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A Trichotomy for Regular Trail Queries [article]

Wim Martens and Matthias Niewerth and Tina Popp
2021 arXiv   pre-print
Regular path queries (RPQs) are an essential component of graph query languages. Such queries consider a regular expression r and a directed edge-labeled graph G and search for paths in G for which the sequence of labels is in the language of r. In order to avoid having to consider infinitely many paths, some database engines restrict such paths to be trails, that is, they only consider paths without repeated edges. In this paper we consider the evaluation problem for RPQs under trail
more » ... in the case where the expression is fixed. We show that, in this setting, there exists a trichotomy. More precisely, the complexity of RPQ evaluation divides the regular languages into the finite languages, the class Ttract (for which the problem is tractable), and the rest. Interestingly, the tractable class in the trichotomy is larger than for the trichotomy for simple paths, discovered by Bagan, Bonifati, and Groz [JCSS 2020]. In addition to this trichotomy result, we also study characterizations of the tractable class, its expressivity, the recognition problem, closure properties, and show how the decision problem can be extended to the enumeration problem, which is relevant to practice.
arXiv:1903.00226v2 fatcat:pch5n4uptzd6dp2skcr2cyygyy

Raman-Spectroscopy Based Cell Identification on a Microhole Array Chip

Ute Neugebauer, Christian Kurz, Thomas Bocklitz, Tina Berger, Thomas Velten, Joachim Clement, Christoph Krafft, Jürgen Popp
2014 Micromachines  
Circulating tumor cells (CTCs) from blood of cancer patients are valuable prognostic markers and enable monitoring responses to therapy. The extremely low number of CTCs makes their isolation and characterization a major technological challenge. For label-free cell identification a novel combination of Raman spectroscopy with a microhole array platform is described that is expected to support high-throughput and multiplex analyses. Raman spectra were registered from regularly arranged cells on
more » ... he chip with low background noise from the silicon nitride chip membrane. A classification model was trained to distinguish leukocytes from myeloblasts (OCI-AML3) and breast cancer cells . The model was validated by Raman spectra of a mixed cell population. The high spectral quality, low destructivity and high classification accuracy suggests that this approach is promising for Raman activated cell sorting. OPEN ACCESS Micromachines 2014, 5 205
doi:10.3390/mi5020204 fatcat:dxb3w6jktrfp3fsivnk6xe2pom

Parent-Child Diagnostic Agreement on Anxiety Symptoms with a Structured Diagnostic Interview for Mental Disorders in Children

Lukka Popp, Murielle Neuschwander, Sandra Mannstadt, Tina In-Albon, Silvia Schneider
2017 Frontiers in Psychology  
Copyright © 2017 Popp, Neuschwander, Mannstadt, In-Albon and Schneider. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).  ... 
doi:10.3389/fpsyg.2017.00404 pmid:28396644 pmcid:PMC5366335 fatcat:3glkw5gzzjcpzf3bghc7j6fcxu

The amyloid precursor protein protects PC12 cells against endoplasmic reticulum stress-induced apoptosis

Donat Kögel, Robert Schomburg, Tina Schürmann, Claus Reimertz, Hans-Georg König, Monika Poppe, Anne Eckert, Walter E. Müller, Jochen H. M. Prehn
2003 Journal of Neurochemistry  
Endoplasmic reticulum (ER) stress is believed to play an important role in neurodegenerative disorders such as Alzheimer's disease. In the present study, we investigated the effect of the human amyloid precursor protein (APP) on the ER stress response in PC12 cells. Tunicamycin, an inhibitor of N-glycosylation, rapidly induced the expression of the ER-resident chaperone Bip/grp78, a known target gene of the unfolded protein response. Prolonged treatment with tunicamycin ( ‡ 12 h) resulted in
more » ... activation of executioner caspases 3 and 7. Interestingly, PC12 cells overexpressing human wild-type APP (APPwt) showed increased resistance to tunicamycin-induced apoptosis compared with empty vectortransfected controls. This neuroprotective effect was significantly diminished in cells expressing the Swedish mutation of APP (KM670/671NL). Similar effects were observed when ER stress was induced with brefeldin A, an inhibitor of ER-to-Golgi protein translocation. Of note, APP-mediated neuroprotection was not associated with altered expression of Bip/grp78 or transcription factor C/EBP homologous protein-10 (CHOP/GADD153), suggesting that APP acted either downstream or independently of ER-to-nucleus signaling. Our data indicate that APP plays an important physiological role in protecting neurons from the consequences of prolonged ER stress, and that APP mutations associated with familial Alzheimer's disease may impair this protective activity.
doi:10.1046/j.1471-4159.2003.02000.x pmid:12969271 fatcat:nwb3qmgwlfc6bo2j5s7qyzqsci

The molecular cell death machinery in the simple cnidarian Hydra includes an expanded caspase family and pro- and anti-apoptotic Bcl-2 proteins

Margherita Lasi, Barbara Pauly, Nikola Schmidt, Mihai Cikala, Beate Stiening, Tina Käsbauer, Gerhardt Zenner, Tanja Popp, Anita Wagner, Regina T Knapp, Andreas H Huber, Michaela Grunert (+3 others)
2010 Cell Research  
The fresh water polyp Hydra belongs to the phylum Cnidaria, which diverged from the metazoan lineage before the appearance of bilaterians. In order to understand the evolution of apoptosis in metazoans, we have begun to elucidate the molecular cell death machinery in this model organism. Based on ESTs and the whole Hydra genome assembly, we have identified 15 caspases. We show that one is activated during apoptosis, four have characteristics of initiator caspases with N-terminal DED, CARD or DD
more » ... domain and two undergo autoprocessing in vitro. In addition, we describe seven Bcl-2-like and two Bak-like proteins. For most of the Bcl-2 family proteins, we have observed mitochondrial localization. When expressed in mammalian cells, HyBak-like 1 and 2 strongly induced apoptosis. Six of the Bcl-2 family members inhibited apoptosis induced by camptothecin in mammalian cells with HyBcl-2-like 4 showing an especially strong protective effect. This protein also interacted with HyBak-like 1 in a yeast two-hybrid assay. Mutation of the conserved leucine in its BH3 domain abolished both the interaction with HyBak-like 1 and the anti-apoptotic effect. Moreover, we describe novel Hydra BH-3-only proteins. One of these interacted with Bcl-2-like 4 and induced apoptosis in mammalian cells. Our data indicate that the evolution of a complex network for cell death regulation arose at the earliest and simplest level of multicellular organization, where it exhibited a substantially higher level of complexity than in the protostome model organisms Caenorhabditis and Drosophila.
doi:10.1038/cr.2010.66 pmid:20479784 fatcat:kkp4lwgaerbgzbobutiqxjtzt4

President's Column

Kevin Smith
2014 Virginia Libraries  
, and Tina McPherson.  ...  lobbying efforts, including delegates Christie Hoerneman, Mutahara Mobashar, Margaret Howard, Jacqueline Sullivan, James Sanderson, Katie Hoskins, Alan Sonner, Suzanna Panter, Lisa Varga, Laura Horne-Popp  ...  , and Tina McPherson.  ... 
doi:10.21061/valib.v60i2.1294 fatcat:g5xdhvrhsrf6fpqehwvdjgkhsm

Page 115 of Congregational Quarterly Vol. 13, Issue 1 [page]

1871 Congregational Quarterly  
CMR POPP C— DH ONTOS HK ETH HoOMman SS Othe Or Ot satoBebe aaKResss Seuessssces eaSSSEunR aSe ‘ en SH OoOnSes SP OSCOCOCH HH NTH OH OH OHM ORO NONAUNSSH a6 =  ...  Bennington, Ist, 1762 2a, 1836 North, 1868 1790 1820 179 “ Benson, Berkshire, East, Berlin, 98 West, 1865 1817 1818 “ Bethel, Bradford, Braintree, 1794 Brandon, 1785 Brattleboro, West, 1770 East, 1516 tina  ... 

2002 Hand Therapy Certification Examination

2003 Journal of Hand Therapy  
Patel, Nisha Paulovits, Ildiko Pavlov Krause, Ellie Peic, Patricia Pelenski, Walter Pena, Anthony Penwell, Neil Piazza, Amy Pietroburgo, Ann Pillon, Sharon Plachy, Linda Poirier, Lisa Pollock, Virginia Popp  ...  Heinitz, Elizabeth Heinzelman, Keith Heitmiller, Shannon Hodge, Mary Hole, Marie Holmes, Lois Honaker, Cecil Hornberger, Jean Hove, Renee Howerton, Catalina Hubacz, Dina Ingram, Rita Jaya, Tina Johnson  ... 
doi:10.1016/s0894-1130(03)80004-2 fatcat:swubxbefvbebjmaoxpraihwz4y

Page 643 of Guernsey Breeders' Journal Vol. 138, Issue 6 [page]

1976 Guernsey Breeders' Journal  
viceroy tranquil FAROFIELO reflections tootsie RUSHCREEK V VICEROY 8-05 305-2X 15160 623 MED 0 BLOOM GAYLORD BETH MED 0 BLOOM JEFF BETH HORNEACK FARM N GAYLORD 4-03 305-2X 14630 776 MED 0 BLOOM DARI POPPE  ...  MAJESTY 2-09 305-2X 12750 589 •BERT G GERT S CHWINGHAMER, SCHWINGHAMER GUERNSEY FARM, ALBANY SCHWINGHAMER FARM QUARTZ SCHWINGHAMER FARM KORAL WESTERN GLOW OAPIMOST 6-11 365-2X 15300 752 MAYWOOD ROAD TINA  ... 

Page 73 of American Chiropractic Association. The ACA Journal of Chiropractic Vol. 32, Issue 5 [page]

1995 American Chiropractic Association. The ACA Journal of Chiropractic  
Bolton, Lexington; Tina A. Car¬ ter, Murray. Louisiana Nicholas J. Arcement, Lockport; Victor K. Flynn, Boutte. Maine Thomas F. Mogan, Lewiston; Scott D. Popp, Windham; George E Roy, Jr., Scarborou^.  ... 

Page 1042 of Guernsey Breeders' Journal Vol. 140, Issue 6 [page]

1977 Guernsey Breeders' Journal  
BLOOM WISTAR FRANN IE MED 0 BLOOM MED 0 BLOOM WISTAR BUNN IE MED 0 BLOOM MED 0 BLOOM WINSTON EMILIA MED 0 BLOOM MED a BLOOM WINSTON LILLY MED 0 BLOOM MED 0 BLOOM WISTAR TILLY MED 0 BLOOM LEVITY BINOY AL POPPE  ...  LEAF L MYRA MAPLE LEAF N LINDA ROETTA P PENNYS COPPER MAPLE LEAF B THEALICE MAPLE LEAF NANCE GOLDEN MAPLE LEAF NANCE LOLLY SANDE HILL DOUBLE EMORY NORGERTS ROYAL NANCE LYRENE MAY ROSE PRINCE LINOEANS TINA  ... 

Selected Posters

2005 Journal of Agricultural and Applied Economics  
Paul Scott Poag and Michael Popp, University of Arkansas.  ...  Cetrangolo, Unidad de Agronegocios e Industria Alimenticia, Uni- versidad de San Andres, Buenos Aires, Argen- tina. Programs: Potential Tools for Conserving Agricultural Wetlands. John V.  ... 
doi:10.1017/s1074070800006994 fatcat:2qtn3267azdorn3zw44fgkiwpa

Page 1305 of Linguistics and Language Behavior Abstracts: LLBA Vol. 28, Issue 3 [page]

1994 Linguistics and Language Behavior Abstracts: LLBA  
N., 9404169 Poppe, Erich, 94102200 Poppe, Erich (Ed), 94r01596, 94r01857 Porquier, Rémy, 39 Porten, Bezalel, 9406073 Porter, Laurence M., 94r01680 Portillo Mayorga, Maria Rosario, Posner, Rebecca, 94r02377  ...  ., 9406401, 94r01725 Oxer, Tina, 9406675 Oxford, Rebecca, 9404532 Oxford, Rebecca L., 94102268 Oyharcabal, Bernard, 9405686 Ozkut, Iffet E., 9404361 Paakkénen, Matti, 9406160 Pacholczyk, Tadeusz, 9404362  ... 

Page 370 of The Gentleman's Magazine Vol. 65, Issue 5 [page]

1795 The Gentleman's Magazine  
near- ly fimiar to that mentioned by your corefpondent : THIS PRESENT FIGVRE 18 THE Sry- MYLYTVDE OF OVR LORD JESVS ove SAVOVR IMPRINTED JN AMYRLD BY TUE PRYDECESSOVRS OF THE GREAT TVRKE AND SENT TO POPPE  ...  withing to redeem his brother, yearly remitted to Rome 40,000 gold crowns, left the Pope fhould fet him at liberty on account of the expence of mainiain- ing hin. ; * Onuporius, the continuator of Pla- tina  ... 

A Randomized Trial of a Transglutaminase 2 Inhibitor for Celiac Disease

Detlef Schuppan, Markku Mäki, Knut E A Lundin, Jorma Isola, Tina Friesing-Sosnik, Juha Taavela, Alina Popp, Jari Koskenpato, Jost Langhorst, Øistein Hovde, Marja-Leena Lähdeaho, Stefano Fusco (+15 others)
2021
BACKGROUND In celiac disease, small intestinal transglutaminase 2 causes deamidation of glutamine residues in gluten peptides, which enhances stimulation of T cells and leads to mucosal injury. Inhibition of transglutaminase 2 is a potential treatment for celiac disease. METHODS In a proof-ofconcept trial, we assessed the efficacy and safety of a 6-week treatment with ZED1227, a selective oral transglutaminase 2 inhibitor, at three dose levels as compared with placebo, in adults with
more » ... lled celiac disease who underwent a daily gluten challenge. The primary end point was the attenuation of gluten-induced mucosal damage, as measured by the ratio of villus height to crypt depth. Secondary end points included intraepithelial lymphocyte density, the Celiac Symptom Index score, and the Celiac Disease Questionnaire score (for assessment of health-related quality of life). RESULTS Of the 41 patients assigned to the 10-mg ZED1227 group, the 41 assigned to the 50-mg group, the 41 assigned to the 100-mg group, and the 40 assigned to the placebo group, 35, 39, 38, and 30 patients, respectively, had adequate duodenal-biopsy samples for the assessment of the primary end point. Treatment with ZED1227 at all three dose levels attenuated gluten-induced duodenal mucosal injury. The estimated difference from placebo in the change in the mean ratio of villus height to crypt depth from baseline to week 6 was 0.44 (95% confidence interval [CI], 0.15 to 0.73) in the 10-mg group (P = 0.001), 0.49 (95% CI, 0.20 to 0.77) in the 50-mg group (P<0.001), and 0.48 (95% CI, 0.20 to 0.77) in the 100-mg group (P<0.001). The estimated differences from placebo in the change in intraepithelial lymphocyte density were -2.7 cells per 100 epithelial cells (95% CI, -7.6 to 2.2) in the 10-mg group, -4.2 cells per 100 epithelial cells (95% CI, -8.9 to 0.6) in the 50-mg group, and -9.6 cells per 100 epithelial cells (95% CI, -14.4 to -4.8) in the 100-mg group. Use of the 100-mg dose may have improved symptom and quality-of-life scores. The most common adverse events, the incidences of which were similar across all groups, were headache, nausea, diarrhea, vomiting, and abdominal pain. Rash developed in 3 of 40 patients (8%) in the 100-mg group. CONCLUSIONS In this preliminary trial, treatment with ZED1227 attenuated gluten-induced duodenal mucosal damage in patients with celiac disease. (Funded by Dr. Falk Pharma; CEC-3 EudraCT number, 2017-002241-30.).
doi:10.5167/uzh-208773 fatcat:t2wwc5y32nazve4knsjpkcouvq
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