Filters








402 Hits in 1.2 sec

The Alternative Library

Timothy Collinson, Alison Williams
2004 ASLIB Proceedings  
Much time and effort has been devoted to designing and developing library Web sites that are easy to navigate by both new students and experienced researchers. In a review of the Southampton Institute Library it was decided that in addition to updating the existing homepage an alternative would be offered. Drawing on theory relating to user interface design, learning styles and creative thinking, an Alternative Library navigation system was added to the more traditional library homepage. The
more » ... was to provide students with a different way to explore and discover the wide range of information resources available by taking a less formal approach to navigation based on the metaphor of physical space and playful exploration.
doi:10.1108/00012530410539322 fatcat:lw6inaahs5fyzizjixaeyzsdp4

Virtual worlds in computing education

Jonathan Crellin, Emma Duke-Williams, Jane Chandler, Timothy Collinson
2009 Computer Science Education  
There have been a number of projects that have simulated real physical environments to support learning, for example (Collinson & Williams, 2004; Pablo, 2005) .  ... 
doi:10.1080/08993400903384950 fatcat:oogml4nrpne7jacvdp37o6mzfe

Library e-induction: alleviating anxiety with digital doughnuts: a case study

Timothy Collinson, Alison Williams
2006 ITALICS  
The purpose, explained more thoroughly in Collinson & Williams (1994) , is to encourage students to explore and thus find library resources through serendipity as much as actively seeking them out.  ...  (Collinson and Williams, 2004) The Alternative Library grew out of a creative thinking course the authors took part in, and encourages exploration both by being somewhat unusual and by including 'easter  ... 
doi:10.11120/ital.2006.05040174 fatcat:lfepr3cvt5e27flnhv4t7th4fy

A virtual library world for pre-entry university students

Timothy Collinson, Marie Kendall
2009 2009 First International Conference on Networked Digital Technologies  
The University of Portsmouth's pre-entry project, PrepUp, contains a Library section which endeavours to use simple graphics and a virtual world metaphor to acculturate students to the University Library before they begin their course. Using graphical elements it contains informative items and fun features to encourage exploration and discovery. Usage and feedback suggest that this is a useful addition to the project which engages students and assists them in getting to grips with their early days at University.
doi:10.1109/ndt.2009.5272195 fatcat:gavzs3fbnjfxljx4767abidsmi

The prevalence of scabies in Monrovia, Liberia: a population-based survey [article]

Shelui Collinson, Joseph Timothy, Samuel Zayzay, Karsor Kollie, Eglantine Lebas, Katherine Halliday, Rachel Pullan, Mosoka Fallah, Steve Walker, Michael Marks
2020 biorxiv/medrxiv   pre-print
Scabies is known to be a public health problem in many settings but the majority of recent data is from rural settings in the Pacific. There is a need for high quality data from sub-Saharan Africa and peri-Urban settings to inform scale up of scabies control efforts. There have been anecdotal reports of scabies being a public health problem in Liberia but robust data are lacking. Methods We conducted a cross-sectional cluster-randomised prevalence survey for scabies in a peri-urban community in
more » ... Monrovia, Liberia in February-March 2020. Participants underwent a standardised examination conducted by trained local health care workers. Health related quality of life (HRQoL) was assessed using age-appropriate dermatology life quality indices (DLQIs). Prevalence estimates were calculated accounting for clustering at community and household levels and associations with key demographic variables assessed through multivariable random-effects logistic regression. Results 1,318 participants from 477 households were surveyed. The prevalence of scabies prevalence was 9.3% (95% CI: 6.5-13.2%), across 75 (19.7%) households; impetigo or infected scabies prevalence was 0.8% (95% CI: 0.4-1.9%). The majority (52%) of scabies cases were classified as severe. Scabies prevalence was lower in females and higher in the youngest age group; no associations were found with other collected demographic or socio-economic variables. DLQI scores indicated a very or extremely large effect on HRQoL in 29% of adults and 18% of children diagnosed with scabies. Conclusions Our study indicates a substantial burden of scabies in this peri-Urban population in Liberia. This was associated with significant impact on quality of life, highlighting the need for action to control scabies in this population. Further work is needed to assess the impact of interventions in this context on both the prevalence of scabies and quality of life.
doi:10.1101/2020.06.25.20139808 fatcat:sh2xkyaihjfhfpyt47fxphmyfy

Ultra rigid cross-bridged tetraazamacrocycles as ligands—the challenge and the solution

Timothy J. Hubin, James M. McCormick, Simon R. Collinson, Daryle H. Busch, Nathaniel W. Alcock
1998 Chemical Communications  
N N N N R R n m 1 n = m = 0, R = H 2 n = m = 0, R = Me 3 n = m = 0, R = Bn 4 n = m = 1, R = H 5 n = m = 1, R = Me 6 n = m = 1, R = Bn 7 n = 1, m = 0, R = Me Ultra rigid cross-bridged tetraazamacrocycles as ligands-the challenge and the solution The challenge to metal ion binding that is represented by the proton-sponge nature of two-carbon cross-bridged tetraazamacrocycles has been overcome and a general method developed for the synthesis of their transiton, and other, metal complexes; these
more » ... ra-rigid ligands form complexes having remarkable kinetic stabilities.
doi:10.1039/a802060d fatcat:eusnsvhujjhjbdhqysd4lyqd5u

Is lateral bias anomalous in early-onset schizophrenia? Selected comparisons with normal populations

Simon L. Collinson, Tania Jane Phillips, Anthony C.D. James, Digby J. Quested, Timothy J. Crow
2004 Psychiatry Research  
Collinson). ing anomalies in the direction and strength of lateral bias (e.g. hand, eye and foot preferences).  ... 
doi:10.1016/j.psychres.2003.12.018 pmid:15051182 fatcat:xwmeko223vgpvlailks5fw4rmy

An E2-F12 complex is required for intracellular enveloped virus morphogenesis during vaccinia infection

Mark P. Dodding, Timothy P. Newsome, Lucy M. Collinson, Ceri Edwards, Michael Way
2009 Cellular Microbiology  
The vaccinia virus protein, F12, has been suggested to play an important role in microtubulebased transport of intracellular enveloped virus (IEV). We found that GFP-F12 is recruited to IEV moving on microtubules but is released from virus particles when they switch to actin-based motility. In the absence of F12, although the majority of IEV remain close to their peri-nuclear site of assembly, a small number of IEV still move with linear trajectories at speeds of 0.85 mm s -1 , consistent with
more » ... icrotubule transport. Using a recombinant virus expressing GST-F12, we found that the viral protein E2 interacts directly with F12. In infected cells, GFP-E2 is observed on moving IEV as well as in the Golgi region, but is not associated with actin tails. In the absence of E2L, IEV accumulate in the peri-nuclear region and F12 is not recruited. Conversely, GFP-E2 is not observed on IEV in the absence of F12. Ultra-structural analysis of DE2Land DF12L-infected cells reveals that loss of either protein results in defects in membrane wrapping during IEV formation. We suggest that E2 and F12 function as a complex that is necessary for IEV morphogenesis prior to their microtubule-based transport towards the plasma membrane.
doi:10.1111/j.1462-5822.2009.01296.x pmid:19207726 pmcid:PMC2688674 fatcat:aa2fiv34vvhffghda6p4oi7xwa

Brain volume, asymmetry and intellectual impairment in relation to sex in early-onset schizophrenia

Simon L. Collinson, Clare E. Mackay, Anthony C. James, Digby J. Quested, Tania Phillips, Neil Roberts, Timothy J. Crow
2003 British Journal of Psychiatry  
Accumulating evidence suggests that early-onset schizophrenia arises from a disturbance in the normal trajectory of cerebral development. Aims To investigate brain structure, asymmetry and IQ in early-onset schizophrenia. Method Volumes of left and right cerebral hemispheres and IQ were assessed in 33 participants with early-onset DSM – IV schizophrenia and 30 members of a matched, normal control group. Results Total brain volume was significantly smaller in the group with early-onset disease
more » ... cases') relative to the control group (4.5%), especially for the left hemisphere in males (6.0%). A significant sex x diagnosis interaction in hemisphere asymmetry revealed that the female cases group had significantly reduced rightward asymmetry relative to the female control group and that the male cases tended to have reduced leftward asymmetry relative to the male control group. Decreased left hemisphere volume in males and decreased rightward hemispheric asymmetry in females correlated with reduced IQ. Conclusions Sexually dimorphic alterations in asymmetry correlate with degree of intellectual impairment in early-onset schizophrenia.
doi:10.1192/bjp.183.2.114 pmid:12893664 fatcat:exiosf26i5ec3i6xgmpcyljeia

The prevalence of scabies in Monrovia, Liberia: A population-based survey

Shelui Collinson, Joseph Timothy, Samuel K. Zayzay, Karsor K. Kollie, Eglantine Lebas, Neima Candy, Katherine E. Halliday, Rachel Pullan, Mosoka Fallah, Stephen L. Walker, Michael Marks, Claire Fuller
2020 PLoS Neglected Tropical Diseases  
Investigation: Shelui Collinson, Joseph Timothy, Samuel K. Zayzay, Neima Candy, Michael Marks.  ...  , Joseph Timothy, Michael Marks. acquisition: Stephen L.  ... 
doi:10.1371/journal.pntd.0008943 pmid:33284821 fatcat:pbdk4ctj2vglxlwucdvanwb6yu

A community-based validation of the International Alliance for the Control of Scabies Consensus Criteria by expert and non-expert examiners in Liberia [article]

Steve Walker, Shelui Collinson, Joseph Timothy, Samuel Zayzay, Karsor Kollie, Eglantine Lebas, Katherine Halliday, Rachel Pullan, Mosoka Fallah, Michael Marks
2020 medRxiv   pre-print
The International Alliance for the Control of Scabies (IACS) recently published expert consensus criteria for scabies diagnosis. Formal validation of these criteria is needed to guide implementation. We conducted a study to provide detailed description of the morphology and distribution of scabies lesions as assessed by dermatologists and validate the IACS criteria for diagnosis by both expert and non-expert examiners. Methods Participants from a community in Monrovia, Liberia, were
more » ... y assessed by two dermatologists and six mid-level healthcare workers. Lesion morphology and distribution were documented based on the dermatologist examination. Diagnoses were classified by IACS criteria and the sensitivity and specificity of MLHW assessments calculated. Results Papules were the most common lesions (97.8%). Burrows were found in just under half (46.7%) and dermatoscopy was positive in a minority (13.3%). Scabies lesions were found in all body regions but more than 90% of patients could have been diagnosed by an examination of only the limbs. Severity of itch was associated with lesion number (p=0.003). The sensitivity of MLHWs to detect typical scabies ranged between 69-83% and specificity 70-96%. The sensitivity of MLHWs was higher in more extensive disease (78-94%). Conclusions The IACS criteria proved a valid tool for scabies diagnosis. For the purposes of implementation papules and burrows represent truly typical scabies lesions. MLHWs are able to diagnose scabies with a high degree of accuracy, demonstrating they could form a key component in population-level control strategies.
doi:10.1101/2020.06.08.20125682 fatcat:engldfgyrjbobbip5bvwa4jqqy

Response to Prakash et al

Marcus A. Tuke, Katherine S. Ruth, Andrew R. Wood, Robin N. Beaumont, Jessica Tyrrell, Samuel E. Jones, Hanieh Yaghootkar, Claire L. S. Turner, Mollie E. Donohoe, Antonia M. Brooke, Morag N. Collinson, Rachel M. Freathy (+3 others)
2018 Genetics in Medicine  
doi:10.1038/s41436-018-0412-y pmid:30573795 fatcat:fkmtflc2r5fnvjerkrxvhhuyhy

Synthesis and X-ray crystal structures of iron(II) and manganese(II) complexes of unsubstituted and benzyl substituted cross-bridged tetraazamacrocycles

Timothy J Hubin, James M McCormick, Simon R Collinson, Nathaniel W Alcock, Howard J Clase, Daryle H Busch
2003 Inorganica Chimica Acta  
The Mn 2' and Fe 2' complexes of the cross-bridged tetraazamacrocyclic ligands, 4,11-dibenzyl-1,4,8,11-tetraazabicyclo[6.6.2]hexadecane (1), 4,10-dibenzyl-1,4,7,10-tetraazabicyclo[5.5.2]tetradecane (2), 1,4,8,11-tetraazabicyclo[6.6.2]hexadecane (3), and 1,4,7,10-tetraazabicyclo[5.5.2]tetradecane (4) provide new compounds of these elements for fundamental studies and applications. These unsubstituted and benzyl substituted derivatives were prepared for comparison of their structures and
more » ... s with the known catalytically active dimethyl cross-bridged ligand complexes, which are especially notable for their exceptional kinetic stabilities and redox activity. The X-ray crystal structures of five complexes demonstrate that the ligands enforce a distorted octahedral geometry on the metals with two cis sites occupied by labile ligands. The Fe 2' complexes of the unsubstitued ligands form m-oxo dimers upon exposure to air, which have also been structurally characterized. Cyclic voltammetry of the monomeric complexes shows reversible redox processes for the M 3' /M 2' couples, which are sensitive to solvent, ring size, and ring substitution. #
doi:10.1016/s0020-1693(02)01427-5 fatcat:hcx3izbudvgqveasujxbv6ktsi

Mosaic Turner syndrome shows reduced penetrance in an adult population study

Marcus A. Tuke, Katherine S. Ruth, Andrew R. Wood, Robin N. Beaumont, Jessica Tyrrell, Samuel E. Jones, Hanieh Yaghootkar, Claire L. S. Turner, Mollie E. Donohoe, Antonia M. Brooke, Morag N. Collinson, Rachel M. Freathy (+3 others)
2018 Genetics in Medicine  
Many women with X chromosome aneuploidy undergo lifetime clinical monitoring for possible complications. However, ascertainment of cases in the clinic may mean that the penetrance has been overestimated.
doi:10.1038/s41436-018-0271-6 pmid:30181606 pmcid:PMC6752315 fatcat:2gugybdrhvegppkhqi54gwexyi

Mosaic Turner syndrome shows reduced phenotypic penetrance in an adult population study compared to clinically ascertained cases [article]

Marcus A. Tuke, Katherine S. Ruth, Andrew R. Wood, Robin N. Beaumont, Jessica Tyrrell, Samuel E. Jones, Hanieh Yaghootkar, Claire L. S. Turner, Mollie E. Donohoe, Antonia M. Brooke, Morag N. Collinson, Rachel M. Freathy (+3 others)
2017 bioRxiv   pre-print
Women with X chromosome aneuploidy such as 45,X (Turner syndrome) or 47,XXX (Triple X syndrome) present with characteristics including differences in stature, increased cardiovascular disease risk and primary ovarian insufficiency. Many women with X chromosome aneuploidy undergo lifetime clinical monitoring for possible complications. However, ascertainment of cases in the clinic may mean that the phenotypic penetrance is overestimated. Studies of prenatally ascertained X chromosome aneuploidy
more » ... ases have limited follow-up data and so the long-term consequences into adulthood are often not reported. We aimed to characterise the prevalence and phenotypic consequences of X chromosome aneuploidy in a large population of women over 40 years of age. We detected 30 women with 45,X, 186 with mosaic 45,X/46,XX and 110 with 47,XXX among 244,848 UK Biobank women, using SNP array data. The prevalence of non-mosaic 45,X (1/8,162) and 47,XXX (1/2,226) was lower than expected, but was higher for mosaic 45,X/46,XX (1/1,316). The characteristics of women with 45,X were consistent with the characteristics of a clinically recognised Turner syndrome phenotype, including a 17.2cm shorter stature (SD = 5.72cm; P = 1.5 x 10-53) and 16/30 did not report an age at menarche. The phenotype of women with 47,XXX included taller stature (5.3cm; SD = 5.52cm; P = 5.8 x 10-20), earlier menopause age (5.12 years; SD = 5.1 years; P = 1.2 x 10-14) and a lower fluid intelligence score (24%; SD = 29.7%; P = 3.7 x 10-8). In contrast, the characteristics of women with mosaic 45,X/46,XX were much less pronounced than expected. Women with mosaic 45,X/46,XX were less short, had a normal reproductive lifespan and birth rate, and no reported cardiovascular complications. In conclusion, the availability of data from 244,848 women allowed us to assess the phenotypic penetrance of traits associated with X chromosome aneuploidy in an adult population setting. Our results suggest that the clinical management of women with 45,X/46,XX mosaicism should be minimal, particularly those identified incidentally.
doi:10.1101/177659 fatcat:jt7utwir5nh4dfzgxbdxx7a56e
« Previous Showing results 1 — 15 out of 402 results