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The primary transcriptome of the major human pathogen Helicobacter pylori

Cynthia M. Sharma, Steve Hoffmann, Fabien Darfeuille, Jérémy Reignier, Sven Findeiß, Alexandra Sittka, Sandrine Chabas, Kristin Reiche, Jörg Hackermüller, Richard Reinhardt, Peter F. Stadler, Jörg Vogel
2010 Nature  
Genome sequencing of Helicobacter pylori has revealed the potential proteins and genetic diversity of this prevalent human pathogen, yet little is known about its transcriptional organization and noncoding  ...  Our approach establishes a paradigm for mapping and annotating the primary transcriptomes of many living species.  ...  Author Information Raw data are available from the NCBI Short Read Archive (http://www.ncbi.nlm.nih.gov/Traces/sra) under accession number SRA010186.  ... 
doi:10.1038/nature08756 pmid:20164839 fatcat:linbcircincihktu2buefhq74i

Transcriptome Complexity and Riboregulation in the Human Pathogen Helicobacter pylori

Sandy R. Pernitzsch, Cynthia M. Sharma
2012 Frontiers in Cellular and Infection Microbiology  
The Gram-negative Epsilonproteobacterium Helicobacter pylori is considered as one of the major human pathogens and many studies have focused on its virulence mechanisms as well as genomic diversity.  ...  However, analysis of the H. pylori primary transcriptome using RNA-seq revealed a very complex transcriptional output from its small genome.  ...  ACKNOWLEDGMENTS This publication was funded by the German Research Foundation (DFG) and the University of Würzburg in the funding program Open Access Publishing.  ... 
doi:10.3389/fcimb.2012.00014 pmid:22919606 pmcid:PMC3417511 fatcat:iqzezhnrgreh7br23d26xy2hsu

A bioinformatics approach revealed the transcription factors of helicobacter pylori pathogenic genes and their regulatory network nodes

Yu Bai, Wenliang Li, Guangyu Xu, Guihua Cui
2020 Electronic Journal of Biotechnology  
., A bioinformatics approach revealed the transcription factors of helicobacter pylori pathogenic genes and their regulatory network nodes, Electronic Journal of Biotechnology (2020), https://doi.  ...  Significant mutations of key regulatory factors in the PI3K signaling pathway have been identified in a majority of human tumors.  ...  Introduction Helicobacter pylori is a chronic pathogenic bacterium with a high rate of infection throughout the world.  ... 
doi:10.1016/j.ejbt.2020.04.002 fatcat:qcdp2f5grvga3p6ik4lqatk7gm

Metal homeostasis in pathogenic Epsilonproteobacteria: Mechanisms of acquisition and regulation

Brittni R Kelley, Jacky Lu, Kathryn P Haley, Jennifer A Gaddy, Jeremiah G Johnson
2020 Metallomics  
Epsilonproteobacteria are a diverse class of eubacteria within the Proteobacteria phylum that includes environmental sulfur-reducing bacteria and the human pathogens, Campylobacter jejuni and Helicobacter  ...  These pathogens infect and proliferate within the gastrointestinal tracts of multiple animal hosts, including humans, and cause a variety of disease outcomes.  ...  Zinc Competition for zinc within the host gut during infection is of interest, as the gut is a major site of zinc absorption in humans.  ... 
doi:10.1093/mtomcs/mfaa002 pmid:33570133 pmcid:PMC8043183 fatcat:ueyj7msgijalbotamy44tpzdby

New approaches for Helicobacter vaccine development--difficulties and progress

Elzbieta K Jagusztyn-Krynicka, Renata Godlewska
2008 Polish Journal of Microbiology  
Despite the enormous progress in understanding the process of bacterial pathogenesis and interactions of pathogens with eucaryotic cells the infectious diseases still remain the main cause of human premature  ...  It is now recognized that Helicobacter pylori infects about half of the world's population.  ...  Recently developed strategies allowing analysis of the transcriptome and proteome of eukaryotic cells are promising technologies in studying these issues, especially the Helicobacter pylori effect on the  ... 
pmid:18610650 fatcat:sz6lppadtvbfzomtscl6mlltv4

Parallel evolution of genome structure and transcriptional landscape in the Epsilonproteobacteria

Ida Porcelli, Mark Reuter, Bruce M Pearson, Thomas Wilhelm, Arnoud HM van Vliet
2013 BMC Genomics  
A cross-species comparison of the primary transcriptomes of C. jejuni and the related Epsilonproteobacterium Helicobacter pylori highlighted a lack of conservation of operon organisation, position of intragenic  ...  Here we present the primary transcriptome of the pathogenic Epsilonproteobacterium Campylobacter jejuni, and have used this for comparative and predictive transcriptomics in the Epsilonproteobacteria.  ...  of Liverpool Centre for Genomic Research for 454 sequencing, Vertis Biotech for cDNA library generation, Sacha Lucchini for assistance with microarray analysis, and the members of the IFR Campylobacter  ... 
doi:10.1186/1471-2164-14-616 pmid:24028687 pmcid:PMC3847290 fatcat:cxb2fj5m3rb7tfmakn5afixvki

Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing

Daniel Pohl, Peter M Keller, Valentine Bordier, Karoline Wagner
2019 World Journal of Gastroenterology  
First, the terms "Helicobacter pylori AND transcriptome OR transcriptomic" were searched and yielded 134 results, of which 12 were original research articles meeting the inclusion criteria Table 4  ...  In contrast, using meta-transcriptomics allows to investigate only the viable and transcriptionally active proportion of the human gut microbial community.  ... 
doi:10.3748/wjg.v25.i32.4629 fatcat:gdwtowahrrgfjp2h4ia2feg4t4

Chronic Helicobacter pylori Infection and DNA-Damaged Stem Cells: A Recipe for Disaster

Richard M. Peek
2012 Digestive Diseases and Sciences  
cells using specimens harvested from patients, an important approach since the human stomach represents the primary endogenous ecological niche for H. pylori.  ...  Epidemiologic data supporting the presence of aberrant ß-catenin signaling in the majority of gastric malignancies, in conjunction with evidence that cancer-associated H. pylori cagA ?  ... 
doi:10.1007/s10620-012-2466-z pmid:23108565 pmcid:PMC3558627 fatcat:bq2itmc62bbw7olsoogm7wpbiu

Helicobacter pylori: current status and future prospects

Rachel O'Mahony, Dino Vaira, John Holton, Christelle Basset
2004 Science Progress  
Helicobacter pylori is a global pathogen that causes severe gastrointestinal diseases leading to a significant morbidity and mortality.  ...  One approach is to inhibit the first step in the pathogenic process-adhesion of the organism to the host tissue.  ...  A more recent study has demonstrated that the inhibition of the proliferation of activated primary human CD4+ T cells by VacA is not dependent either on the inhibition of the secretion of IL-2 or the activation  ... 
doi:10.3184/003685004783238481 fatcat:kyxyul6zbrfnzbp6bfycmwxqwq

Campylobacter and helicobacter in the etiology of gastrointestinal diseases

Biljana Miljkovic-Selimovic, Branislava Kocic, Tatjana Babic
2012 Archives of Biological Sciences  
While Helicobacter pylori are restricted to humans, other helicobacter species can be found in different mammals and occasionally in humans.  ...  Several Campylobacter species are recognized as human pathogens, while distinct species are pathogenic only occasionally, in children, the elderly and immunocompromised patients.  ...  INTRODUCTION Originally discovered as etiological agents of animal diseases, campylobacters appear to be one of the most important human pathogens.  ... 
doi:10.2298/abs1204389s fatcat:pxgrlg5stfgp7jcnipz246v7hq

Pathophysiology of H. pylori [chapter]

Karam Dawood, Israa Mamdooh
2021 Esophagitis and Gastritis - Recent Updates  
The source of H. pylori is mostly unknown. H. pylori has a small host range and is present in people and some non-human primates nearly exclusively.  ...  Helicobacter species were known for long as a causative agent of gastritis. H. pylori associated gastritis is characterized by the presence of acute and chronic inflammation.  ...  Interestingly, a major portion of the secreted toxin does not go to the environment, but is bound to the outer membrane of H. pylori.  ... 
doi:10.5772/intechopen.96763 fatcat:44trkb6wnbehxlk4wy2ezx56na

In Vivo Analysis of the Viable Microbiota and Helicobacter pylori Transcriptome in Gastric Infection and Early Stages of Carcinogenesis

Kaisa Thorell, Johan Bengtsson-Palme, Oscar Hsin-Fu Liu, Reyna Victoria Palacios Gonzales, Intawat Nookaew, Linda Rabeneck, Lawrence Paszat, David Y. Graham, Jens Nielsen, Samuel B. Lundin, Åsa Sjöling, Vincent B. Young
2017 Infection and Immunity  
Finally, we quantified the expression of a large number of Helicobacter pylori genes and found high expression of genes involved in pH regulation and nickel transport.  ...  Helicobacter pylori , the causative agent of gastric cancer and duodenal and gastric ulcers, was early associated with gastric disease, but it has also been proposed that the accompanying microbiota in  ...  Sequencing was performed at the Genomics Core Facility, Sahlgrenska Academy, University of Gothenburg, and the Center of Translational Microbiome Research (CTMR), Karolinska Institutet, Stockholm, Sweden  ... 
doi:10.1128/iai.00031-17 pmid:28694295 pmcid:PMC5607399 fatcat:kiwskacnhbeenouhte3eaivp6m

The Dawning Era of Comprehensive Transcriptome Analysis in Cellular Microbiology

Chihiro Aikawa, Fumito Maruyama, Ichiro Nakagawa
2010 Frontiers in Microbiology  
Here we summarize recent studies using these new technologies and discuss the utility of transcriptome analysis.  ...  Information resulting from these high-throughput techniques will continue to provide novel information on the complexity, plasticity, and regulation of bacterial transcriptomes as well as their adaptive  ...  The authors presented a single-nucleotide resolution map of the primary transcriptome of H. pylori through discrimination of primary transcripts with native 5′ (5′PPP) ends from processed species (5′P)  ... 
doi:10.3389/fmicb.2010.00118 pmid:21687718 pmcid:PMC3109594 fatcat:ck2if2udyvhkdp2x7lxc4fklde

MicroRNAs in the interaction between host and bacterial pathogens

Claire Maudet, Miguel Mano, Ana Eulalio
2014 FEBS Letters  
The emerging role of commensal bacteria, as part of the gut microbiota, on host miRNA expression in the presence or absence of bacterial pathogens is also discussed.  ...  Here, we review the current knowledge of bacterial pathogens that modulate host miRNA expression, focusing on mammalian host cells, and the implications of miRNA regulation on the outcome of infection.  ...  Helicobacter pylori H. pylori, a highly prevalent Gram-negative pathogen estimated to chronically infect the gastric mucosa of roughly half the world's population, is the primary etiological cause of gastritis  ... 
doi:10.1016/j.febslet.2014.08.002 pmid:25128459 fatcat:wwki3xhlarb4tcz7lbcbaop4tm

Interactions between gastric epithelial stem cells and Helicobacter pylori in the setting of chronic atrophic gastritis

Jung D Oh, Helene Kling-Bäckhed, Marios Giannakis, Lars G Engstrand, Jeffrey I Gordon
2006 Current Opinion in Microbiology  
Introduction The pathogenesis of H. pylori-associated ChAG ChAG favors interactions between H. pylori and gastric epithelial progenitors Finding shelter: H. pylori liaisons with gastric epithelial progenitors  ...  Prospectus References and recommended reading Acknowledgements References gastritis associated with Helicobacter pylori infection increases risk of gastric cancer, Int J Cancer 109 (2004) , pp. 138-143  ...  Acknowledgements Work cited from the authors' laboratories was supported by grants from the National Institutes of Health (DK58529 and DK63483) and the Swedish Cancer Society (3913-B97-O1XAB).  ... 
doi:10.1016/j.mib.2005.12.013 pmid:16406776 fatcat:f6tdvnicvrh3nolh7m4lf6q3sa
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