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How affinity influences tolerance in an idiotypic network

Emma Hart, Hugues Bersini, Francisco C. Santos
2007 Journal of Theoretical Biology  
In this paper, we provide new evidence that the manner in which affinity is defined in an idiotypic network model imposes a definite topology on the connectivity of the potential idiotypic network that  ...  In the networks whose topologies exhibit high clustering, the tolerant and intolerant zones are so intertwined that the networks either reject all antigen or tolerate all antigen.  ...  not it is possible for tolerant and intolerant zones to co-exist in a idiotypic immune networks.  ... 
doi:10.1016/j.jtbi.2007.07.019 pmid:17904580 fatcat:m5jh6ec3czawffzgwv3cv7lntm

B-cell composition in the blood and cerebrospinal fluid of multiple sclerosis patients treated with dimethyl fumarate

Rune A. Høglund, Justyna Polak, Frode Vartdal, Trygve Holmøy, Andreas Lossius
2018 Multiple Sclerosis and Related Disorders  
CNS protein models in the graphical abstract were built using SWISS-MODEL [70]. The models are for illustration only. We are grateful for the patients' sample contributions for this study.  ...  The term was made famous and became widely used upon Niels Jerne's immune network theory, claiming the immune system is a functional network of idiotypic and anti-idiotypic antibodies (67) .  ...  Figures S1 Artificial neural network perceptron topology The perceptron used for prediction of cleavage has three layers: an input layer consisting of the vectors of the first three principal components  ... 
doi:10.1016/j.msard.2018.08.032 pmid:30243235 fatcat:kxukfj2qjfbdjc6xjhgntnzmoi

Indoleamine 2,3-Dioxygenase [chapter]

Kazuhiko Ino, Fumitaka Kikkawa
2011 Encyclopedia of Cancer  
With over 27,000 somatic and 550 germ line mutations and 3,000 citations in the world literature, this database is recognized as a major source of information on TP53 mutation patterns in human cancer.  ...  It can be searched and analyzed online and is useful to draw hypotheses on the nature of the molecular events involved in TP53 mutagenesis and on the natural history of cancer.  ...  Another crucial context in which idiotype vaccination specialists still struggle is that of defining the relevance of idiotype vaccine-induced humoral and cellular responses.  ... 
doi:10.1007/978-3-642-16483-5_3037 fatcat:ruhceyprszcm5d6te5rrm74bfq

ICL670A [chapter]

2017 Encyclopedia of Cancer  
Another crucial context in which idiotype vaccination specialists still struggle is that of defining the relevance of idiotype vaccine-induced humoral and cellular responses.  ...  Formulation Although idiotypic vaccination has been tested in humans with different formulations, such as soluble protein idiotype associated with an immunogenic carrier and an immunologic adjuvant, ▶  ...  In addition, as a result of the emerging (systematic) use of screening tests in combination with higher symptom awareness, colorectal cancer is more often detected in an earlier stage (▶ colorectal cancer  ... 
doi:10.1007/978-3-662-46875-3_101180 fatcat:66hbagjkhzalvc3i2pzbhoe7aa

In silico study of protein-protein interactions [article]

Anna Vangone, Universita' Degli Studi Di Salerno, Universita' Degli Studi Di Salerno
In particular, the interaction between proteins involved in the autoimmune response in celiac disease6,7 (Chapters 5 and 6) has been studied in collaboration with the group directed by Prof.  ...  In the second part of the thesis, these methods have been applied, in combination with classical state-of-art computational biology techniques, to predict and analyse the binding mode in real biological  ...  Idiotype, anti-idiotype network of autoantibodies: pathogenetic considerations and clinical application. Autoimmunity reviews 9, 631-633 (2010).  ... 
doi:10.14273/unisa-53 fatcat:2teb7juzyrae7cuwzeyzdaoxxy

32nd Annual Meeting and Pre-Conference Programs of the Society for Immunotherapy of Cancer (SITC 2017): Part One

2017 Journal for ImmunoTherapy of Cancer  
long-term receptor affinity.  ...  BMS-986178, an OX40 agonist, given alone and in combination with cells in 6 of 7 regressing lesions indicating an abscopal effect of this nivolumab, was well tolerated; the combination had  ... 
doi:10.1186/s40425-017-0289-3 fatcat:vtk3uddmajfqfjzebor3hqn64e

Chapter 7 Non-professional Histamine Producing Cells, Immune Responses and Autoimmunity [chapter]

Histamine H4 Receptor: A Novel Drug Target in Immunoregulation and Inflammation  
These channels might play an important role in balancing, maintaining and regulating low-level histamine fluctuations, which tend to occur due to variation in the histamine content of the food, histamine  ...  An oligoclonal, Ag-driven response defines a set of idiotopes, which is collectively referred to as an idiotype.  ...  3 (p<0.001) and monocytes were 11 vs . 1 (NS), whereas the MCs were 124 vs. 88 (NS) and eosinophils were 134 vs. 3 (p<0.001).  ... 
doi:10.2478/9788376560564.c7 fatcat:p6ncluimevhixgppzvry4ebtqi


1992 FEBS Letters  
Alterations of the CAMP-adenylate cyclase system in the failing human heart.  ...  Recent advances in solid-phase peptide synthesis and preparation of antibodies to synthetic peptides  ...  Bioph#vs.  ... 
doi:10.1016/0014-5793(92)80006-3 fatcat:znfzvmsvbvhe3epfomzrzwi5vm