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Quantitative analysis of liver tumors at different stages using microscopic hyperspectral imaging technology

Jiansheng Wang, Qingli Li
2018 Journal of Biomedical Optics  
However, in terms of pathology, liver cancer is traditionally clinically diagnosed based on observation of microscopic images of pathological liver sections.  ...  The example-based feature extraction method used in this paper mainly includes two algorithms: a morphological watershed algorithm is applied to find object and segment pathological components of pathological  ...  Guanzhen Yu for providing the pathological information of liver samples.  ... 
doi:10.1117/1.jbo.23.10.106002 pmid:30277033 fatcat:xwyxdaoswbed3b3xsret7qu6sq

Discrimination of liver malignancies with 1064 nm dispersive Raman spectroscopy

Isaac J. Pence, Chetan A. Patil, Chad A. Lieber, Anita Mahadevan-Jansen
2015 Biomedical Optics Express  
A quantitative metric called feature importance is defined based on classification outputs and is used to guide the association of spectral features with biological indicators of healthy and diseased liver  ...  Here we report the use of a dispersive 1064 nm Raman system using a low-noise Indium-Gallium-Arsenide (InGaAs) array to discriminate highly autofluorescent bulk tissue ex vivo specimens from healthy liver  ...  Tissue samples were provided by the Cooperative Human Tissue Network which is funded by the National Cancer Institute. Other investigators may have received specimens from the same subjects.  ... 
doi:10.1364/boe.6.002724 pmid:26309739 pmcid:PMC4541503 fatcat:k2fbh3l4tzeurdccpcsik2szvi

Applications of hyperspectral imaging in the detection and diagnosis of solid tumors

Yating Zhang, Xiaoqian Wu, Li He, Chan Meng, Shunda Du, Jie Bao, Yongchang Zheng
2020 Translational Cancer Research  
This imaging modality is based on the principle that different tissues inherit different spectral reflectance responses that present as unique spectral fingerprints.  ...  In particular, the advantages of HSI applied to solid tumors are highlighted to show its potential for clinical use.  ...  (56) used infrared imaging spectroscopy of human liver tissue to identify and characterize a liver metastasis originating from the breast without fixation or dehydration.  ... 
doi:10.21037/tcr.2019.12.53 pmid:35117471 pmcid:PMC8798535 fatcat:2to5tff3tnde7jb4jqyccqj3yi

Tissue Intrinsic Fluorescence Spectra-Based Digital Pathology of Liver Fibrosis by Marker-Controlled Segmentation

Takashi Saitou, Sota Takanezawa, Hiroko Ninomiya, Takao Watanabe, Shin Yamamoto, Yoichi Hiasa, Takeshi Imamura
2018 Frontiers in Medicine  
Because of its unique feature of spectral profiles depending on tissue types, spectroscopic imaging is a promising tool for accurate evaluation of endogenous fluorophores.  ...  Through the analyses, we showed that spectral imaging of native fluorescence from liver tissues have the capability of differentiating not only between normal and diseased, but also between progressive  ...  Therefore, only the image patterns of the RC objects characterized the liver tissue pathological state between the 2-and 4-weeks models.  ... 
doi:10.3389/fmed.2018.00350 pmid:30619861 pmcid:PMC6297145 fatcat:ewzqj3tv5nfqlj3e6ck7c4veia

Image analysis technologies for digital pathology

2015 Medical Imaging and Information Sciences  
In this paper, after the review of the significance of digital imaging in pathology, a fully− automatic image analysis system developed aiming at quantitative pathology is introduced.  ...  Digital imaging is now being introduced in pathology, owing to the recent advancement of whole slide imaging, or digital slide technology.  ...  Ohyama : Digital staining of pathological tissue specimens using spectral transmittance, Proc.  ... 
doi:10.11318/mii.32.19 fatcat:gj52f5e635gahbvxv7inlrssdi

Ex vivo imaging and quantification of liver fibrosis using second-harmonic generation microscopy

Tzu-Lin Sun, Yuan Liu, Ming-Chin Sung, Hsiao-Ching Chen, Chun-Hui Yang, Vladimir Hovhannisyan, Wei-Chou Lin, Yung-Ming Jeng, Wei-Liang Chen, Ling-Ling Chiou, Guan-Tarn Huang, Ki-Hean Kim (+4 others)
2010 Journal of Biomedical Optics  
"Ex vivo imaging and quantification of liver fibrosis using second-harmonic generation microscopy." Journal of Biomedical Optics 15.3 (2010): 036002-6.  ...  NSC 98-2112-M-002-008-MY3 in Taiwan and was completed in the Optical Molecular Imaging Microscopy Core Facility ͑A5͒ of NRPGM.  ...  We found that qualitative SHG imaging can be used for the effective identification of the associated features of liver fibrosis specimens graded METAVIR 0 to 4.  ... 
doi:10.1117/1.3427146 pmid:20615004 fatcat:ntcwnrghe5fftbjgu5jxtlgtt4

Perspective review on solid-organ transplant: needs in point-of-care optical biomarkers

2018 Journal of Biomedical Optics  
Point-of-procedure laparoscopic optical biomarkers of liver injuries and tissue ischemia may also facilitate post-transplant management that is currently difficult for or devoid of pathological consultation  ...  The more general and overarching challenges of point-of-procedure optical biomarkers for liver transplant pathology, including the shielding effect of the liver capsule that was quantitated only recently  ...  The contribution of E.M.R. to this work is supported in part by the James Park Dewer, MD, professorship of pathology in the Department of Pathology at OUHSC.  ... 
doi:10.1117/1.jbo.23.8.080601 pmid:30160078 fatcat:wpn6zufxvjat7o2licwsbklg7q

New Intraoperative Imaging Tools and Image-Guided Surgery in Gastric Cancer Surgery

Luise Knospe, Ines Gockel, Boris Jansen-Winkeln, René Thieme, Stefan Niebisch, Yusef Moulla, Sigmar Stelzner, Orestis Lyros, Michele Diana, Jacques Marescaux, Claire Chalopin, Hannes Köhler (+4 others)
2022 Diagnostics  
and tumor classification are promising.  ...  for the application of HSI in intraoperative tissue diagnostics.  ...  Based on the differences in features between gastric cancer tissue and normal tissue in the spectral ra Exemplary determination of reflectance spectra in hematoxylin and eosin stained stomach specimens  ... 
doi:10.3390/diagnostics12020507 pmid:35204597 pmcid:PMC8871069 fatcat:fquhbz6ovvekrgy2fddgpuojvy

Differentiation of Cancerous Lesions in Excised Human Breast Specimens Using Multiband Attenuation Profiles From Ultrasonic Transmission Tomography

Jeong-Won Jeong, Dae C. Shin, Syn-Ho Do, Cesar Blanco, Nancy E. Klipfel, Dennis R. Holmes, Linda J. Hovanessian-Larsen, Vasilis Z. Marmarelis
2008 Journal of ultrasound in medicine  
These features are classified through a novel algorithm of "segment-wise classification" that identifies the disjoint segments of various tissue types and subsequently classifies them into respective diagnostic  ...  The results have shown the potential of the HUTT technology for reliable differentiation of cancerous lesions from benign changes and normal tissue in mastectomy specimens using frequencydependent ultrasound  ...  Differentiation of benign and normal tissue using pixel-wise classification. A, Diagnostic map from pathologic review of breast tissue slides.  ... 
doi:10.7863/jum.2008.27.3.435 pmid:18314522 fatcat:3ychaveabbbcvhct6kqzzsusvq

Assessment of pathological response to therapy using lipid mass spectrometry imaging

Nathan Heath Patterson, Balqis Alabdulkarim, Anthoula Lazaris, Aurélien Thomas, Mieczyslaw M. Marcinkiewicz, Zu-hua Gao, Peter B. Vermeulen, Pierre Chaurand, Peter Metrakos
2016 Scientific Reports  
Here we use MALDI mass spectrometry imaging to generate lipid signatures from colorectal cancer liver metastasis specimens resected from patients preoperatively treated with chemotherapy.  ...  In many cancers, the establishment of a patient's future treatment regime often relies on histopathological assessment of tumor tissue specimens in order to determine the extent of the 'pathological response  ...  using the Bruker Solarix MALDI-FT-ICR and Dr A Reynolds for his critical reading of the manuscript.  ... 
doi:10.1038/srep36814 pmid:27841360 pmcid:PMC5107952 fatcat:xbdllwquhnb67cqlggoe5qyeqa

Ultrasound-Guided Characterization of Interstitial Ablated Tissue Using RF Time Series: Feasibility Study

F. Imani, P. Abolmaesumi, M. Z. Wu, A. Lasso, E. C. Burdette, G. Ghoshal, T. Heffter, E. Williams, P. Neubauer, G. Fichtinger, P. Mousavi
2013 IEEE Transactions on Biomedical Engineering  
Spatial and temporal features of these signals are used to characterize ablated and non-ablated tissue in a supervised-learning framework.  ...  Results: In crossvalidation evaluation, a subset of four features extracted from RF time series produce a classification accuracy of 84.5%, and an area under ROC curve of 0.91 for ex vivo data, and an  ...  ACKNOWLEDGMENT The authors would like to acknowledge the help of Lance Frith and Bruce Komadina for preparing the mechanical components used in the in situ experiments, and assisting with the experiments  ... 
doi:10.1109/tbme.2013.2240300 pmid:23335657 fatcat:sz4fm7mofva23aigtdjstmypsm

A quantitative framework for the analysis of multimodal optical microscopy images

Andrew J. Bower, Benjamin Chidester, Joanne Li, Youbo Zhao, Marina Marjanovic, Eric J. Chaney, Minh N. Do, Stephen A. Boppart
2017 Quantitative Imaging in Medicine and Surgery  
features in tissues slices.  ...  Supervised classification of cell death modes was performed through support vector machines (SVM) and semi-supervised classification of tissue slices was performed through the use of the expectation maximization  ...  Footnote Conflicts of Interest: The authors have no conflicts of interest to declare.  ... 
doi:10.21037/qims.2017.02.07 pmid:28275557 pmcid:PMC5337182 fatcat:kwyqcucazrhz3cjbuzujjvyiqa

Multispectral Band Analysis: Application on the Classification of Hepatocellular Carcinoma Cells in High-Magnification Histopathological Images

Oranit B Chamidu A
2015 Journal of Cytology & Histology  
This paper utilizes multispectral images which have spatial and spectral information for nuclear analysis. The proposed framework is based on texture analysis of nuclei.  ...  The system aim to analyze the significant of multispectral bands for discriminating cancer and non-cancer nuclei. The textural features were extracted using Gabor descriptors.  ...  Each spectrum represents a specific characteristic of its spatial point in image cube. Normal liver and HCC tissue microarray specimen were purchased from US Biomax, Inc., (Rockville, MD, USA).  ... 
doi:10.4172/2157-7099.s3-006 fatcat:cdl7ibguynf5netjcvcewv3zou

Multispectral tissue mapping: developing a concept for the optical evaluation of liver disease

Crispin Schneider, Daniil Nikitichev, Wenfeng Xia, Kurinchi Gurusamy, Adrien E. Desjardins, Brian R. Davidson
2020 Journal of Medical Imaging  
Purpose: Alterations in the optical absorption behavior of liver tissue secondary to pathological processes can be evaluated by multispectral analysis, which is increasingly being explored as an imaging  ...  adjunct for use in liver surgery.  ...  The views expressed in this publication are those of the author(s) and not necessarily those of the Wellcome Trust or the Department of Health.  ... 
doi:10.1117/1.jmi.7.6.066001 pmid:33376759 pmcid:PMC7757517 fatcat:qdf53gwqcvgr7kvrwwimemgofm

Multispectral Enhancement towards Digital Staining

Pinky A. Bautista, Yukako Yagi
2012 Analytical Cellular Pathology  
To implement digital staining, a spectral transformation process is introduced prior to spectral shifting.Results: The enhancement method is applied to multispectral images of H&E stained liver tissue.  ...  The resulting digitally stained images show good correlation with the serial-section images of the tissue which are physically stained with Masson's trichrome.Conclusion: We have presented a multispectral  ...  The method consisted of two steps: (i) classification of the image pixels using spectral features; and (ii) spectral transformation.  ... 
doi:10.1155/2012/326061 pmid:22002722 pmcid:PMC4605786 fatcat:nuia4sas7jft7lof7bnuab4iqa
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