 2014) or crop simulation models (Vossen and Rijks, 1995; Supit, 59 1997; Bezuidenhout and Singels, 2007a/b; de Wit et al., 2010; Kogan et al., 2013; Pagani et al., 2017). 60 Crop models are indeed able to interpret reality, e.g., by capturing the effects of weather anomalies or 61 other factors affecting crop yields better than simpler systems. As an example, they are able to 62 simulate the effect of thermal shocks-induced spikelet sterility (Shimono et al., 2005) . A forecasting 63 grown in the province of Vercellirepresenting about 15% of the national rice production. In Spain 132
doi:10.1016/j.agsy.2018.05.007 fatcat:4sn5llmlvjejvdg24apd3hbecu

What Quality and Safety of Care for Patients Admitted to Clinically Inappropriate Wards: a Systematic Review

Micaela La Regina, Francesca Guarneri, Elisa Romano, Francesco Orlandini, Roberto Nardi, Antonino Mazzone, Andrea Fontanella, Mauro Campanini, Dario Manfellotto, Tommaso Bellandi, Gualberto Gussoni, Riccardo Tartaglia (+1 others)
2019 Journal of general internal medicine  
In countries with public health system, hospital bed reductions and increasing social and medical frailty have led to the phenomenon of "outliers" or "outlying hospital in-patients." They are often medical patients who, because of unavailability of beds in their clinically appropriate ward, are admitted wherever unoccupied beds are. The present work is aimed to systematically review literature about quality and safety of care for patients admitted to clinically inappropriate wards.
doi:10.1007/s11606-019-05008-4 pmid:31011980 pmcid:PMC6614225 fatcat:vhucimz3rjf33a6eyr2ranu2cm

Exceptional and Durable Responses to TDM-1 After Trastuzumab Failure for Breast Cancer Skin Metastases: Potential Implications of an Immunological Sanctuary

Tommaso Giarratano, Federica Miglietta, Carlo A. Giorgi, Vassilena Tsvetkova, Silvia Michieletto, Laura Evangelista, Ilaria Polico, Maria V. Dieci, Valentina Guarneri
2018 Frontiers in Oncology  
Breast Cancer (BC) skin metastases represent a challenging clinical scenario. Although they usually arise when other distant metastases are already present, they may also represent a form of locoregional recurrence (LRR). Systemic therapy in this setting may have a role both in case a radical locoregional approach is unfeasible in order to achieve disease control, and as adjuvant strategy after radical removal of cutaneous lesions, in order to prevent or delay subsequent disease spread.
more » ... therapy for HER2+ metastatic BC (MBC) currently relies on anti-HER2 targeted agents. In this context TDM1 is an option in trastuzumab-resistant patients.Here we present 2 cases of isolated skin metastases in patients with HER2+ BC progressing during or early after trastuzumab-based therapy, showing impressive responses to TDM1. We hypothesize that the unique properties of skin immune microenvironment may explain the failure of trastuzumab, which exerts its action also through immunological mechanisms, and the subsequent outlier responses to TDM1, that relies on a partially different mechanism of action.
doi:10.3389/fonc.2018.00581 pmid:30560092 pmcid:PMC6287048 fatcat:zc4xnjs2nfenzda6tb3t26smry

Violation of Bell inequalities in larger Hilbert spaces: robustness and challenges

Werner Weiss, Giuliano Benenti, Giulio Casati, Italo Guarneri, Tommaso Calarco, Mauro Paternostro, Simone Montangero
2016 New Journal of Physics  
We explore the challenges posed by the violation of Bell-like inequalities by d-dimensional systems exposed to imperfect state-preparation and measurement settings. We address, in particular, the limit of high-dimensional systems, naturally arising when exploring the quantum-to-classical transition. We show that, although suitable Bell inequalities can be violated, in principle, for any dimension of given subsystems, it is in practice increasingly challenging to detect such violations, even if
more » ... he system is prepared in a maximally entangled state. We characterize the effects of random perturbations on the state or on the measurement settings, also quantifying the efforts needed to certify the possible violations in case of complete ignorance on the system state at hand.
doi:10.1088/1367-2630/18/1/013021 fatcat:qnfitdnqordsdbtgbbw5is3a6m

Adult height in girls with Turner syndrome treated from before 6 years of age with a fixed per kilogram GH dose

Malgorzata Wasniewska, Tommaso Aversa, Laura Mazzanti, Maria Pia Guarneri, Patrizia Matarazzo, Filippo De Luca, Fortunato Lombardo, Maria Francesca Messina, Mariella Valenzise
2013 European Journal of Endocrinology  
ObjectiveTo evaluate adult height (AH) in 25 girls with Turner syndrome (TS) who were treated from before 6 years of age for 10.0±1.7 years with a fixed GH dose of 0.33 mg/kg per week.Patients and designAfter a 6-month pretreatment assessment all patients were measured 6-monthly under therapy to assess height SDS (H-SDS) and height velocity (HV) until AH achievement.ResultsFollowing initial acceleration, HV declined after the first 4 years of therapy. At the end of the sixth year of therapy,
more » ... DS gain was 1.9±1.1. Thereafter, H-SDS gain from baseline decreased, becoming 0.9±0.9 SDS at AH achievement. Bone maturation velocity did not significantly change throughout the prepubertal period. According to Lyon standards for TS, mean AH SDS was significantly higher than pretreatment H-SDS (P<0.0001), with a mean H-SDS change of 0.9±0.9. However, the prevalence of patients with AH <−2 SDS (according to Sempé standards) was close to those recorded at the start of therapy (16/25 vs 18/25). No significant differences in terms of AH were found between patients with either X monosomy or X-chromosomal abnormalities and between girls with either spontaneous or induced puberty.ConclusionsWe infer that the therapeutic regimen adopted in this prospective study is sufficient to induce a significant growth acceleration during the first year, but the response waned after 6 years of treatment.
doi:10.1530/eje-12-1032 pmid:23904278 fatcat:metfh3bd7ndgnbndo75y4rc6uy

Prognostic factors in phyllodes tumours of the breast: retrospective study on 166 consecutive cases

Elisabetta Di Liso, Michele Bottosso, Marcello Lo Mele, Vassilena Tsvetkova, Maria Vittoria Dieci, Federica Miglietta, Cristina Falci, Giovanni Faggioni, Giulia Tasca, Carlo Alberto Giorgi, Tommaso Giarratano, Eleonora Mioranza (+5 others)
2020 ESMO Open  
BackgroundPhyllodes tumours (PTs) are rare fibroepithelial tumours accounting for <1% of all breast tumours. We assessed clinicopathological features and their prognostic effect in a single-institution patients' cohort.MethodsPatients diagnosed with PT between 2001 and 2018 at our institution were identified. Clinical, surgical and pathological features were collected. Phyllodes-related relapse was defined as locoregional or distant recurrence (contralateral excluded), whichever first.ResultsA
more » ... otal of 166 patients were included: 115 with benign, 30 with borderline and 21 with malignant PTs. Features associated with malignant PT were younger age, larger T size, higher mitotic count, marked cytological atypia, stromal overgrowth, stromal hypercellularity, necrosis and heterologous differentiation (all p<0.01). The majority of patients with malignant PT underwent mastectomy (63.2% vs 3% of benign/borderline, p<0.001) and had negative surgical margins (83.3%). 4-year cumulative phyllodes-related relapse incidence was 7% for benign/borderline PT and 21.3% for malignant PT (p=0.107). In the entire cohort, marked cellular atypia and heterologous differentiation were associated with worse phyllodes-related relapse-free survival (HR 14.10, p=0.036 for marked vs mild atypia; HR 4.21, p=0.031 for heterologous differentiation present vs absent). For patients with benign PT, larger tumour size was associated with worse phyllodes-related relapse-free survival (HR 9.67, p=0.013 for T>5 cm vs T≤2 cm). Higher tumour-infiltrating lymphocytes (TILs) were associated with borderline and malignant PT (p=0.023); TILs were not associated with phyllodes-related relapse-free survival (HR 0.58, p=0.361 for TILs>2% vs≤2%). Overall, four patients died because of PT: three patients with malignant and one with borderline PT.ConclusionsPatients with malignant PT had increased rates of phyllodes-related relapse and phyllodes-related death. Cellular atypia and heterologous differentiation were poor prognostic factors in the entire cohort; large tumour size was associated with an increased risk of phyllodes-related relapse in benign PT.
doi:10.1136/esmoopen-2020-000843 pmid:33020219 fatcat:c3j2htd6tbhuzj6wok7dezhkwi

Androgen Receptor Expression and Association With Distant Disease-Free Survival in Triple Negative Breast Cancer: Analysis of 263 Patients Treated With Standard Therapy for Stage I-III Disease

Maria Vittoria Dieci, Vassilena Tsvetkova, Gaia Griguolo, Federica Miglietta, Mara Mantiero, Giulia Tasca, Enrico Cumerlato, Carlo Alberto Giorgi, Tommaso Giarratano, Giovanni Faggioni, Cristina Falci, Grazia Vernaci (+7 others)
2019 Frontiers in Oncology  
Copyright © 2019 Dieci, Tsvetkova, Griguolo, Miglietta, Mantiero, Tasca, Cumerlato, Giorgi, Giarratano, Faggioni, Falci, Vernaci, Menichetti, Mioranza, Di Liso, Frezzini, Saibene, Orvieto and Guarneri.  ... 
doi:10.3389/fonc.2019.00452 pmid:31245286 pmcid:PMC6563384 fatcat:fwdqocbz5rhsbevkbsvoobpibe

ERBB2 mRNA Expression and Response to Ado-Trastuzumab Emtansine (T-DM1) in HER2-Positive Breast Cancer

Gaia Griguolo, Fara Brasó-Maristany, Blanca González-Farré, Tomás Pascual, Núria Chic, Tamara Saurí, Ronald Kates, Oleg Gluz, Débora Martínez, Laia Paré, Vassilena Tsvetkova, David Pesantez (+17 others)
2020 Cancers  
Trastuzumab emtansine (T-DM1) is approved for the treatment of human epidermal growth factor receptor 2 (HER2)-positive (HER2+) metastatic breast cancer (BC) and for residual disease after neoadjuvant therapy; however, not all patients benefit. Here, we hypothesized that the heterogeneity in the response seen in patients is partly explained by the levels of human epidermal growth factor receptor 2 gene (ERBB2) mRNA. We analyzed ERBB2 expression using a clinically applicable assay in
more » ... ed paraffin-embedded (FFPE) tumors (primary or metastatic) from a retrospective series of 77 patients with advanced HER2+ BC treated with T-DM1. The association of ERBB2 levels and response was further validated in 161 baseline tumors from the West German Study (WGS) Group ADAPT phase II trial exploring neoadjuvant T-DM1 and 9 in vitro BC cell lines. Finally, ERBB2 expression was explored in 392 BCs from an in-house dataset, 368 primary BCs from The Cancer Genome Atlas (TCGA) dataset and 10,071 tumors representing 33 cancer types from the PanCancer TCGA dataset. High ERBB2 mRNA was found associated with better response and progression-free survival in the metastatic setting and higher rates of pathological complete response in the neoadjuvant setting. ERBB2 expression also correlated with in vitro response to T-DM1. Finally, our assay identified 0.20–8.41% of tumors across 15 cancer types as ERBB2-high, including gastric and esophagus adenocarcinomas, urothelial carcinoma, cervical squamous carcinoma and pancreatic cancer. In particular, we identified high ERBB2 mRNA in a patient with HER2+ advanced gastric cancer who achieved a long-lasting partial response to T-DM1. Our study demonstrates that the heterogeneity in response to T-DM1 is partly explained by ERBB2 levels and provides a clinically applicable assay to be tested in future clinical trials of breast cancer and other cancer types.
doi:10.3390/cancers12071902 pmid:32674482 fatcat:3ouuf23ff5aalmeajw77xq44qu

First Prospective Multicenter Italian Study on the Impact of the 21‐Gene Recurrence Score in Adjuvant Clinical Decisions for Patients with ER Positive/HER2 Negative Breast Cancer

Maria Vittoria Dieci, Valentina Guarneri, Tommaso Giarratano, Marta Mion, Giampaolo Tortora, Costanza De Rossi, Stefania Gori, Cristina Oliani, Laura Merlini, Felice Pasini, Giorgio Bonciarelli, Gaia Griguolo (+6 others)
2017 The Oncologist  
Dieci, Guarneri, Giarratano et al. Regarding patients with N1 cancer, there is a lack of data from European studies.  ...  Dieci, Guarneri, Giarratano et al. 299 O c AlphaMed Press 2017 in treatment recommendations were performed.  ... 
doi:10.1634/theoncologist.2017-0322 pmid:29133514 pmcid:PMC5905682 fatcat:rhxpemv72nanbltvz4km6y5f2u

Page 1014 of Revue Neurologique Vol. 12, Issue 19 [page]

1904 Revue Neurologique  
Depuis la description premiére, les faits ont été confirmés par divers auteurs (Daddi, Bertorelli, Volpino, Martinotti, Guarneri, Celli, di Blasi, Pace, d’ Amato, Bose, Luzzani).  ...  SAINTON, 1314) Hydarthrose des deux genoux et disparition des troubles Visuels dans un cas d’Acromégalie (Gonoidastro bilaterale e scomparsa dei disturbi visivi in un caso di acromegalia), par TomMAsO  ... 

L'analisi Stratigrafica dello Strumento Antico: un Approccio Microtomografico

Tommaso Rovetta, Giacomo Fiocco, Michela Albano, Claudia Invernizzi, Gabriele Natale Lanzafame, Alessandro Re
2020 Archeomatica  
Ed è proprio di Andrea Guarneri il frammento di violoncello osservato al sincrotrone. In questo caso la preparazione è penetrata profondamente nel legno per circa 200 μm (Figura 4a,b).  ...  Fig. 4 - 4 Fig. 4 -Sezioni tomografiche radiali corrispondenti ai tre strati osservati nel frammento di Guarneri: legno (a), strato di preparazione (b) e vernice esterna (c); ricostruzione tomografica  ... 
doi:10.48258/arc.v11i1.1712 doaj:9a8964957aaf46d2a05cc06b2b5c3df9 fatcat:7vwukwatfjd3zbmzmwkgans6fm
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