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Modulation of electrocorticographic seizure features predicts response to closed-loop brain stimulation [article]

Vasileios Kokkinos, Nathaniel D Sisterson, Thomas A Wozny, R. Mark Richardson
2018 bioRxiv   pre-print
Isolated samples of recordings and corresponding spectrograms that support this hypothesis have been presented sporadically in the literature (Skarpaas and Morrell, 2009; Thomas and Jobst, 2015; Geller  ...  or a combination of both (patient 2).  ... 
doi:10.1101/408567 fatcat:4hampfdod5ah7imphiqhmnfuii

Simultaneous cortical and subcortical recordings in humans with movement disorders: Acute and chronic paradigms

Thomas A. Wozny, Doris D. Wang, Philip A. Starr
2020 NeuroImage  
A recent technical advance has been the addition of electrocorticography to basal ganglia recording, for evaluating distributed motor networks.  ...  rationale, results, and ethics of this multisite recording technique in movement disorders, as well as its application in chronic recording paradigms utilizing implantable neural interfaces that include a  ...  In applications where neural activity preceding a detection is of importance, detection-triggered recordings can also be programmed to include a period of pre-detection time through the use of a looping  ... 
doi:10.1016/j.neuroimage.2020.116904 pmid:32387742 fatcat:mmygvzjwvzes7hp7rasru2lsly

Oblique Lumbar Interbody Fusion From L2 to S1: 2-Dimensional Operative Video

Gregory A Kuzmik, Thomas A Wozny, Simon Ammanuel, Charles M Eichler, Praveen V Mummaneni, Dean Chou
2021 Operative Neurosurgery  
interbody fusion (ALIF), but in a lateral position and at an oblique angle.  ...  The patient consented to this procedure and for filming a video of this case.  ...  Dr Chou is a consultant for and receives royalties from Globus.  ... 
doi:10.1093/ons/opab283 pmid:34409982 fatcat:lcwdfqmdhna4djt4f4fpwmb33u

Development of Sensory Gamma Oscillations and Cross-Frequency Coupling from Childhood to Early Adulthood

Raymond Y. Cho, Christopher P. Walker, Nicola R. Polizzotto, Thomas A. Wozny, Catherine Fissell, Chi-Ming A. Chen, David A. Lewis
2013 Cerebral Cortex  
CFC followed a similar pattern, with strongest age-related modulation of 40-Hz amplitude by the phase of delta oscillations.  ...  In the current study, age-related changes in sensory cortical gamma were studied using the auditory steady-state response (ASSR), indexing cortical activity entrained to a periodic auditory stimulus.  ...  Notes The authors acknowledge Debra Montrose and Alicia Thomas for their contributions to subject recruitment and RyAnna Verbiest, Megan Carl, Polina Radchenkova, Tanisha Hill-Jarrett, Annette Richard  ... 
doi:10.1093/cercor/bht341 pmid:24334917 pmcid:PMC4428298 fatcat:ew5bnklts5awdkfxzwyw2c3rr4

Association of Closed-Loop Brain Stimulation Neurophysiological Features With Seizure Control Among Patients With Focal Epilepsy

Vasileios Kokkinos, Nathaniel D. Sisterson, Thomas A. Wozny, R. Mark Richardson
2019 JAMA Neurology  
A bidirectional brain-computer interface that performs neurostimulation has been shown to improve seizure control in patients with refractory epilepsy, but the therapeutic mechanism is unknown.  ...  Retrospective review of ECOG recordings and accompanying clinical meta-data from 11 consecutive patients with focal epilepsy who were implanted with a neurostimulation system between January 28, 2015,  ...  Spectral analysis was performed for each sample by using the fast Fourier transform of a 128-point window and a 125-point overlap for frequencies from 0.05 to 60.00 Hz at a step of 0.05 Hz.  ... 
doi:10.1001/jamaneurol.2019.0658 pmid:30985902 pmcid:PMC6583077 fatcat:rpahjmu7krb3nfv3h75uprhlpm

Closed-Loop Brain Stimulation for Drug-Resistant Epilepsy: Towards an Evidence-Based Approach to Personalized Medicine

Nathaniel D. Sisterson, Thomas A. Wozny, Vasileios Kokkinos, Alexander Constantino, R. Mark Richardson
2018 Neurotherapeutics  
major challenges of working with a closed-loop device.  ...  We then propose an evidence-based solution for individualizing therapy that is driven by a bottom-up informatics approach.  ...  Pattern A triggers when Pattern A Detector 1 or Pattern A Detector 2 trigger. Pattern B2 is enabled with a bandpass detector to trigger when a detection occurs on either channel 2.  ... 
doi:10.1007/s13311-018-00682-4 pmid:30378004 pmcid:PMC6361057 fatcat:ec5tm6o22feoxnzuhlsb3d2nr4

Network effects of deep brain stimulation

Ahmad Alhourani, Michael M. McDowell, Michael J. Randazzo, Thomas A. Wozny, Efstathios D. Kondylis, Witold J. Lipski, Sarah Beck, Jordan F. Karp, Avniel S. Ghuman, R. Mark Richardson
2015 Journal of Neurophysiology  
The ability to differentially alter specific brain functions via deep brain stimulation (DBS) represents a monumental advance in clinical neuroscience, as well as within medicine as a whole.  ...  This limited knowledge is a barrier to improving efficacy and reducing side effects in clinical brain stimulation.  ...  These findings may suggest a discrepancy between DBS affects during task-related epochs compared with epochs in which a subject is not engaged in a task.  ... 
doi:10.1152/jn.00275.2015 pmid:26269552 pmcid:PMC4595613 fatcat:vept4beftrdkxgbdykbsb7xhbm

Magnetoencephalography-based identification of functional connectivity network disruption following mild traumatic brain injury

Ahmad Alhourani, Thomas A. Wozny, Deepa Krishnaswamy, Sudhir Pathak, Shawn A. Walls, Avniel S. Ghuman, Donald N. Krieger, David O. Okonkwo, R. Mark Richardson, Ajay Niranjan
2016 Journal of Neurophysiology  
Alhourani A, Wozny TA, Krishnaswamy D, Pathak S, Walls SA, Ghuman AS, Krieger DN, Okonkwo DO, Richardson RM, Niranjan A.  ...  In this study, we used magnetoencephalography (MEG) to examine functional connectivity during a resting state in a group of mTBI subjects (n ϭ 9) compared with age-matched control subjects (n ϭ 15).  ...  A T1-weighted brain volume was used to generate a cortical surface model with the FreeSurfer software package.  ... 
doi:10.1152/jn.00513.2016 pmid:27466136 pmcid:PMC5144712 fatcat:mwiplw2x5vfzrooaz72irkj42m

GABA Bouton Subpopulations in the Human Dentate Gyrus Are Differentially Altered in Mesial Temporal Lobe Epilepsy

Ahmad Alhourani, Kenneth N. Fish, Thomas A. Wozny, Vivek Sudhakar, Ronald L Hamilton, Robert Mark Richardson
2019 Journal of Neurophysiology  
We developed a multi-label immunofluorescence confocal microscopy and a custom segmentation algorithm to quantitatively assess PVBC and PVChC bouton densities and to infer relative synaptic protein content  ...  Medically-intractable temporal lobe epilepsy is a devastating disease, for which surgical removal of the seizure onset zone is the only known cure.  ...  A and B: hematoxylin and eosin stain staining shows preservation of the dentate granule cell layer in a nonsclerotic epilepsy patient (A) and clear cell loss in the dentate gyrus in a sample from a sclerotic  ... 
doi:10.1152/jn.00523.2018 pmid:31800363 pmcid:PMC6985857 fatcat:zqzq37c5hjcg3c75pjtfalveiu

Movement-related dynamics of cortical oscillations in Parkinson's disease and essential tremor

Efstathios D. Kondylis, Michael J. Randazzo, Ahmad Alhourani, Witold J. Lipski, Thomas A. Wozny, Yash Pandya, Avniel S. Ghuman, Robert S. Turner, Donald J. Crammond, R. Mark Richardson
2016 Brain  
visually cued, incentivized handgrip task in subjects with Parkinson's disease (n = 11), with essential tremor (n = 9) and without a movement disorder (n = 6).  ...  We also show that the spatial extent of cortical phase-amplitude decoupling during movement is much greater in subjects with Parkinson's disease and essential tremor than in subjects without a movement  ...  10 À3 , P 5 1 Â 10 À12 ).  ... 
doi:10.1093/brain/aww144 pmid:27329771 pmcid:PMC5022700 fatcat:vphavgdnwnfwfc2x2oretmh4ee

Short segment rib resection to mitigate risk of pleural violation during retropleural lateral thoracic interbody fusion

Bo Li, Gregory A. Kuzmik, Saman Shabani, Nitin Agarwal, Alysha Jamieson, Thomas Wozny, Simon Ammanuel, Praveen V. Mummaneni, Dean Chou
2022 Neurosurgical Focus: Video  
In this video, the authors resect a short segment of rib to allow more room for pleural dissection during a minimally invasive (MIS) lateral retropleural approach.  ...  After a lateral MIS skin incision, the rib is dissected and removed, clearly identifying the retropleural space.  ...  And using a bipolar cautery, the edges are bipolared, and the disc is accessed with a small window through the diaphragm.  ... 
doi:10.3171/2022.3.focvid21138 fatcat:w5xbczmlojgbtc2pe3y3yz6elm

Dynamics of human subthalamic neuron phase-locking to motor and sensory cortical oscillations during movement

Witold J. Lipski, Thomas A. Wozny, Ahmad Alhourani, Efstathios D. Kondylis, Robert S. Turner, Donald J. Crammond, Robert Mark Richardson
2017 Journal of Neurophysiology  
Lipski WJ, Wozny TA, Alhourani A, Kondylis ED, Turner RS, Crammond DJ, Richardson RM. Dynamics of human subthalamic neuron phase-locking to motor and sensory cortical oscillations during movement.  ...  We found that during movement, the magnitude of this synchronization was dynamically modulated in a phase-frequency-specific manner.  ...  Fig. 1 . 1 Examples of voltage traces and power spectra of STN recordings from a single unit with theta and beta (A), a multiunit with low-beta (B), and a single unit with high-beta oscillatory frequencies  ... 
doi:10.1152/jn.00964.2016 pmid:28592690 fatcat:p2lrqutdn5h4fjt6qceisfsaua

Detection of High-Frequency Oscillations by Hybrid Depth Electrodes in Standard Clinical Intracranial EEG Recordings

Efstathios D. Kondylis, Thomas A. Wozny, Witold J. Lipski, Alexandra Popescu, Vincent J. DeStefino, Behnaz Esmaeili, Vineet K. Raghu, Anto Bagic, R. Mark Richardson
2014 Frontiers in Neurology  
In order to investigate the presence of HFOs in clinical data, we first obtained continuous intracranial recordings in a typical clinical environment using a commercially available, commonly utilized data  ...  A and Richardson RM (2014) Detection of high-frequency oscillations by hybrid depth electrodes in standard clinical intracranial EEG recordings. Front. Neurol. 5:149.  ...  The project described was supported by Grant Number UL1 TR0000005 from the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH) and NIH Roadmap  ... 
doi:10.3389/fneur.2014.00149 pmid:25147541 pmcid:PMC4123606 fatcat:hsago3ivajhvzlg2innc6gemwa

Quantitatively validating the efficacy of artifact suppression techniques to study the cortical consequences of deep brain stimulation with magnetoencephalography

Matthew J. Boring, Zachary F. Jessen, Thomas A. Wozny, Michael J. Ward, Ashley C. Whiteman, R. Mark Richardson, Avniel Singh Ghuman
2019 NeuroImage  
Magnetoencephalography (MEG) is a safe, passive imaging modality with relatively high spatiotemporal resolution, which makes it a potentially powerful method for examining the cortical network effects  ...  Deep brain stimulation (DBS) is an established and effective treatment for several movement disorders and is being developed to treat a host of neuropsychiatric disorders including epilepsy, chronic pain  ...  Stimuli were shown for 900 ms with a random 1.5-1.9 s inter-trial interval. Patients were asked to respond if an image was presented twice in a row, which occurred with a probability of 1/10.  ... 
doi:10.1016/j.neuroimage.2019.05.080 pmid:31154045 pmcid:PMC6688933 fatcat:5d2z6p4wdrbebphqtedr3rpqlm

Sortilin-related Receptor with A-type Repeats (SORLA) Affects the Amyloid Precursor Protein-dependent Stimulation of ERK Signaling and Adult Neurogenesis

Michael Rohe, Anne-Sophie Carlo, Henning Breyhan, Anje Sporbert, Daniel Militz, Vanessa Schmidt, Christian Wozny, Anja Harmeier, Bettina Erdmann, Kelly R. Bales, Susanne Wolf, Gerd Kempermann (+5 others)
2008 Journal of Biological Chemistry  
kinase; A␤, amyloid ␤-peptide; BrdUrd, bromodeoxyuridine.  ...  4 The abbreviations used are: SORLA, sortilin-related receptor with A-type repeats; AD, Alzheimer disease; LTP, long term potentiation; APP, amyloid precursor protein; ERK, extracellular signal-regulated  ...  with respective controls (A).  ... 
doi:10.1074/jbc.m710574200 pmid:18362153 fatcat:vzzx4ij7gjgbrf6xnepooxiddq
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