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G Cornélissen, F Halberg, E E Bakken, Z Wang, R Tarquini, F Perfetto, G Laffi, C Maggioni, Y Kumagai, P Homolka, A Havelková, J Dušek (+3 others)
2007 Scripta medica  
BIOCOS, the project aimed at studying BIOlogical systems in their COSmos, has obtained a great deal of expertise in the fields of blood pressure (BP) and heart rate (HR) monitoring and of marker rhythmometry  ...  Prolonging the monitoring reduces the uncertainty in the estimation of circadian parameters; the current recommendation of BIOCOS requires monitoring for at least 7 days.  ...  the upper 95% prediction limit), BP-ecphasia (a condition characterized by a deviant circadian acrophase of blood pressure), and DHRV (decreased heart rate variability, defined as a below-threshold standard  ... 
pmid:19122770 pmcid:PMC2613367 fatcat:apvdtx2vtvdyjooexvxtacqyue

Time-Qualified Reference Values for Ambulatory Blood Pressure Monitoring in Pregnancy

Ramón C. Hermida, Diana E. Ayala, Artemio Mojón, José R. Fernández
2001 Hypertension  
Accordingly, we derived time-specified reference standards for blood pressure as a function of gestational age.  ...  To recognize the highly statistically significant circadian variability of blood pressure in pregnancy is to admit that the diagnosis of gestational hypertension or preeclampsia should be based not just  ...  Acknowledgments This research was supported in part by grants from Dirección General de Enseñanza Superior e Investigación Científica, DGES (PM98-0106); Xunta de Galicia (PGICT99-PXI-32202B and PGICT00  ... 
doi:10.1161/01.hyp.38.3.746 pmid:11566969 fatcat:hydkfc2kprcuxgzu3vopv7vtwi


O Schwartzkopff, G Cornélissen, C Halpin, G Katinas, J Siegelová, B Fišer, J Dušek, F Halberg
2005 Scripta medica  
In addition to diagnosing deviations in a chronome (time structure)-adjusted mean value, a chronobiological approach identifies abnormalities in the variability of BP and/or HR, gauged by the circadian  ...  of blood pressure (BP) and heart rate (HR) (and a much longer record if the 7 day record so indicates) and, second, of analysing the data chronobiologically in the light of reference values specified  ...  Circadian rhythm characteristics are interpreted in the light of reference values consisting of 90% prediction limits derived from records of clinically healthy people of the same gender and a similar  ... 
pmid:19018290 pmcid:PMC2583359 fatcat:p4ow3huebjhytaqdt7iddwiemi

Chronobiology Predicts Actual and Proxy Outcomes when Dipping Fails

G. Cornelissen, F. Halberg, K. Otsuka, R.B. Singh, C.-H. Chen
2006 Hypertension  
Abnormality in the normal range can occur as (1) a (circadian) blood pressure overswing or circadian hyperamplitude-tension (CHAT) gauged by a circadian amplitude exceeding the upper prediction limit of  ...  prediction limit of clinically healthy peers matched by gender and age had a relative risk of 4 (Figure) .  ... 
doi:10.1161/01.hyp.0000250392.51418.64 pmid:17075031 pmcid:PMC2613012 fatcat:kjdpbnde3vdohju6r2pas2ybau

Association of Western Diet and Lifestyle with Circadian Hyperamplitude Tension and Mesor Hypertension Measured by Ambulatory Blood Pressure Monitoring

Miki Tokunaga
2013 The Open Nutraceuticals Journal  
Moderation in diet and lifestyle reversed the blood pressure variability, demonstrated by ambulatory blood pressure monitoring.  ...  Effects of Western diet and lifestyle factors resulting in hypertension are known, however, the effects of lifestyle on blood pressure variability measured by ambulatory blood pressure monitoring are not  ...  ACKNOWLEDGEMENTS Acknowledgements are due to The Tsim Tsoum Institute, International College of Nutrition and International College of Cardiology for providing logistic support to write this article.  ... 
doi:10.2174/1876396001306010056 fatcat:5d4eb5gkafhdzhb2x2ffw5l2dm

Opportunity of detecting pre-hypertension: worldwide data on blood pressure overswinging

G. Cornélissen, A. Delcourt, G. Toussaint, K. Otsuka, Y. Watanabe, J. Siegelova, B. Fiser, J. Dusek, P. Homolka, R.B. Singh, A. Kumar, R.K. Singh (+10 others)
2005 Biomedicine and Pharmacotherapy  
Overswinging or CHAT (brief for Circadian Hyper-Amplitude-Tension), that is an excessive circadian variation in blood pressure (BP), has been associated with a large increase in cardiovascular disease  ...  Once diagnosed, however, a usual circadian BP pattern can be restored by means of certain non-pharmacologic or pharmacologic interventions timed appropriately.  ...  HR variability, gauged by a circadian standard deviation below the lower 5% prediction limit of peers.  ... 
doi:10.1016/s0753-3322(05)80023-x pmid:16275485 pmcid:PMC2581881 fatcat:2xyldu5wjze5bhe7djz27irttq

Chronobiology of Aging: A Mini-Review

Germaine Cornelissen, Kuniaki Otsuka
2016 Gerontology  
The quantitative estimation of circadian rhythm characteristics interpreted in the light of time-specified reference values helps (1) to distinguish effects of natural healthy aging from those associated  ...  there is overt disease; and (3) to individually optimize by timing prophylactic and/or therapeutic interventions aimed at restoring a disturbed circadian system and/or enhancing a healthy life span.  ...  An excessive circadian amplitude of blood pressure and an acrophase of blood pressure, but not of heart rate, occurring outside the 90% prediction limits of clinically healthy peers matched by gender and  ... 
doi:10.1159/000450945 pmid:27771728 fatcat:auk3wofpongupe3gijutt25w5y

Diagnosing vascular variability anomalies, not only MESOR-hypertension

Franz Halberg, Deborah Powell, Kuniaki Otsuka, Yoshihiko Watanabe, Larry A. Beaty, Paul Rosch, Jerzy Czaplicki, Dewayne Hillman, Othild Schwartzkopff, Germaine Cornelissen
2013 American Journal of Physiology. Heart and Circulatory Physiology  
age; circadian hyper-amplitude-tension (CHAT; middle left, and middle) is an elevation of the 24-h amplitude of blood pressure above the upper 95% prediction limit of clinically healthy peers matched  ...  This danger applies to some patients with hypertension (who tend to have a large circadian amplitude of blood pressure) to whom treatment time is not specified (or is specified for bedtime) by the care  ... 
doi:10.1152/ajpheart.00212.2013 pmid:23709604 pmcid:PMC4073984 fatcat:fellql64xrdw3jyligighp5my4

Circadian blood pressure and heart rate characteristics in haemorrhagic vs ischaemic stroke in Chinese people

Z Jiang, W Li, Y Liu, Y Wang, Z Wang, J Xiao, H Guo, G Cornélissen, F Halberg
2009 Journal of Human Hypertension  
(measures of extent and timing of predictable daily change).  ...  BP MESOR and pulse pressure (Po0.001) and in the circadian amplitude of SBP (Po0.005).  ...  and age. 16 Each participant's original data were also compared with the upper chronodesmic limit (derived as the time-specified upper 95% prediction limit from independent groups of clinically healthy  ... 
doi:10.1038/jhh.2009.53 pmid:19571828 fatcat:6emcmrzdzraj5mtaw5bx5elqim

Chronobiologically Interpreted Ambulatory Blood Pressure Monitoring in Health and Disease

Franz Halberg, Germaine Cornélissen, Dewayne Hillman, Larry A. Beaty, Shiyu Hong, Othild Schwartzkopff, Yoshihiko Watanabe, Kuniaki Otsuka, Jarmila Siegelova
2012 Global Advances in Health and Medicine  
To detect vascular variability anomalies (VVAs), a blood pressure and heart rate profile around the clock for at least 7 days is a start.  ...  As a minimum, measurement every 60 or preferably 30 minutes for a week is needed, to be continued if abnormality is found, to assess the about 24-hour (circadian) variability that exists in all individuals  ...  This danger applies to some hypertensives (who tend to have a large circadian amplitude of blood pressure) to whom treatment time is not specified by the care provider, as was the case for TT (or is specified  ... 
doi:10.7453/gahmj.2012.1.2.012 pmid:23710422 pmcid:PMC3663595 fatcat:piqcpuw4nfbu3dslc2khxlqgqe

Duration of abpm as an important prerequisite for a reliable diagnosis of vascular variability disorders (VVDs)

L Z Gumarova, G Cornelissen, F Halberg, A T Mansharipova, K Otsuka, E V Syutkina, A V Masalov, S M Chibisov, V A Frolov
2013 RUDN Journal of Medicine  
The large day-to-day variability in circadian characteristics of blood pressure and heart rate observed in Tosa City and the associated presence or absence of VVA(s) on a given day indicate the need to  ...  ABPM records from 26 clinically healthy residents of Tosa City, Japan over 6 or 7 days were analyzed overall and day-by-day in order to determine the frequency of occurrence of vascular variability abnormalities  ...  monitoring (ABPM) in clinical health served to derive time-specified reference limits computed as 90% prediction limits specified by gender and age [1] .  ... 
doaj:4c1f9e05a4c540e09179d25db9289083 fatcat:5uxdllrjizeuvp3fauiv64zkse

Variations in 7-day/24-h circadian pattern of ambulatory blood pressure and heart rate of type 2 diabetes patients

Shipra Bhardwaj, Narsingh Verma, Baby Anjum, Kshitij Bhardwaj
2014 Journal of Diabetes Investigation  
A 7-day timed analysis of BP through ambulatory blood pressure monitoring has been used not only to diagnose day and night dipping patterns of blood pressure, but also to measure day-to-day variability  ...  General health records were individually maintained, and 7-day/24-h ambulatory blood pressure monitoring using an ambulatory blood pressure monitor was carried out.  ...  ACKNOWLEDGMENT The authors are grateful to the Halberg Chronobiology Center, University of Minnesota, for ABPM statistics help.  ... 
doi:10.1111/jdi.12224 pmid:25422775 pmcid:PMC4234238 fatcat:jgl2r52fzrfondmbjfuad7zdbm

Personalized chronome (time structure) complements genome detecting vascular variability disorders (vvds), including mesor-hypertension

G Cornélissen, V Frolov, S Chibisov, E Kharlitskaya, F Halberg
2010 RUDN Journal of Medicine  
Computer-aided, automatic, inferential statistical, self-help-based preventive health care is better and cheaper when the personal surveillance is done by a secure Internet, without the need for a care  ...  promises dividends from research on space weather in the spirit of Alexander Leonidovich Chizhevsky, that was not possible in the pre-computer era.  ...  Blood pressure (BP) measurements taken 6 times each day for 17 days by staff at the Clinical Cen ter of the U.S.  ... 
doaj:b16bacd3cf304764b6e8de2f22873263 fatcat:6llpqnamcreetand6yhlp57syq

Circadian and circaseptan (about-weekly) aspects of immigrant Indians' blood pressure and heart rate in California, USA

B. Sundaram, D.C. Holley, G. Cornélissen, D. Naik, R. Hanumansetty, R.B. Singh, K. Otsuka, F. Halberg
2005 Biomedicine and Pharmacotherapy  
In this study, 30 clinically healthy subjects underwent 7-day monitoring and provided a series of findings, including the detection of Circadian Hyper-Amplitude-Tension (CHAT), that is blood pressure overswinging  ...  Time structurally (chronomically) interpreted half-hourly monitoring of blood pressure (BP) and heart rate (HR) for at least 7 days and preferably for 17 days is recommended, separately for a diagnosis  ...  Illustrative time plot of systolic blood pressure from a case of circadian hyper-amplitudetension (CHAT).  ... 
doi:10.1016/s0753-3322(05)80014-9 pmid:16275512 pmcid:PMC2576448 fatcat:k4loyp5obngpvpbbsppuwmq4xq

Falls Risk, Circadian Rhythms and Melatonin: Current Perspectives

Nandu Goswami, Carolina Abulafia, Daniel Vigo, Maximilian Moser, Germaine Cornelissen, Daniel Cardinali
2020 Clinical Interventions in Aging  
the scheduling of hospital staff, or changing the timing of anti-hypertensive medication if falls are related to undesirable circadian patterns of blood pressure and/or heart rate).  ...  Whether one is concerned with disease prediction and prevention or maintenance of healthy aging, the study of circadian rhythms and the broader time structure underlying physiopathology is helpful in terms  ...  The analysis of their data can determine whether their circadian variation in blood pressure and heart rate is within acceptable limits or whether it deviates from norms.  ... 
doi:10.2147/cia.s283342 pmid:33204081 pmcid:PMC7666981 fatcat:mqnnb77zsbbvpn54r3kptskq5u
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