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Savage Grace : Tom Kalin

Kathrin Halter
2008
F ILM BULLETIN 5.OB NEU IM KINO SAVAGE GRACE Tom Kaiin Barbara Baekeland ist keine Unbekannte: Die tragisch gefallene Millionärsgattin war bereits ein Fall für die Massenmedien, ehe sich mehrere  ...  Bücher der skandalträchtigen Geschichte der Baekeland-Dynastie annahmen; Tom Kaiin hat in seinem Erstling nun nach einem Drehbuch von Howard A.  ... 
doi:10.5169/seals-863923 fatcat:dirul32kxfdtvojh6ut5j26dmi

Common Grace, Like Sense, Certainly Not as Common as It Should Be

Tom Skelton
2019 Bible and the Contemporary World  
COMMON GRACE 3 In scripture it is the stuff of life Williams, Liberation, 15. Williams, Liberation, 10. 20 21 Holmes, 3. 22 23  ...  and effective methodology in engaging with the public square; however his argument in the lecture does not allow for less intelligent, considerate and gracious agents who take his method without his grace  ... 
doi:10.15664/bcw.v1i1.1864 fatcat:onhs673ucrcjxlpxekyh5gyp7y

Monitoring Groundwater Change in California's Central Valley Using Sentinel-1 and GRACE Observations

Zhen Liu, Pang-Wei Liu, Elias Massoud, Tom G Farr, Paul Lundgren, James S. Famiglietti
2019 Geosciences  
We observed a very good temporal correlation between the Gravity Recovery and Climate Experiment (GRACE) satellite groundwater anomaly (GWA) variation and long-term subsidence records, regardless of local  ...  -1 and other satellites, we anticipate decadal-scale subsidence records with a spatial resolution of tens to hundreds of meters will be available in the near future to be combined with basin-averaged GRACE  ...  -W.L. performed the analysis of GRACE and precipitation data. E.M. and P.-W.L. contributed to the writing of the GRACE and Precipitation section.  ... 
doi:10.3390/geosciences9100436 fatcat:wunc753isjconmgxux3aaxmmbm

Book Review: Grace: A Preaching CommentaryGrace: A Preaching CommentarybyFarrisStephenAbingdon, Nashville. 2003. 150 pp. $19.00. ISBN 0-687-09046-6

Tom Whartenby
2005 Interpretation (Richmond)  
TOM WHARTENBY GALAX PRESBYTERIAN CHURCH GALAX, VIRGINIA Voicing the Vision: Imagination and Prophetic Preaching by Linda L. Clader Morehouse, Harrisburg, 2003. 168 pp. $16.95. ISBN O- 8192-1932-0.  ...  Grace is about receiving, whereas we are much better at giving. Grace is about being dependent; we idolize self-sufficiency. Grace cannot be controlled, and this makes most of us very uneasy.  ... 
doi:10.1177/002096430505900425 fatcat:cf2slxyl3rcsfoolcttikp2lxu

GRACES: Gemini remote access to CFHT ESPaDOnS Spectrograph through the longest astronomical fiber ever made (Experimental phase completed.) [article]

André-Nicolas Chené, John Pazder, Gregory Barrick, Andre Anthony, Tom Benedict, David Duncan, Pedro Gigoux, Scot Kleinman, Lison Malo, Eder Martioli, Claire Moutou, Vinicius Placco, Vlad Reshetovand (+6 others)
2014 arXiv   pre-print
GRACES achieved delivering spectra with a resolution power of R = 40,000 and R = 66,000 between 400 and 1,000 nm. It has a ~8% throughput and is sensitive to target fainter than 21st mag in 1 hour.  ...  We are very grateful to all the numerous teams who made this challenging project successful, and more specifically to the day crews at both CFHT and Gemini for their kind contribution and for making GRACES  ...  GRACES data files.  ... 
arXiv:1409.7448v1 fatcat:eigbxzw7bfbbhbbqtc5frmjuhe

Validation of hippocampal biomarkers of cumulative affective experience

Colline Poirier, Melissa Bateson, Fabio Gualtieri, Elena Armstrong, Grace C. Laws, Timothy Boswell, Tom V. Smulders
2019 Zenodo  
Preprint of review paper to be published in Neurscience & Biobehavioral Reviews
doi:10.5281/zenodo.2445797 fatcat:p6sbqylb2zbphn76wedzpjsuqa

Computational Deorphaning of Mycobacterium tuberculosis Targets [chapter]

Lorraine Yamurai Bishi, Dr Sundeep Chaitanya Vedithi, Tom L. Blundell, Grace Mugumbate
2019 Tuberculosis - Beyond the Biomedical [Working Title]  
Tuberculosis (TB) continues to be a major health hazard worldwide due to the resurgence of drug discovery strains of Mycobacterium tuberculosis (Mtb) and co-infection. For decades drug discovery has concentrated on identifying ligands for ~10 Mtb targets, hence most of the identified essential proteins are not utilised in TB chemotherapy. Here computational techniques were used to identify ligands for the orphan Mtb proteins. These range from ligand-based and structure-based virtual screening
more » ... delling the proteome of the bacterium. Identification of ligands for most of the Mtb proteins will provide novel TB drugs and targets and hence address drug resistance, toxicity and the duration of TB treatment.
doi:10.5772/intechopen.82374 fatcat:m246owirwbfwllenxnf64zqzgu

Validation of a cumulative affective experience biomarker: hippocampal plasticity

Colline Poirier, Melissa Bateson, Fabio Gualtieri, Elena Armstrong, Grace C. Laws, Timothy Boswell, Tom V. Smulders
2018 Zenodo  
Preprint of review paper.
doi:10.5281/zenodo.2445798 fatcat:bpwpw5ntsrckfbj4d6x6sbux5m

The Wisdom to Know the Difference

Simon J. Haines, John Gleeson, Peter Kuppens, Tom Hollenstein, Joseph Ciarrochi, Izelle Labuschagne, Caitlin Grace, Peter Koval
2016 Psychological Science  
They are a picture of what grace can do. You might know, if you know a lot about Bible stuff, that the Christmas story is basically a story for the people of Israel.  ...  There are just people who are train wrecks apart from God and then God's grace. So here's a question…Who's going to sit on the throne of your life? You are not a good option for that role.  ... 
doi:10.1177/0956797616669086 pmid:27738099 fatcat:4l62y5zkt5dm3fd75nlxlmfrh4

Using xSearch for Accelerating Research-Review of Deep Web Technologies Federated Search Service

Grace Baysinger, Tom Cramer
2011 Charleston Advisor  
Tom Cramer is the Chief Technology Strategist and Associate Director of Digital Library Systems and Services for the Stanford University Libraries.  ...  After receiving her library degree in 1981 from the University of Michigan, Grace held professional positions at UM's Natural Sciences and Chemistry Libraries.  ... 
doi:10.5260/chara.13.2.55 fatcat:wjlkvou3g5fnvgh54y6gc4upii

HIV drug resistance among adults initiating antiretroviral therapy in Uganda

Christine Watera, Deogratius Ssemwanga, Grace Namayanja, Juliet Asio, Tom Lutalo, Alice Namale, Grace Sanyu, Isaac Ssewanyana, Jesus Fidel Gonzalez-Salazar, Jamirah Nazziwa, Maria Nanyonjo, Elliot Raizes (+7 others)
2021 Journal of Antimicrobial Chemotherapy  
Background WHO revised their HIV drug resistance (HIVDR) monitoring strategy in 2014, enabling countries to generate nationally representative HIVDR prevalence estimates from surveys conducted using this methodology. In 2016, we adopted this strategy in Uganda and conducted an HIVDR survey among adults initiating or reinitiating ART. Methods A cross-sectional survey of adults aged ≥18 years initiating or reinitiating ART was conducted at 23 sites using a two-stage cluster design sampling
more » ... Participants provided written informed consent prior to enrolment. Whole blood collected in EDTA vacutainer tubes was used for preparation of dried blood spot (DBS) specimens or plasma. Samples were shipped from the sites to the Central Public Health Laboratory (CPHL) for temporary storage before transfer to the Uganda Virus Research Institute (UVRI) for genotyping. Prevalence of HIVDR among adults initiating or reinitiating ART was determined. Results Specimens from 491 participants (median age 32 years and 61.5% female) were collected between August and December 2016. Specimens from 351 participants were successfully genotyped. Forty-nine had drug resistance mutations, yielding an overall weighted HIVDR prevalence of 18.2% with the highest noted for NNRTIs at 14.1%. Conclusions We observed a high HIVDR prevalence for NNRTIs among adults prior to initiating or reinitiating ART in Uganda. This is above WHO's recommended threshold of 10% when countries should consider changing from NNRTI- to dolutegravir-based first-line regimens. This recommendation was adopted in the revised Ugandan ART guidelines. Dolutegravir-containing ART regimens are preferred for first- and second-line ART regimens.
doi:10.1093/jac/dkab159 pmid:33993252 pmcid:PMC8361362 fatcat:hiyryquwdrb7hojtprsl7r24ym

Si-Containing Recessed Ohmic Contacts and 210 GHz Quaternary Barrier InAlGaN High-Electron-Mobility Transistors

Ronghua Wang, Guowang Li, Jai Verma, Tom Zimmermann, Zongyang Hu, Oleg Laboutin, Yu Cao, Wayne Johnson, Xiang Gao, Shiping Guo, Gregory Snider, Patrick Fay (+4 others)
2011 Applied Physics Express  
The effects of recess etch in alloyed ohmic contacts have been studied on InAl(Ga)N/AlN/GaN high-electron-mobility transistors (HEMTs) using a Si-containing ohmic metal stack. The optimized contact resistance is as low as 0.23 mm. With decent ohmic contacts, an In 0:13 Al 0:83 Ga 0:04 N barrier HEMT with a 66-nm long gate and dielectric-free passivation followed by a 5 nm Al 2 O 3 deposition, shows a maximum drain current density I d,max of 2.3 A/mm, a peak extrinsic transconductance g m,ext of
more » ... 560 mS/mm and a current gain cut-off frequency f T of 210 GHz, which are among the highest reported values in quaternary InAlGaN/AlN/GaN HEMTs. #
doi:10.1143/apex.4.096502 fatcat:vugfstvdizbbfbtnxlu4fho5xa

Inter-slice leakage and intra-slice aliasing in simultaneous multi-slice echo-planar images [article]

Carolyn Beth Mcnabb, Michael Lindner, Shan Shen, Kou Murayama, Laura Grace Burgess, Tom Johnstone
2018 bioRxiv   pre-print
Simultaneous multi-slice (SMS; multiband) imaging has become an increasingly popular technique owing to vast improvements in acquisition speed and spatial resolution of echo-planar (EPI) and diffusion-weighted images. However, SMS data are prone to motion sensitivity as well as slice leakage artefacts, which spread signal between simultaneously acquired slices. Here we report on an artefact temporally coinciding with signal fluctuations in the eye and spatially distributed in correspondence
more » ... multiband slice acceleration (inter-slice leakage) and parallel imaging (intraslice leakage) factors. In data collected using commonly used SMS-EPI protocols, we measured the intensity of signal fluctuations (artefact severity) at expected artefact positions. Control positions (outside the expected areas of signal leakage) were additionally specified. We demonstrated a direct relationship between eye movements and artefact severity and showed that time series of seed and artefact regions were highly correlated. Use of split slice-GRAPPA did not appear to mitigate the leakage artefacts. Artefacts from slice leakage were visually obvious in this case due to large signal fluctuations associated with eye movement. Less obvious but potentially serious artefacts would result from any signal, and warrant careful consideration when designing experiments employing SMS-EPI.
doi:10.1101/458042 fatcat:xbh3kyd2yrhzti4hf4fn2bjaxi

Structural diversity in de novo cyclic peptide ligands from genetically encoded library technologies

Tom E. McAllister, Oliver D. Coleman, Grace Roper, Akane Kawamura
2020 Peptide Science  
Cyclic peptides discovered by genetically encoded library technologies have emerged as a class of promising molecules in chemical biology and drug discovery. Here we review the cyclic peptides identified through these techniques reported in the period 2015 to 2019, with a particular focus on the three-dimensional structures that peptides adopt when binding to their targets. A range of different structures have been revealed through co-crystal structures, highlighting how versatile and adaptable
more » ... these molecules are in binding to diverse protein targets, such as enzymes and receptors, or challenging shallow surfaces involved in protein-protein interfaces. Analysis of the properties of the peptides reported shows some interesting trends, with further insight for those with structural information suggestive that larger peptides are more likely to adopt secondary structure. We highlight examples where co-crystal structures have informed the key interactions that promote high affinity and selectivity of cyclic peptides against their targets, identified novel inhibitor binding sites, and provided new insights into the biology of their targets. The structure-guided modifications have also aided the design of cyclic peptides with improved activity and physicochemical properties. These examples highlight the importance of crystallography in future cyclic peptide drug discovery initiatives. K E Y W O R D S chemical biology, crystal structures, cyclic peptides, display technologies, drug discovery | INTRODUCTION Cyclic peptides (CPs) are an emerging class of molecules that occupy the 'Goldilocks space between small molecules and large biologics', [1] with the potential to combine the best attributes of antibodies (high specificity and affinity) and small molecules (bioavailability and pharmacokinetics). Thus CPs have recently been attracting significant attention for use in a therapeutic setting [2, 3] and as tools for chemical biology owing to the high specificity and high affinities that they can achieve against a wide range of targets. One of the particularly intriguing properties of CPs is the diversity of the chemical space they can cover and three-dimensional structures they are able to adopt in order to achieve binding to their target protein. Unlike linear peptides, which are conformationally flexible and highly dynamic, the constraint of cyclisation in CPs restricts the number of conformations the peptide chain can adopt, thus reducing the entropic penalty for binding to its target. Small molecules, on the other hand, are typically very conformationally constrained, making them ideal for targeting pockets and presenting binding groups in a defined arrangement, but are limited when targeting large, shallow protein surfaces often considered to be 'undruggable' biological interaction space, such as protein-protein interactions (PPIs).
doi:10.1002/pep2.24204 fatcat:cyi3thj5vveptdigpxhxa3ubzq

Attitudes Toward Consumption and Conservation of Tigers in China

Brian Gratwicke, Judy Mills, Adam Dutton, Grace Gabriel, Barney Long, John Seidensticker, Belinda Wright, Wang You, Li Zhang, Tom Tregenza
2008 PLoS ONE  
A heated debate has recently emerged between tiger farmers and conservationists about the potential consequences of lifting the ban on trade in farmed tiger products in China. This debate has caused unfounded speculation about the extent of the potential market for tiger products. To fill this knowledge gap, we surveyed 1880 residents from a total of six Chinese cities to understand Urban Chinese tiger consumption behavior, knowledge of trade issues and attitudes towards tiger conservation. We
more » ... ound that 43% of respondents had consumed some product alleged to contain tiger parts. Within this user-group, 71% said that they preferred wild products over farmed ones. The two predominant products used were tiger bone plasters (38%) and tiger bone wine (6.4%). 88% of respondents knew that it was illegal to buy or sell tiger products, and 93% agreed that a ban in trade of tiger parts was necessary to conserve wild tigers. These results indicate that while Urban Chinese people are generally supportive of tiger conservation, there is a huge residual demand for tiger products that could resurge if the ban on trade in tiger parts is lifted in China. We suspect that the current supply of the market is predominantly met by fakes or substitutes branded as tiger medicines, but not listing tiger as an ingredient. We suggest that the Traditional Chinese Medicine community should consider re-branding these products as bone-healing medicines in order to reduce the residual demand for real tiger parts over the long-term. The lifting of the current ban on trade in farmed tiger parts may cause a surge in demand for wild tiger parts that consumers say are better. Because of the low input costs associated with poaching, wild-sourced parts would consistently undercut the prices of farmed tigers that could easily be laundered on a legal market. We therefore recommend that the Chinese authorities maintain the ban on trade in tiger parts, and work to improve the enforcement of the existing ban.
doi:10.1371/journal.pone.0002544 pmid:18596926 pmcid:PMC2435601 fatcat:shmilss2zjf47erhvay4a4c56y
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