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Lowry, Mercer H. J. LeperBersc 154 Patriarche, Robert G. Martin, Robert S. Campbell, and Timothy R. O'Connell, Jr. ...doi:10.1086/400100 fatcat:bpdhfdz3zvd6xia7uvd47sirdi
Timothy Ballard, MD, Don A. Lowry, MD, and Richard A. ...doi:10.1016/s0883-5403(05)80073-7 pmid:8749759 fatcat:xm4yah62yfgkdhld5ihyqfsjzu
In this study, an accelerated migration test on food can coatings into food simulants was investigated. Food simulants covering a wide range of polarity were used to conduct migration tests at 60 °C with storage times ranging from 4 h to 30 days. Epoxy-resins, acrylic–phenolic, polyester, and vinyl coatings were exposed to water, 3% acetic acid, 50% ethanol, and Miglyol 812®. Using liquid chromatography coupled to a variety of detectors (UHPLC-Q-Orbitrap-MS, UFLC-MS/MS, and HPLC-DAD), migrationdoi:10.3390/molecules24173123 pmid:31466267 pmcid:PMC6749474 fatcat:uimlwgcknnd67k7r44t2rhdxzi
more »... of several monomers and previously identified oligomers, as well as some unidentified migrants, were determined during the experiment. The data from this study was compared to our findings from previous long-term migration studies with storage times ranging from 24 h to 540 days at 40 °C using the same can coating applications. The results illustrate that performing migration experiments for short time periods at 60 °C may mimic migration results that would be obtained at 40 °C after long-term migration tests (up to 1.5 years) from food can coatings into food simulants.
Lowry, David Pimentel, Amanda K. Glazer, Timothy W. Koglin, Grace A. Moe, & Marianna M. Knysh, If You Provide, Will They Ride? Motivators and Deterrents to Shared Micro-Mobility, 6 INT'L J. ... Credit for design and creation of the searchable state law database, and all the coding it required, belongs exclusively to Timothy Koglin. ...doi:10.36635/jlm.2020.innovation fatcat:o7ywxqlojfeovpoxdh664ro6ve
The use of methyl methacrylate (MMA) bone cement during orthopedic procedures has been seen as a potential exposure hazard to health care professionals. However, that assessment is based on a number of investigations with problems in experimental design, analysis, and data interpretation. The current investigation quantified differences in MMA vapors produced during the preparation of competing bone cements using various methods of preparation. Unlike previous investigations, this effortdoi:10.1080/15459620701223843 pmid:17365499 fatcat:gd5ea6s7erewvdm2r5bq7lph7e
more »... modern validated sampling and analytical methods, and considers the affect of censored results. Measurements of sufficient quality and number were collected to allow for a statistical treatment of the data. The ability of two controlled preparation techniques to reduce MMA emissions were compared with a traditional open container. The results confirmed that the preparation of bone cement releases MMA vapors into the breathing zone of the preparer. One preparation technique (Stryker Bowl) controlled emissions during mixing and curing and affected a 73% reduction in measured MMA concentrations. In addition to mixing and curing, the second technique (UltraMix System) also controlled the MMA during pouring of the monomer and affected a 90% reduction in MMA concentrations. An ANOVA test of interaction indicates that the reductions are attributable to the preparation technique regardless of the type of cement being used. Both a Fisher's PLSD and Games/Howell post hoc test of the results indicate that the mean differences between the uncontrolled open container and the controlled preparation techniques are significant (p < 0.05).
Lowry, Mercer H. Patriarche, Missouri Conservation Commission; Robert G. Martin, Virginia Commission of Game and Inland Fisheries; and Robert 8S. Camp- bell and Timothy R. ...doi:10.2307/3797089 fatcat:d6k23gyvfbhwvg5mf5fzquo4ve
doi:10.1100/tsw.2002.47 pmid:29973821 pmcid:PMC6009748 fatcat:llby5tvb5vawzhdz6oox5xry7q
Recent imaging and clinical studies have challenged the concept that the functional role of the cerebellum is exclusively in the motor domain. We present evidence of slowed covert orienting of visuospatial attention in patients with developmental cerebellar abnormality (patients with autism, a disorder in which at least 90% of all postmortem cases reported to date have Purkinje neuron loss), and in patients with cerebellar damage acquired from tumor or stroke. In spatial cuing tasks, normaldoi:10.1523/jneurosci.19-13-05632.1999 pmid:10377369 fatcat:2dlcnoax5vb3nnofoswzbemip4
more »... rol subjects across a wide age range were able to orient attention within 100 msec of an attention-directing cue. Patients with cerebellar damage showed little evidence of having oriented attention after 100 msec but did show the effects of attention orienting after 800-1200 msec. These effects were demonstrated in a task in which results were independent of the motor response. In this task, smaller cerebellar vermal lobules VI-VII (from magnetic resonance imaging) were associated with greater attention-orienting deficits. Although eye movements may also be disrupted in patients with cerebellar damage, abnormal gaze shifting cannot explain the timing and nature of the attention-orienting deficits reported here. These data may be consistent with evidence from animal models that suggest damage to the cerebellum disrupts both the spatial encoding of a location for an attentional shift and the subsequent gaze shift. These data are also consistent with a model of cerebellar function in which the cerebellum supports a broad spectrum of brain systems involved in both nonmotor and motor function.
IEEE Sensors Journal
Timothy T-Y. Lam received the B.E. degree from the Australian National University, Canberra, in 2007. He is currently working towards the Ph.D. degree at the Australian National University. ...doi:10.1109/jsen.2009.2024040 fatcat:ay7fwyh5jfhkjmudkki3vqvbpm
Estuaries and Coasts
Surf smelt Hypomesus pretiosus are an important part of the Salish Sea food web and obligate beach spawners, yet little is known about the spatiotemporal distribution of spawning and beach characteristics related to spawning success. We counted smelt eggs at 51 sites around Camano Island, Puget Sound, Washington every 2 weeks for 1 year and at 13 of those 51 sites each month in the following year. At each site, we measured beach characteristics hypothesized to affect spawning habitatdoi:10.1007/s12237-012-9511-1 fatcat:ii2geweej5gfdldjcjvudwayoq
more »... as measured by egg abundance and mortality. Eggs were collected at 45 sites and pooled by month for analyses. Few sites (N 010, 19.6 %) contributed 87 % of total eggs and 89 % of all live eggs collected. Mean total egg counts at sites were higher (p< 0.019) in Jul-Sep (1,790.7, SE0829.5) than in Jan-Mar (26.1, SE010.2). Principal component and regression analyses suggested that aspect, fetch, solar radiation, and beach temperature predicted egg abundance but not mortality. Because a small proportion of sites appear to support most spawning activity, a conclusion consistent with year 2 egg counts, impacts to relatively few beaches could greatly affect surf smelt production.
The synthesis of new benzo[a]-and [b]xanthene dye frameworks is described. A unique benzo-[a] xanthene, seminaphtho[a]fluorone (SNAFR-1), is studied in a variety of media. The optimization of solution parameters and excitation wavelengths allows SNAFR-1 to display red, green, and blue emission bands of approximately equal intensities and also to produce white light. Ratiometric red (anion) and green (neutral) emissions are observed upon varying solution pH. A pH-independent violet-blue emissiondoi:10.1021/ja0632207 pmid:17061891 pmcid:PMC2662356 fatcat:s2tfoy4banfyfjp67gvnakolnu
more »... band is due to the addition of nucleophiles to the benzylic carbon of SNAFR-1.
Tom Hayman Tim Lowry ...doi:10.1038/npre.2010.5058 fatcat:ew5vm6dayvfsflwqrizonr64my
Tom Hayman Tim Lowry ...doi:10.1038/npre.2010.5058.1 fatcat:5cdxuwuhyfacvgzf5dlmb6qweu
Objectives: Our model of a systemic-pulmonary shunt exhibits enhanced reactivity of pulmonary arteries contralateral to a localized shunt between the left lower lobe pulmonary artery and aorta relative to those of ipsilateral or control pulmonary arteries 48 hours after anastomosis. We examined the contribution of nitric oxide, cyclooxygenase, lipoxygenase, or cytochrome P450 production to mediating this enhanced reactivity. Methods: We created a surgical end-to-side anastomosis of the leftdoi:10.1016/j.jtcvs.2010.07.007 pmid:21075383 pmcid:PMC3052931 fatcat:llmftpt66zfivp3twxmbwi5wa4
more »... r lobe pulmonary artery to the aorta. Forty-eight hours later, we tested tension of pulmonary artery rings from the right and left lower lobes for contraction to the thromboxane mimetic U46619 in the presence of vehicle or inhibitors of nitric oxide synthase, cyclooxygenase, cytochrome P450, or lipoxygenase. Western blots of pulmonary artery homogenates were probed for endothelial nitric oxide synthase or isoforms metabolizing arachidonic acid. Eicosanoid products from intact pulmonary artery rings were detected using labeled arachidonic acid and high-performance liquid chromatography separation. Results: Enhanced reactivity of unshunted right pulmonary arteries over that of left pulmonary arteries from high-flow hosts was not eliminated by inhibitors of nitric oxide synthase, cyclooxygenase, cytochrome P450. Treatment with 2 different lipoxygenase inhibitors, nordihydroguaiaretic acid and cinnamyl-3,4-dihydroxy-acyanocinnamate, closed the difference in contractility of shunted and unshunted pulmonary arteries. Pulmonary arteries contralateral to shunts metabolized arachidonic acid to 12-hydroxyeicosatetraenoic acid in greater quantities than analogous pulmonary arteries from the experimental left or control pulmonary arteries. Conclusions: Forty-eight hours after anastomosis, enhanced reactivity of contralateral pulmonary arteries is attributable in part to increased lipoxygenase products as opposed to nitric oxide or other eicosanoid products. (J Thorac Cardiovasc Surg 2011;141:425-31) High flow and pressure are reported to increase or decrease elaboration of both prodilatory and proconstrictive factors in the pulmonary circulation. 1-3 Variability in these findings has been attributed to differences in the duration of exposure to high flow rates, with the implication that a shift from predominance of provasodilatory to proconstrictive factors occurs at some point after initiation of high flow. The effect of a localized anastomosis on endothelium-derived products of pulmonary arteries not directly exposed to high flow or pressure in vivo has not been examined to our knowledge. We developed a model of localized high flow to the left lower lobe and examined reactivity of pulmonary arteries from ipsilateral and contralateral pulmonary arteries 48 hours later. We chose the time frame of 48 hours because changes in protein expression potentially related to differences in vasoactivity should reasonably be expected by this time, and pilot experiments supported changes in vascular reactivity within 2 days. Our experiments demonstrated enhanced endotheliumdependent reactivity of pulmonary arteries contralateral to the shunt 4 relative to that of control and ipsilateral pulmonary arteries. We hypothesized that either decreased synthesis of a vasodilatory product or enhanced release of a constrictor from right (contralateral) pulmonary arteries would account for this difference in reactivity to thromboxane agonists. Because nitric oxide (NO) and metabolites of arachidonic acid are known to modulate pulmonary vascular tone, we blocked the synthesis of these products to test the contribution of these mediators to enhanced constriction of unshunted pulmonary arteries. METHODS AND MATERIALS Materials The following materials were used: nordihydroguaiaretic acid (NDGA)
The Pathway Ontology (PW) developed at the Rat Genome Database (RGD), covers all types of biological pathways, including altered and disease pathways and captures the relationships between them within the hierarchical structure of a directed acyclic graph. The ontology allows for the standardized annotation of rat, and of human and mouse genes to pathway terms. It also constitutes a vehicle for easy navigation between gene and ontology report pages, between reports and interactive pathwaydoi:10.1186/2041-1480-5-7 pmid:24499703 pmcid:PMC3922094 fatcat:ljtud6bsx5dnhpn76pzpy6u5fq
more »... ms, between pathways directly connected within a diagram and between those that are globally related in pathway suites and suite networks. Surveys of the literature and the development of the Pathway and Disease Portals are important sources for the ongoing development of the ontology. User requests and mapping of pathways in other databases to terms in the ontology further contribute to increasing its content. Recently built automated pipelines use the mapped terms to make available the annotations generated by other groups. Results: The two released pipelinesthe Pathway Interaction Database (PID) Annotation Import Pipeline and the Kyoto Encyclopedia of Genes and Genomes (KEGG) Annotation Import Pipeline, make available over 7,400 and 31,000 pathway gene annotations, respectively. Building the PID pipeline lead to the addition of new terms within the signaling node, also augmented by the release of the RGD "Immune and Inflammatory Disease Portal" at that time. Building the KEGG pipeline lead to a substantial increase in the number of disease pathway terms, such as those within the 'infectious disease pathway' parent term category. The 'drug pathway' node has also seen increases in the number of terms as well as a restructuring of the node. Literature surveys, disease portal deployments and user requests have contributed and continue to contribute additional new terms across the ontology. Since first presented, the content of PW has increased by over 75%. Conclusions: Ongoing development of the Pathway Ontology and the implementation of pipelines promote an enriched provision of pathway data. The ontology is freely available for download and use from the RGD ftp site at
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