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Extracellular Matrix Remodeling in Virus-Induced Liver Disease. Review

<span title="">2015</span> <i title="Satu Mare College of Physicians"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/kfd3rntd5ffy5eky2hntrarugy" style="color: black;">Medical Connections</a> </i> &nbsp;
Untreated, chronic viral hepatitis evolves into cirrhosis and hepatocellular carcinoma.  ...  In this paper, we aim to discuss the immunological behaviour in chronic liver disease, by analysing the process of hepatic fibrogenesis from the perspective of the complex interactions between factors  ...  The main cause chronic hepatitis is viral infection: hepatitis B virus, hepatitis C virus, and others. Untreated, chronic viral hepatitis may evolve into cirrhosis and hepatocellular carcinoma.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.33311/medcon.2015.33.1.7">doi:10.33311/medcon.2015.33.1.7</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/kp6x3ylwj5fn5cyp5op4jlfqfq">fatcat:kp6x3ylwj5fn5cyp5op4jlfqfq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20220226143703/https://www.medicalconnections.ro/fisiere/0676.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/ef/ae/efaea2f4a4a2b2afaf573c33c4c876c80569eedb.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.33311/medcon.2015.33.1.7"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>

A Comprehensive Analysis of the Dynamic Biological Networks in HCV Induced Hepatocarcinogenesis

Bing He, Hao Zhang, Tieliu Shi, Syed A. Aziz
<span title="2011-04-19">2011</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
Hepatocellular carcinoma (HCC) is a primary malignancy of the liver, which is closely related to hepatitis C and cirrhosis.  ...  By integrating data from protein-protein interactions, transcriptional regulation, and disease related microarray analysis, we carried out a dynamic biological network analysis on the progression of HCV  ...  Conceived and designed the experiments: BH TS. Performed the experiments: BH. Analyzed the data: BH. Contributed reagents/ materials/analysis tools: BH. Wrote the paper: BH HZ TS.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0018516">doi:10.1371/journal.pone.0018516</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/21526182">pmid:21526182</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3079719/">pmcid:PMC3079719</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/wnvp7usa5vfjpp6algkfisuhn4">fatcat:wnvp7usa5vfjpp6algkfisuhn4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20170928150917/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0018516&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/68/e1/68e1f223cf9fbc6a29ff00ebd85a8c5a77b12a7c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0018516"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079719" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Dynamic protein interaction modules in human hepatocellular carcinoma progression

Hui Yu, Chen-Ching Lin, Yuan-Yuan Li, Zhongming Zhao
<span title="">2013</span> <i title="Springer Nature"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/xua5vbjwszdirewaoqnikiu5zm" style="color: black;">BMC Systems Biology</a> </i> &nbsp;
Hepatocellular carcinoma (HCC), which is often interrelated with the Hepatitis C virus, typically develops through multiple stages.  ...  Gene expression profiles have been frequently integrated with the human protein interactome to uncover functional modules under specific conditions like disease state.  ...  The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1752-0509-7-s5-s2">doi:10.1186/1752-0509-7-s5-s2</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24564909">pmid:24564909</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4029569/">pmcid:PMC4029569</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/2jip43a5dze2tlaqeriusubmwa">fatcat:2jip43a5dze2tlaqeriusubmwa</a> </span>
<a target="_blank" rel="noopener" href="https://archive.org/download/pubmed-PMC4029569/PMC4029569-1752-0509-7-S5-S2.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> File Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/1752-0509-7-s5-s2"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4029569" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Identification and functional analysis of a core gene module associated with hepatitis C virus-induced human hepatocellular carcinoma progression

Gaobo Bai, Wenling Zheng, Wenli Ma
<span title="2018-03-09">2018</span> <i title="Spandidos Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/un7oyzvfxnc6tk32ekgnlwouje" style="color: black;">Oncology Letters</a> </i> &nbsp;
Hepatitis C virus (HCV)-induced human hepatocellular carcinoma (HCC) progression may be due to a complex multi-step processes.  ...  The four genes perform an intermediary role between the HCV viral proteins and the dysfunctional module in the HCV key genes interaction network.  ...  Availability of data and materials The datasets analyzed during the current study are available in the Gene Expression Omnibus (GEO) repository (https://www.ncbi.nlm.nih.gov/geo/query/acc. cgi?  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3892/ol.2018.8221">doi:10.3892/ol.2018.8221</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/29725417">pmid:29725417</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5920388/">pmcid:PMC5920388</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/xi34zitmfja4ra5vogp6jyf4ea">fatcat:xi34zitmfja4ra5vogp6jyf4ea</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180725064734/https://www.spandidos-publications.com/ol/15/5/6815/download" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/90/63/906320ff9dadf1bcb9ad59f991e804cf6154cc41.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3892/ol.2018.8221"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5920388" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Identification of CD14 as a potential biomarker of hepatocellular carcinoma using iTRAQ quantitative proteomics

Jiao Guo, Rui Jing, Jian-Hong Zhong, Xin Dong, Yun-Xi Li, Yin-Kun Liu, Tian-Ren Huang, Chun-Yan Zhang
<span title="2017-06-29">2017</span> <i title="Impact Journals, LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yubgl6cdcrekxpjzhshpw23l3i" style="color: black;">OncoTarget</a> </i> &nbsp;
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors without effective diagnostic biomarkers.  ...  Patients with hepatitis B virus (HBV) infection, liver cirrhosis (LC), or HCC together with healthy controls (HC) were enrolled.  ...  The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/oncotarget.18782">doi:10.18632/oncotarget.18782</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/28977922">pmid:28977922</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5617482/">pmcid:PMC5617482</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/giidrllq4jgirmdgb27azu37zm">fatcat:giidrllq4jgirmdgb27azu37zm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180723183135/http://www.oncotarget.com/index.php?journal=oncotarget&amp;page=article&amp;op=download&amp;path%5B%5D=18782&amp;path%5B%5D=60320" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/oncotarget.18782"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5617482" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Altered expression of A20 gene in peripheral blood mononuclear cells is associated with the progression of chronic hepatitis B virus infection

Yu-Chen Fan, Yuan-Yuan Zhang, Yan-Yan Sun, Na Wang, Xiao-Yan Xiao, Kai Wang
<span title="2016-09-13">2016</span> <i title="Impact Journals, LLC"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/yubgl6cdcrekxpjzhshpw23l3i" style="color: black;">OncoTarget</a> </i> &nbsp;
A total of 236 chronic HBV patients were included and consisted of 63 hepatocellular carcinoma (HCC), 87 liver cirrhosis (LC) and 86 chronic hepatitis B (CHB).  ...  A20 is an important negative immune regulator but its role in chronic hepatitis B virus (HBV) infection is still unknown.  ...  In summary, our study demonstrated the dynamic change of A20 gene in different progression of chronic HBV infection ranging from chronic hepatitis, liver cirrhosis to hepatocellular carcinoma, and revealed  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/oncotarget.11993">doi:10.18632/oncotarget.11993</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27634895">pmid:27634895</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC5356592/">pmcid:PMC5356592</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/rlcfpiypsvfjrly7owcc33lvme">fatcat:rlcfpiypsvfjrly7owcc33lvme</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180723141548/http://www.oncotarget.com/index.php?journal=oncotarget&amp;page=article&amp;op=download&amp;path%5B%5D=11993&amp;path%5B%5D=38941" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.18632/oncotarget.11993"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356592" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Mechanism of Hepatitis B Virus Persistence in Hepatocytes and Its Carcinogenic Potential

Maura Dandri, Joerg Petersen
<span title="2016-05-17">2016</span> <i title="Oxford University Press (OUP)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/fqtbedntkradrazql46dneyyry" style="color: black;">Clinical Infectious Diseases</a> </i> &nbsp;
Despite the existence of an effective vaccine, at least 240 million people are chronically infected worldwide, and are at risk of developing liver cirrhosis and hepatocellular carcinoma.  ...  The availability of improved experimental systems and molecular techniques have started to provide new information about the complex network of interactions that HBV establishes within the hepatocyte and  ...  Table 1 . 1 Clinically Relevant Risk Factors for Hepatocellular Carcinoma in Patients With Chronic Hepatitis B Coinfection with hepatitis C virus, hepatitis D virus, or HIV Abbreviations: HBV, hepatitis  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/cid/ciw023">doi:10.1093/cid/ciw023</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/27190317">pmid:27190317</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4889895/">pmcid:PMC4889895</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/iixnqekkffaofogtrhnkj5dpiq">fatcat:iixnqekkffaofogtrhnkj5dpiq</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208005215/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4889895&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/46/e1/46e164430eb1f663cc8367f053b183bbe34f65a9.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1093/cid/ciw023"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> oup.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889895" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Role of Rab GTPases in Hepatocellular Carcinoma

Chun-Cheng Yang, Guang-Xiao Meng, Zhao-Ru Dong, Tao Li
<span title="2021-11-19">2021</span> <i title="Informa UK Limited"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/hgq7eu5nzfe5fpbjc7ntjauyly" style="color: black;">Journal of Hepatocellular Carcinoma</a> </i> &nbsp;
Rab GTPases not only play important roles in genome replication, morphogenesis and the release of hepatitis B virus (HBV) or hepatitis C virus (HCV), but also contribute to hepatitis-related hepatocarcinogenesis  ...  and hepatocellular carcinoma (HCC) progression.  ...  Acknowledgments We thank all of the original studies for sharing their data.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2147/jhc.s336251">doi:10.2147/jhc.s336251</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/34824998">pmid:34824998</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC8610749/">pmcid:PMC8610749</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/dogf4czh4jfmlpfqasdioad3g4">fatcat:dogf4czh4jfmlpfqasdioad3g4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20211128175507/https://www.dovepress.com/getfile.php?fileID=75990" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/63/c7/63c71b400c52e86ad1c1e680b9d4d197bf51a4da.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.2147/jhc.s336251"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8610749" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Lessons from rare tumors: Hepatic lymphoepithelioma-like carcinomas

Antonio Solinas
<span title="">2015</span> <i title="Baishideng Publishing Group Inc."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a3xjvcwxwjb5nmupgyl3jid3em" style="color: black;">World Journal of Gastroenterology</a> </i> &nbsp;
model of interaction between the immune system and neoplastic cells.  ...  Compared with classical hepatocellular carcinoma and intrahepatic cholangiocarcinoma of corresponding stage, lymphoepithelioma-like hepatic carcinomas are characterized by lower rates of recurrence after  ...  LEL-HCC was associated with liver cirrhosis in 13 cases, with hepatitis C virus (HCV) infection in 16 cases, hepatitis B virus (HBV) in 3 cases, and EBV in 1 case.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3748/wjg.v21.i12.3472">doi:10.3748/wjg.v21.i12.3472</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25834311">pmid:25834311</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4375568/">pmcid:PMC4375568</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/yru6dc42wrhaxk56h4ifwdwtiy">fatcat:yru6dc42wrhaxk56h4ifwdwtiy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200207172300/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4375568&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/51/e7/51e7bc2aaaf257662b229459caec5a0059aa875c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3748/wjg.v21.i12.3472"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375568" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Cytokinome profile evaluation in patients with hepatitis C virus infection

Francesca Capone, Eliana Guerriero, Giovanni Colonna, Patrizia Maio, Alessandra Mangia, Giuseppe Castello, Susan Costantini
<span title="2014-07-28">2014</span> <i title="Baishideng Publishing Group Co"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a3xjvcwxwjb5nmupgyl3jid3em" style="color: black;">World Journal of Gastroenterology</a> </i> &nbsp;
The fourth is the comparison of cytokine levels evaluated in patients with chronic hepatitis C virus (HCV) or with HCV-related cirrhosis.  ...  And lastly, we present a comparison of cytokine levels evaluated in patients with HCV-related cirrhosis in the presence and absence of hepatocellular carcinoma.  ...  An interesting example for this phenomenon is chronic hepatitis C virus (HCV) that induces, after some years, the development of liver fibrosis, cirrhosis, and hepatocellular carcinoma (HCC).  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3748/wjg.v20.i28.9261">doi:10.3748/wjg.v20.i28.9261</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25071319">pmid:25071319</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4110556/">pmcid:PMC4110556</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/z6mxmqzlwzb3pbqch2yg73ccdy">fatcat:z6mxmqzlwzb3pbqch2yg73ccdy</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200208062236/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4110556&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/79/5b/795bd217abf4f483ad3481ade716d676995f46c8.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3748/wjg.v20.i28.9261"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110556" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Diffusion of Information throughout the Host Interactome Reveals Gene Expression Variations in Network Proximity to Target Proteins of Hepatitis C Virus

Ettore Mosca, Roberta Alfieri, Luciano Milanesi, Ranjit Ray
<span title="2014-12-02">2014</span> <i title="Public Library of Science (PLoS)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/s3gm7274mfe6fcs7e3jterqlri" style="color: black;">PLoS ONE</a> </i> &nbsp;
Hepatitis C virus infection is one of the most common and chronic in the world, and hepatitis associated with HCV infection is a major risk factor for the development of cirrhosis and hepatocellular carcinoma  ...  Simulating the impact of HCV-host molecular interactions throughout the host protein-protein interaction (PPI) network, we ranked the host proteins in relation to their network proximity to viral targets  ...  Selected the virus-host interaction data and the expression datasets, performed gene expression data analysis, functional annotation, text mining and biological explanation of PPI networks: RA.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0113660">doi:10.1371/journal.pone.0113660</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/25461596">pmid:25461596</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4251971/">pmcid:PMC4251971</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/b3xlzbw5rfem7boawn3ev7xpy4">fatcat:b3xlzbw5rfem7boawn3ev7xpy4</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20171010114659/http://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0113660&amp;type=printable" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/96/d4/96d40c0d8fcdcb2a65ca639346e4868c7aec25e0.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1371/journal.pone.0113660"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> plos.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251971" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Production and pathogenicity of hepatitis C virus core gene products

Hui-Chun Li
<span title="">2014</span> <i title="Baishideng Publishing Group Inc."> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/a3xjvcwxwjb5nmupgyl3jid3em" style="color: black;">World Journal of Gastroenterology</a> </i> &nbsp;
Hepatitis C virus (HCV) is a major cause of chronic liver diseases, including steatosis, cirrhosis and hepatocellular carcinoma, and its infection is also associated with insulin resistance and type 2  ...  The HCV core protein is cleaved first at residue 191 by the host signal peptidase and further cleaved by the host signal peptide peptidase at about residue 177 to generate the mature core protein (a.a.  ...  Role of core protein in hepatocellular carcinoma The major risk factor for the development of HCC in HCV-infected patients is pre-existing cirrhosis.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3748/wjg.v20.i23.7104">doi:10.3748/wjg.v20.i23.7104</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/24966583">pmid:24966583</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC4064058/">pmcid:PMC4064058</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/57wcw33wxza7dp6bdifg5o4axm">fatcat:57wcw33wxza7dp6bdifg5o4axm</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200209140333/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC4064058&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/52/36/52367b8b3561f84b8d567db753d7191b817989a7.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3748/wjg.v20.i23.7104"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> Publisher / doi.org </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4064058" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Epidemiology and Management of Hepatocellular Carcinoma

Ju Dong Yang, Lewis R. Roberts
<span title="">2010</span> <i title="Elsevier BV"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/zkqejxjra5e45e2u7wpthkuxw4" style="color: black;">Infectious Disease Clinics of North America</a> </i> &nbsp;
is relatively low and up to two-thirds of HCCs in these regions are attributable to chronic hepatitis C virus (HCV) infection (see Fig. 1 ). 3 The incidence of HCC has been rapidly increasing in Western  ...  EPIDEMIOLOGY Hepatocellular carcinoma (HCC) is the seventh most common cancer and the third leading cause of cancer-related death worldwide, with an estimated 748,000 new liver cancer cases and 696,000  ...  The role of hepatitis B virus integrations in the pathogenesis of human hepatocellular carcinoma. J Hepatol. 2005; 42(5):760-77. [PubMed: 15826727] 21. Ferber MJ, Montoya DP, Yu C, et al.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.idc.2010.07.004">doi:10.1016/j.idc.2010.07.004</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/20937457">pmid:20937457</a> <a target="_blank" rel="external noopener" href="https://pubmed.ncbi.nlm.nih.gov/PMC3949429/">pmcid:PMC3949429</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/bk347gcxqzejdfegc4xpzxqb6m">fatcat:bk347gcxqzejdfegc4xpzxqb6m</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20200207171610/http://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3949429&amp;blobtype=pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/b1/c6/b1c65390e48c80199dc70b57e074148a8f8b9a7d.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1016/j.idc.2010.07.004"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> elsevier.com </button> </a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3949429" title="pubmed link"> <button class="ui compact blue labeled icon button serp-button"> <i class="file alternate outline icon"></i> pubmed.gov </button> </a>

Proteomics-based identification of TMED9 is linked to vascular invasion and poor prognoses in patients with hepatocellular carcinoma

Yi-Chieh Yang, Ming-Hsien Chien, Tsung-Ching Lai, Min-Che Tung, Yi-Hua Jan, Wei-Ming Chang, Shih-Ming Jung, Ming-Huang Chen, Chun-Nan Yeh, Michael Hsiao
<span title="2021-04-22">2021</span> <i title="Springer (Biomed Central Ltd.)"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/3t63hhfz45hilghgy2elkdj3dq" style="color: black;">Journal of Biomedical Science</a> </i> &nbsp;
Due to the difficulties in early diagnosing and treating hepatocellular carcinoma (HCC), prognoses for patients remained poor in the past decade.  ...  Ours is the first work to identify an oncogenic role of TMED9 in HCC cells and may provide insights into the application of TMED9 as a novel predictor of clinical outcomes and a potential therapeutic target  ...  Tracy Tsai for her assistance with the immunohistochemical work. We also thank Dr. Hao-Jan Lei for providing the HCC patient samples.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12929-021-00727-5">doi:10.1186/s12929-021-00727-5</a> <a target="_blank" rel="external noopener" href="https://www.ncbi.nlm.nih.gov/pubmed/33888099">pmid:33888099</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/7nixq2vcvjfa3ev5r5bt2pojli">fatcat:7nixq2vcvjfa3ev5r5bt2pojli</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20210425155750/https://jbiomedsci.biomedcentral.com/track/pdf/10.1186/s12929-021-00727-5.pdf" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/56/86/56869c3215cbec2b7f769a4a4126808a7c11ce7f.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.1186/s12929-021-00727-5"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="unlock alternate icon" style="background-color: #fb971f;"></i> springer.com </button> </a>

EPIGENETIC MECHANISMS IN HEPATITIS C VIRUS-ASSOCIATED HEPATOCELLULAR CARCINOMA: A POTENTIAL NEW LINK BETWEEN STEM CELLS, VIROLOGY AND CANCER

Feng
<span title="2013-01-01">2013</span> <i title="Science Publications"> <a target="_blank" rel="noopener" href="https://fatcat.wiki/container/qxngzlp6bbdl5ohnlhiv7q5bcm" style="color: black;">Current Research in Medicine</a> </i> &nbsp;
Infection with Hepatitis C Virus (HCV) is a major risk factor for the development of HCC.  ...  Despite the fact that HCV is a RNA virus without a DNA intermediate, recent studies demonstrate that HCV viral proteins may actively participate in epigenetic regulation of hepatic cancer stem cell phenotypes  ...  Identification of genes preferentially methylated in hepatitis C virus-related hepatocellular carcinoma. Cancer Sci., 101: 1501-1510. DOI: 10.1111/j.1349-7006.2010.01549.x Duong, F.H., V.  ... 
<span class="external-identifiers"> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3844/amjsp.2013.21.35">doi:10.3844/amjsp.2013.21.35</a> <a target="_blank" rel="external noopener" href="https://fatcat.wiki/release/da3fsf7vhnda5fvb7nxxe6xf3a">fatcat:da3fsf7vhnda5fvb7nxxe6xf3a</a> </span>
<a target="_blank" rel="noopener" href="https://web.archive.org/web/20180719190219/http://thescipub.com/pdf/10.3844/amjsp.2013.21.35" title="fulltext PDF download" data-goatcounter-click="serp-fulltext" data-goatcounter-title="serp-fulltext"> <button class="ui simple right pointing dropdown compact black labeled icon button serp-button"> <i class="icon ia-icon"></i> Web Archive [PDF] <div class="menu fulltext-thumbnail"> <img src="https://blobs.fatcat.wiki/thumbnail/pdf/9e/fe/9efe7376bf426565b42afe60cf981e59d436e07c.180px.jpg" alt="fulltext thumbnail" loading="lazy"> </div> </button> </a> <a target="_blank" rel="external noopener noreferrer" href="https://doi.org/10.3844/amjsp.2013.21.35"> <button class="ui left aligned compact blue labeled icon button serp-button"> <i class="external alternate icon"></i> Publisher / doi.org </button> </a>
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