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Arterial Spin Labeling (ASL) fMRI: Advantages, Theoretical Constrains and Experimental Challenges in Neurosciences

Ajna Borogovac, Iris Asllani
2012 International Journal of Biomedical Imaging  
Cerebral blood flow (CBF) is a well-established correlate of brain function and therefore an essential parameter for studying the brain at both normal and diseased states.  ...  Arterial spin labeling (ASL) is a noninvasive fMRI technique that uses arterial water as an endogenous tracer to measure CBF.  ...  ., for insightful discussions regarding the application of fMRI in disease. They also thank the anonymous reviewer for his/her thorough critique and invaluable suggestions.  ... 
doi:10.1155/2012/818456 pmid:22966219 pmcid:PMC3432878 fatcat:mm5qzhspjnacfi6kt6ldtnzk7e

Measuring brain beats: cardiac-aligned fast fMRI signals [article]

Dora Hermes, Hua Wu, Adam B Kerr, Brian Wandell
2022 bioRxiv   pre-print
Cardiac pulsations with a local minimum following systole are observed in blood vessels, with earlier extrema in the carotid and basilar arteries and in branches of the anterior, posterior and middle cerebral  ...  Recent developments in fast MRI, specifically simultaneous multislice (SMS) acquisition methods, provide a new opportunity to rapidly and broadly assess cardiac-driven flow, including CSF spaces, surface  ...  Acknowledgements The authors thank Aviv Mezer, Ariel Rokem, Rosemary Le and Dominic Konrad for their help in collecting the data. This work was supported by a Stanford CNI innovation grant.  ... 
doi:10.1101/2022.02.18.480957 fatcat:5w2m4q2rnfcofa2i2lfib6laam

Resolving intrinsic ambiguities of the fMRI signal in the human brain [article]

Eulanca Y. Liu, Frank Haist, David D Shin, Richard B Buxton
2019 bioRxiv   pre-print
Functional magnetic resonance imaging (fMRI) using the blood oxygenation level dependent (BOLD) signal is a standard tool in human neuroscience studies.  ...  In addition to the assessment of drug effects in the human brain, these methods make it possible to resolve ambiguities of the BOLD signal in studies of development, aging, and disease.  ...  Caffeine-induced uncoupling of cerebral blood flow and oxygen metabolism: a calibrated BOLD fMRI study.  ... 
doi:10.1101/833681 fatcat:bwwivzkyojfivktld2ox7vzp2e

Technical aspects and utility of fMRI using BOLD and ASL

John A. Detre, Jiongjiong Wang
2002 Clinical Neurophysiology  
In particular, fMRI methods based on blood oxygenation level dependent (BOLD) contrast and arterial spin labeling (ASL) perfusion contrast have enabled imaging of changes in blood oxygenation and cerebral  ...  Although the exact mechanisms underlying the coupling between neural function and fMRI signal changes remain unclear, fMRI studies have been successful in confirming task-specific activation in a variety  ...  Acknowledgements Grant support: NS37488, MH59934, and HD39621.  ... 
doi:10.1016/s1388-2457(02)00038-x pmid:11976042 fatcat:7d6aw4iizfh3lmy53fjadpnqeu

Separating vascular and neuronal effects of age on fMRI BOLD signals [article]

Kamen A. Tsvetanov, Richard N.A. Henson, James B. Rowe
2020 arXiv   pre-print
A common tool used to investigate neurocognitive ageing is functional magnetic resonance imaging (fMRI).  ...  neuronal function in health and disease.  ...  The signal intensity is generated by applying a magnetic label to proton spins of the inflowing arterial blood water, termed arterial-spin labelling (ASL) (Detre et al., 2009) .  ... 
arXiv:1912.02899v2 fatcat:tq4mkl776vdzpialwczs5hgama

Pitfalls in fMRI

Sven Haller, Andreas J. Bartsch
2009 European Radiology  
A background framework is provided for the systematic and critical interpretation of fMRI results.  ...  Several different techniques allow a functional assessment of neuronal activations by magnetic resonance imaging (fMRI).  ...  Acknowledgements We thank Georg Homola for assisting with data analyses and figure generations. Andreas Bartsch's work has been generously facilitated by the Vera and Volker Doppelfeld Foundation.  ... 
doi:10.1007/s00330-009-1456-9 pmid:19504107 fatcat:dnd7t5ite5dj3fjm7rlm4hi2dm

Mapping Brain Function Using a 30-Day Interval between Baseline and Activation: A Novel Arterial Spin Labeling fMRI Approach

Ajna Borogovac, Christian Habeck, Scott A Small, Iris Asllani
2010 Journal of Cerebral Blood Flow and Metabolism  
Here, we address this issue by empirically testing the feasibility of arterial spin labeling (ASL) fMRI to detect changes in cerebral blood flow (CBF) with baseline and task separated by 1 month.  ...  To increase the sensitivity of the method, we applied an algorithm that yielded flow density (CBFd) images that were independent of tissue content.  ...  Acknowledgements The authors are grateful to Drs Truman R Brown, and Joy Hirsch for their crucial support, and Steven Dashnaw and Glenn Castillo for their assistance with data acquisition and transfer.  ... 
doi:10.1038/jcbfm.2010.89 pmid:20648039 pmcid:PMC3023398 fatcat:lkfzwpcpmza6piwitypakx6vwa

Brain oxygenation responses to an autonomic challenge: a quantitative fMRI investigation of the Valsalva manoeuvre

Iwo Bohr, Claire McDonald, Jiabao He, Simon Kerr, Julia L. Newton, Andrew M. Blamire
2015 Age  
Abbreviations ACA Anterior artery perfusion territory ANS Autonomic nervous system BOLD Blood oxygenation level dependent CBF Cerebral blood flow EPI Echo planar imaging GLM General linear model AGE (2015  ...  ) 37: 91 GM Gray matter HWGFS Half-width of the gamma function smoothing of the input waveform MCA Medial cerebral artery territory R 2 * Effective transverse relaxation rate TE Echo time TR Repetition  ...  Geriatric Society and Research into Ageing Fund; a fund set up and managed by Age UK.  ... 
doi:10.1007/s11357-015-9833-6 pmid:26318855 pmcid:PMC5005835 fatcat:mt62ivsyknbatkfxzdyaud3i4y

Abnormal resting state functional connectivity in patients with chronic fatigue syndrome: an arterial spin-labeling fMRI study

Jeff Boissoneault, Janelle Letzen, Song Lai, Andrew O'Shea, Jason Craggs, Michael E. Robinson, Roland Staud
2016 Magnetic Resonance Imaging  
Recent work from our laboratory and others utilizing arterial spin labeling functional magnetic resonance imaging (ASL) indicated that ME/CFS patients have lower resting state regional cerebral blood flow  ...  All participants underwent T1-weighted structural MRI as well as a 6-minute pseudo-continuous arterial spin labeling (pCASL) sequence, which quantifies CBF by magnetically labeling blood as it enters the  ...  Arterial spin labeling is a technique that can provide estimates of cerebral blood flow with good spatial and temporal resolution, without the limitations of radioactive tracer studies such as PET and  ... 
doi:10.1016/j.mri.2015.12.008 pmid:26708036 pmcid:PMC4801728 fatcat:yst2uubba5etzizlyl65dipex4

Improved partial volume correction method for detecting brain activation in disease using Arterial Spin Labeling (ASL) fMRI

Dylan E. Bruening, Shazia Dharssi, Ronald M. Lazar, Randolph S. Marshall, Iris Asllani
2015 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)  
One such method is Arterial Spin Labeling (ASL) fMRI, which provides images of cerebral blood flow (CBF) in physiologically meaningful units.  ...  In order for the clinical field to successfully apply fMRI, two main challenges posed by aging and diseased brains need to be overcome: (1) difficulties in signal measurement and interpretation, and (2  ...  Alternate fMRI modalities, such as arterial spin labeling (ASL) fMRI, can provide a direct measurement of a given physiological correlate of function, cerebral blood flow (CBF) for ASL, and therefore could  ... 
doi:10.1109/embc.2015.7319622 pmid:26737522 pmcid:PMC4791174 dblp:conf/embc/BrueningDLMA15 fatcat:h7tl3jk2tvb7jnfrz5zlpiag5q

Contrasting resting-state fMRI abnormalities from sickle and non-sickle anemia

Julie Coloigner, Yeun Kim, Adam Bush, Soyoung Choi, Melissa C. Balderrama, Thomas D. Coates, Sharon H. O'Neil, Natasha Lepore, John C. Wood, Andrea Kassner
2017 PLoS ONE  
Sickle cell disease (SCD) is a chronic blood disorder that is often associated with acute and chronic cerebrovascular complications, including strokes and impaired cognition.  ...  We compared the ALFF of 20 SCD patients to that observed in 19 healthy, age and ethnicity-matched, control subjects.  ...  Acknowledgments This work was supported by the National Heart Lung and Blood Institute U01 HL117718 and the Clinical Translational Science Institute at Children's Hospital Los Angeles (UL1 TR001855-02)  ... 
doi:10.1371/journal.pone.0184860 pmid:28981541 pmcid:PMC5628803 fatcat:h4w27lm6qjcern4bctdzxd3x4a

Clinical Challenges of fMRI [chapter]

Nader Pouratian, Susan Y. Bookheimer
2010 BOLD fMRI  
essential and critical for executing a given task.  ...  Because of the differences in methodology, fMRI maps and lesion maps will inevitably differ.  ...  Yang and colleagues 32 developed a reverse spiral scanning technique simultaneous with perfusion imaging with arterial spin labeling.  ... 
doi:10.1007/978-1-4419-1329-6_5 fatcat:ntij6r7q5jge5k7uokh233jlke

Translational research of temporomandibular joint pathology: a preliminary biomarker and fMRI study

Andre Barkhordarian, Gary Demerjian, Francesco Chiappelli
2020 Journal of Translational Medicine  
magnetic resonance imaging (fMRI) activity of the brain, with and without a custom-made dental orthotic.  ...  The fMRI study of TMD patients showed an abnormal hyper-connected salience network and a diminished blood flow to the anterior frontal lobes when they did not wear their customized dental orthotics.  ...  Bradley Jabour and his team for the fMRI analysis studies.  ... 
doi:10.1186/s12967-019-02202-0 pmid:31931814 pmcid:PMC6956559 fatcat:vdz5hnfl2fgzpb2mq57ftgbcqy

Altered amplitude of low-frequency fluctuation and regional cerebral blood flow in females with primary dysmenorrhea: a resting-state fMRI and arterial spin labeling study

Ya-Nan Zhang, Jian-Wei Huo, Yi-Ran Huang, Ying Hao, Zi-Yue Chen
2019 Journal of Pain Research  
Patients and methods: A total of 34 female subjects including 20 PD patients and 14 HCs underwent resting-state functional magnetic resonance imaging (rs-fMRI) and arterial spin labeling technique (ASL  ...  cerebral blood flow (CBF) between PD patients and healthy controls (HCs).  ...  Acknowledgments This study was supported by National Natural Science Foundation of China (NSFC): The central analgesic mechanism of moxibustion in treating Primary Dysmenorrhea: a multimodal functional  ... 
doi:10.2147/jpr.s177502 pmid:31114306 pmcid:PMC6489567 fatcat:geymjmyltnbtdoodhhsxxj74ty

Arterial spin labeling fMRI measurements of decreased blood flow in primary visual cortex correlates with decreased visual function in human glaucoma

Robert O. Duncan, Pamela A. Sample, Christopher Bowd, Robert N. Weinreb, Linda M. Zangwill
2012 Vision Research  
Methods: Arterial spin labeling (ASL) functional magnetic resonance imaging (fMRI) was conducted in 10 participants with POAG.  ...  Resting cerebral blood flow (CBF) was measured from dorsal and ventral V1.  ...  Liu, Kun Lu, and Joanna E. Perthen for their excellent guidance and technical assistance.  ... 
doi:10.1016/j.visres.2012.03.012 pmid:22465941 pmcid:PMC3340501 fatcat:rwpvvrvoubgg7nmqqhoji76id4
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