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Buccal Micronucleus Cytome Assay [chapter]

Philip Thomas, Michael Fenech
2010 Msphere  
doi:10.1007/978-1-60327-409-8_17 pmid:21057932 fatcat:kabjiuvgwbe7fkj7v6lzxxc6gm

Association of micronucleus frequency with neurodegenerative diseases

L. Migliore, F. Coppede, M. Fenech, P. Thomas
2010 Mutagenesis  
doi:10.1093/mutage/geq067 pmid:21164187 fatcat:f4rzc77id5ax5cyuifbrqkizvi

The role of zinc in genomic stability

Razinah Sharif, Philip Thomas, Peter Zalewski, Michael Fenech
2012 Mutation research  
Secondly, I would like to thank my amazing supervisors (Prof Michael Fenech, Dr Philip Thomas and Dr Peter Zalewski) for giving me the opportunity to undertake this PhD project and for their guidance through  ... 
doi:10.1016/j.mrfmmm.2011.08.009 pmid:21939673 fatcat:yzcyds3rjnfhleurlfdzu2yezy

Buccal micronucleus cytome assay

Philip Thomas, Nina Holland, Claudia Bolognesi, Micheline Kirsch-Volders, Stefano Bonassi, Errol Zeiger, Siegfried Knasmueller, Michael Fenech
2009 Nature Protocols  
doi:10.1038/nprot.2009.53 pmid:19444240 fatcat:zyb242jdc5ftxeqjvjxx5uzdei

A quantitative real-time PCR method for absolute telomere length

Nathan J. O'Callaghan, Varinderpal S. Dhillon, Philip Thomas, Michael Fenech
2008 BioTechniques  
Dhillon, Philip Thomas, and Michael Fenech Commonwealth Scientific and Industrial Research Organization (CSIRO)-Human Nutrition, Adelaide, Australia BioTechniques 44:807-809 (May 2008) doi 10.2144/000112761  ... 
doi:10.2144/000112761 pmid:18476834 fatcat:6jrdbhpu4rddlkr3nzqha4dere

Effect of dietary intervention on human micronucleus frequency in lymphocytes and buccal cells

P. Thomas, J. Wu, V. Dhillon, M. Fenech
2010 Mutagenesis  
Thomas et al.  ...  Thomas et al. Fig. 1. Metabolism of folic acid. Adapted from (28) .  ... 
doi:10.1093/mutage/geq072 pmid:21164185 fatcat:gvbzuw3vkfgphksyjivci6yi4e

Nucleoplasmic bridges are a sensitive measure of chromosome rearrangement in the cytokinesis-block micronucleus assay

P. Thomas, K. Umegaki, M. Fenech
2003 Mutagenesis  
Finally, these data, together with those published previously (Fenech et al., 1999; Umegaki and Fenech, 2000; Crott et al., 2001; Fenech and Crott, 2002) , indicate that the CBMN assay has matured into  ...  Scoring criteria for selection of BNCs, MN and NPB were as described previously (Fenech, 2000) .  ... 
doi:10.1093/mutage/18.2.187 pmid:12621075 fatcat:zcktljku6jggtaclp344o3evly

Folate and methionine metabolism in autism: a systematic review

Penelope AE Main, Manya T Angley, Philip Thomas, Catherine E O'Doherty, Michael Fenech
2010 American Journal of Clinical Nutrition  
Autism is a complex neurodevelopmental disorder that is increasingly being recognized as a public health issue. Recent evidence has emerged that children with autism may have altered folate or methionine metabolism, which suggests the folate-methionine cycle may play a key role in the etiology of autism. Objective: The objective was to conduct a systematic review to examine the evidence for the involvement of alterations in folatemethionine metabolism in the etiology of autism. Design: A
more » ... tic literature review was conducted of studies reporting data for metabolites, interventions, or genes of the folate-methionine pathway in autism. Eighteen studies met the inclusion criteria, 17 of which provided data on metabolites, 5 on interventions, and 6 on genes and their related polymorphisms. Results: The findings of the review were conflicting. The variance in results can be attributed to heterogeneity between subjects with autism, sampling issues, and the wide range of analytic techniques used. Most genetic studies were inadequately powered to provide more than an indication of likely genetic relations. Conclusions: The review concluded that further research is required with appropriately standardized and adequately powered study designs before any definitive conclusions can be made about the role for a dysfunctional folate-methionine pathway in the etiology of autism. There is also a need to determine whether functional benefits occur when correcting apparent deficits in folate-methionine metabolism in children with autism. Am J Clin Nutr 2010;91:1598-620.
doi:10.3945/ajcn.2009.29002 pmid:20410097 fatcat:lik44awxnnefbclmo2gpho2foi

Biomarkers of Alzheimer's Disease Risk in Peripheral Tissues; Focus on Buccal Cells

Maxime Francois, Wayne Leifert, Ralph Martins, Philip Thomas, Michael Fenech
2014 Current Alzheimer Research  
Proc Natl Acad Sci U S A 2008 Sep [22] Migliore L, Coppede F, Fenech M, Thomas P. Association of micronucleus frequency 606 with neurodegenerative diseases.  ...  [ 19 ] 19 Thomas P, O'Callaghan NJ, Fenech M. Telomere length in white blood cells, buccal cells 594 and brain tissue and its variation with ageing and Alzheimer's disease.  ... 
doi:10.2174/1567205011666140618103827 pmid:24938500 pmcid:PMC4166904 fatcat:7b33jdswlrbdxmsk6s4plp66tm

Telomere length in white blood cells, buccal cells and brain tissue and its variation with aging and Alzheimer's disease

Michael Fenech, Philip Thomas
2010 Alzheimer's & Dementia  
P3 P3-207 TELOMERE LENGTH IN WHITE BLOOD CELLS, BUCCAL CELLS AND BRAIN TISSUE AND ITS VARIATION WITH AGING AND ALZHEIMER'S DISEASE Michael Fenech, Philip Thomas, CSIRO, Adelaide, Australia.  ... 
doi:10.1016/j.jalz.2010.05.1706 fatcat:qcqciepxdjdwbewl5t67qm525y

Buccal Cytome Biomarkers and Their Association with Plasma Folate, Vitamin B12 and Homocysteine in Alzheimer's Disease

Philip Thomas, Michael Fenech
2015 Journal of Nutrigenetics and Nutrigenomics  
Modified and adapted from Thomas et al. [19] .  ...  All values were within the normal range for plasma Adapted from Thomas et al. [19] .  ... 
doi:10.1159/000435784 pmid:26228832 fatcat:l4ctrflc6zdm5mlp3zuuscmw2a

The state of SQL-on-Hadoop in the cloud

Nicolas Poggi, Josep Ll. Berral, Thomas Fenech, David Carrera, Jose Blakeley, Umar Farooq Minhas, Nikola Vujic
2016 2016 IEEE International Conference on Big Data (Big Data)  
In this paper, we report a work consisting in using deep convolutional neural networks (CNNs) for curating and filtering photos posted by social media users (Instagram and Twitter). The final goal is to facilitate searching and discovering user-generated content (UGC) with potential value for digital marketing tasks. The images are captured in real time and automatically annotated with multiple CNNs. Some of the CNNs perform generic object recognition tasks while others perform what we call
more » ... al brand identity recognition. We report experiments with 5 real brands in which more than 1 million real images were analyzed. In order to speed-up the training of custom CNNs we applied a transfer learning strategy.
doi:10.1109/bigdata.2016.7840751 dblp:conf/bigdataconf/PoggiBFCBMV16 fatcat:vf4hkq3dtrhu7dvby7kdrpo6c4

Zinc deficiency or excess within the physiological range increases genome instability and cytotoxicity, respectively, in human oral keratinocyte cells

Razinah Sharif, Philip Thomas, Peter Zalewski, Michael Fenech
2011 Genes & Nutrition  
Such simultaneous repair events will lead to DNA double strand breaks and MN formation (Fenech and Crott 2002; Bull and Fenech 2008) .  ...  lifestyle factors (Nersesyan and Chobanyan 2010; Nersesyan 2006; Nersesyan and Adamyan 2004; Li et al. 1998; Munoz et al. 1987; Piyathilake et al. 1995; Prasad et al. 1995; Ramirez and Saldanha 2002; Thomas  ... 
doi:10.1007/s12263-011-0248-4 pmid:21935692 pmcid:PMC3316759 fatcat:7hcu7fhbfrhhpikzo266aml4le

Effect of common polymorphisms in folate uptake and metabolism genes on frequency of micronucleated lymphocytes in a South Australian cohort

Varinderpal Dhillon, Philip Thomas, Michael Fenech
2009 Mutation research  
Fenech). enzymes required for folate uptake, transport and metabolism on validated biomarkers of genome damage such as micronucleus frequency which has been linked prospectively with elevated risk for  ... 
doi:10.1016/j.mrfmmm.2009.02.007 pmid:19427504 fatcat:guak7i6mhjg2baa25hitvprtua

Altered cytological parameters in buccal cells from individuals with mild cognitive impairment and Alzheimer's disease

Maxime François, Wayne Leifert, Jane Hecker, Jeffrey Faunt, Ralph Martins, Philip Thomas, Michael Fenech
2014 Cytometry Part A  
Authors Maxime François, Wayne Leifert, Jane Hecker, Jeffrey Faunt, Ralph Martins, Philip Thomas, and Michael Fenech Introduction Alzheimer's disease (AD) is a neurodegenerative disorder characterised  ... 
doi:10.1002/cyto.a.22453 pmid:24616437 fatcat:6kotmc6dajazdlvvqebqw2ythu
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