Filters








78 Hits in 1.4 sec

Cardiovascular Disease Related Proteomic Biomarkers of Alcohol Consumption [article]

Xianbang Sun, Jennifer Ho, He Gao, Evangelos Evangelou, Chen Yao, Tianxiao Huan, Shih-Jen Hwang, Paul Courchesne, Martin Larson, Daniel Levy, Jiantao Ma, Chunyu Liu
<span title="2020-10-17">2020</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
The relationship between alcohol consumption, circulating proteins, and cardiovascular disease (CVD) risk has not been well studied. We performed association analyses of alcohol consumption with three CVD risk factors and 71 CVD-related circulating proteins measured in 6,745 Framingham Heart Study participants (mean age, 49 years; 53% women). We found that an increase in alcohol consumption was associated with a higher risk of incident hypertension (P=7.2E-3) but a lower risk of incident
more &raquo; ... (P=5.7E-4) and type 2 diabetes (P=1.4E-5) in a 14-year of follow-up. Using independent discovery (n=4,348) and validation (n=2,397) samples, we identified 20 alcohol-associated proteins (FDR<0.05 in discovery and P<0.05/n in validation), with majority (18 of 20 proteins) inversely associated with alcohol consumption. The alcohol-protein associations remained similar after removing heavy drinkers. Four proteins demonstrated consistent triangular relationships, as expected, with alcohol consumption and CVD risk factors. For example, a greater level of APOA1, which was associated with a higher alcohol consumption (P=1.2E-65), was associated with a lower risk of type 2 diabetes (P=3.1E-5). However, several others showed inconsistent triangular relationships, e.g., a greater level of GDF15, which was associated with a lower alcohol consumption (P=1.0E-13), was associated with an increased risk of hypertension (P=2.4E-4). In conclusion, we identified 20 alcohol-associated proteins and demonstrated complex relationships between alcohol consumption, circulating proteins and CVD risk factors. Future studies with integration of more proteomic markers and larger sample size are warranted to unravel the complex relationship between alcohol consumption and CVD risk.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.10.17.332197">doi:10.1101/2020.10.17.332197</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/i36daglxtbcplaatgmoeiimc6a">fatcat:i36daglxtbcplaatgmoeiimc6a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201210022202/https://www.biorxiv.org/content/biorxiv/early/2020/10/18/2020.10.17.332197.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/6c/7b/6c7b0dfa8c8640a72afd24a0386b12e0e779ba2c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.10.17.332197"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

The contrary intracellular and extracellular functions of PEDF in HCC development

Cen Li, Zhijian Huang, Liuqing Zhu, Xianhuan Yu, Tianxiao Gao, Juan Feng, Honghai Hong, Haofan Yin, Ti Zhou, Weiwei Qi, Zhonghan Yang, Chao Liu (+2 others)
<span title="2019-10-03">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/glpuqq6s5zas3iz6q32stxybcq" style="color: black;">Cell Death and Disease</a> </i> &nbsp;
Pigment epithelium-derived factor (PEDF), a classic angiogenic inhibitor, has been reported to function as a tumor suppression protein and to downregulate in many types of solid tumors. However, the expression level of PEDF and its role in hepatocellular carcinoma (HCC) are contradictory. The present study investigates the expression and different activities of secreted and intracellular PEDF during HCC development, as well as the underlying mechanism of PEDF on HCC lipid disorders. We found
more &raquo; ... t PEDF had no association with patients' prognosis, although PEDF was highly expressed and inhibited angiogenesis in HCC tumor tissues. The animal experiments indicated that full-length PEDF exhibited equalizing effects on tumor growth activation and tumor angiogenesis inhibition in the late stage of HCC progression. Importantly, the pro-tumor activity was mediated by the intracellular PEDF, which causes accumulation of free fatty acids (FFAs) in vivo and in vitro. Based on the correlation analysis of PEDF and lipid metabolic indexes in human HCC tissues, we demonstrated that the intracellular PEDF led to the accumulation of FFA and eventually promoted HCC cell growth by inhibiting the activation of AMPK via ubiquitin-proteasome-mediated degradation, which causes increased de novo fatty acid synthesis and decreased FFA oxidation. Our findings revealed why elevated PEDF did not improve the patients' prognosis as the offsetting intracellular and extracellular activities. This study will lead to a comprehensive understanding of the diverse role of PEDF in HCC and provide a new selective strategy by supplement of extracellular PEDF and downregulation of intracellular PEDF for the prevention and treatment of liver cancer.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41419-019-1976-4">doi:10.1038/s41419-019-1976-4</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31582735">pmid:31582735</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6776659/">pmcid:PMC6776659</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xvbuiypourapppiibtyrqovpve">fatcat:xvbuiypourapppiibtyrqovpve</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20191123035907/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC6776659&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/07/b0/07b0a8eb5771d171bb3c9606a5332bcd8dec340f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41419-019-1976-4"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6776659" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Spatio-Temporal Recurrent Networks for Event-Based Optical Flow Estimation [article]

Ziluo Ding, Rui Zhao, Jiyuan Zhang, Tianxiao Gao, Ruiqin Xiong, Zhaofei Yu, Tiejun Huang
<span title="2022-04-05">2022</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Event camera has offered promising alternative for visual perception, especially in high speed and high dynamic range scenes. Recently, many deep learning methods have shown great success in providing promising solutions to many event-based problems, such as optical flow estimation. However, existing deep learning methods did not address the importance of temporal information well from the perspective of architecture design and cannot effectively extract spatio-temporal features. Another line
more &raquo; ... research that utilizes Spiking Neural Network suffers from training issues for deeper architecture.To address these points, a novel input representation is proposed that captures the events' temporal distribution for signal enhancement. Moreover, we introduce a spatio-temporal recurrent encoding-decoding neural network architecture for event-based optical flow estimation, which utilizes Convolutional Gated Recurrent Units to extract feature maps from a series of event images. Besides, our architecture allows some traditional frame-based core modules, such as correlation layer and iterative residual refine scheme, to be incorporated. The network is end-to-end trained with self-supervised learning on the Multi-Vehicle Stereo Event Camera dataset. We have shown that it outperforms all the existing state-of-the-art methods by a large margin. The code link is https://github.com/ruizhao26/STE-FlowNet.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2109.04871v2">arXiv:2109.04871v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ggtzrfhodzhxhky2dmlmhrs64u">fatcat:ggtzrfhodzhxhky2dmlmhrs64u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210917224944/https://arxiv.org/pdf/2109.04871v1.pdf" title="fulltext PDF download [not primary version]" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <span style="color: #f43e3e;">&#10033;</span> <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e7/ab/e7aba6657da4240fff741a698fbdee0e94836d63.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2109.04871v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Broadband Magnetic-Manipulated Spintronic Terahertz Emitter with Arbitrarily Tunable Polarizations [article]

Xiaojun Wu, Deyin Kong, Tianxiao Nie, Bo Wang, Meng Xiao, Chandan Pandey, Yang Gao, Lianggong Wen, Weisheng Zhao, Cunjun Ruan, Jungang Miao, Li Wang (+1 others)
<span title="2018-09-27">2018</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Flexible manipulation of terahertz-wave polarization during the generation process is very important for terahertz applications, especially for the next-generation on-chip functional terahertz sources. However, current terahertz emitters could not satisfy such demand, hence calling for new mechanism and conceptually new terahertz source. Here we demonstrate a magnetic-field-controlled, highly-efficient, cost-effective, and broadband terahertz source with flexible switch of terahertz
more &raquo; ... states in ferromagnetic heterostructures driven by femtosecond laser pulses. We verify that the chirality, azimuthal angle, and ellipticity of the generated elliptical terahertz waves can be independently manipulated by delicately engineering of the external applied magnetic fields via effectively manipulating the photo-induced spin currents. Such an ultrafast photomagnetic interaction-based, magnetic-field-controlled, and broadband tunable solid-state terahertz source integrated with terahertz polarization tunability function not only has the capability to reveal physical mechanisms of femtosecond spin dynamics, but also demonstrates the feasibility to realize novel on-chip terahertz functional devices, boosting the potential applications for controlling elementary molecular rotations, phonon vibrations, spin precessions, high-speed terahertz communication, and accelerating the development of ultrafast terahertz opto-spintronics.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1809.10474v1">arXiv:1809.10474v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/5iqqageoyngvldbrrtto7fxpda">fatcat:5iqqageoyngvldbrrtto7fxpda</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200914125324/https://arxiv.org/ftp/arxiv/papers/1809/1809.10474.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/61/e4/61e4e1ac057a1a927df85e58905f7141c82187a1.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1809.10474v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

PEDF inhibits lymphatic metastasis of nasopharyngeal carcinoma as a new lymphangiogenesis inhibitor

Chuanghua Luo, Haofan Yin, Tianxiao Gao, Caiqi Ma, Junxi Liu, Ting Zhang, Zumin Xu, Xi Wang, Danrui Zhang, Weiwei Qi, Zhonghan Yang, Guoquan Gao (+2 others)
<span title="2021-03-17">2021</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/glpuqq6s5zas3iz6q32stxybcq" style="color: black;">Cell Death and Disease</a> </i> &nbsp;
AbstractNasopharyngeal carcinoma (NPC) is one of the most malignant tumors in southern China and Asia, and lymph node metastasis is an important cause for treatment failure. Lymphangiogenesis is a crucial step in lymphatic metastasis of NPC, while little is known about lymphangiogenesis in NPC. Similar to angiogenesis, lymphangitic neovascularization is a process of balance between pro-lymphangiogenesis and anti-lymphangiogenesis factors, but there are few studies on endogenous
more &raquo; ... inhibitors. Pigment epithelium-derived factor (PEDF) is a well-known effective endogenous angiogenesis inhibitor. However, the relationship between PEDF and lymphangiogenesis remains unknown. Our present study reveals that PEDF is lowly expressed in human NPC tissues with poor prognosis and is negatively correlated with lymphatic vessel density (LVD). Consistently, PEDF inhibits lymphangiogenesis and lymphatic metastasis of NPC in vivo experiments. Mechanistically, PEDF inhibits the proliferation, migration, and tube formation of lymphatic endothelial cells and promotes cell apoptosis. On the other hand, PEDF reduces the expression and secretion of vascular endothelial growth factor C (VEGF-C) of NPC cells through the nuclear factor-κB (NF-κB) signaling pathway. Our findings indicate that PEDF plays a vital role in lymphatic metastasis by targeting both lymphatic endothelial cells and NPC cells, and PEDF may represent a novel therapeutic target for NPC.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41419-021-03583-1">doi:10.1038/s41419-021-03583-1</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33731707">pmid:33731707</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2az4ccal4ndpdagpand7ys3trq">fatcat:2az4ccal4ndpdagpand7ys3trq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718085550/https://www.nature.com/articles/s41419-021-03583-1.pdf?error=cookies_not_supported&amp;code=a8bde91e-57d5-4de4-be80-41a592cd2072" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b1/e8/b1e81251b3a4e6da897da4bbe2dfcbe6acc0a727.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/s41419-021-03583-1"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Research on the Rapid and Accurate Positioning and Orientation Approach for Land Missile-Launching Vehicle

Kui Li, Lei Wang, Yanhong Lv, Pengyu Gao, Tianxiao Song
<span title="2015-10-20">2015</span> <i title="MDPI AG"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/taedaf6aozg7vitz5dpgkojane" style="color: black;">Sensors</a> </i> &nbsp;
Kui Li, Lei Wang, Yanhong Lv, Pengyu Gao and Tianxiao Song all participated and performed the experiments.  ...  Kui Li and Pengyu Gao wrote and edited the manuscript, Lei Wang and Tianxiao Song reviewed the manuscript. All authors read and approved the manuscript.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/s151026606">doi:10.3390/s151026606</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26492249">pmid:26492249</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4634410/">pmcid:PMC4634410</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/3tfmfucbtjaydcoguxewcglrnq">fatcat:3tfmfucbtjaydcoguxewcglrnq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170830194448/http://www.mdpi.com/1424-8220/15/10/26606/pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/4e/71/4e7133c0de47271db12c45b9063aca16127e89c8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3390/s151026606"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> mdpi.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4634410" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

The Influence of Home Buyer Sentiment on Chinese Housing Prices—— Based on Media Text Mining

Qing Gao, Tianxiao Zhao
<span title="2018-08-30">2018</span> <i title="Canadian Center of Science and Education"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/aysn2vmlu5c2rpmdymcgk7pzve" style="color: black;">International Journal of Economics and Finance</a> </i> &nbsp;
Gao et al. (2013) mentioned that while housing prices have risen sharply since 2003, the per capita disposable income of urban residents has increased rapidly.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5539/ijef.v10n9p145">doi:10.5539/ijef.v10n9p145</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lukoc24iv5a3nipaxptp74gh6u">fatcat:lukoc24iv5a3nipaxptp74gh6u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190228172435/http://pdfs.semanticscholar.org/95e4/06f27b5acca7ea39c6f0edd1bf59e000e167.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/95/e4/95e406f27b5acca7ea39c6f0edd1bf59e000e167.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5539/ijef.v10n9p145"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

CI-Net: Contextual Information for Joint Semantic Segmentation and Depth Estimation [article]

Tianxiao Gao, Wu Wei, Zhongbin Cai, Zhun Fan, Shane Xie, Xinmei Wang, Qiuda Yu
<span title="2021-09-01">2021</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Monocular depth estimation and semantic segmentation are two fundamental goals of scene understanding. Due to the advantages of task interaction, many works study the joint task learning algorithm. However, most existing methods fail to fully leverage the semantic labels, ignoring the provided context structures and only using them to supervise the prediction of segmentation split, which limit the performance of both tasks. In this paper, we propose a network injected with contextual
more &raquo; ... (CI-Net) to solve the problem. Specifically, we introduce self-attention block in the encoder to generate attention map. With supervision from the ideal attention map created by semantic label, the network is embedded with contextual information so that it could understand scene better and utilize correlated features to make accurate prediction. Besides, a feature sharing module is constructed to make the task-specific features deeply fused and a consistency loss is devised to make the features mutually guided. We evaluate the proposed CI-Net on the NYU-Depth-v2 and SUN-RGBD datasets. The experimental results validate that our proposed CI-Net could effectively improve the accuracy of semantic segmentation and depth estimation.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2107.13800v2">arXiv:2107.13800v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rrbfn5u3ubcbrh5nb2m7l26qcy">fatcat:rrbfn5u3ubcbrh5nb2m7l26qcy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210906195951/https://arxiv.org/pdf/2107.13800v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ae/30/ae30c7199df1991de6a90508d40c593bfee760e0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2107.13800v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

FUBP1 promotes neuroblastoma proliferation via enhancing glycolysis-a new possible marker of malignancy for neuroblastoma

Ping Jiang, Mao Huang, Weiwei Qi, Fenghua Wang, Tianyou Yang, Tianxiao Gao, Chuanghua Luo, Jing Deng, Zhonghan Yang, Ti Zhou, Yan Zou, Guoquan Gao (+1 others)
<span title="2019-09-11">2019</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/ylpmmneaw5g43f4f6ghypj6lii" style="color: black;">Journal of Experimental &amp; Clinical Cancer Research</a> </i> &nbsp;
Neuroblastoma (NB) is one of the deadliest paediatric solid tumours due to its rapid proliferative characteristics. Amplified copies of MYCN are considered the most important marker for the prediction of tumour relapse and progression in NB, but they were only detected in 20-30% of NB patients, indicating there might be other oncogenes in the development of NB. The far upstream element binding protein 1 (FUBP1) was first identified as a transcriptional regulator of the proto-oncogene MYC.
more &raquo; ... r, the expression and role of FUBP1 in NB have not been documented. FUBP1 expression was analysed from GEO database and verified by immunohistochemistry (IHC) and western blotting (WB) in NB tissues and cell lines. Cell proliferation and apoptosis were detected by Cell Counting Kit-8, Colony formation assay, EDU, TUNEL staining and flow cytometric analysis. Several glycolytic metabolites production was confirmed by ELISA and oxygen consuming rate (OCR). Luciferase assay, WB, chromatin immunoprecipitation (CHIP) were used to explore the mechanisms of the effect of FUBP1 on NB. FUBP1 mRNA levels were increased along with the increase in International Neuroblastoma Staging System (INSS) stages. High expression of FUBP1 with low N-Myc expression accounted for 44.6% of NB patient samples (n = 65). In addition, FUBP1 protein levels were remarkably increased with NB malignancy in the NB tissue microarray (NB: n = 65; ganglioneuroblastoma: n = 31; ganglioneuroma: n = 27). Furthermore, FUBP1 expression was negatively correlated with patient survival rate but positively correlated with ki67 content. In vitro experiments showed that FUBP1 promotes NB cell proliferation and inhibits cell apoptosis via enhancing glycolysis and ATP production. Mechanistically, FUBP1 inhibited the degradation of HIF1α via downregulation of Von Hippel-Lindau (VHL), the E3 ligase for HIF1α, resulting in upregulation of lactate dehydrogenase isoform B (LDHB) expression to enhance glycolysis. Overexpressed or silenced N-Myc could not regulate FUBP1 or LDHB levels. Taken together, our findings demonstrate for the first time that elevated FUBP1 promotes NB glycolysis and growth by targeting HIF1α rather than N-Myc, suggesting that FUBP1 is a novel and powerful oncogene in the development of NB independent of N-Myc and may have potential in the diagnosis and treatment of NB.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13046-019-1414-6">doi:10.1186/s13046-019-1414-6</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/31511046">pmid:31511046</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC6737630/">pmcid:PMC6737630</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ntcclc5dofh5bmpvhk7q2iwjpi">fatcat:ntcclc5dofh5bmpvhk7q2iwjpi</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200215042353/https://jeccr.biomedcentral.com/track/pdf/10.1186/s13046-019-1414-6" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fa/8e/fa8e1bb73d2042c393207d332063ea2278ca3162.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s13046-019-1414-6"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737630" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Integrating Climate, Biodiversity, and Sustainable Land Use Strategies: Innovations from China

Guido Schmidt-Traub, Harvey Locke, Jixi Gao, Zhiyun Ouyang, Justin Adams, Lin Li, Enric Sala, M Rebecca Shaw, Sebastian Troëng, Jing Xu, Chunquan Zhu, Changxin Zou (+2 others)
<span title="2020-06-23">2020</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/u4bdhpukkbe3ncikyibr6q4x7e" style="color: black;">National Science Review</a> </i> &nbsp;
Ahead of landmark biodiversity and climate conferences in 2021, China's policy innovations in land-use planning and the Ecological Conservation Redline offer lessons for other countries in developing integrated strategies on climate, biodiversity, and desertification. Spatial planning is also critical for greening international supply chains and the Belt and Road Initiative.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/nsr/nwaa139">doi:10.1093/nsr/nwaa139</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34691678">pmid:34691678</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8310734/">pmcid:PMC8310734</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2hg2v55d4jbdxecqg4a4z73f6e">fatcat:2hg2v55d4jbdxecqg4a4z73f6e</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210804021929/https://watermark.silverchair.com/nwaa139.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAsEwggK9BgkqhkiG9w0BBwagggKuMIICqgIBADCCAqMGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQM8bJIxlwBX3wwAvWwAgEQgIICdAb1gEX51disOPTAS75zK3eN2r4f_dW9rgYiFYHWpVGLaPgzUQmGQQwoDzisGUOp7dFXNNndTxVybsFahuBJUeFShfhCFzeaz3lXqk_e-TKSXZBkNhJnEiW-JWGddj8tJgQITlXZvtWlmEgMgCO-TNgNoWFCTxJA_KmhNEGpineAg00i3CsmJvoowvugYrrxvKWGvCP2Fjjzc8_OqkfC4pLqmdPPBFbyoixeWOBUtHqHDyegm0TcFYBvPc7WNBpJ8eA-sxnOHnL-zVnmwzds--BG4vLTda9bDCA81zptdtWgtPw0qUJD-4g74LF1iUklpAnG7XlfF70uyxwJ3cSKOwoonyz-7cQS1wS6R3x4SUZLtCpOfPNRYptfKptnD1-91eqsa6AqUFgq7Jojo7E9OPhRyl8Fuhgh6WtFR6RWiIznz4kLo0VyEw7gsslfXy090LhHyJ34-DqhrSiBbxk6uoso1me3xCnSnit_9siNSCdDHDcTMBc3RTT0JkDRXW0OkYZfldbZfvrCLiWMmVreGoCydBMDMmP9LrY2O5DxEYXSLoQe4w2Ye60yYj73F6iTJOYgCynBK8q57-xSnmSE-hJAgGoKgk7GVSz18cB8R8Uq9X-B9dhODSRNIg9G2WaCeTwe_Knqu4ii6VBIw_2GEVdDccZGzvJr8CfPMZqW85zAXtxeKifINZYTOfmTjI-D5YRUzdFrKhgh5hHwGDWWmjZ5GSGs-UKVez10LuoTIt9nQDDXhJLUmm2HBV6I1MrS7_hkiS9_YLWO-IoP6IhVF0yK439zkvg90l7wz_Q2NMiytHAZFjpwNNzIs0obM9mNf1DawhY" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/02/46/0246e7ce95adfece44b7078b2a32ef75e91c8136.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/nsr/nwaa139"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8310734" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Enhancement of Spintronic Terahertz Emission via Annealing in Ferromagnetic Heterostructures [article]

Xiaojun Wu, Yang Gao, Yanbin He, Tianxiao Nie, Chun Wang, Deyin Kong, Chandan Pandey, Bo Wang, Lianggong Wen, Cunjun Ruan, Jungang Miao, Li Wang, Yutong Li, Weisheng Zhao
<span title="2019-02-03">2019</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
We systematically investigate the influence of annealing effect on terahertz (THz) generation from CoFeB based magnetic nanofilms driven by femtosecond laser pulses. Three times enhancement of THz yields are achieved in W/CoFeB through annealing effect, and double boosting is obtained in Pt/CoFeB. The mechanism of annealing effect originates from the increase of hot electron mean free path induced by crystallization, which is experimentally corroborated by THz transmission measurement on
more &raquo; ... main spectroscopy. Comparison studies of the thickness dependent THz efficiency after annealing are also implemented, and we eventually conclude that annealing and thickness optimization are of importance for scaling up THz intensity. Our observations not only deepen understanding of the spintronic THz radiation mechanism but also provide normal platform for high speed spintronic opto-electronic devices.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1812.07113v2">arXiv:1812.07113v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/lfv6iukcpfe4fjziteyznhlika">fatcat:lfv6iukcpfe4fjziteyznhlika</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200901021651/https://arxiv.org/ftp/arxiv/papers/1812/1812.07113.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/28/93/28936811a7e025c91fa4b2605ce2c8c1a91a416a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1812.07113v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Femtosecond control of terahertz spin-charge conversion in ferromagnetic heterostructures [article]

Xiaojun Wu, Tianxiao Nie, Bo Wang, Meng Xiao, Deyin Kong, Chandan Pandey, Yang Gao, Lianggong Wen, Weisheng Zhao, Cunjun Ruan, Jungang Miao, Li Wang (+2 others)
<span title="2018-12-01">2018</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Employing electron spin instead of charge to develop spintronic devices holds the merits of low-power consumption in information technologies. Meanwhile, the demand for increasing speed in spintronics beyond current CMOS technology has further triggered intensive researches for ultrafast control of spins even up to unprecedent terahertz regime. The femtosecond laser has been emerging as a potential technique to generate an ultrafast spin-current burst for magnetization manipulation. However,
more &raquo; ... re is a great challenge to establish all-optical control and monitor of the femtosecond transient spin current. Deep insights into the physics and mechanism are extremely essential for the technique. Here, we demonstrate coherently nonthermal excitation of femtosecond spin-charge current conversion parallel to the magnetization in W/CoFeB/Pt heterostructures driven by linearly polarized femtosecond laser pulses. Through systematical investigation we observe the terahertz emission polarization depends on both the magnetization direction and structural asymmetry. We attribute this phenomenon of the terahertz generation parallel to the magnetization induced by linearly polarized femtosecond laser pulses probably to inverse spin-orbit torque effect. Our work not only is beneficial to the deep understanding of spin-charge conversion and spin transportation, but also helps develop novel on-chip terahertz opto-spintronic devices.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1809.05391v2">arXiv:1809.05391v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hyrvwr6755gk5cv4k5llinh75a">fatcat:hyrvwr6755gk5cv4k5llinh75a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200909024816/https://arxiv.org/ftp/arxiv/papers/1809/1809.05391.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e3/0e/e30e5fd3ebe0dd893cb69933a3cfbfbc62f8ac46.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1809.05391v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Kallistatin inhibits lymphangiogenesis and lymphatic metastasis of gastric cancer by downregulating VEGF-C expression and secretion

Caiqi Ma, Chuanghua Luo, Haofan Yin, Yang Zhang, Wenjun Xiong, Ting Zhang, Tianxiao Gao, Xi Wang, Di Che, Zhenzhen Fang, Lei Li, Jinye Xie (+10 others)
<span title="2017-12-14">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/4ntdc2qrw5cvhorf6o4czcm4f4" style="color: black;">Gastric Cancer</a> </i> &nbsp;
Tumor-induced lymphangiogenesis and lymphatic metastasis are predominant during the metastasis of many types of cancers. However, the endogenous inhibitors that counterbalance the lymphangiogenesis and lymphatic metastasis of tumors have not been well evaluated. Kallistatin has been recognized as an endogenous angiogenesis inhibitor. Methods and results Our recent study showed for the first time that the lymphatic vessel density (LVD) was reduced in lung and stomach sections from
more &raquo; ... rexpressing transgenic mice. Kallistatin expresses anti-lymphangiogenic activity by inhibiting the proliferation, migration, and tube formation of human lymphatic endothelial cells (hLECs). Therefore, the present study focuses on the relationships of changes in kallistatin expression with the lymphangiogenesis and lymphatic metastasis of gastric cancer and its underlying mechanisms. Our results revealed that the expression of kallistatin in cancer tissues, metastatic lymph nodes, and plasma of gastric cancer patients was significantly downregulated and that the plasma level of kallistatin was negatively associated with the phase of lymph node metastasis. Furthermore, treatment with kallistatin recombinant protein decreased LVD and lymph node metastases in the implanted gastric xenograft tumors of nude mice. Mechanically, kallistatin suppressed the lymphangiogenesis and lymphatic metastasis by downregulating VEGF-C expression and secretion through the LRP6/IKK/IҡB/NF-ҡB signaling pathway in gastric cancer cells. Conclusions These findings demonstrated that kallistatin functions as an endogenous lymphangiogenesis inhibitor and has an important part in the lymphatic metastasis of gastric cancer.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10120-017-0787-5">doi:10.1007/s10120-017-0787-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29243194">pmid:29243194</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/j22x7rfr6vcljbj3ybtt4hymmm">fatcat:j22x7rfr6vcljbj3ybtt4hymmm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190426063136/https://link.springer.com/content/pdf/10.1007%2Fs10120-017-0787-5.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/50/c6/50c66f032425fb480e453d8b816d649562e223b4.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s10120-017-0787-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Metformin selectively inhibits metastatic colorectal cancer with the KRAS mutation by intracellular accumulation through silencing MATE1

Jinye Xie, Liangping Xia, Wei Xiang, Wenzhuo He, Haofan Yin, Fang Wang, Tianxiao Gao, Weiwei Qi, Zhonghan Yang, Xia Yang, Ti Zhou, Guoquan Gao
<span title="2020-05-22">2020</span> <i title="Proceedings of the National Academy of Sciences"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nvtuoas5pbdsllkntnhizy4f4q" style="color: black;">Proceedings of the National Academy of Sciences of the United States of America</a> </i> &nbsp;
Metastatic colorectal cancer (mCRC) patients have poor overall survival despite using irinotecan- or oxaliplatin-based chemotherapy combined with anti-EGFR (epidermal growth factor receptor) drugs, especially those with the oncogene mutation of KRAS. Metformin has been reported as a potentially novel antitumor agent in many experiments, but its therapeutic activity is discrepant and controversial so far. Inspiringly, the median survival time for KRAS-mutation mCRC patients with diabetes on
more &raquo; ... rmin is 37.8 mo longer than those treated with other hypoglycemic drugs in combination with standard systemic therapy. In contrast, metformin could not improve the survival of mCRC patients with wild-type KRAS. Interestingly, metformin is preferentially accumulated in KRAS-mutation mCRC cells, but not wild-type ones, in both primary cell cultures and patient-derived xenografts, which is in agreement with its tremendous effect in KRAS-mutation mCRC. Mechanistically, the mutated KRAS oncoprotein hypermethylates and silences the expression of multidrug and toxic compound extrusion 1 (MATE1), a specific pump that expels metformin from the tumor cells by up-regulating DNA methyltransferase 1 (DNMT1). Our findings provide evidence that KRAS-mutation mCRC patients benefit from metformin treatment and targeting MATE1 may provide a strategy to improve the anticancer response of metformin.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.1918845117">doi:10.1073/pnas.1918845117</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32444490">pmid:32444490</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xvp3jujh45ab3ckkhhom5b2qba">fatcat:xvp3jujh45ab3ckkhhom5b2qba</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201104134109/https://www.pnas.org/content/pnas/117/23/13012.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a7/d6/a7d6a0c9ec2a3399d029eb91322a3b23a2fe62a0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1073/pnas.1918845117"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a>

Regulation of Estradiol and Progesterone Production by CRH-R1 and -R2 Is through Divergent Signaling Pathways in Cultured Human Placental Trophoblasts

Lu Gao, Yi Tao, Tianxiao Hu, Weina Liu, Chen Xu, Jie Liu, Xingji You, Hang Gu, Xin Ni
<span title="">2012</span> <i title="The Endocrine Society"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/nhzrr2hfqbbgflowmeedppzwgu" style="color: black;">Endocrinology</a> </i> &nbsp;
CRH and its related peptides urocortins (UCN) have been identified in placenta and implicated to play pivotal roles in the regulation of pregnancy and parturition in humans. The objectives of present study were to investigate the effects of endogenous CRH and its related peptides in the regulation of steroid production in placenta. Placental trophoblasts were isolated from term placenta tissues and cultured for 72 h. Estradiol (E 2 ) and progesterone (P 4 ) contents in culture media were
more &raquo; ... ned by radioimmunoassay. Treatment of cultured trophoblasts with CRH or UCNI antibody showed decreased E 2 , whereas increased P 4 production. Treatment of cells with CRH receptor type 1 antagonist antalarmin or CRH receptor type 2 (CRH-R2) antagonist astressin-2b also decreased
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1210/en.2012-1453">doi:10.1210/en.2012-1453</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/22865371">pmid:22865371</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/cxs3iz5honf5npzelf6q6vi5xy">fatcat:cxs3iz5honf5npzelf6q6vi5xy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180729110045/https://watermark.silverchair.com/endo4918.pdf?token=AQECAHi208BE49Ooan9kkhW_Ercy7Dm3ZL_9Cf3qfKAc485ysgAAAagwggGkBgkqhkiG9w0BBwagggGVMIIBkQIBADCCAYoGCSqGSIb3DQEHATAeBglghkgBZQMEAS4wEQQMOscH3mXGCe3YZ9KaAgEQgIIBW55LoDl2MBxdiC_Qm6FdmezxhmuibWt_cFcL7SNMuP8yTWeM2Mfyb2QqCq1RfJzZwilO4o1adtRid2y53JtM7YrBC8hnB0y5TeE9wt12Jv0Xw0Fw8tRDD8MKxL9yR5koieql2dwdWADcvQ0pGGqScARnIBpqf8G0fNOES7MJfLYqQhJO1Fkcl4KjUwd0B20MfqhlSA8fBc5wZ4LmdH1C5n1rNsPioTZimEfGSSyT0zoP6xpGw4zqgAvWXFtrnwYmc2NwUQzIC4goK8Ifs0Fh6Uvrl9kir8xQCxvLdrzj1QTnYsweVtcqQF-x_gLdcL7cdeWvj_p1A_uLdPGWACPmwdMTaQt4XMDfIWSDKD-fDylU2oSdDMDMLP9fjn5YpZjznCQBLmC-I-sdwUaXu7gkpBkycB-0eG-s-EHXOS67XUH4KhiBS9lZKVTk7Z-_UF009bTnSw0Q1bXMyz4s" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9c/8d/9c8dfc251cc04c8bef90298fe29cf3cc93753edf.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1210/en.2012-1453"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>
&laquo; Previous Showing results 1 &mdash; 15 out of 78 results