Filters








5,342 Hits in 2.7 sec

Seeing Things in Random-Dot Videos [article]

Thomas Dagès, Michael Lindenbaum, Alfred M. Bruckstein
<span title="2020-01-29">2020</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Humans possess an intricate and powerful visual system in order to perceive and understand the environing world. Human perception can effortlessly detect and correctly group features in visual data and can even interpret random-dot videos induced by imaging natural dynamic scenes with highly noisy sensors such as ultrasound imaging. Remarkably, this happens even if perception completely fails when the same information is presented frame by frame rather than in a video sequence. We study this
more &raquo; ... perty of surprising dynamic perception with the first goal of proposing a new detection and spatio-temporal grouping algorithm for such signals when, per frame, the information on objects is both random and sparse and embedded in random noise. The algorithm is based on the succession of temporal integration and spatial statistical tests of unlikeliness, the a contrario framework. The algorithm not only manages to handle such signals but the striking similarity in its performance to the perception by human observers, as witnessed by a series of psychophysical experiments on image and video data, leads us to see in it a simple computational Gestalt model of human perception with only two parameters: the time integration and the visual angle for candidate shapes to be detected.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1907.12195v2">arXiv:1907.12195v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/i634k7bmcnaq3ozit2qtdrmbyq">fatcat:i634k7bmcnaq3ozit2qtdrmbyq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200321005449/https://arxiv.org/pdf/1907.12195v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1907.12195v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

A Bound on the Edge-Flipping Distance between Triangulations (Revisiting the Proof) [article]

Thomas Dagès, Alfred M. Bruckstein
<span title="2021-06-28">2021</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
We revisit here a fundamental result on planar triangulations, namely that the flip distance between two triangulations is upper-bounded by the number of proper intersections between their straight-segment edges. We provide a complete and detailed proof of this result in a slightly generalised setting using a case-based analysis that fills several gaps left by previous proofs of the result.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2106.14408v1">arXiv:2106.14408v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4tuvlxtwe5ctrf6i2v2idiwk2u">fatcat:4tuvlxtwe5ctrf6i2v2idiwk2u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210728164127/https://arxiv.org/pdf/2106.14408v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/1b/4d/1b4da6a79b7aee5def6fe94a267c2a6fc9212082.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2106.14408v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Probabilistic Gathering Of Agents With Simple Sensors [article]

Ariel Barel, Thomas Dagès, Rotem Manor, Alfred M. Bruckstein
<span title="2020-04-13">2020</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
DAGÈS, R. MANOR, AND A. M.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1902.00294v2">arXiv:1902.00294v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/stcz5krbtnhtfkk3n3yhhnfeey">fatcat:stcz5krbtnhtfkk3n3yhhnfeey</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200415032706/https://arxiv.org/pdf/1902.00294v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1902.00294v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Doubly Stochastic Pairwise Interactions for Agreement and Alignment [article]

Thomas Dagès, Alfred M. Bruckstein
<span title="2021-03-15">2021</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Random pairwise encounters often occur in large populations, or groups of mobile agents, and various types of local interactions that happen at encounters account for emergent global phenomena. In particular, in the fields of swarm robotics, sociobiology, and social dynamics, several types of local pairwise interactions were proposed and analysed leading to spatial gathering or clustering and agreement in teams of robotic agents coordinated motion, in animal herds, or in human societies. We
more &raquo; ... propose a very simple stochastic interaction at encounters that leads to agreement or geometric alignment in swarms of simple agents, and analyse the process of converging to consensus. Consider a group of agents whose "states" evolve in time by pairwise interactions: the state of an agent is either a real value (a randomly initialised position within an interval) or a vector that is either unconstrained (e.g. the location of the agent in the plane) or constrained to have unit length (e.g. the direction of the agent's motion). The interactions are doubly stochastic, in the sense that, at discrete time steps, pairs of agents are randomly selected and their new states are independently and uniformly set at random in (local) domains or intervals defined by the states of the interacting pair. We show that such processes lead, in finite expected time (measured by the number of interactions that occurred) to agreement in case of unconstrained states and alignment when the states are unit vectors.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2012.13727v2">arXiv:2012.13727v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4d7o3xu3k5gfnhs63youte6b7u">fatcat:4d7o3xu3k5gfnhs63youte6b7u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210324192313/https://arxiv.org/pdf/2012.13727v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/cb/7f/cb7fa1d22db44f9c416f1fea67236814ac82fe3b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2012.13727v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Colloidal transport in bacteria suspensions: from bacteria scattering to anomalous and enhanced diffusion [article]

Antoine Lagarde, Noémie Dagès, Takahiro Nemoto, Vincent Démery, Denis Bartolo, Thomas Gibaud
<span title="2020-02-24">2020</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Colloids coupled to a bath of swimming cells generically display enhanced diffusion. This transport dynamics stems from a subtle interplay between the active and passive particles that still resists our understanding despite decades of intense research. Here, we tackle the root of the problem by providing a quantitative characterisation of the single scattering events between a colloid and a bacterium. Based on our experiments, we build a minimal model that quantitatively predicts the geometry
more &raquo; ... f the scattering trajectories, and enhanced colloidal diffusion at long times. This quantitative confrontation between theory and experiments elucidates the microscopic origin of enhanced transport. Collisions are solely ruled by stochastic contact interactions responsible both for genuine anomalous diffusion at short times and enhanced diffusion at long times with no ballistic regime at any scale.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2002.10144v1">arXiv:2002.10144v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/japthpfnlre67c32cc3u5letde">fatcat:japthpfnlre67c32cc3u5letde</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200321111554/https://arxiv.org/pdf/2002.10144v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2002.10144v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

DNA Nanotubes: Construction and Characterization of Filaments Composed of TX-tile Lattice [chapter]

Dage Liu, John H. Reif, Thomas H. La Bean
<span title="">2003</span> <i title="Springer Berlin Heidelberg"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/2w3awgokqne6te4nvlofavy5a4" style="color: black;">Lecture Notes in Computer Science</a> </i> &nbsp;
DNA-based nanotechnology is currently being developed for use in biomolecular computation, fabrication of 2D tile lattices, and engineering of 3D periodic matter. Here we present recent results on the construction and characterization of DNA nanotubes -a new self-assembling superstructure composed of DNA tiles. Triple-crossover (TAO) tiles modified with thiol-containing dsDNA stems projected out of the tile plane were utilized as the basic building block. TAO nanotubes display a constant
more &raquo; ... r of approximately 25 nm and have been observed with lengths up to 20 microns. We present high resolution images of the constructs from transmission electron microscopy (TEM) and atomic force microscopy (AFM) as well as preliminary data on successful metallization of the nanotubes. DNA nanotubes represent a potential breakthrough in the self-assembly of nanometer scale circuits for electronics layout since they can be targeted to connect at specific locations on largerscale structures and can subsequently be metallized to form nanometer scale wires. The dimensions of these nanotubes are also perfectly suited for applications involving interconnection of molecular scale devices with macroscale components fabricated by conventional photolithographic methods.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/3-540-36440-4_2">doi:10.1007/3-540-36440-4_2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/trjjq33vgfgbvkz3hgpcmgff3a">fatcat:trjjq33vgfgbvkz3hgpcmgff3a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20060922070605/http://www.cs.duke.edu/~thl/papers/DNA8.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/af/7e/af7e84508e08c4c9bf772ca059bb8202bc277dcf.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/3-540-36440-4_2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> springer.com </button> </a>

Ultraluminous X-ray Sources in Seven Edge-On Spiral Galaxies [article]

Kristen C. Dage, Noah Vowell, Erica Thygesen, Arash Bahramian, Daryl Haggard, Konstantinos Kovlakas, Arunav Kundu, Thomas J. Maccarone, Jay Strader, Ryan Urquhart, Stephen E. Zepf
<span title="2021-09-29">2021</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Elliptical galaxies are known to host off-centre ULXs, but those are associated with globular clusters Dage et al. (2021) .  ...  Roberts & Warwick 2000; Qiu et al. 2019 and references therein) , although a small number have been identified in globular clusters associated with elliptical galaxies (see Maccarone et al. 2007; Dage  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2109.14407v1">arXiv:2109.14407v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wnsi25daazfcvbiaummyjjraaq">fatcat:wnsi25daazfcvbiaummyjjraaq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20211001105042/https://arxiv.org/pdf/2109.14407v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/45/f9/45f9dcfda2d7f455a0fdb4e09ef08b2d201468b7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2109.14407v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Mechanics and structure of carbon black gels under high-power ultrasound [article]

Noémie Dagès, Pierre Lidon, Guillaume Jung, Frédéric Pignon, Sébastien Manneville, Thomas Gibaud
<span title="2021-03-02">2021</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Colloidal gels made of carbon black particles dispersed in light mineral oil are "rheo-acoustic" materials, i.e., their mechanical and structural properties can be tuned using high-power ultrasound, sound waves with submicron amplitude and frequency larger than 20~kHz . The effects of high-power ultrasound on the carbon black gel are demonstrated using two experiments: rheology coupled to ultrasound to test for the gel mechanical response and a timeresolved ultra small-angle X-ray scattering
more &raquo; ... eriment (TRUSAXS) coupled to ultrasound to test for structural changes within the gel. We show that high-power ultrasound above a critical amplitude leads to a complex viscoelastic transient response of the gels within a few seconds: a softening of its storage modulus accompanied by a strong overshoot in its loss modulus. Under high-power ultrasound, the gel displays a viscoelastic spectrum with glass-like features and a significant decrease in its yield strain. Those effects are attributed to the formation of intermittent micro-cracks in the bulk of the gel as evidenced by TRUSAXS. Provided that the shear rate is not large enough to fully fluidize the sample, high-power ultrasound also facilitates the flow of the gel, reducing its yield stress as well as increasing the shear-thinning index, thanks again to the formation of micro-cracks.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2011.06809v2">arXiv:2011.06809v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/facw7foucfdi3kxevl6keqbj6y">fatcat:facw7foucfdi3kxevl6keqbj6y</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210305212613/https://arxiv.org/pdf/2011.06809v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fc/fc/fcfcb8ca1fdd1d497d613cddf5ebde3cde7a7348.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2011.06809v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

X-Ray Spectroscopy of Newly Identified ULXs Associated With M87's Globular Cluster Population [article]

Kristen C. Dage, Stephen E. Zepf, Erica Thygesen, Arash Bahramian, Arunav Kundu, Thomas J. Maccarone, Mark B. Peacock, Jay Strader
<span title="2020-07-01">2020</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
et al. 2019a) , two associated with NGC 4649 (Roberts et al. 2012; Dage et al. 2019a) , and five associated with NGC 4472 Dage et al. 2019a) .  ...  It varies both in L X and in its spectral parameter in a similar fashion to GCU1 in NGC 4472 Dage et al. 2019a) .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2007.00671v1">arXiv:2007.00671v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/b7p63orgpfhv3dpclg2phpvpiy">fatcat:b7p63orgpfhv3dpclg2phpvpiy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200722190555/https://arxiv.org/pdf/2007.00671v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7d/53/7d534c443735f94eee516225343851360310e7a3.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2007.00671v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Three Ultraluminous X-ray Sources Hosted by Globular Clusters in NGC 1316 [article]

Kristen C. Dage, Arunav Kundu, Erica Thygesen, Arash Bahramian, Daryl Haggard, Jimmy A. Irwin, Thomas J. Maccarone, Sneha Nair, Mark B. Peacock, Jay Strader, Stephen E. Zepf
<span title="2021-03-30">2021</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
(Dage et al. 2018 (Dage et al. , 2019a (Dage et al. , 2020 . Figure 1 . 1 Left: X-ray image of NGC 1316 (ObsID 20341) with positions of the three GC ULXs overlaid.  ...  al. (2019a Dage et al. ( , 2020 for more).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2103.16576v1">arXiv:2103.16576v1</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/hzhbfzf7dnfgph5hmvklfgd2q4">fatcat:hzhbfzf7dnfgph5hmvklfgd2q4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210409214357/https://arxiv.org/pdf/2103.16576v1.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e6/c7/e6c759d32c8f609955c5a91bee2595e0645288d5.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2103.16576v1" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Interpenetration of fractal clusters drives elasticity in colloidal gels formed upon flow cessation [article]

Noémie Dagès, Louis V. Bouthier, Lauren Matthews, Sébastien Manneville, Thibaut Divoux, Arnaud Poulesquen, Thomas Gibaud
<span title="2022-03-23">2022</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Colloidal gels are out of equilibrium soft solids composed of attractive Brownian particles that form a space-spanning network at low volume fractions. The elastic properties of these systems result from the network microstructure, which is very sensitive to shear history. Here, we take advantage of such sensitivity to tune the viscoelastic properties of a colloidal gel made of carbon black nanoparticles. Starting from a fluidized state under an applied shear rate γ̇_0, we use an abrupt flow
more &raquo; ... sation to trigger a liquid-to-solid transition. We observe that the resulting gel is all the more elastic when the shear rate γ̇_0 is low and that the viscoelastic spectra can be mapped on a master curve. Moreover, coupling rheometry to small angle X-ray scattering allows us to show that the gel microstructure is composed of a percolated network of fractal clusters that interpenetrate each other. Experiments on gels prepared with various shear histories reveal that cluster interpenetration increases with decreasing values of the shear rate γ̇_0 applied before flow cessation. These observations strongly suggest that cluster interpenetration drives the gel elasticity, which we confirm using a structural model. Our results, which are in stark contrast with previous literature, where gel elasticity was either linked to cluster connectivity or to bending modes, highlight a novel local parameter controlling the macroscopic viscoelastic properties of colloidal gels.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2203.08675v2">arXiv:2203.08675v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jb7bdhiqsjg7lpceyhhn6a36lq">fatcat:jb7bdhiqsjg7lpceyhhn6a36lq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220327070720/https://arxiv.org/pdf/2203.08675v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/00/06/00062a8db2c3c91cf0499cd5d0f38ce7c002b6bd.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/2203.08675v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>

Rheoacoustic Gels: Tuning Mechanical and Flow Properties of Colloidal Gels with Ultrasonic Vibrations

Thomas Gibaud, Noémie Dagès, Pierre Lidon, Guillaume Jung, L. Christian Ahouré, Michael Sztucki, Arnaud Poulesquen, Nicolas Hengl, Frédéric Pignon, Sébastien Manneville
<span title="2020-02-10">2020</span> <i title="American Physical Society (APS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/34iggvr2oraezibenzxlccincy" style="color: black;">Physical Review X</a> </i> &nbsp;
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1103/physrevx.10.011028">doi:10.1103/physrevx.10.011028</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/gr4s6nsqiffddmr2hjdkhjdp2u">fatcat:gr4s6nsqiffddmr2hjdkhjdp2u</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200508071859/https://dspace.mit.edu/bitstream/handle/1721.1/124677/PhysRevX.10.011028.pdf;jsessionid=8E1EC1425099FF88403E13E5F6E573B7?sequence=1" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/39/ec/39ec04099778598c68092ab0e1990a137a8cb24f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1103/physrevx.10.011028"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> aps.org </button> </a>

Cellular localization of p-tau217 in brain and its association with p-tau217 plasma levels

Malin Wennström, Shorena Janelidze, K. Peter R. Nilsson, Geidy E. Serrano, Thomas G. Beach, Jeffrey L. Dage, Oskar Hansson, The Netherlands Brain Bank
<span title="2022-01-06">2022</span> <i title="Springer Science and Business Media LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/qqr6njvfwvemjeu43gipkmiwyi" style="color: black;">Acta Neuropathologica Communications</a> </i> &nbsp;
AbstractRecent studies highlight phosphorylated tau (p-tau) at threonine tau 217 (p-tau217) as a new promising plasma biomarker for pathological changes implicated in Alzheimer's disease (AD), but the specific brain pathological events related to the alteration in p-tau217 plasma levels are still largely unknown. Using immunostaining techniques of postmortem AD brain tissue, we show that p-tau217 is found in neurofibrillary tangles (NFTs) and neuropil threads that are also positive for
more &raquo; ... 202, 202/205, 231, and 369/404. The p-tau217, but not the other five p-tau variants, was also prominently seen in vesicles structure positive for markers of granulovacuolar degeneration bodies and multi-vesicular bodies. Further, individuals with a high likelihood of AD showed significantly higher p-tau217 area fraction in 4 different brain areas (entorhinal cortex, inferior temporal gyrus, and superior frontal gyrus) compared to those with Primary age related tauopathy or other non-AD tauopathies. The p-tau217 area fraction correlated strongly with total amyloid-beta (Aβ) and NFT brain load when the whole group was analyzed. Finally, the mean p-tau217 area fraction correlated significantly with p-tau217 concentrations in antemortem collected plasma specifically in individuals with amyloid plaques and not in those without amyloid plaques. These studies highlight differences in cellular localization of different p-tau variants and suggest that plasma levels of p-tau217 reflect an accumulation of p-tau217 in presence of Aβ plaque load.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s40478-021-01307-2">doi:10.1186/s40478-021-01307-2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34991721">pmid:34991721</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8734209/">pmcid:PMC8734209</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kksi32urtzhpvivx4p4yzdftjm">fatcat:kksi32urtzhpvivx4p4yzdftjm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220206140235/https://actaneurocomms.biomedcentral.com/track/pdf/10.1186/s40478-021-01307-2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a4/bf/a4bfbbad4e2b39a2f363cc5d6f8ae3b159354b10.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s40478-021-01307-2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8734209" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived NRXN1-Mutant Neurons [article]

ChangHui Pak, Tamas Danko, Vincent R Mirabella, Jinzhao Wang, Xianglong Zhang, Thomas Ward, Sarah Grieder, Madhuri Vangipuram, Yu-Wen Alvin Huang, Yingfei Liu, Kang Jin, Phillip Dexheimer (+13 others)
<span title="2020-11-03">2020</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Heterozygous NRXN1 deletions constitute the most prevalent currently known single-gene mutation predisposing to schizophrenia. Previous studies showed that engineered heterozygous NRXN1 deletions impaired neurotransmitter release in human neurons, suggesting a synaptic pathophysiological mechanism. Utilizing this observation for drug discovery, however, requires confidence in its robustness and validity. Here, we describe a multi-center effort to test the generality of this pivotal observation,
more &raquo; ... using independent analyses at two laboratories of patient-derived and newly engineered human neurons with heterozygous NRXN1 deletions. We show that in neurons that were trans-differentiated from induced pluripotent stem cells derived from three NRXN1-deletion patients, the same impairment in neurotransmitter release was observed as in engineered NRXN1-deficient neurons. This impairment manifested as a decrease in spontaneous synaptic events and in evoked synaptic responses, and an alteration in synaptic paired-pulse depression. Nrxn1-deficient mouse neurons generated from embryonic stem cells by the same method as human neurons did not exhibit impaired neurotransmitter release, suggesting a human-specific phenotype. NRXN1 deletions produced a reproducible increase in the levels of CASK, an intracellular NRXN1-binding protein, and were associated with characteristic gene expression changes. Thus, heterozygous NRXN1 deletions robustly impair synaptic function in human neurons regardless of genetic background, enabling future drug discovery efforts.
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.11.03.366617">doi:10.1101/2020.11.03.366617</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/g4hmp25winciteikhasuaac254">fatcat:g4hmp25winciteikhasuaac254</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20201210202657/https://www.biorxiv.org/content/biorxiv/early/2020/11/03/2020.11.03.366617.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/74/a4/74a4fc2d3fb741d8ae733ed6d0d508aa0085c6cd.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2020.11.03.366617"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Rheo-acoustic gels: Tuning mechanical and flow properties of colloidal gels with ultrasonic vibrations [article]

Thomas Gibaud, Noémie Dagès, Pierre Lidon, Guillaume Jung, L. Christian Ahouré, Michael Sztucki, Arnaud Poulesquen, Nicolas Hengl, Frédéric Pignon, Sébastien Manneville
<span title="2019-12-21">2019</span> <i > arXiv </i> &nbsp; <span class="release-stage" >pre-print</span>
Colloidal gels, where nanoscale particles aggregate into an elastic yet fragile network, are at the heart of materials that combine specific optical, electrical and mechanical properties. Tailoring the viscoelastic features of colloidal gels in real-time thanks to an external stimulus currently appears as a major challenge in the design of "smart" soft materials. Here we introduce "rheo-acoustic" gels, a class of materials that are sensitive to ultrasonic vibrations. By using a combination of
more &raquo; ... eological and structural characterization, we evidence and quantify a strong softening in three widely different colloidal gels submitted to ultrasonic vibrations (with submicron amplitude and frequency 20-500 kHz). This softening is attributed to micron-sized cracks within the gel network that may or may not fully heal once vibrations are turned off depending on the acoustic intensity. Ultrasonic vibrations are further shown to dramatically decrease the gel yield stress and accelerate shear-induced fluidization. Ultrasound-assisted fluidization dynamics appear to be governed by an effective temperature that depends on the acoustic intensity. Our work opens the way to a full control of elastic and flow properties by ultrasonic vibrations as well as to future theoretical and numerical modeling of such rheo-acoustic gels.
<span class="external-identifiers"> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1905.07282v2">arXiv:1905.07282v2</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ovfwv5riz5ckrohjctvzu7lohq">fatcat:ovfwv5riz5ckrohjctvzu7lohq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200321024850/https://arxiv.org/pdf/1905.07282v2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener" href="https://arxiv.org/abs/1905.07282v2" title="arxiv.org access"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> arxiv.org </button> </a>
&laquo; Previous Showing results 1 &mdash; 15 out of 5,342 results