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The primary transcriptome of the major human pathogen Helicobacter pylori
2010
Nature
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Genome sequencing of Helicobacter pylori has revealed the potential proteins and genetic diversity of this prevalent human pathogen, yet little is known about its transcriptional organization and noncoding ...
Our approach establishes a paradigm for mapping and annotating the primary transcriptomes of many living species. ...
Author Information Raw data are available from the NCBI Short Read Archive (http://www.ncbi.nlm.nih.gov/Traces/sra) under accession number SRA010186. ...
doi:10.1038/nature08756
pmid:20164839
fatcat:linbcircincihktu2buefhq74i
Transcriptome Complexity and Riboregulation in the Human Pathogen Helicobacter pylori
2012
Frontiers in Cellular and Infection Microbiology
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The Gram-negative Epsilonproteobacterium Helicobacter pylori is considered as one of the major human pathogens and many studies have focused on its virulence mechanisms as well as genomic diversity. ...
However, analysis of the H. pylori primary transcriptome using RNA-seq revealed a very complex transcriptional output from its small genome. ...
ACKNOWLEDGMENTS This publication was funded by the German Research Foundation (DFG) and the University of Würzburg in the funding program Open Access Publishing. ...
doi:10.3389/fcimb.2012.00014
pmid:22919606
pmcid:PMC3417511
fatcat:iqzezhnrgreh7br23d26xy2hsu
A bioinformatics approach revealed the transcription factors of helicobacter pylori pathogenic genes and their regulatory network nodes
2020
Electronic Journal of Biotechnology
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., A bioinformatics approach revealed the transcription factors of helicobacter pylori pathogenic genes and their regulatory network nodes, Electronic Journal of Biotechnology (2020), https://doi. ...
Significant mutations of key regulatory factors in the PI3K signaling pathway have been identified in a majority of human tumors. ...
Introduction Helicobacter pylori is a chronic pathogenic bacterium with a high rate of infection throughout the world. ...
doi:10.1016/j.ejbt.2020.04.002
fatcat:qcdp2f5grvga3p6ik4lqatk7gm
Metal homeostasis in pathogenic Epsilonproteobacteria: Mechanisms of acquisition and regulation
2020
Metallomics
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Epsilonproteobacteria are a diverse class of eubacteria within the Proteobacteria phylum that includes environmental sulfur-reducing bacteria and the human pathogens, Campylobacter jejuni and Helicobacter ...
These pathogens infect and proliferate within the gastrointestinal tracts of multiple animal hosts, including humans, and cause a variety of disease outcomes. ...
Zinc Competition for zinc within the host gut during infection is of interest, as the gut is a major site of zinc absorption in humans. ...
doi:10.1093/mtomcs/mfaa002
pmid:33570133
pmcid:PMC8043183
fatcat:ueyj7msgijalbotamy44tpzdby
New approaches for Helicobacter vaccine development--difficulties and progress
2008
Polish Journal of Microbiology
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Despite the enormous progress in understanding the process of bacterial pathogenesis and interactions of pathogens with eucaryotic cells the infectious diseases still remain the main cause of human premature ...
It is now recognized that Helicobacter pylori infects about half of the world's population. ...
Recently developed strategies allowing analysis of the transcriptome and proteome of eukaryotic cells are promising technologies in studying these issues, especially the Helicobacter pylori effect on the ...
pmid:18610650
fatcat:sz6lppadtvbfzomtscl6mlltv4
Parallel evolution of genome structure and transcriptional landscape in the Epsilonproteobacteria
2013
BMC Genomics
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A cross-species comparison of the primary transcriptomes of C. jejuni and the related Epsilonproteobacterium Helicobacter pylori highlighted a lack of conservation of operon organisation, position of intragenic ...
Here we present the primary transcriptome of the pathogenic Epsilonproteobacterium Campylobacter jejuni, and have used this for comparative and predictive transcriptomics in the Epsilonproteobacteria. ...
of Liverpool Centre for Genomic Research for 454 sequencing, Vertis Biotech for cDNA library generation, Sacha Lucchini for assistance with microarray analysis, and the members of the IFR Campylobacter ...
doi:10.1186/1471-2164-14-616
pmid:24028687
pmcid:PMC3847290
fatcat:cxb2fj5m3rb7tfmakn5afixvki
Review of current diagnostic methods and advances in Helicobacter pylori diagnostics in the era of next generation sequencing
2019
World Journal of Gastroenterology
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First, the terms "Helicobacter pylori AND transcriptome OR transcriptomic" were
searched and yielded 134 results, of which 12 were original research articles meeting
the inclusion criteria
Table 4 ...
In contrast, using meta-transcriptomics allows to investigate only the viable and transcriptionally active proportion of the human gut microbial community. ...
doi:10.3748/wjg.v25.i32.4629
fatcat:gdwtowahrrgfjp2h4ia2feg4t4
Chronic Helicobacter pylori Infection and DNA-Damaged Stem Cells: A Recipe for Disaster
2012
Digestive Diseases and Sciences
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cells using specimens harvested from patients, an important approach since the human stomach represents the primary endogenous ecological niche for H. pylori. ...
Epidemiologic data supporting the presence of aberrant ß-catenin signaling in the majority of gastric malignancies, in conjunction with evidence that cancer-associated H. pylori cagA ? ...
doi:10.1007/s10620-012-2466-z
pmid:23108565
pmcid:PMC3558627
fatcat:bq2itmc62bbw7olsoogm7wpbiu
Helicobacter pylori: current status and future prospects
2004
Science Progress
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Helicobacter pylori is a global pathogen that causes severe gastrointestinal diseases leading to a significant morbidity and mortality. ...
One approach is to inhibit the first step in the pathogenic process-adhesion of the organism to the host tissue. ...
A more recent study has demonstrated that the inhibition of the proliferation of activated primary human CD4+ T cells by VacA is not dependent either on the inhibition of the secretion of IL-2 or the activation ...
doi:10.3184/003685004783238481
fatcat:kyxyul6zbrfnzbp6bfycmwxqwq
Campylobacter and helicobacter in the etiology of gastrointestinal diseases
2012
Archives of Biological Sciences
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While Helicobacter pylori are restricted to humans, other helicobacter species can be found in different mammals and occasionally in humans. ...
Several Campylobacter species are recognized as human pathogens, while distinct species are pathogenic only occasionally, in children, the elderly and immunocompromised patients. ...
INTRODUCTION Originally discovered as etiological agents of animal diseases, campylobacters appear to be one of the most important human pathogens. ...
doi:10.2298/abs1204389s
fatcat:pxgrlg5stfgp7jcnipz246v7hq
Pathophysiology of H. pylori
[chapter]
2021
Esophagitis and Gastritis - Recent Updates
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The source of H. pylori is mostly unknown. H. pylori has a small host range and is present in people and some non-human primates nearly exclusively. ...
Helicobacter species were known for long as a causative agent of gastritis. H. pylori associated gastritis is characterized by the presence of acute and chronic inflammation. ...
Interestingly, a major portion of the secreted
toxin does not go to the environment, but is bound to the outer membrane of
H. pylori. ...
doi:10.5772/intechopen.96763
fatcat:44trkb6wnbehxlk4wy2ezx56na
In Vivo Analysis of the Viable Microbiota and Helicobacter pylori Transcriptome in Gastric Infection and Early Stages of Carcinogenesis
2017
Infection and Immunity
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Finally, we quantified the expression of a large number of Helicobacter pylori genes and found high expression of genes involved in pH regulation and nickel transport. ...
Helicobacter pylori , the causative agent of gastric cancer and duodenal and gastric ulcers, was early associated with gastric disease, but it has also been proposed that the accompanying microbiota in ...
Sequencing was performed at the Genomics Core Facility, Sahlgrenska Academy, University of Gothenburg, and the Center of Translational Microbiome Research (CTMR), Karolinska Institutet, Stockholm, Sweden ...
doi:10.1128/iai.00031-17
pmid:28694295
pmcid:PMC5607399
fatcat:kiwskacnhbeenouhte3eaivp6m
The Dawning Era of Comprehensive Transcriptome Analysis in Cellular Microbiology
2010
Frontiers in Microbiology
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Here we summarize recent studies using these new technologies and discuss the utility of transcriptome analysis. ...
Information resulting from these high-throughput techniques will continue to provide novel information on the complexity, plasticity, and regulation of bacterial transcriptomes as well as their adaptive ...
The authors presented a single-nucleotide resolution map of the primary transcriptome of H. pylori through discrimination of primary transcripts with native 5′ (5′PPP) ends from processed species (5′P) ...
doi:10.3389/fmicb.2010.00118
pmid:21687718
pmcid:PMC3109594
fatcat:ck2if2udyvhkdp2x7lxc4fklde
MicroRNAs in the interaction between host and bacterial pathogens
2014
FEBS Letters
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The emerging role of commensal bacteria, as part of the gut microbiota, on host miRNA expression in the presence or absence of bacterial pathogens is also discussed. ...
Here, we review the current knowledge of bacterial pathogens that modulate host miRNA expression, focusing on mammalian host cells, and the implications of miRNA regulation on the outcome of infection. ...
Helicobacter pylori H. pylori, a highly prevalent Gram-negative pathogen estimated to chronically infect the gastric mucosa of roughly half the world's population, is the primary etiological cause of gastritis ...
doi:10.1016/j.febslet.2014.08.002
pmid:25128459
fatcat:wwki3xhlarb4tcz7lbcbaop4tm
Interactions between gastric epithelial stem cells and Helicobacter pylori in the setting of chronic atrophic gastritis
2006
Current Opinion in Microbiology
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Introduction The pathogenesis of H. pylori-associated ChAG ChAG favors interactions between H. pylori and gastric epithelial progenitors Finding shelter: H. pylori liaisons with gastric epithelial progenitors ...
Prospectus References and recommended reading Acknowledgements References gastritis associated with Helicobacter pylori infection increases risk of gastric cancer, Int J Cancer 109 (2004) , pp. 138-143 ...
Acknowledgements Work cited from the authors' laboratories was supported by grants from the National Institutes of Health (DK58529 and DK63483) and the Swedish Cancer Society (3913-B97-O1XAB). ...
doi:10.1016/j.mib.2005.12.013
pmid:16406776
fatcat:f6tdvnicvrh3nolh7m4lf6q3sa
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