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The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein

Tiziana Sonati, Regina R. Reimann, Jeppe Falsig, Pravas Kumar Baral, Tracy O'Connor, Simone Hornemann, Sine Yaganoglu, Bei Li, Uli S. Herrmann, Barbara Wieland, Mridula Swayampakula, Muhammad Hafizur Rahman (+6 others)
<span title="2013-07-31">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/drfdii35rzaibj3aml5uhvr5xm" style="color: black;">Nature</a> </i> &nbsp;
These deletions did not appreciably compromise globular domain antibody binding, suggesting that the flexible tail is required to transmit toxic signals that originate from the globular domain and trigger  ...  Octapeptide ligands also prolonged the life of mice expressing the toxic PrP(C) mutant, PrP(Δ94-134), indicating that the flexible tail mediates toxicity in two distinct PrP(C)-related conditions.  ...  . *: P<0.05; **: P<0.01; ***: P<0.001, ****: P<0.0001. 1 . 1 Models of PrP-mediated toxicity. a, The cellular prion protein PrP C consists of a long flexible tail (FT) and a globular domain (GD) tethered  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/nature12402">doi:10.1038/nature12402</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23903654">pmid:23903654</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/x2k3jy5mbbfk7fjeuhjs3gqps4">fatcat:x2k3jy5mbbfk7fjeuhjs3gqps4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20181104072926/https://www.zora.uzh.ch/id/eprint/79615/5/Sonati_2013_mergedSNF.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/05/75/0575eb52f6a2bbddc53e3207d01aab20204653a0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1038/nature12402"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> nature.com </button> </a>

Differential Toxicity of Antibodies to the Prion Protein

Regina R. Reimann, Tiziana Sonati, Simone Hornemann, Uli S. Herrmann, Michael Arand, Simon Hawke, Adriano Aguzzi, Neil A. Mabbott
<span title="2016-01-28">2016</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bcchuruegramvpr4vupdzp5jfm" style="color: black;">PLoS Pathogens</a> </i> &nbsp;
We conclude that antibodies directed to this region may not be suitable as therapeutics. No such toxicity was found when antibodies against the flexible tail of PrP C were administered.  ...  However, the safety profile of such antibodies is controversial.  ...  Mechanistically, the flexible tail at the amino-terminus of the prion protein mediates the toxicity of antiprion antibodies by binding to the globular domain of PrP [15] .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.ppat.1005401">doi:10.1371/journal.ppat.1005401</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/26821311">pmid:26821311</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4731068/">pmcid:PMC4731068</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/d4bix5qz7bdpbhslq7lenbtu4m">fatcat:d4bix5qz7bdpbhslq7lenbtu4m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171015215604/http://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1005401&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/7e/40/7e40c14d14c00514e2da27cdb8dad7c296c5c577.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.ppat.1005401"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4731068" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Prion Infections and Anti-PrP Antibodies Trigger Converging Neurotoxic Pathways

Uli S. Herrmann, Tiziana Sonati, Jeppe Falsig, Regina R. Reimann, Paolo Dametto, Tracy O'Connor, Bei Li, Agnes Lau, Simone Hornemann, Silvia Sorce, Uli Wagner, Despina Sanoudou (+2 others)
<span title="2015-02-24">2015</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/bcchuruegramvpr4vupdzp5jfm" style="color: black;">PLoS Pathogens</a> </i> &nbsp;
Antibodies targeting the flexible tail of PrP that prevent toxicity of GD ligands reduced the toxicity induced by prions. Endoplasmic reticulum stress, which is PLOS Pathogens |  ...  Secondly, antibodies against the flexible tail (FT) of PrP C reduced neurotoxicity in both GDL-exposed and prion-infected COCS, suggesting that the FT executes toxicity in both paradigms.  ...  To determine whether the FT also mediates toxicity in prion infection, we treated prion-infected COCS with the POM2 antibody, which recognizes the octapeptide repeats of the FT.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.ppat.1004662">doi:10.1371/journal.ppat.1004662</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25710374">pmid:25710374</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4339193/">pmcid:PMC4339193</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ljhwke6tmfabxe5v7wtnw7m5ki">fatcat:ljhwke6tmfabxe5v7wtnw7m5ki</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171015210515/http://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1004662&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/dc/52/dc524a14d3e153a0ffe22b94ec22de5173120f4f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.ppat.1004662"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339193" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Ligands binding to the cellular prion protein induce its protective proteolytic release with therapeutic potential in neurodegenerative proteinopathies [article]

Luise Linsenmeier, Behnam Mohammadi, Mohsin Shafiq, Karl Frontzek, Julia Baer, Amulya N Shrivastava, Markus Damme, Alexander Schwarz, Stefano Da Vela, Tania Massignan, Sebastian Jung, Angela Correia (+21 others)
<span title="2021-04-20">2021</span> <i title="Cold Spring Harbor Laboratory"> bioRxiv </i> &nbsp; <span class="release-stage" >pre-print</span>
The cellular prion protein (PrPC) is a central player in neurodegenerative diseases caused by protein misfolding, such as prion diseases or Alzheimer's disease (AD).  ...  disease) and is markedly redistributed in murine brain in the presence of prion deposits or AD-associated amyloid plaques indicating a blocking and sequestrating activity.  ...  Molecular graphics and analyses were performed with UCSF Chimera, developed by the Resource for Biocomputing, Visualization, and Informatics at the University of California, San Francisco, with support  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.04.19.440495">doi:10.1101/2021.04.19.440495</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/oxdo5polurdbxf6fafpyv6gn4q">fatcat:oxdo5polurdbxf6fafpyv6gn4q</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210718061856/https://www.biorxiv.org/content/biorxiv/early/2021/04/20/2021.04.19.440495.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/a1/4b/a14b29c7045f06ac78210ff2511e5bace70cccdc.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1101/2021.04.19.440495"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> biorxiv.org </button> </a>

Toward Therapy of Human Prion Diseases

Adriano Aguzzi, Asvin K.K. Lakkaraju, Karl Frontzek
<span title="2018-01-06">2018</span> <i title="Annual Reviews"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/jxqqgho7bncrvgfyfznramju3q" style="color: black;">Annual Review of Pharmacology and Toxicology</a> </i> &nbsp;
The presence of cellular prion protein is not only necessary for the de novo generation of prions, but also for the host organism to experience prion-related neurotoxicity (9).  ...  Prions and prion diseases Prion diseases, or transmissible spongiform encephalopathies (TSEs), are caused by the ordered aggregation of PrP Sc , a misfolded version of the cellular prion protein PrP C  ...  Acknowledgements AA is the recipient of an Advanced Grant of the European Research Council, the Swiss National Foundation, the Clinical Research Priority Programs "Small RNAs" and "Human Hemato-Lymphatic  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1146/annurev-pharmtox-010617-052745">doi:10.1146/annurev-pharmtox-010617-052745</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28961066">pmid:28961066</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rks6kuh2rjhhzk6ucofpxhtr2m">fatcat:rks6kuh2rjhhzk6ucofpxhtr2m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200210015258/https://www.zora.uzh.ch/id/eprint/141186/1/Aguzzi_et_al%3B_2017_revised.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/fa/79/fa79e4a2e578b8cb413695405ae15e731e256284.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1146/annurev-pharmtox-010617-052745"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Prions: Protein Aggregation and Infectious Diseases

Adriano Aguzzi, Anna Maria Calella
<span title="">2009</span> <i title="American Physiological Society"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yyps7nsgzngdlnxq7zhtlsei5y" style="color: black;">Physiological Reviews</a> </i> &nbsp;
ACKNOWLEDGMENTS This article honors the present and past members of the  ...  It is possible that the flexible tail of PrP C acquires a defined structure when PrP C is present within membrane rafts (362) .  ...  Toxicity mediated by abnormal topology or altered trafficking of PrP C .  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1152/physrev.00006.2009">doi:10.1152/physrev.00006.2009</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/19789378">pmid:19789378</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ktvicfmvjnae7ounjzsq66qfo4">fatcat:ktvicfmvjnae7ounjzsq66qfo4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190223113834/http://pdfs.semanticscholar.org/46ad/e1bfd55f065801a63a1eac88e15e272aa783.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/46/ad/46ade1bfd55f065801a63a1eac88e15e272aa783.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1152/physrev.00006.2009"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

Autoantibodies against the prion protein in individuals with PRNP mutations

Karl Frontzek, Manfredi Carta, Marco Losa, Mirka Epskamp, Georg Meisl, Alice Anane, Jean-Philippe Brandel, Ulrike Camenisch, Joaquín Castilla, Stéphane Haïk, Tuomas Knowles, Ewald Lindner (+9 others)
<span title="2020-02-25">2020</span> <i title="Ovid Technologies (Wolters Kluwer Health)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/dogs2nidlzdtxigbzvv6d2bbc4" style="color: black;">Neurology</a> </i> &nbsp;
Antibody reactivity was measured using an indirect ELISA for the detection of human immunoglobulin G1–4 antibodies against wild-type human prion protein.  ...  Autoantibody levels were not influenced by PRNP mutation status or clinical manifestation of prion disease.  ...  Collection of samples at Massachusetts General Hospital was funded by Prion Alliance.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1212/wnl.0000000000009183">doi:10.1212/wnl.0000000000009183</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/32098855">pmid:32098855</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC7682844/">pmcid:PMC7682844</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4gbjlqq7qnbyhav3z3xhb4bb54">fatcat:4gbjlqq7qnbyhav3z3xhb4bb54</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210427163824/https://n.neurology.org/content/neurology/95/14/e2028.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/c1/28/c128b4b0a58c69ae50d79963613f0cf3e4ac1808.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1212/wnl.0000000000009183"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7682844" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Research Progress of Prion Characteristics and Pathogenesis

Ayana Enbiyale Dembel, Field Practitioner at University of Gondar Veterinary Clinic, College of Veterinary Medicine and science, University of Gondar, P.O. Box. 196, Gondar, Ethiopia "
<span title="2021-12-30">2021</span> <i title="Century Science Publishing Co"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/5yi5j5zcmzf33bj33tbh6r5apy" style="color: black;">Journal of Theory and Practice of Engineering Science</a> </i> &nbsp;
The normal, cellular protein PrP (PrPC) is converted into PrPSc through a post translational process during which it acquires a high β-sheet content which made the protein resistant to degradation by proteinase  ...  Prions are infectious proteins that cause disease in variable species of animals, including human being.  ...  These data suggest the feasibility of antiprion immunoprophylaxis, which could be implemented as passive immunization (transfer of antibodies) or active immunization (administration of antigens as vaccines  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.53469/jtpes.2021.01(01).02">doi:10.53469/jtpes.2021.01(01).02</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/4gbbb7aqfbdf7bz4reugwoieue">fatcat:4gbbb7aqfbdf7bz4reugwoieue</a> </span>
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Prion 2015 Poster Abstracts

<span title="2015-04-24">2015</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/auhjmzxuvfcn3kwip3acbiejx4" style="color: black;">Prion</a> </i> &nbsp;
Several receptor targets have been found to link oligomers with cell toxicity, one of which is the cellular prion protein (PrPC).  ...  The sizes of prion protein oligomers are considered to drive the toxicity within the brain of infect animals.  ...  In vascular injury, including stroke, one of the key cell death-triggering events is the release of toxic levels of free hemin.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/19336896.2015.1033248">doi:10.1080/19336896.2015.1033248</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25970046">pmid:25970046</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5019499/">pmcid:PMC5019499</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/s6evgzfy4bgozaqcvk7mig2uzm">fatcat:s6evgzfy4bgozaqcvk7mig2uzm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209100805/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC5019499&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/e7/27/e727d803b648aeae556df4a10f044748342a3db8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1080/19336896.2015.1033248"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> tandfonline.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5019499" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Protein Structure and Biology: Poster Abstracts

<span title="">2013</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/auhjmzxuvfcn3kwip3acbiejx4" style="color: black;">Prion</a> </i> &nbsp;
This project was supported through a strategic program grant to The Roslin Institute by the Biotechnology and Biological Sciences Research Council, UK. Acknowledgments.  ...  Supported by NIAID (NIH), CNPq and FAPERJ.  ...  This nuclear localization is mediated by the (25-61) fragment of mouse Sho encompassing an (RXXX)8 motif.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4161/pri.24866">doi:10.4161/pri.24866</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29095079">pmid:29095079</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4031664/">pmcid:PMC4031664</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/mijzcvd7vre2dhg2ipk22yaw3i">fatcat:mijzcvd7vre2dhg2ipk22yaw3i</a> </span>
<a target="_blank" rel="noopener" href="https://archive.org/download/pubmed-PMC4031664/PMC4031664-24866.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> File Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.4161/pri.24866"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031664" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Detection and Control of Prion Diseases in Food Animals

Peter Hedlin, Ryan Taschuk, Andrew Potter, Philip Griebel, Scott Napper
<span title="">2012</span> <i title="Hindawi Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zfqaezrhvjahdm4nhiholn35ca" style="color: black;">ISRN Veterinary Science</a> </i> &nbsp;
While the immediate threat posed by BSE has been successfully addressed through surveillance and improved management practices, another prion disease is rapidly spreading.  ...  Prion diseases of food animals gained notoriety during the bovine spongiform encephalopathy (BSE) outbreak of the 1980s.  ...  Cellular PrP The human version of PrP C is a 253 amino acid (aa) protein which is encoded by the prion gene Prnp located on the short arm of chromosome 20.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5402/2012/254739">doi:10.5402/2012/254739</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/23738120">pmid:23738120</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3658581/">pmcid:PMC3658581</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/tpzzukldgncrbe4wylvmpho6lm">fatcat:tpzzukldgncrbe4wylvmpho6lm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20190221205937/http://pdfs.semanticscholar.org/2d05/4bd11d11d559710385f60f2edcc1c9ba7d03.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/2d/05/2d054bd11d11d559710385f60f2edcc1c9ba7d03.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.5402/2012/254739"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3658581" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Prions: Beyond a Single Protein

Alvin S. Das, Wen-Quan Zou
<span title="2016-05-25">2016</span> <i title="American Society for Microbiology"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/qhog6viejbhxzp457e5gjyus74" style="color: black;">Clinical Microbiology Reviews</a> </i> &nbsp;
The significance of these fascinating developments in prion biology is far beyond the scope of a single cellular protein and its related disease.  ...  The unique traits and genetic information of prions are believed to be encoded within the conformational structure and posttranslational modifications of the proteins.  ...  The PERK inhibitor is a significant mediator of the unfolded-protein response (UPR) pathway, as it prevents UPR-mediated translational repression.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1128/cmr.00046-15">doi:10.1128/cmr.00046-15</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27226089">pmid:27226089</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4978610/">pmcid:PMC4978610</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/si643qgfjzcptjxmirnvq7lecm">fatcat:si643qgfjzcptjxmirnvq7lecm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180721051012/http://cmr.asm.org/content/29/3/633.full.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/f1/d9/f1d979d88ed4a92f6c5cf0d328a09e9da4e56229.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1128/cmr.00046-15"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> asm.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4978610" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Technische Universität München [chapter]

<span title="2017-01-20">2017</span> <i title="Wiley-VCH Verlag GmbH &amp; Co. KGaA"> Geschichte der anorganischen Chemie </i> &nbsp;
Mechanisms of neurodegeneration in prion diseases Transmission of prion diseases is mediated by prions which mainly consist of the pathological prion protein isoform PrP Sc that accumulates in the brain  ...  Saponin is a detergent mediating permeabilisation of cellular membranes to enable the antibodies to enter the cell interior.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/9783527693009.ch38">doi:10.1002/9783527693009.ch38</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/jyyip3a3gvddxi3s532x4s2auu">fatcat:jyyip3a3gvddxi3s532x4s2auu</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170706040819/http://mediatum.ub.tum.de/doc/680411/document.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/30/17/3017fc62ef2f05700171a9f8d13b788053ff332a.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1002/9783527693009.ch38"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> wiley.com </button> </a>

Protease resistance of infectious prions is suppressed by removal of a single atom in the cellular prion protein

Henning Leske, Simone Hornemann, Uli Simon Herrmann, Caihong Zhu, Paolo Dametto, Bei Li, Florent Laferriere, Magdalini Polymenidou, Pawel Pelczar, Regina Rose Reimann, Petra Schwarz, Elisabeth Jane Rushing (+3 others)
<span title="2017-02-16">2017</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
The amino acid sequence is depicted by one-letter symbols, conserved residues by dots, and the amino acid substitution is indicated in red.  ...  Detection of proteinase K-resistant prion protein (PrP Sc ) still represents the diagnostic gold standard for prion diseases in humans, sheep and cattle.  ...  It is well-established that prions contain aggregates of misfolded cellular prion protein (PrP C ).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0170503">doi:10.1371/journal.pone.0170503</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28207746">pmid:28207746</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5313174/">pmcid:PMC5313174</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/47radzxhivfyxm3kdtcfrc3bqq">fatcat:47radzxhivfyxm3kdtcfrc3bqq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171012072225/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0170503&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b0/15/b0159e08cb16db1ef5ec128bb31d95fee6e2735b.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0170503"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5313174" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Prion disease: experimental models and reality

Sebastian Brandner, Zane Jaunmuktane
<span title="2017-01-13">2017</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fu2v5yy75zfitiwkzgznutnkvq" style="color: black;">Acta Neuropathologica</a> </i> &nbsp;
As with other neurodegenerative diseases caused by protein misfolding, the pathogenesis of prion disease is complex, full of conundra and contradictions.  ...  Whilst clinical research and studies on human tissue are an essential component of prion research, much of the understanding of the mechanisms governing transmission, replication, and toxicity comes from  ...  Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1007/s00401-017-1670-5">doi:10.1007/s00401-017-1670-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28084518">pmid:28084518</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5250673/">pmcid:PMC5250673</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/ehqp3ax555ed5b4lqu57mwj5p4">fatcat:ehqp3ax555ed5b4lqu57mwj5p4</a> </span>
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