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Tissue magnetic susceptibility mapping as a marker of tau pathology in Alzheimer's disease
2017
NeuroImage
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A B S T R A C T Alzheimer's disease is connected to a number of other neurodegenerative conditions, known collectively as 'tauopathies', by the presence of aggregated tau protein in the brain. ...
Despite the identification of myelin and iron concentration as major sources of contrast in quantitative susceptibility maps of the brain, the sensitivity of this technique to tau pathology has yet to ...
These findings suggest that tissue magnetic susceptibility provided by QSM may be useful as a non-invasive marker of tau pathology in its early stages. ...
doi:10.1016/j.neuroimage.2017.08.003
pmid:28797738
pmcid:PMC5678288
fatcat:gowljys7mvhv3asqcwh5cgzupq
Studying Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis with 7-T magnetic resonance
2021
European Radiology Experimental
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These potential advantages come, however, at a cost: in the majority of UHF-MR clinical protocols, potential drawbacks may include signal inhomogeneity, geometrical distortions, artifacts introduced by ...
Ultra-high-field (UHF) magnetic resonance (MR) scanners, that is, equipment operating at static magnetic field of 7 tesla (7 T) and above, enable the acquisition of data with greatly improved signal-to-noise ...
Iron mapping Iron dysregulation is thought to play a significant role in the pathogenesis of neurodegenerative diseases such as Alzheimer's disease [64] , Parkinson's disease [65] , and amyotrophic lateral ...
doi:10.1186/s41747-021-00221-5
pmid:34435242
pmcid:PMC8387546
fatcat:w2ikouzghbbjflbhkplqgkrqea
Cerebrospinal Fluid Markers of Alzheimer's Disease Pathology and Microglial Activation are Associated with Altered White Matter Microstructure in Asymptomatic Adults at Risk for Alzheimer's Disease
2016
Journal of Alzheimer's Disease
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With regard to AD pathology, CSF Aβ42 and tau phosphorylated at threonine 181 (P-Tau181) were used as markers of amyloid and tau pathology, respectively. ...
BACKGROUND: The immune response in Alzheimer's disease (AD) involves activation of microglia which may remove amyloid-β (Aβ). ...
INTRODUCTION Inflammation is a well-established feature of Alzheimer's disease (AD) [1, 2] . ...
doi:10.3233/jad-150897
pmid:26836182
pmcid:PMC4760877
fatcat:qggfizfyqbbgzegt6f5rhjyf5e
Cellular Senescence and Iron Dyshomeostasis in Alzheimer's Disease
2019
Pharmaceuticals
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Iron dyshomeostasis is a feature of Alzheimer's disease (AD). ...
However, the source of iron accumulation in pathologically relevant regions of the brain and its contribution to AD remains unclear. ...
Conflicts of Interest: A.I.B. is a shareholder in Prana Biotechnology Ltd., Cogstate Ltd., Brighton Biotech LLC, Grunbiotics Pty Ltd., Eucalyptus Pty Ltd., and Mesoblast Ltd. ...
doi:10.3390/ph12020093
pmid:31248150
pmcid:PMC6630536
fatcat:6i72uzsk6jfvhav2rsmldxijj4
White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease
2018
Brain
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Lastly, we assessed the association between mean diffusivity and cerebrospinal fluid biomarkers of amyloid, tau, phosphorylated-tau, and soluble TREM2, i.e. a marker of microglia activity. ...
for a scientific commentary on this article. White matter alterations are present in the majority of patients with Alzheimer's disease type dementia. ...
Acknowledgements We would like to thank all the researchers in the DIAN (www.dian-info.org/personnel.htm) and DELCODE study. We acknowledge the altruism of the DIAN participants and their families. ...
doi:10.1093/brain/awy229
pmid:30239611
pmcid:PMC6158739
fatcat:gjlorvw7y5cjvirngjx2dzmafa
Role of Body-Fluid Biomarkers in Alzheimer's Disease Diagnosis
2020
Diagnostics
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Alzheimer's disease (AD) is a complex neurodegenerative disease that requires extremely specific biomarkers for its diagnosis. ...
Body-fluid biomarkers might closely reflect synaptic dysfunction in the brain and, thereby, could contribute to improving diagnostic accuracy and monitoring disease progression, and serve as markers for ...
Biomarkers in Alzheimer's Disease Biomarkers that can be used in vivo are essential in mapping the chain of events in AD, from the preclinical stage to the clinical stage. ...
doi:10.3390/diagnostics10050326
pmid:32443860
pmcid:PMC7277970
fatcat:ndyjjuaamjcg5mbqkzzlxczxva
Associations of Quantitative Susceptibility Mapping with Alzheimer's Disease Clinical and Imaging Markers
2020
NeuroImage
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Quantitative susceptibility mapping (QSM) is a recently popularized MR technique to infer local tissue susceptibility secondary to the presence of iron as well as other minerals. ...
In this work we study QSM signal characteristics and associations between susceptibility measured on QSM and established clinical and imaging markers of Alzheimer's disease. ...
Declaration of Competing Interest B.B.B. has served as an investigator for a clinical trial sponsored for Biogen. ...
doi:10.1016/j.neuroimage.2020.117433
pmid:33035667
pmcid:PMC7860631
fatcat:k46chjq4avfnlmstv7ed6niwlm
White matter changes in Alzheimer's disease: a focus on myelin and oligodendrocytes
2018
Acta Neuropathologica Communications
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Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark pathological changes in grey matter: extracellular amyloid plaques and neurofibrillary tangles. ...
between white matter changes and the hallmarks of Alzheimer's disease. ...
Introduction Alzheimer's disease (AD) is conceptualized as a progressive consequence of two hallmark pathological changes: extracellular neuritic plaques, which are composed of amyloid-beta (Aβ) surrounded ...
doi:10.1186/s40478-018-0515-3
pmid:29499767
pmcid:PMC5834839
fatcat:6xvjnm7j5fa3zezecqvjqj2jwy
Garbage Truck of the Brain
2013
Science
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For example, tau and β-amyloid can accumulate as stable aggregates that are neurotoxic in conditions such as Alzheimer's disease (1). ...
Essentially all neurodegenerative diseases are associated with misaccumulation of cellular waste products. ...
As a result of axon damage, the tau concentration in CSF increases by as much as a factor of 40,000 (11) . ...
doi:10.1126/science.1240514
pmid:23812703
pmcid:PMC3749839
fatcat:lchjozebqzg23cah5zhbyxkbbe
Quantitative multimodal multiparametric imaging in Alzheimer's disease
2016
Brain Informatics
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Alzheimer's disease (AD) is a progressive neurodegenerative disorder, causing changes in memory, thinking, and other dysfunction of brain functions. ...
Recent advances in magnetic resonance (MR) techniques, such as functional MR imaging (fMRI) and diffusion MRI, give opportunities to display not only anatomy and atrophy of the medial temporal lobe, but ...
tau pathology in AD transgenic mouse [44] . ...
doi:10.1007/s40708-015-0028-9
pmid:27747597
pmcid:PMC4883163
fatcat:dj7x4hkj4vg4fp55ib3mscjtgu
A nonhuman primate model of early Alzheimer's disease pathologic change: Implications for disease pathogenesis
2019
Alzheimer's & Dementia
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Nonhuman primates may serve as excellent models of sporadic age-associated brain β-amyloid deposition and Alzheimer's disease pathologic changes. ...
We examined whether a vervet nonhuman primate model recapitulated pathologic, physiologic, and behavioral features of early Alzheimer's disease. ...
Assessment of Alzheimer's Disease [21] ; results are summarized in Table 1 . ...
doi:10.1016/j.jalz.2018.06.3057
pmid:30467082
pmcid:PMC6383152
fatcat:lwohrm6vrrgm5dgxkwtoq34wh4
Multivariate MR Biomarkers Better Predict Cognitive Dysfunction in Mouse Models of Alzheimers Disease
[article]
2018
arXiv
pre-print
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To understand multifactorial conditions such as Alzheimers disease (AD) we need brain signatures that predict the impact of multiple pathologies and their interactions. ...
We used in vivo manganese enhanced MRI voxel based analyses to reveal regional differences in volume (morphometry), signal intensity (activity), and magnetic susceptibility (iron deposition, demyelination ...
Acknowledgments Imaging was performed at the Center for In Vivo Microscopy, supported through P41 EB015897 (G Allan Johnson). ...
arXiv:1812.11001v1
fatcat:x4bog23b2nf27gcemorkepugda
A literature review of MRI techniques used to detect amyloid-beta plaques in Alzheimer's disease patients
2021
Annals of Palliative Medicine
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In this review, we aim to provide an overview of the imaging techniques most commonly used to study Alzheimer's disease (AD). ...
A literature search was performed on PubMed using the search term combinations "Alzheimer's disease", "Amyloid-beta plaques", and "MRI". ...
as Aβ plaques and iron sediments can affect the magnetic susceptibility of tissues (47) (48) (49) . ...
doi:10.21037/apm-21-825
pmid:34551578
fatcat:uksfnszrtjfghjehcarsr4a4da
Imaging biomarkers in neurodegeneration: current and future practices
2020
Alzheimer's Research & Therapy
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This review forms part of a series of articles which stem from the University College London/University of Gothenburg course "Biomarkers in neurodegenerative diseases". ...
There is an increasing role for biological markers (biomarkers) in the understanding and diagnosis of neurodegenerative disorders. ...
Acknowledgements This research did not receive any specific grant from funding agencies in the public, commercial or not-for-profit sectors. ...
doi:10.1186/s13195-020-00612-7
pmid:32340618
fatcat:ar2ijzszy5fa5jopytcvau2nva
Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers
2019
Experimental and Molecular Medicine
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Current technological advancements in clinical and research settings have permitted a more intensive and comprehensive understanding of Alzheimer's disease (AD). ...
However, research attempting to establish the reliability of Aβ and tau as biomarkers has culminated in an amalgamation of contradictory results and theories regarding the biomarker concentrations necessary ...
Biomarkers obtained from blood samples can act as surrogate markers, which are capable of indirectly indicating the pathological progression of a disease. ...
doi:10.1038/s12276-019-0250-2
pmid:31073121
pmcid:PMC6509326
fatcat:pgsjj7453rd5hjdm4tjqhbjv2u
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