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The Little Ice Age glacier maximum in Iceland and the North Atlantic Oscillation: evidence from Lambatungnajökull, southeast Iceland

Tom Bradwell, Andrew Dugmore, David Sugden
2006 Boreas  
doi:10.1080/03009480500359202 fatcat:4t5xlfhuezaqhgadiy7eb4gdze

The Little Ice Age glacier maximum in Iceland and the North Atlantic Oscillation: evidence from Lambatungnajökull, southeast Iceland

TOM BRADWELL, ANDREW J. DUGMORE, DAVID E. SUGDEN
2008 Boreas  
doi:10.1111/j.1502-3885.2006.tb01113.x fatcat:ftoewzwg6nh75gcn6jl3wh2afy

Growth and decay of a marine terminating sector of the last British–Irish Ice Sheet: a geomorphological reconstruction

Andrew Finlayson, Derek Fabel, Tom Bradwell, David Sugden
2014 Quaternary Science Reviews  
Sugden, 1968; 22 Hall and Sugden, 1987; Kleman and Glasser, 2007; Golledge et al., 2009), thereby providing a key 23 link between long-term ice dynamics and the subglacial landscape. 24 In this paper we  ... 
doi:10.1016/j.quascirev.2013.10.009 fatcat:5fqaqwh6hfa3rmwlh2jtf7thui

Signaling properties and expression in normal and tumor tissues of two phospholipase C epsilon splice variants

Sonia Caroline Sorli, Tom D Bunney, Peter H Sugden, Hugh F Paterson, Matilda Katan
2004 Oncogene  
Phospholipase Ce (PLCe) is a novel member of phosphoinositide-specific phospholipase C enzymes with a unique regulatory link to Ras GTP-ases. In the present studies, we establish existence of two splice variants (PLCe1a and PLCe1b) derived from human PLCe1 gene. When expressed in COS or HEK293 cells, PLCe1a and PLCe1b have similar potential to be stimulated by diverse signaling pathways via tyrosine kinase and G-protein coupled receptors and share the ability to function as an effector of Ras.
more » ... he expression pattern shows broader mRNA expression of PLCe1a in normal tissues; furthermore, in most cell lines expressing PLCe, PLCe1a is the only splice variant present. Analysis of normal/tumor matched pairs derived from colon and rectum demonstrates greatly reduced expression levels in tumor tissues. Further studies in a colorectal tumor cell line lacking PLCe show restoration of transcription of PLCe1a and PLCe1b by demethylating agent 5-aza-2 0 -deoxycytidine, suggesting epigenetic silencing through hypermethylation. In addition, expression of exogenous PLCe in this cell line demonstrates inhibitory effects of PLCe on cell viability and proliferation. Taken together, our findings suggest that regulatory mechanisms controlling expression of PLCe, broadened by diversity introduced by splice variants, could play important role in PLCe regulation in normal and tumor cells.
doi:10.1038/sj.onc.1208168 pmid:15558028 fatcat:oczqms3lwbb3vban7dl7tii37u

Characterisation of femtosecond laser inscribed long period gratings in photonic crystal fibre

Tom Allsop, Kyriacos Kalli, Kaiming Zhou, Graham Smith, Yicheng Lai, Michael Dubov, Kate Sugden, David Webb, Ian Bennion, Michael Komodromos, Kyriacos Kalli, Waclaw Urbanczyk
2008 Photonic Crystal Fibers II  
The use of high intensity femtosecond laser sources for inscribing fibre gratings has attained significant interest. The principal advantage of high-energy pulses is their ability for grating inscription in any material type without preprocessing or special core doping -the inscription process is controlled multi-photon absorption, void generation and subsequent local refractive index changes. The formation of grating structures in photonics crystal fibre has proven difficult, as the presence
more » ... holes within the fibre that allow wave-guidance impair and scatter the femtosecond inscription beam. Here we report on the consistent manufacture of long period gratings in endlessly single mode microstructure fibre and on their characterisation to external perturbations. Long period gratings are currently the subject of considerable research interest due to their potential applications as filters and as sensing devices, responsive to strain, temperature, bending and refractive index. Compared to the more mature fibre Bragg grating sensors, LPGs have more complex spectra, usually with broader spectral features. On the other hand they are intrinsically sensitive to bending and refractive index. Perhaps more importantly, the fibre design and choice of grating period can have a considerable influence over the sensitivity to the various parameters, for example allowing the creation of a bend sensor with minimal temperature cross-sensitivity. This control is not possible with FBG sensors. Here we compare the effects of symmetric and asymmetric femtosecond laser inscription.
doi:10.1117/12.781104 fatcat:r57mpiustvaudkhphva2r3s3my

The design and implementation of Grid database services in OGSA-DAI

Mario Antonioletti, Malcolm Atkinson, Rob Baxter, Andrew Borley, Neil P. Chue Hong, Brian Collins, Neil Hardman, Alastair C. Hume, Alan Knox, Mike Jackson, Amy Krause, Simon Laws (+6 others)
2005 Concurrency and Computation  
Initially, Grid technologies were principally associated with supercomputer centres and large-scale scientific applications in physics and astronomy. They are now increasingly seen as being relevant to many areas of e-Science and e-Business. The emergence of the Open Grid Services Architecture (OGSA), to complement the ongoing activity on Web Services standards, promises to provide a service-based platform that can meet the needs of both business and scientific applications. Early Grid
more » ... ons focused principally on the storage, replication and movement of file-based data. Now the need for the full integration of database technologies with Grid middleware is widely recognized. Not only do many Grid applications already use databases for managing metadata, but increasingly many are associated with large databases of domain-specific information (e.g. biological or astronomical data). This paper describes the design and implementation of OGSA-DAI, a service-based architecture for database access over the Grid. The approach involves the design of Grid Data Services that allow consumers to discover the properties of structured data stores and to access their contents. The initial focus has been on support for access to Relational and XML data, but the overall architecture has been designed to be extensible to accommodate different storage paradigms. The paper describes and motivates the design decisions that have been taken, and illustrates how the approach supports a range of application scenarios. The OGSA-DAI software is freely available from http://www.ogsadai.org.uk.
doi:10.1002/cpe.939 fatcat:tubmud4xnre63mgfrvi43ju3la

In vitro expression of NGN3 identifies RAB3B as the predominant Ras-associated GTP-binding protein 3 family member in human islets

Karen Piper Hanley, Tom Hearn, Andrew Berry, Melanie J Carvell, Ann-Marie Patch, Louise J Williams, Sarah A Sugden, David I Wilson, Sian Ellard, Neil A Hanley
2010 Journal of Endocrinology  
Neurogenin 3 (NGN3) commits pancreatic progenitors to an islet cell fate. We have induced NGN3 expression and identified upregulation of the gene encoding the Ras-associated small molecular mass GTP-binding protein, RAB3B. RAB3B localised to the cytoplasm of human β-cells, both during the foetal period and post natally. Genes encoding alternative RAB3 proteins and RAB27A were unaltered by NGN3 expression and in human adult islets their transcripts were many fold less prevalent than those of
more » ... B. The regulation of insulin exocytosis in rodent β-cells and responsiveness to incretins are reliant on Rab family members, notably Rab3a and Rab27a, but not Rab3b. Our results support an important inter-species difference in regulating insulin exocytosis where RAB3B is the most expressed isoform in human islets.
doi:10.1677/joe-10-0120 pmid:20807725 pmcid:PMC2951179 fatcat:t7n5hbmgvvglpg2p5eb6g7c52q

Page 352 of Political Studies Vol. 35, Issue 2 [page]

1987 Political Studies  
HOWARD WILLIAMS, University College of Wales, Aberystwyth Tom Campbell, David Goldberg, Sheila McLean and Tom Mullen (eds), Human Rights: From Rhetoric to Reality (Oxford, Basil Blackwell, 1986), 262 pp  ...  This book contains 11 chapters (including an introduction by Tom Campbell), contributed by 9 authors.  ... 

Page 339 of McMillan's Magazine Vol. 16, Issue 95 [page]

1867 McMillan's Magazine  
Mary’s when they got the news of Tom Silcote’s death. There was not the slightest reason for Betts moving; but he claimed great credit for taking active possession of Silcotes.  ...  Sugden and Mr. Betts sat down to a very good dinner indeed. Not that Mr. Betts had the slightest business to take possession of Silvotes. Sugden was staying with him at St.  ... 

Page 374 of Foreign Quarterly and Westminster Review Vol. 9, Issue 18 [page]

1832 Foreign Quarterly and Westminster Review  
Wyttenbachii, tom. i, p. 42. Amst. 1822, 2 tom. 8vo.  ...  (Tom. ii. p- 140.) See likewise G. d’Arnaud, Variarum Conjecturarum libri duo, p. 204. Franequera, 1738, 4to.  ... 

Page 327 of McMillan's Magazine Vol. 14, Issue 83 [page]

1866 McMillan's Magazine  
One of the most beautiful touches in that most beautiful book, “Tom Brown” (a book which only yesterday was as fresh and as good as ever), is the infinite grief of Tom when he finds that his letter has  ...  James Sugden the elder sat, in the evening, at the door of his cottage, sadly, with his face buried in his hands.  ... 

Page 394 of Every Saturday: A Journal of Choice Reading Vol. 4, Issue 91 [page]

1867 Every Saturday: A Journal of Choice Reading  
Mary’s when they got the news of Tom Silcote’s death. There was not the slightest reason for Betts moving; but he claimed great credit for taking active possession of Silcotes.  ...  Sugden ? ” said Betts, after the I soup. I “ Whvi no,” said Sugden. “ I got so heavily used I in the Crimea, that a^r a feeble attempt I gave it ! up” . “ A wise resolution, nephew.” “ Nephew ?  ... 

Page 348 of United States Law Intelligencer and Review Vol. 1, Issue 11 [page]

1829 United States Law Intelligencer and Review  
should render it necessary, at the present time, to repeat, that the only object of forensic disputation is to inform the jury or the judge of all the bearings of the case, to sift the affair to the bot- tom  ...  Sugden, who after consulting with his junior (Mr. Ja- cob) appeared not a little disconcerted, said that he found he had mistaken his side.  ... 

Page 45 of Ainslee's Vol. 21, Issue 4 [page]

1908 Ainslee's  
Sugden ?”  ...  Sugden, listen to me. I come here to Chilham Abbey a stranger, with my record still to make.  ... 

Page 124 of McMillan's Magazine Vol. 16, Issue 92 [page]

1867 McMillan's Magazine  
But this wonderful Sugden - Tom - Silcote a a a a oo whe > | i be  ...  Tom,” cried Silcote after along talk with Arthur, “dinner is ready. I can’t live by talking non- sense to curly-headed youngsters, if you can. Arthur, my dear boy, take in Mrs. Tom.”  ... 
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