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The spatiotemporal hemodynamic response function for depth-dependent functional imaging of human cortex

Alexander M. Puckett, Kevin M. Aquino, P.A. Robinson, Michael Breakspear, Mark M. Schira
2016 NeuroImage  
The spatiotemporal hemodynamic response function for depth-dependent functional imaging of human cortex. NeuroImage, 139 (October), 240-248.  ...  To advance this endeavor, we present a detailed spatiotemporal hemodynamic response function (HRF) reconstructed through the use of high-resolution, submillimeter fMRI.  ...  This constitutes the first 76 characterization of the spatiotemporal HRF that can be used for depth-dependent 77 functional imaging of human cortex. 78 79 We also relate our empirical measurements to a  ... 
doi:10.1016/j.neuroimage.2016.06.019 pmid:27321045 fatcat:ocrngrggo5bpzggpk26omfntki

Laminar fMRI: What can the time domain tell us?

Natalia Petridou, Jeroen C.W. Siero
2017 NeuroImage  
, for example by differences in the onset times of the response across cortical depth.  ...  Few studies have examined temporal features of the hemodynamic response across cortical depth.  ...  Acknowledgments This work has supported by a Netherlands Organization for Scientific Research (NWO) Vidi Grant 13339 (N.P.) and the National Institute of Mental Health of the National Institutes of Health  ... 
doi:10.1016/j.neuroimage.2017.07.040 pmid:28736308 pmcid:PMC5775945 fatcat:rjkqnyzlbbcadck4wewflqrjhq

Cortical Depth-Dependent Temporal Dynamics of the BOLD Response in the Human Brain

Jeroen CW Siero, Natalia Petridou, Hans Hoogduin, Peter R Luijten, Nick F Ramsey
2011 Journal of Cerebral Blood Flow and Metabolism  
In the present work, we characterize the temporal dynamics of the BOLD response across cortical depth in the human primary motor (M1) and visual cortex (V1), at 7T.  ...  Recent animal studies at high field (≥7T) have shown that BOLD can be specific to the laminar vascular architecture of the cortex, by differences in its temporal dynamics in reference to cortical depth  ...  The spatiotemporal heterogeneity of the BOLD response matches the known vascular organization across cortical depth [11] , which is expected to be closely related to functional organization in the human  ... 
doi:10.1038/jcbfm.2011.57 pmid:21505479 pmcid:PMC3208150 fatcat:swuja7hxyvfxjg7yb5znyop7yy

Coupling of the cortical hemodynamic response to cortical and thalamic neuronal activity

A. Devor, I. Ulbert, A. K. Dunn, S. N. Narayanan, S. R. Jones, M. L. Andermann, D. A. Boas, A. M. Dale
2005 Proceedings of the National Academy of Sciences of the United States of America  
§ I.U. recently founded and is the majority owner of Neurotrack, a company that develops and markets laminar electrophysiology equipment for animal research.  ...  The stimulus amplitude dependence of the surround negativity, along with the results of principal component analysis, suggests a spatiotemporal separability of the neurovascular transfer function for HbO  ...  We demonstrate that the hemodynamic response is a spatiotemporal convolution of the neuronal activation.  ... 
doi:10.1073/pnas.0407789102 pmid:15734797 pmcid:PMC550644 fatcat:cs2cgtp2infhvkfumcw4g7on6a

Early fMRI responses to somatosensory and optogenetic stimulation reflect neural information flow

Won Beom Jung, Geun Ho Im, Haiyan Jiang, Seong-Gi Kim
2021 Proceedings of the National Academy of Sciences of the United States of America  
Blood oxygenation level–dependent (BOLD) functional magnetic resonance imaging (fMRI) has been widely used to localize brain functions.  ...  The order of early BOLD responses was consistent with the canonical understanding of somatosensory network connections and cannot be explained by regional variabilities in the hemodynamic response functions  ...  Chanhee Lee for maintaining the magnetic resonance imaging (MRI) instruments.  ... 
doi:10.1073/pnas.2023265118 pmid:33836602 fatcat:5sxx752ynvbi3mfn26vnhymw4e

Contributions and complexities from the use of in vivo animal models to improve understanding of human neuroimaging signals

Chris Martin
2014 Frontiers in Neuroscience  
This approach has been successful partly because it provides opportunities to measure both the hemodynamic changes that underpin many human functional brain imaging techniques and the neuronal activity  ...  Although research into the coupling of neuronal and hemodynamic responses using animal models has provided a general validation of the correspondence of neuroimaging signals to specific types of neuronal  ...  Improvements in our understanding of the fine detail of the spatiotemporal hemodynamic response function would have two main benefits.  ... 
doi:10.3389/fnins.2014.00211 pmid:25191214 pmcid:PMC4137227 fatcat:cabjlfu7lnh7pmyuicvb6w7pli

Optics in Neuroscience

David A. Boas, Ron D. Frostig
2005 Journal of Biomedical Optics  
They confirm the cerebral origin of the hemodynamic response with simultaneous optical and function magnetic resonance imaging (fMRI).  ...  The authors use a combination of experimental results and modeling to highlight the advantages of this technique for elucidating functional networks in the cortex.  ... 
doi:10.1117/1.1851511 fatcat:wd6knov6ofctvdshtaculyg4ey

Imaging small animal whole-body dynamics by single-impulse panoramic photoacoustic computed tomography

Lei Li, Liren Zhu, Cheng Ma, Li Lin, Junjie Yao, Lidai Wang, Konstantin Maslov, Ruiying Zhang, Wanyi Chen, Junhui Shi, Lihong V. Wang, Alexander A. Oraevsky (+1 others)
2017 Photons Plus Ultrasound: Imaging and Sensing 2017  
However, current non-optical imaging techniques lack either spatiotemporal resolution or functional contrasts, and pure optical imaging suffers from either shallow penetration (up to ~1 mm) or a poor resolution-to-depth  ...  Such capabilities allow us to image, for the first time, mouse wholebody dynamics in real time with clear sub-organ anatomical and functional details and without motion artifacts.  ...  ACKNOWLEDGMENTS We thank Yun He, Chiye Li, Yang Li, and Jun Xia for technical support, and James Ballard for close reading of the manuscript.  ... 
doi:10.1117/12.2251593 fatcat:wdjujvorpjgundyyqq4kl7fzhy

Direct imaging of macrovascular and microvascular contributions to BOLD fMRI in layers IV–V of the rat whisker–barrel cortex

Xin Yu, Daniel Glen, Shumin Wang, Stephen Dodd, Yoshiyuki Hirano, Ziad Saad, Richard Reynolds, Afonso C. Silva, Alan P. Koretsky
2012 NeuroImage  
The spatiotemporal characteristics of the hemodynamic response to increased neural activity were investigated at the level of individual intracortical vessels using BOLD-fMRI in a well-established rodent  ...  Functional maps of the rat barrel cortex were obtained at 150×150×500µm spatial resolution every 200ms.  ...  Acknowledgments This research was supported by the Intramural Research Program of the NIH, NINDS. We thank Ms. Nadia Bouraoud and Ms. Kathryn Sharer for their technical support.  ... 
doi:10.1016/j.neuroimage.2011.08.001 pmid:21851857 pmcid:PMC3230765 fatcat:4rf4frt3fbfvzpljt5vfcvs7zy

Resolving the transition from negative to positive blood oxygen level-dependent responses in the developing brain

Mariel G. Kozberg, Brenda R. Chen, Sarah E. DeLeo, Matthew B. Bouchard, Elizabeth M. C. Hillman
2013 Proceedings of the National Academy of Sciences of the United States of America  
blood oxygen level-dependent (BOLD) signal in functional magnetic resonance imaging (fMRI), respectively.  ...  We propose that this confound may account for much of the variability in prior studies of neonatal cortical hemodynamics.  ...  Barclay Morrison and his laboratory for providing rat pups; and members of the Laboratory for Functional Optical Imaging for support and helpful discussions, particularly Sean Burgess for analysis software  ... 
doi:10.1073/pnas.1212785110 pmid:23426630 pmcid:PMC3600493 fatcat:iyinc6uhwvaqpjng2jf5vvcgpu

Inverted optical intrinsic response accompanied by decreased cerebral blood flow are related to both neuronal inhibition and excitation

Zengguang Ma, Pengjia Cao, Pengcheng Sun, Linna Zhao, Liming Li, Shanbao Tong, Yiliang Lu, Yan Yan, Yao Chen, Xinyu Chai
2016 Scientific Reports  
Negative hemodynamic response has been widely reported in blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging studies, however its origin is still controversial.  ...  We then investigated the property of this negative response to TcES and its relationship with cerebral blood flow (CBF) and neuronal activity.  ...  Functional imaging of visual cortex with LSCI was performed to provide a two-dimensional real-time, full-field imaging of CBF with high spatiotemporal resolution.  ... 
doi:10.1038/srep21627 pmid:26860040 pmcid:PMC4748280 fatcat:rkoho2otkzhczcs2faefy4hxou

Depth-dependent cerebral hemodynamic responses following Direct Cortical Electrical Stimulation (DCES) revealed by in vivo dual-optical imaging techniques

Seungduk Lee, Dalkwon Koh, Areum Jo, Hae Young Lim, Young-Jin Jung, Choong-Ki Kim, Youngwook Seo, Chang-Hwan Im, Beop-Min Kim, Minah Suh
2012 Optics Express  
that the upper brain region reacted faster than the deep region. , "Functional architecture of cortex revealed by optical imaging of intrinsic signals," Nature 324(6095), 361-364 (1986). 2.  ...  We studied depth-dependent cerebral hemodynamic responses of rat brain following direct cortical electrical stimulation (DCES) in vivo with optical recording of intrinsic signal (ORIS) and near-infrared  ...  Acknowledgments This work was supported by the National Research Foundation (NRF) grant funded by the Ministry of Education, Science and Technology (2011-0018042) and Brain Research Center (2011K000284  ... 
doi:10.1364/oe.20.006932 pmid:22453371 fatcat:v6rycvxmabanpotqouowsdb6vm

Cerebral microvascular network geometry changes in response to functional stimulation

Liis Lindvere, Rafal Janik, Adrienne Dorr, David Chartash, Bhupinder Sahota, John G. Sled, Bojana Stefanovic
2013 NeuroImage  
This work yields the first characterization of the spatiotemporal pattern of geometric changes on the level of the cortical microvascular network as a whole and provides the basis for bottom-up modeling  ...  of the hemodynamically-weighted neuroimaging signals.  ...  Chinta for his contributions to image analysis. This work was supported by Canadian Institutes of Health Research (CIHR). Disclosure/conflict of interest The authors declare no conflict of interest.  ... 
doi:10.1016/j.neuroimage.2013.01.011 pmid:23353600 fatcat:es6braeclfbwjpftn7xuz4fp7i

Temporal profiles and 2-dimensional oxy-, deoxy-, and total-hemoglobin somatosensory maps in rat versus mouse cortex

Neal Prakash, Jonathan D. Biag, Sameer A. Sheth, Satoshi Mitsuyama, Jeremy Theriot, Chaithanya Ramachandra, Arthur W. Toga
2007 NeuroImage  
Conclusions-2DOS using image splitting optics is feasible across species for brain mapping and quantifying the map topography of cortical hemodynamics.  ...  However, previous work suggests that the highly cellular dense mouse somatosensory cortex has different functional hemodynamic changes compared to other species.  ...  Acknowledgements This work was supported by NIH: MH52083 (A.T.) and the Adelson Program in Neural Repair and Rehabilitation (N.P.)  ... 
doi:10.1016/j.neuroimage.2007.04.063 pmid:17574868 pmcid:PMC2227950 fatcat:afgynddfxvh2fksigjhb6i7qia

Validating Linear Systems Analysis for Laminar fMRI: Temporal Additivity for Stimulus Duration Manipulations

Jelle A. van Dijk, Alessio Fracasso, Natalia Petridou, Serge O. Dumoulin
2020 Brain Topography  
AbstractAdvancements in ultra-high field (7 T and higher) magnetic resonance imaging (MRI) scanners have made it possible to investigate both the structure and function of the human brain at a sub-millimeter  ...  We thus show that the temporal additivity assumption holds across cortical depth for sub-millimeter gradient-echo BOLD fMRI in early visual cortex.  ...  Introduction Magnetic resonance imaging (MRI) is the dominant method to non-invasively study the structure and function of the living human brain.  ... 
doi:10.1007/s10548-020-00808-y pmid:33210193 fatcat:3pneoahsxvgqjcvytaz5mrkpv4
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