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A New Approach to Analysing and Visualizing the Management of Corporate Innovation Projects [chapter]

Karolin Gebhardt, Andreas Riel, Tom Maes
2019 Communications in Computer and Information Science  
Innovating in a complex corporate context requires managing novelty, risk and uncertainty within an environment that strives for stability, efficiency and profitability on a daily basis. Resolving this conflict confront innovation project (IP) managers with extraordinary difficulties, which are normally addressed using classical project management methods and tools. This paper proposes an approach to analyze and capitalize the power of different project management methods within one IP in order
more » ... to increase both the probability of success and speed to success. This is achieved based on the classification of project tasks and subtasks according to their uncertainty levels with respect to the design problem and the solution. The success of work packages is assessed against pre-defined output criteria. This methodological approach is complemented by the stakeholder dimension, which takes into consideration the involved stakeholders as well as their relationships and influences in the project. The analysis of an ongoing IP at a leading global industrial player in the life science industry serves as validation platform for the presented tool set.
doi:10.1007/978-3-030-28005-5_59 fatcat:hl6lpodcrzbm3b3wgozjdvpznm

Evolution of computational models in BioModels Database and the Physiome Model Repository

Martin Scharm, Tom Gebhardt, Vasundra Touré, Andrea Bagnacani, Ali Salehzadeh-Yazdi, Olaf Wolkenhauer, Dagmar Waltemath
2018 BMC Systems Biology  
A useful model is one that is being (re)used. The development of a successful model does not finish with its publication. During reuse, models are being modified, i.e. expanded, corrected, and refined. Even small changes in the encoding of a model can, however, significantly affect its interpretation. Our motivation for the present study is to identify changes in models and make them transparent and traceable. Methods: We analysed 13734 models from BioModels Database and the Physiome Model
more » ... itory. For each model, we studied the frequencies and types of updates between its first and latest release. To demonstrate the impact of changes, we explored the history of a Repressilator model in BioModels Database. Results: We observed continuous updates in the majority of models. Surprisingly, even the early models are still being modified. We furthermore detected that many updates target annotations, which improves the information one can gain from models. To support the analysis of changes in model repositories we developed MoSt, an online tool for visualisations of changes in models. The scripts used to generate the data and figures for this study are available from GitHub and as a Docker image at The website provides interactive access to model versions and their evolutionary statistics. Conclusion: The reuse of models is still impeded by a lack of trust and documentation. A detailed and transparent documentation of all aspects of the model, including its provenance, will improve this situation. Knowledge about a model's provenance can avoid the repetition of mistakes that others already faced. More insights are gained into how the system evolves from initial findings to a profound understanding. We argue that it is the responsibility of the maintainers of model repositories to offer transparent model provenance to their users. Background The reuse of knowledge is key for the advancement of science [1] . Reusable computational models are provided by public repositories. Two major resources are BioModels Database [2] and the Physiome Model Repository [3] . Both repositories collect, curate, and publish models in standard formats, namely Systems Biology Markup
doi:10.1186/s12918-018-0553-2 pmid:29650016 pmcid:PMC5898004 fatcat:r636hi3sjnh23b5sgt44jiir54

Single-molecule imaging of transcription factor binding to DNA in live mammalian cells

J Christof M Gebhardt, David M Suter, Rahul Roy, Ziqing W Zhao, Alec R Chapman, Srinjan Basu, Tom Maniatis, X Sunney Xie
2013 Nature Methods  
1,5 , David M Suter 1,5 , Rahul Roy 1,4 , Ziqing W Zhao 1,2 , Alec R Chapman 1,2 , Srinjan Basu 1,3,4 , Tom Maniatis 3 & X Sunney Xie 1 Figure 1 | 1 Visualization of single fluorescently labeled DNA  ...  b τ int /τ tl + k off ) ,7 , distinguishing higher concentrations of single molecules requires a single-molecule imaging of transcription factor binding to dnA in live mammalian cells J Christof M Gebhardt  ... 
doi:10.1038/nmeth.2411 pmid:23524394 pmcid:PMC3664538 fatcat:mrffbjhap5af7dgivnzhgxfkki

Acidified Nitrite Contributes to the Antitumor Effect of Cold Atmospheric Plasma on Melanoma Cells

Tom Zimmermann, Lisa A Gebhardt, Lucas Kreiss, Christin Schneider, Stephanie Arndt, Sigrid Karrer, Oliver Friedrich, Michael J.M. Fischer, Anja-Katrin Bosserhoff
2021 International Journal of Molecular Sciences  
Cold atmospheric plasma (CAP) is partially ionized gas near room temperature with previously reported antitumor effects. Despite extensive research and growing interest in this technology, active components and molecular mechanisms of CAP are not fully understood to date. We used Raman spectroscopy and colorimetric assays to determine elevated nitrite and nitrate levels after treatment with a MiniFlatPlaster CAP device. Previously, we demonstrated CAP-induced acidification. Cellular effects of
more » ... itrite and strong extracellular acidification were assessed using live-cell imaging of intracellular Ca2+ levels, cell viability analysis as well as quantification of p21 and DNA damage. We further characterized these observations by analyzing established molecular effects of CAP treatment. A synergistic effect of nitrite and acidification was found, leading to strong cytotoxicity in melanoma cells. Interestingly, protein nitration and membrane damage were absent after treatment with acidified nitrite, thereby challenging their contribution to CAP-induced cytotoxicity. Further, phosphorylation of ERK1/2 was increased after treatment with both acidified nitrite and indirect CAP. This study characterizes the impact of acidified nitrite on melanoma cells and supports the importance of RNS during CAP treatment. Further, it defines and evaluates important molecular mechanisms that are involved in the cancer cell response to CAP.
doi:10.3390/ijms22073757 pmid:33916572 pmcid:PMC8038463 fatcat:olon43bwkff4jajxbaxao6fa4m

Computational Models for Clinical Applications in Personalized Medicine—Guidelines and Recommendations for Data Integration and Model Validation

Catherine Bjerre Collin, Tom Gebhardt, Martin Golebiewski, Tugce Karaderi, Maximilian Hillemanns, Faiz Muhammad Khan, Ali Salehzadeh-Yazdi, Marc Kirschner, Sylvia Krobitsch, EU-STANDSPM consortium, Lars Kuepfer
2022 Journal of Personalized Medicine  
Acknowledgments: The EU-STANDS4PM consortium: Rolf Apweiler, Stephan Beck, Catherine Bjerre Collin, Niklas Blomberg, Søren Brunak, Tom Gebhardt, Eugenijus Gefenas, Martin Golebiewski, Kalle Günther, Mette  ... 
doi:10.3390/jpm12020166 pmid:35207655 pmcid:PMC8879572 fatcat:2a4w3rohivarbajtbzie24mrjm

Detection and Investigation of Atypical Porcine Pestivirus within a Breed-to-Finish Farm and Off-Site Nursery and Finisher Locations

C. Grace Elijah, Cassandra K. Jones, Jason C. Woodworth, Rachel Palinski, Chad B. Paulk, Tom Petznick, Jordan T. Gebhardt
2021 Kansas Agricultural Experiment Station Research Reports  
Paulk, 2 Tom Petznick, 3 and Jordan T. Gebhardt 1 Figure 1 .Figure 2 . 12 Figure 1. Percentage of litters with either congenital tremors or splay legs over time at a farrow-to-finish farm.  ... 
doi:10.4148/2378-5977.8217 fatcat:bzapngsbzbc3tf7a2csm7tuxru

Cell Proliferation in the Adult Chicken Hippocampus Correlates With Individual Differences in Time Spent in Outdoor Areas and Tonic Immobility

Elena A. Armstrong, Bernhard Voelkl, Sabine Voegeli, Sabine G. Gebhardt-Henrich, Jonathan H. Guy, Victoria Sandilands, Tim Boswell, Michael J. Toscano, Tom V. Smulders
2020 Frontiers in Veterinary Science  
Copyright © 2020 Armstrong, Voelkl, Voegeli, Gebhardt-Henrich, Guy, Sandilands, Boswell, Toscano and Smulders.  ... 
doi:10.3389/fvets.2020.00587 pmid:33005647 pmcid:PMC7479223 fatcat:hoysuspfzbgj7bpq7ll7ezqv6u

Current status of the Hobby-Eberly Telescope wide field upgrade

Gary J. Hill, John A. Booth, Mark E. Cornell, John M. Good, Karl Gebhardt, Herman J. Kriel, Hanshin Lee, Ron Leck, Walter Moreira, Phillip J. MacQueen, Dave M. Perry, Marc D. Rafal (+21 others)
2012 Ground-based and Airborne Telescopes IV  
The Hobby-Eberly Telescope (HET) is an innovative large telescope of 9.2 meter aperture, located in West Texas at the McDonald Observatory (MDO). The HET operates with a fixed segmented primary and has a tracker which moves the four-mirror corrector and prime focus instrument package to track the sidereal and non-sidereal motions of objects. A major upgrade of the HET is in progress that will increase the pupil size to 10 meters and the field of view to 22′ by replacing the corrector, tracker
more » ... d prime focus instrument package. In addition to supporting the existing suite of instruments, this wide field upgrade will feed a revolutionary new integral field spectrograph called VIRUS, in support of the Hobby-Eberly Telescope Dark Energy Experiment (HETDEX χ ). This paper discusses the current status of this upgrade. Downloaded From: on 07/01/2013 Terms of Use: Proc. of SPIE Vol. 8444 84440K-2 Downloaded From: on 07/01/2013 Terms of Use: Proc. of SPIE Vol. 8444 84440K-3 Downloaded From: on 07/01/2013 Terms of Use: Proc. of SPIE Vol. 8444 84440K-4 Downloaded From: on 07/01/2013 Terms of Use: Proc. of SPIE Vol. 8444 84440K-7 Downloaded From: on 07/01/2013 Terms of Use: Proc. of SPIE Vol. 8444 84440K-8 Downloaded From: on 07/01/2013 Terms of Use: Proc. of SPIE Vol. 8444 84440K-12 Downloaded From: on 07/01/2013 Terms of Use:
doi:10.1117/12.925435 fatcat:dukbe2z7hvd77g2hxwgawbjbui

Exploring the evolution of biochemical models at the network level

Tom Gebhardt, Vasundra Touré, Dagmar Waltemath, Olaf Wolkenhauer, Martin Scharm
Author Contributions Conceptualization: Tom Gebhardt, Martin Scharm. Methodology: Tom Gebhardt.  ... 
doi:10.1371/journal.pone.0265735 pmid:35312734 pmcid:PMC8936491 fatcat:v3m4w6yyt5guzkpd445pbjeg5a

Page 109 of Guernsey Breeders' Journal Vol. 7, Issue 7 [page]

1915 Guernsey Breeders' Journal  
Becker & Son, Fort Atkinson, Wis. 32890 Captain Tom of Locust Hill Sire Arbitrator of Elkview (18032) Dam Nora of Lacust Hill (219.53) Born—Sept. 30, 1914 Breeder and owner: W'’alter T.  ...  Mena's Masher (17604) Dam Mena's Golden Queen (39969) Born—Dec. 27, 1914 Breeder and owner: Gebhardt Bros., Palmyra, Mo. 32888 Mena’s Masher 2d Sire Imp.  ... 

Page 369 of American Spirit Vol. 82, Issue 5 [page]

1948 American Spirit  
MARTHA BRADLEY, MRS, TOM B, THROCKMORTON, -MRS, ADA MAY DAVIS Mrs. Tom B. Throckmorton, Des Moines, Honorary State Regent and past third Vice President General of the National Society. Mrs.  ...  Dixie Gebhardt, would be re- placed with a new Iowa flag and the old -one sent to Mrs. Gebhardt. “D. A. R. stands for military training but not for war,” said Mrs. Throckmorton. thought,” said Mrs.  ... 

K jednomu Spinozovu dopisu …

Martin Hemelík
2020 E-LOGOS  
Gebhardt, Felix Meiner Verlag, Leipzig 1914, str. 111.  ...  Gebhardt, jsou tyto informace uvedeny pod označením "List č. XLVIIIb".  ... 
doi:10.18267/j.e-logos.468 fatcat:qmc7qokkn5hwtaqxyc5dhkdvji

Page 216 of The New Jersey Law Journal Vol. 56, Issue 8 [page]

1933 The New Jersey Law Journal  
Herbert, c/o Gebhardt & Gebhardt, Clinton. Lange, Harry W., Jr., 3 Yale Ter- race, Montclair. Licks, Robert L., 6 West South Or- ange Ave., South Orange.  ...  Tanner, Francis J., c/o Camp, Toms River. Topken, William J., 519 36th St., North Bergen. 576 Roosevelt Percy 216 THE NEW JERSEY LAW JOURNAL Ward, Edward F., Morris Plains.  ... 

Page 342 of American Society of Civil Engineers. Collected Journals Vol. 119, Issue 4 [page]

1993 American Society of Civil Engineers. Collected Journals  
(Townsend and Gebhardt 1990). .  ...  BEGINNING Fig. 1 summarizes the process used by HDR for implementing TOM. In 1989, one of HDR’s senior engineers attended a two-day seminar on TOM.  ... 

Page 639 of Guernsey Breeders' Journal Vol. 68, Issue 6 [page]

1945 Guernsey Breeders' Journal  
From Oklahoma, Tom Cooper Farms— 5, Meadow Lodge—3, Gaylord Farms—4.  ...  Gebhardt—1, St. Albans—2, Geo. Nixon—1, M. E. Wallis & Son—2. From Kansas, John Nelson—2, Lloyd Ringer—2, C. H. Pugh—2, Chet Ash- craft—l, Hugo Hiebert—2, Keith Van Horn—2, W. L.  ... 
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