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The predictive value of segmentation metrics on dosimetry in organs at risk of the brain
2021
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In this study, we present results investigating the correlation between popular geometric segmentation metrics and dose parameters for Organs-At-Risk (OAR) in brain tumor patients, and investigate properties ...
that might be predictive for dose changes in brain radiotherapy. ...
Acknowledgement This work was supported by Innosuisse grant number 31274.1 and the Swiss Cancer League. ...
doi:10.48350/158387
fatcat:isanwoyyabaw7kxurfevu76gom
iPhantom: a framework for automated creation of individualized computational phantoms and its application to CT organ dosimetry
[article]
2020
arXiv
pre-print
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Result: iPhantom was validated on both the XCAT (n=50) and an independent clinical (n=10) dataset with similar accuracy. iPhantom precisely predicted all organ locations with good accuracy of Dice Similarity ...
The framework is applied to assess radiation dose to radiosensitive organs in CT imaging of individual patients. ...
layers to preserve the size and information. The last layer is a Softmax function, with the number of the output set as the number of anchor organs types. ...
arXiv:2008.08730v1
fatcat:6loo5tutbvarbbf5ebbgmvwj6e
Analysis of Geometric Performance and Dosimetric Impact of Using Automatic Contour Segmentation for Radiotherapy Planning
2020
Frontiers in Oncology
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brain, to 0.36 for the chiasm of the HN group. ...
Conclusion: Varying AS performance among structures suggests a differential approach of using AS on a subset of structures and focus MS on the rest. ...
INTRODUCTION Accurate and efficient contouring is essential to the quality of treatment planning in radiation therapy because incorrect delineation of the target volume and organs at risk (OARs) can lead ...
doi:10.3389/fonc.2020.01762
pmid:33102206
pmcid:PMC7546883
fatcat:w5wskk66lfgd3jq6paoqgvyjsu
The promise of artificial intelligence and deep learning in PET and SPECT imaging
2021
Physica medica (Testo stampato)
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Finally, the challenges, opportunities, and barriers to full-scale validation and adoption of AI-based solutions for improvement of image quality and quantitative accuracy of PET and SPECT images in the ...
This review sets out to discuss the foremost applications of artificial intelligence (AI), particularly deep learning (DL) algorithms, in single-photon emission computed tomography (SPECT) and positron ...
Acknowledgments This work was supported by the Swiss National Science Foundation under grant SNRF 320030_176052 and the Private Foundation of Geneva University Hospitals under grant RC-06-01. ...
doi:10.1016/j.ejmp.2021.03.008
pmid:33765602
fatcat:onw4fm22y5cxndxiwyy5bdw4t4
OC-0522 Characterising dose changes due to unplanned gas cavities in Magnetic Resonance guided Radiotherapy
2019
Radiotherapy and Oncology
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In addition to dosimetry metrics, delivery parameters including treatment plan geometry, delivery time and monitor units were analysed for the top 50 plans. ...
Figure 1: Waterfall plot of plan scores for the top 50 plans with delivery or planning technique denoted by colour Figure 2: (a) 100% CI (b) 50% CI (c) volume of normal brain receiving 12 Gy and (d) delivery ...
Little work has been done on characterising the dosimetric effects of unplanned gas cavities in MRgRT on Organs At Risk (OAR), which could affect their dose constraints, depending on beam directions and ...
doi:10.1016/s0167-8140(19)30942-9
fatcat:635cux65qfbl7gbzvrs22i2wl4
Use of Normal Tissue Complication Probability Models in the Clinic
2010
International Journal of Radiation Oncology, Biology, Physics
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A summary of organ-specific dose/volume/outcome data, based on the QUANTEC reviews, is included. ...
A "clinician's view" on using the QUANTEC information in a responsible manner is presented along with a description of the most commonly-used normal tissue complication probability (NTCP) models. ...
Acknowledgments Special thanks to Jessica Hubbs for her assistance in the preparation of this manuscript. ...
doi:10.1016/j.ijrobp.2009.07.1754
pmid:20171502
pmcid:PMC4041542
fatcat:w72fmkchxvehdalmoex7u2to5m
Neurotoxic and pharmacokinetic responses to trichloroethylene as a function of exposure scenario
2000
Environmental Health Perspectives
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For the acute effects of TCE on behavior and visual function, the estimated concentration of TCE in blood at the time of testing correlated well with outcomes, whereas cumulative exposure, measured as ...
Examination of all three measures of neurotoxicity showed that if Haber's Rule were used to predict outcomes across exposure durations, the risk would be overestimated when extrapolating from shorter to ...
TCEA was chosen as the dose metric because of its close relationship to target organ (brain) concentration and because of the ready accessibility of blood from experimental animals. ...
doi:10.1289/ehp.00108s2317
pmid:10807561
pmcid:PMC1637762
fatcat:2qzdcayaw5fk3nchw3glh2ixiu
Development and Validation of an Age-Scalable Cardiac Model with Substructures for Dosimetry in Late-Effects Studies of Childhood Cancer Survivors
2020
Radiotherapy and Oncology
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In order to develop substructure dose-response models, the heart model previously used for pediatric cohort dosimetry needed enhancement and substructure delineation. ...
Emerging data suggest that dose to cardiac substructures may be more predictive than whole heart metrics. ...
Sarah Bronson from Scientific Publications, Research Medical Library, The University of Texas MD Anderson Cancer Center, for assistance in editing this manuscript. ...
doi:10.1016/j.radonc.2020.10.017
pmid:33075392
pmcid:PMC8132170
fatcat:o2vmort2uzejjbxksedcogfe4m
Overview of the First NRG-NCI Workshop on Dosimetry of Systemic Radiopharmaceutical Therapy (RPT)
2020
Journal of Nuclear Medicine
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In this proceedings, we review the main approaches that are applied clinically to calculate the absorbed dose: These include absorbed doses calculated over a variety of spatial scales including organ, ...
strategies of dosimetry for future clinical trials. ...
This often results in uncertainties in the reporting of the resulting absorbed dose delivered to the tumor volumes and the normal organs including organs at risk given individual patient pharmacokinetics ...
doi:10.2967/jnumed.120.255547
pmid:33277396
pmcid:PMC8833877
fatcat:72h636ohqfhqtjd5sviouls65y
Novel Clinically Weight-Optimized Dynamic Conformal Arcs (WO-DCA) for Liver SBRT: A Comparison with Volumetric Modulated Arc Therapy (VMAT)
2021
Therapeutics and Clinical Risk Management
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Weight of the two arcs using optimization method was adjusted between the arcs to maximize tumor coverage and protect organs at risk (OAR) based on the RTOG-0438 protocol. ...
Similarly, the WO-DCA technique additionally reduced the beam-on time (3.26 vs 4.43; P < 0.001) and monitor unit (1860 vs 2705 for VMAT; P < 0.001) values significantly. ...
to the target volume while sparing healthy liver tissue and the organs at risk (OAR) with extraordinary sensitivity and low toxicity profile, 6-10 specifically with a mild acceptable risk of radiation-induced ...
doi:10.2147/tcrm.s328375
pmid:34611405
pmcid:PMC8487279
fatcat:sfmdxk66bvfonnqek42wehaxj4
Impact of the accuracy of automatic tumour functional volume delineation on radiotherapy treatment planning
2012
Physics in Medicine and Biology
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The different algorithms and resulting plans were compared in terms of segmentation errors and ground-truth volume coverage using different metrics (V 95 , D 95 , homogeneity index and conformity index ...
The objective of this study is to compare different methods in terms of dosimetry. For such comparison, a gold-standard is needed. For this purpose realistic GATE simulated PET images were used. ...
The constraints to the organs at 180 risk (OARs) considered for the IMRT plans are summarized in Tables 1 and 2. ...
doi:10.1088/0031-9155/57/17/5381
pmid:22864012
fatcat:ek2qlbnzjbafhipiny7eslpury
Verification of IMRT and RapidArc Localized Prostate Cancer Treatment Plans Using EPID and Delta4 in vivo Dosimetry Methods
2021
Middle East Journal of Cancer
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Quality assurance for intensity modulated radiation therapy (IMRT) depends on the type of dosimetry system and its evaluation procedure. ...
Delta4 dosimetry system was assessed with RapidArc plan; the agreement between the measured and planned doses was ±1% and gamma analysis resulted in 100% data points with the same agreement conditions. ...
Acknowledgments All of the authors would like to thank the anonymous reviewers for their helpful comments on the original manuscript. ...
doi:10.30476/mejc.2020.84706.1226
doaj:13b173f086ff4b9c9d958727f1b53b75
fatcat:shqcsjkmc5fbhjsmfdsk645sey
Internal radiation dosimetry of a 152Tb-labeled antibody in tumor-bearing mice
2019
EJNMMI Research
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MicroPET-based dosimetry of 152Tb is feasible, and the comparison with organ harvesting resulted in acceptable dose discrepancies for body districts that can be segmented on CT. ...
segmented on CT. ...
Acknowledgements Preliminary results of this paper were reported as an oral presentation at the 30th Annual Congress of the European Association of Nuclear Medicine (EANM 2017) and published in an abstract ...
doi:10.1186/s13550-019-0524-7
pmid:31187358
pmcid:PMC6560118
fatcat:pakjiyxxgvfjzerm5wwq5dhsqa
AAPM Spring Clinical Meeting - Abstract
2021
Journal of Applied Clinical Medical Physics
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However, the conformal dose provided by SRS can prove helpful in avoiding the several organs at risk near the pituitary. ...
Conclusion: On average, PCIs and HIs are comparable between VMAT and HA plans. CI and GI improvements indicate potential superior sparing of organs at risk. ...
Results: Comparable target and organ-at-risk (OAR) DVH metrics were observed in the HIPO and robust plans at baseline. ...
doi:10.1002/acm2.13289
pmid:34002941
fatcat:6oivewssf5gwnnztmhff4nldle
Radiation dosimetry of 18F-AzaFol: A first in-human use of a folate receptor PET tracer
2020
EJNMMI Research
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E in-human exceeded the value of 14.0 μSv/MBq extrapolated from pre-clinical data. ...
TOF-PET images were acquired at 3, 11, 18, 30, 40, 50, and 60 min after the intravenous injection of 327 MBq (range 299-399 MBq) of 18F-AzaFol to establish dosimetry. ...
Annette Krämer for the GMP synthesis of the 18
Availability of data and materials The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable ...
doi:10.1186/s13550-020-00624-2
pmid:32270313
fatcat:cdf4jeijpbfphocamnbnbk2e6u
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