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Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease

J. O'Callaghan, H. Holmes, N. Powell, J.A. Wells, O. Ismail, I.F. Harrison, B. Siow, R. Johnson, Z. Ahmed, A. Fisher, S. Meftah, M.J. O'Neill (+4 others)
2017 NeuroImage  
A B S T R A C T Alzheimer's disease is connected to a number of other neurodegenerative conditions, known collectively as 'tauopathies', by the presence of aggregated tau protein in the brain.  ...  Despite the identification of myelin and iron concentration as major sources of contrast in quantitative susceptibility maps of the brain, the sensitivity of this technique to tau pathology has yet to  ...  These findings suggest that tissue magnetic susceptibility provided by QSM may be useful as a non-invasive marker of tau pathology in its early stages.  ... 
doi:10.1016/j.neuroimage.2017.08.003 pmid:28797738 pmcid:PMC5678288 fatcat:gowljys7mvhv3asqcwh5cgzupq

Studying Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis with 7-T magnetic resonance

Emrah Düzel, Mauro Costagli, Graziella Donatelli, Oliver Speck, Mirco Cosottini
2021 European Radiology Experimental  
These potential advantages come, however, at a cost: in the majority of UHF-MR clinical protocols, potential drawbacks may include signal inhomogeneity, geometrical distortions, artifacts introduced by  ...  Ultra-high-field (UHF) magnetic resonance (MR) scanners, that is, equipment operating at static magnetic field of 7 tesla (7 T) and above, enable the acquisition of data with greatly improved signal-to-noise  ...  Iron mapping Iron dysregulation is thought to play a significant role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease [64] , Parkinson's disease [65] , and amyotrophic lateral  ... 
doi:10.1186/s41747-021-00221-5 pmid:34435242 pmcid:PMC8387546 fatcat:w2ikouzghbbjflbhkplqgkrqea

Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease

Kelsey E. Melah, Sharon Yuan-Fu Lu, Siobhan M. Hoscheidt, Andrew L. Alexander, Nagesh Adluru, Daniel J. Destiche, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Ozioma C. Okonkwo, Carey E. Gleason, N. Maritza Dowling (+7 others)
2016 Journal of Alzheimer's Disease  
With regard to AD pathology, CSF Aβ42 and tau phosphorylated at threonine 181 (P-Tau181) were used as markers of amyloid and tau pathology, respectively.  ...  BACKGROUND: The immune response in Alzheimer's disease (AD) involves activation of microglia which may remove amyloid-β (Aβ).  ...  INTRODUCTION Inflammation is a well-established feature of Alzheimer's disease (AD) [1, 2] .  ... 
doi:10.3233/jad-150897 pmid:26836182 pmcid:PMC4760877 fatcat:qggfizfyqbbgzegt6f5rhjyf5e

Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease

Shashank Masaldan, Abdel Ali Belaidi, Scott Ayton, Ashley I. Bush
2019 Pharmaceuticals  
Iron dyshomeostasis is a feature of Alzheimer's disease (AD).  ...  However, the source of iron accumulation in pathologically relevant regions of the brain and its contribution to AD remains unclear.  ...  Conflicts of Interest: A.I.B. is a shareholder in Prana Biotechnology Ltd., Cogstate Ltd., Brighton Biotech LLC, Grunbiotics Pty Ltd., Eucalyptus Pty Ltd., and Mesoblast Ltd.  ... 
doi:10.3390/ph12020093 pmid:31248150 pmcid:PMC6630536 fatcat:6i72uzsk6jfvhav2rsmldxijj4

White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease

Miguel Ángel Araque Caballero, Marc Suárez-Calvet, Marco Duering, Nicolai Franzmeier, Tammie Benzinger, Anne M Fagan, Randall J Bateman, Clifford R Jack, Johannes Levin, Martin Dichgans, Mathias Jucker, Celeste Karch (+14 others)
2018 Brain  
Lastly, we assessed the association between mean diffusivity and cerebrospinal fluid biomarkers of amyloid, tau, phosphorylated-tau, and soluble TREM2, i.e. a marker of microglia activity.  ...  for a scientific commentary on this article. White matter alterations are present in the majority of patients with Alzheimer's disease type dementia.  ...  Acknowledgements We would like to thank all the researchers in the DIAN ( and DELCODE study. We acknowledge the altruism of the DIAN participants and their families.  ... 
doi:10.1093/brain/awy229 pmid:30239611 pmcid:PMC6158739 fatcat:gjlorvw7y5cjvirngjx2dzmafa

Role of Body-Fluid Biomarkers in Alzheimer's Disease Diagnosis

Thuy Trang Nguyen, Qui Thanh Hoai Ta, Thi Kim Oanh Nguyen, Thi Thuy Dung Nguyen, Van Giau Vo
2020 Diagnostics  
Alzheimer's disease (AD) is a complex neurodegenerative disease that requires extremely specific biomarkers for its diagnosis.  ...  Body-fluid biomarkers might closely reflect synaptic dysfunction in the brain and, thereby, could contribute to improving diagnostic accuracy and monitoring disease progression, and serve as markers for  ...  Biomarkers in Alzheimer's Disease Biomarkers that can be used in vivo are essential in mapping the chain of events in AD, from the preclinical stage to the clinical stage.  ... 
doi:10.3390/diagnostics10050326 pmid:32443860 pmcid:PMC7277970 fatcat:ndyjjuaamjcg5mbqkzzlxczxva

Associations of Quantitative Susceptibility Mapping with Alzheimer's Disease Clinical and Imaging Markers

Petrice M. Cogswell, Heather J. Wiste, Matthew L. Senjem, Jeffrey L. Gunter, Stephen D. Weigand, Christopher G. Schwarz, Arvin Arani, Terry M. Therneau, Val J. Lowe, David S. Knopman, Hugo Botha, Jonathan Graff-Radford (+7 others)
2020 NeuroImage  
Quantitative susceptibility mapping (QSM) is a recently popularized MR technique to infer local tissue susceptibility secondary to the presence of iron as well as other minerals.  ...  In this work we study QSM signal characteristics and associations between susceptibility measured on QSM and established clinical and imaging markers of Alzheimer's disease.  ...  Declaration of Competing Interest B.B.B. has served as an investigator for a clinical trial sponsored for Biogen.  ... 
doi:10.1016/j.neuroimage.2020.117433 pmid:33035667 pmcid:PMC7860631 fatcat:k46chjq4avfnlmstv7ed6niwlm

White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes

Sara E. Nasrabady, Batool Rizvi, James E. Goldman, Adam M. Brickman
2018 Acta Neuropathologica Communications  
Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary tangles.  ...  between white matter changes and the hallmarks of Alzheimer's disease.  ...  Introduction Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark pathological changes: extracellular neuritic plaques, which are composed of amyloid-beta (Aβ) surrounded  ... 
doi:10.1186/s40478-018-0515-3 pmid:29499767 pmcid:PMC5834839 fatcat:6xvjnm7j5fa3zezecqvjqj2jwy

Garbage Truck of the Brain

M. Nedergaard
2013 Science  
For example, tau and β-amyloid can accumulate as stable aggregates that are neurotoxic in conditions such as Alzheimer's disease (1).  ...  Essentially all neurodegenerative diseases are associated with misaccumulation of cellular waste products.  ...  As a result of axon damage, the tau concentration in CSF increases by as much as a factor of 40,000 (11) .  ... 
doi:10.1126/science.1240514 pmid:23812703 pmcid:PMC3749839 fatcat:lchjozebqzg23cah5zhbyxkbbe

Quantitative multimodal multiparametric imaging in Alzheimer's disease

Qian Zhao, Xueqi Chen, Yun Zhou
2016 Brain Informatics  
Alzheimer's disease (AD) is a progressive neurodegenerative disorder, causing changes in memory, thinking, and other dysfunction of brain functions.  ...  Recent advances in magnetic resonance (MR) techniques, such as functional MR imaging (fMRI) and diffusion MRI, give opportunities to display not only anatomy and atrophy of the medial temporal lobe, but  ...  tau pathology in AD transgenic mouse [44] .  ... 
doi:10.1007/s40708-015-0028-9 pmid:27747597 pmcid:PMC4883163 fatcat:dj7x4hkj4vg4fp55ib3mscjtgu

A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis

Caitlin S. Latimer, Carol A. Shively, C. Dirk Keene, Matthew J. Jorgensen, Rachel N. Andrews, Thomas C. Register, Thomas J. Montine, Angela M. Wilson, Bryan J. Neth, Akiva Mintz, Joseph A. Maldjian, Christopher T. Whitlow (+2 others)
2019 Alzheimer's & Dementia  
Nonhuman primates may serve as excellent models of sporadic age-associated brain β-amyloid deposition and Alzheimer's disease pathologic changes.  ...  We examined whether a vervet nonhuman primate model recapitulated pathologic, physiologic, and behavioral features of early Alzheimer's disease.  ...  Assessment of Alzheimer's Disease [21] ; results are summarized in Table 1 .  ... 
doi:10.1016/j.jalz.2018.06.3057 pmid:30467082 pmcid:PMC6383152 fatcat:lwohrm6vrrgm5dgxkwtoq34wh4

Multivariate MR Biomarkers Better Predict Cognitive Dysfunction in Mouse Models of Alzheimers Disease [article]

Alexandra Badea, Natalie A Delpratt, RJ Anderson, Russell Dibb, Yi Qi, Hongjiang Wei, Chunlei Liu, William C Wetsel, Brian B Avants, Carol Colton
2018 arXiv   pre-print
To understand multifactorial conditions such as Alzheimers disease (AD) we need brain signatures that predict the impact of multiple pathologies and their interactions.  ...  We used in vivo manganese enhanced MRI voxel based analyses to reveal regional differences in volume (morphometry), signal intensity (activity), and magnetic susceptibility (iron deposition, demyelination  ...  Acknowledgments Imaging was performed at the Center for In Vivo Microscopy, supported through P41 EB015897 (G Allan Johnson).  ... 
arXiv:1812.11001v1 fatcat:x4bog23b2nf27gcemorkepugda

A literature review of MRI techniques used to detect amyloid-beta plaques in Alzheimer's disease patients

Baoting Yu, Yaming Shan, Jun Ding
2021 Annals of Palliative Medicine  
In this review, we aim to provide an overview of the imaging techniques most commonly used to study Alzheimer's disease (AD).  ...  A literature search was performed on PubMed using the search term combinations "Alzheimer's disease", "Amyloid-beta plaques", and "MRI".  ...  as Aβ plaques and iron sediments can affect the magnetic susceptibility of tissues (47) (48) (49) .  ... 
doi:10.21037/apm-21-825 pmid:34551578 fatcat:uksfnszrtjfghjehcarsr4a4da

Imaging biomarkers in neurodegeneration: current and future practices

Peter N. E. Young, Mar Estarellas, Emma Coomans, Meera Srikrishna, Helen Beaumont, Anne Maass, Ashwin V. Venkataraman, Rikki Lissaman, Daniel Jiménez, Matthew J. Betts, Eimear McGlinchey, David Berron (+7 others)
2020 Alzheimer's Research & Therapy  
This review forms part of a series of articles which stem from the University College London/University of Gothenburg course "Biomarkers in neurodegenerative diseases".  ...  There is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders.  ...  Acknowledgements This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors.  ... 
doi:10.1186/s13195-020-00612-7 pmid:32340618 fatcat:ar2ijzszy5fa5jopytcvau2nva

Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers

Jinny Claire Lee, Soo Jung Kim, Seungpyo Hong, YoungSoo Kim
2019 Experimental and Molecular Medicine  
Current technological advancements in clinical and research settings have permitted a more intensive and comprehensive understanding of Alzheimer's disease (AD).  ...  However, research attempting to establish the reliability of Aβ and tau as biomarkers has culminated in an amalgamation of contradictory results and theories regarding the biomarker concentrations necessary  ...  Biomarkers obtained from blood samples can act as surrogate markers, which are capable of indirectly indicating the pathological progression of a disease.  ... 
doi:10.1038/s12276-019-0250-2 pmid:31073121 pmcid:PMC6509326 fatcat:pgsjj7453rd5hjdm4tjqhbjv2u
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