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TIM-3 and CEACAM1 are Prognostic Factors in Head and Neck Squamous Cell Carcinoma

Fan Yang, Ziqing Zeng, Jing Li, Xiubao Ren, Feng Wei
2021 Frontiers in Molecular Biosciences  
well-known molecule expressed on tumor tissues and/or tumor infiltrating lymphocytes (TILs).Methods: In the present study, we investigated TIM-3 and CEACAM1 immunohistochemical expression in 80 head and  ...  Our current findings suggest both of them were valuable predicting markers that might provide help for clinicians to design effective immunotherapeutic regimen against head and neck carcinoma.  ...  (A) Representative TIM-3 expressions in head and neck squamous cell carcinoma (HNSCC) specimens by immunohistochemistry (×400).  ... 
doi:10.3389/fmolb.2021.619765 fatcat:irnyihju6jblrgifrlsieb5xce

Genomic insights into head and neck cancer

Tim N. Beck, Erica A. Golemis
2016 Cancers of the Head & Neck  
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide and is frequently impervious to curative treatment efforts.  ...  Background Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer, with annual incidence of 600,000 cases worldwide [1] .  ...  Anatomically, head and neck cancer regions include the oral cavity, the pharynx (nasopharynx-behind the nose; oropharynx-soft palate, base of the tongue and the tonsils; hypopharynx-the lowest part of  ... 
doi:10.1186/s41199-016-0003-z pmid:29034103 pmcid:PMC5638139 fatcat:ix2by555bzcndm25mnwgwc6rse

NASA: US space station heads for deep freeze

Tim Beardsley
1986 Nature  
Tim Beardsley  ... 
doi:10.1038/322583a0 fatcat:lgeawjizknhj3ihcgwg3jre3ki

Insights into the Economy of Open Scholarship: A look into Zenodo with Tim Smith, head of collaboration, devices and applications, CERN/IT [article]

Gwen Franck
2019 Zenodo  
Zenodo (CH): Tim Smith Full details of all interviews are available on the Knowledge Exchange website:  ...  About Tim Smith Head of collaboration, devices and applications, CERN/IT Tim is an open science advocate leading initiatives at CERN and in the wider science community.  ...  A look into Zenodo with Tim Smith, head of collaboration, devices and applications, CERN/IT Insights into the Economy of Open Scholarship  ... 
doi:10.5281/zenodo.2842592 fatcat:2gyuytu7tbdphg3n3qf3qsksqi

Increased PD-1 + and TIM-3 + TILs during Cetuximab Therapy Inversely Correlate with Response in Head and Neck Cancer Patients

Hyun-Bae Jie, Raghvendra M. Srivastava, Athanassios Argiris, Julie E. Bauman, Lawrence P. Kane, Robert L. Ferris
2017 Cancer immunology research  
(TIL) and compared them with those of peripheral blood T lymphocytes (PBL) in patients with head and neck cancer (HNSCC) during cetuximab therapy.  ...  Indeed, the increased frequency of PD-1 þ and TIM-3 þ CD8 þ TILs was inversely correlated with clinical outcome of cetuximab therapy.  ...  However, it was reported that the frequency of PD-1 þ TILs positively correlated with a better clinical outcome in HPV-associated head and neck cancer patients (27) .  ... 
doi:10.1158/2326-6066.cir-16-0333 pmid:28408386 pmcid:PMC5497750 fatcat:w42p4d6eurbonae7gf3umy6hwa

Novel Effector Phenotype of Tim-3+ Regulatory T Cells Leads to Enhanced Suppressive Function in Head and Neck Cancer Patients

Zhuqing Liu, Elizabeth L. McMichael, Gulidanna Shayan, Jing Li, Kevin Chen, Raghvendra Srivastava, Lawrence P. Kane, Binfeng Lu, Robert L. Ferris
2018 Clinical Cancer Research  
Experimental Design: CD4 þ CTLA-4 þ CD25 high Treg cells were sorted from freshly excised head and neck squamous cell carcinoma (HNSCC) TIL based on Tim-3 expression.  ...  Results: Despite high PD-1 expression, Tim-3 þ TIL Treg displayed a greater capacity to inhibit na€ ve T-cell proliferation than Tim-3 À Treg.  ...  Introduction Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cause of cancer by incidence worldwide and is one of the most morbid and genetically diverse malignancies (1) .  ... 
doi:10.1158/1078-0432.ccr-17-1350 pmid:29712685 fatcat:majussn24vdepo54twiap75kka

Protocol for head-to-head evaluation of SARS-CoV-2 immunoassays (June 5th 2020) [article]

Monique Andersson, Abbie Bown, Tim Brooks, Derrick Crook, Daniel Ebner, David W. Eyre, Nick Gent, Tim James, Sheila F. Lumley, Bassam Hallis, Peter Hammond, Sarah Hoosdally (+8 others)
2020 Figshare  
Protocol for the evaluation of four commercial immunoassays (Abbott's SARS-CoV-2 Immunoassay, DiaSorin's LIAISON® SARS-CoV-2 S1/S2 IgG, Roche's Elecsys® Anti-SARS-CoV-2, Siemens' SARS-CoV-2 Total [COV2T]) and a novel 384-well format ELISA (the Oxford immunoassay [OIA]) for the detection of SARS-CoV-2 antibodies (author list is alphabetical).
doi:10.6084/m9.figshare.12577904 fatcat:fgmwhpcf3fbvvnsy46gulbnk5e

Outcome of Radial Head Arthroplasty in Comminuted Radial Head Fractures: Short and Midterm Results

Arash Moghaddam, Tim Friedrich Raven, Eike Dremel, Stefan Studier-Fischer, Paul Alfred Grutzner, Bahram Biglari
2016 Trauma Monthly  
Conclusions: Comminuted radial head fractures with elbow instability can be treated well with a modular radial head prosthesis, which restores stability in acute treatment.  ...  Comminuted radial head fractures are often associated with secondary injuries and elbow instability.  ...  , and Tim Friedrich Raven: critical revision of the manuscript for important intellectual content; Arash Moghaddam, Bahram Biglari, Eike Dremel, Stefan Studier Fischer, Tim Friedrich Raven: statistical  ... 
doi:10.5812/traumamon.20201 pmid:27218046 pmcid:PMC4869438 fatcat:mg4gaq35xfa2dktbxn7ncylchu

Adaptive resistance to anti-PD1 therapy by Tim-3 upregulation is mediated by the PI3K-Akt pathway in head and neck cancer

Gulidanna Shayan, Raghvendra Srivastava, Jing Li, Nicole Schmitt, Lawrence P. Kane, Robert L. Ferris
2016 Oncoimmunology  
As anti-PD-1 single agent response rates are only <20% in head and neck squamous cell carcinoma (HNSCC) patients, it is important to understand how multiple inhibitory checkpoint receptors maintain suppressed  ...  We observed that PD-1 and Tim-3 coexpression was associated with a more exhausted phenotype, with the highest PD-1 levels on TIL coexpressing Tim-3.  ...  sustained expression of multiple inhibitory receptors. 1 Among the inhibitory receptors expressed by exhausted T cells, PD-1-blocking mAbs are effective in treatment of multiple cancer types, 4,5 including head  ... 
doi:10.1080/2162402x.2016.1261779 pmid:28197389 pmcid:PMC5283618 fatcat:f5i64btndfde3eb3xijnqdkc2m

Association between comorbidity and survival in head and neck cancer: Results from Head and Neck 5000

Sarah Schimansky, Samantha Lang, Rhona Beynon, Christopher Penfold, Amy Davies, Andrea Waylen, Steve Thomas, Miranda Pring, Michael Pawlita, Tim Waterboer, Andy Ness
2018 Head and Neck  
People with head and neck cancer have higher comorbidity levels but it remains unclear if pretreatment comorbidity is an independent prognosticator in head and neck cancer.  ...  The South West -Frenchay Regional Ethics Committee granted full ethical approval (ref: 10/H0107/57) for Head and Neck 5000 in 2010.  ...  Head and neck cancers (HNC) comprise a group of heterogeneous malignancies affecting the oral cavity, pharynx, larynx, paranasal sinuses, salivary glands and thyroid.  ... 
doi:10.1002/hed.25543 pmid:30549147 pmcid:PMC6890487 fatcat:o5wkm4fg4bg5bfch2g3ql7rioi


Haiqing Liu Kaczkowski, Tim W Kana, Ruben Visser
2018 Coastal Engineering Proceedings  
The 16 kilometer (km) beach along Nags Head (North Carolina, USA) has sustained chronic erosion over the past 50 years.  ...  Following successful completion of the project, the Town of Nags Head monitored performance and developed strategies for beach maintenance and preservation with the goal of improving protection to all  ...  PROJECT BACKGROUND The 16 kilometer (km) beach along Nags Head (North Carolina, USA) has sustained chronic erosion over the past 50 years.  ... 
doi:10.9753/icce.v36.risk.74 fatcat:vdz5tvii6zd43n4mzssmu4kos4

A Foundational "Survival Guide" Overview of Sports-Related Head Injuries

Frank De Stefano, Brian Fiani, Tim Mayo
2020 Cureus  
While most sports-related head injuries are not life-threatening, prompt recognition of acute head injury with expedited care leads to better outcomes.  ...  With this data, we developed a brief, overview regarding common head injuries that occur in sport-related activities.  ...  head injuries [15] .  ... 
doi:10.7759/cureus.11636 pmid:33376648 pmcid:PMC7755598 fatcat:mgwquofvzfag7f3ezuftqfxjou

Head-Related Transfer Function Selection Using Neural Networks

Shu-Nung Yao, Tim Collins, Chaoyun Liang
2017 Archives of Acoustics  
In binaural audio systems, for an optimal virtual acoustic space a set of head-related transfer functions (HRTFs) should be used that closely matches the listener's ones.  ...  The shapes and sizes of listeners' heads and pinnas were measured using digital photography; the measured anthropometric parameters form the feature vectors used by the neural network.  ...  The anthropometry contains ten anthropometric parameters, three of which are head width, head height, and head depth as shown in Fig. 7 .  ... 
doi:10.1515/aoa-2017-0038 fatcat:l7oinrpo3baibjbwz26oyf7r6a

Crime and Happiness Amongst Heads of Households in Malawi

Simon Davies, Tim Hinks
2009 Journal of Happiness Studies  
Kind regards, Simon and Tim Referee 1 • Referee's points 1 and 2.  ...  Table 4 . 4 Impact of Crime on Wellbeing Model All Household Heads Female Household Heads Male Household Heads All Household Heads Female Household Heads Male Household Heads All  ...  Female Head A dummy indicating a female head of household. Age The age of the respondent. Married A dummy indicating whether or not the respondent is married.  ... 
doi:10.1007/s10902-009-9152-7 fatcat:baz2aseucvfmzjzoq4j3l46sbq

Effects of Vision on Head-Putter Coordination in Golf

David Antonio Gonzalez, Stefan Kegel, Tadao Ishikura, Tim Lee
2012 Motor Control  
Hereafter we refer to head and putter movements in the same direction as "isodirectional" and head-putter movements in the opposite directions as "antidirectional".  ...  However, an isodirectional coordinated head-putter movement would likely result in poor quiet eye due to the movement of the head away from the ball.  ...  Figure 5 contains representative head-velocity profiles.  ... 
doi:10.1123/mcj.16.3.371 pmid:22642983 fatcat:cn343istxvhulfi4scs7w6pw3y
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