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The phenotypic expansion and its boundaries [article]

Geoffroy Berthelot
2014 arXiv   pre-print
Here we investigated the following human boundaries: development of performances with time in Olympic and non-Olympic events, development of sport performances with aging among humans and others species  ...  The development of sport performances in the future is a subject of myth and disagreement among experts.  ...  THE PHENOTYPIC EXPANSION chess careers.  ... 
arXiv:1401.7474v1 fatcat:oaveibg3erfu5fdcuwn3wcl3iy

Morpholino artifacts provide pitfalls and reveal a novel role for pro-apoptotic genes in hindbrain boundary development

Sebastian S. Gerety, David G. Wilkinson
2011 Developmental Biology  
and its downstream apoptotic effectors.  ...  We find that the pro-apoptotic Bcl genes puma and bax-a are required for hindbrain boundary marker expression, and that gain of function of the Bcl-caspase pathway leads to ectopic boundary marker expression  ...  Acknowledgments We thank Jim Smith for advice and comments on the manuscript, Reinhard Koster for the Krox20::GAL4 line, and NIMR Biological Services for zebrafish husbandry.  ... 
doi:10.1016/j.ydbio.2010.11.030 pmid:21145318 pmcid:PMC3111810 fatcat:5vrkoefoazci3jis454stbwhou

Epithelial relaxation mediated by the myosin phosphatase regulator Mypt1 is required for brain ventricle lumen expansion and hindbrain morphogenesis

J. H. Gutzman, H. Sive
2010 Development  
By contrast, mutants show continuously high pMRLC levels, with concentration of pMRLC and myosin II at the apical side of the epithelium, and myosin II and actin concentration at rhombomere boundaries.  ...  We demonstrate that in the zebrafish hindbrain, cell shape, rhombomere morphogenesis and, unexpectedly, brain ventricle lumen expansion depend on the contractile state of the neuroepithelium.  ...  for the kind gift of the Competing interests statement The authors declare no competing financial interests.  ... 
doi:10.1242/dev.042705 pmid:20147380 pmcid:PMC2827689 fatcat:eo2o2z7blzhuzngsdjerdwq6su

Epigenetics of fragile X syndrome and fragile X-related disorders

Claudine M Kraan, David E Godler, David J Amor
2018 Developmental Medicine & Child Neurology  
between this version and the Version of Record.  ...  This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences  ...  ACKNOWLEDGEMENTS The authors have stated that they had no interest that could be perceived as posing a conflict or bias.  ... 
doi:10.1111/dmcn.13985 pmid:30084485 fatcat:cf7s3i4udzgqvkmloqm43km22q

Page 408 of The Plant Journal Vol. 23, Issue 3 [page]

2000 The Plant Journal  
This phenotype and the expres- sion of SUP adjacent to the boundary between the third and the fourth whorl suggest that it piays a role in maintaining the boundary between these floral whorls.  ...  The altered phenotypes of the transgenic flowers, which display reduced stamen filament length and smaller petals, point to a novel function of SUP as a regulator of cell expansion.  ... 

Role of bacterial persistence in spatial population expansion [article]

Pintu Patra, Stefan Klumpp
2021 bioRxiv   pre-print
We study the spatial expansion of a population with stochastic switching between two phenotypes in spatially homogeneous conditions and in the presence of an antibiotic barrier.  ...  The interplay of population dynamics at the interface separating the two environments and phenotype switching in the antibiotic region results in a optimal switching rate.  ...  FIG. 4 : 4 (a) Persister fraction at the boundary of growth and antibiotic regions as function of the phenotype switching rate (open circles).  ... 
doi:10.1101/2021.03.16.435668 fatcat:pii7i5gjd5gztf7dkia7gym5yy

Identification of 11-amino acid peptides that disrupt Notch-mediated processes in Drosophila

Haiwei Pi, Yi-Chun Huang, I-Chun Chen, Chung-De Lin, Hsiao-Fong Yeh, Li-Mei Pai
2011 Journal of Biomedical Science  
We also found that pri/tal mRNA is expressed in the DV boundary and the longitudinal proveins, and overexpression of Pri/Tal peptides disrupts the DV boundary formation and helps to expand the width of  ...  Cut and E(spl)mb are target genes of the Notch pathway in DV boundary formation and vein specification, respectively.  ...  Wang and all the members of Pi's laboratory for discussion and technical support.  ... 
doi:10.1186/1423-0127-18-42 pmid:21682860 pmcid:PMC3136413 fatcat:47fyzdculjecpppfn4iljfiprq

Mimics without models: causes and consequences of allopatry in Batesian mimicry complexes

D. W. Pfennig, S. P. Mullen
2010 Proceedings of the Royal Society of London. Biological Sciences  
Batesian mimicry evolves when a palatable species (the 'mimic') co-opts a warning signal from a dangerous species (the 'model') and thereby deceives its potential predators.  ...  Yet, many mimics violate this prediction and occur in areas where their model is absent. Here, we discuss the causes and consequences of such allopatric mimics.  ...  (c) Range expansion and gene flow Range expansion and/or gene flow by mimics from sympatry into allopatry might maintain mimetic phenotypes in allopatry.  ... 
doi:10.1098/rspb.2010.0586 pmid:20484238 pmcid:PMC2982051 fatcat:cdbmbke2bzhehcidaiqqiezwt4

Propagule Limitation, Disparate Habitat Quality, and Variation in Phenotypic Selection at a Local Species Range Boundary

Kara A. Moore, Maureen L. Stanton, Tadashi Fukami
2014 PLoS ONE  
for adaptive range expansion, even across a very local population boundary.  ...  for selection, and selection on phenotypic traits.  ...  This study population and the habitat zones at its boundary (described below) are characteristic of other Gilia population boundaries in grasslands both locally and regionally.  ... 
doi:10.1371/journal.pone.0089404 pmid:24717472 pmcid:PMC3981700 fatcat:r57a5ziqzrfejoofilsoex774m

Apc1 is required for maintenance of local brain organizers and dorsal midbrain survival

Judith T.M.L. Paridaen, Catherine Danesin, Abu Tufayal Elas, Sandra van de Water, Corinne Houart, Danica Zivkovic
2009 Developmental Biology  
Caudal expansion of Fgf8 from IsO into the cerebellum is accompanied by hyperproliferation and abnormal cerebellar morphogenesis.  ...  Chemical activation of the Wnt/β-catenin in wild-type embryos during late brain maintenance stages phenocopies the IsO and tectal phenotypes of the apc mutants.  ...  Oliveira and I. Wibowo for technical assistance. We are indebted to H. Clevers and B. Hogan for commenting on the manuscript. We thank R. Dorsky and R. Moon for providing TOPdGFP fish, R.  ... 
doi:10.1016/j.ydbio.2009.04.022 pmid:19397905 fatcat:xfej4drqwvh2pgbsocbdgu3bsa

Spatial Genetic Structure Patterns of Phenotype-Limited and Boundary-Limited Expanding Populations: A Simulation Study

Qiang Dai, Xiangjiang Zhan, Bin Lu, Jinzhong Fu, Qian Wang, Dunwu Qi, Norman Johnson
2014 PLoS ONE  
Using individual-based models, we examined spatial genetic patterns under two expansion scenarios, boundary-limited range expansions (BLRE) and phenotype-limited range expansions (PhLRE).  ...  It is possible that that the number of homogeneous domains was determined by the interaction of merging and newly emerging homogeneous domains.  ...  Author Contributions Conceived and designed the experiments: QD BL JF DQ. Performed the experiments: QD. Analyzed the data: QD QW DQ. Contributed reagents/ materials/analysis tools: QD.  ... 
doi:10.1371/journal.pone.0085778 pmid:24465700 pmcid:PMC3896401 fatcat:tf45n32lajhtvdyn62svw5vogq

A conserved function for Arabidopsis SUPERMAN in regulating floral-whorl cell proliferation in rice, a monocotyledonous plant

Ashis Kumar Nandi, Kumuda Kushalappa, Kalika Prasad, Usha Vijayraghavan
2000 Current Biology  
We predict that SUP is a conserved regulator of floral whorl boundaries and that it affects cell proliferation.  ...  The Arabidopsis gene SUPERMAN (SUP), which encodes a putative transcription factor, maintains the boundary between stamens and carpels [3-5], possibly by regulating cell proliferation.  ...  Sakai and E. Meyerowitz for the SUP cDNA. The SEM facility of the Department of Metallurgy, IISc., and input from our laboratory members is gratefully acknowledged. T. Ito, H. Sakai, D. Weigel, J.  ... 
doi:10.1016/s0960-9822(00)00341-9 pmid:10704413 fatcat:mp4s4yn4ubaeleg3yj4qxsl62a

The Time is Crucial for Ex Vivo Expansion of T Regulatory Cells for Therapy

Natalia Marek, Maria Bieniaszewska, Adam Krzystyniak, Jolanta Juścińska, Jolanta Myśliwska, Piotr Witkowski, Andrzej Hellmann, Piotr Trzonkowski
2011 Cell Transplantation  
Here, we followed expanding CD4 + CD25 high CD127 − Tregs and their naive (CD45RA + ) and memory-like (CD45RA − ) subsets in order to establish the best conditions of the expansion.  ...  However, due to the plasticity of Tregs lineage and artificial environment present during ex vivo expansion, Tregs easily lose suppressive activity.  ...  In fact, it should not be surprising as Tregs are not exceptional and like other CD4 + T cells may transform to other phenotypes, the effect called plasticity (36).  ... 
doi:10.3727/096368911x566217 pmid:21457615 fatcat:fi4itkf6tfcanmgemjtnzkemda

Three Brick genes have distinct functions in a common pathway promoting polarized cell division and cell morphogenesis in the maize leaf epidermis

M. J. Frank
2003 Development  
for its use as a marker for mosaic analysis, the Maize Genetics Coop. for seeds and RFLP markers, Nam-Hai Chua for the pYSC14 GFP-talin plasmid, the Torrey Mesa Research Institute for use of their particle  ...  gun, and Shiping Zhang for his help with use of the gun.  ...  By analogy to its well-established role in tip growth, it has been proposed that the primary role of F-actin in diffusely growing cells is to guide the deposition of secreted wall components (Baskin and  ... 
doi:10.1242/dev.00290 pmid:12506005 fatcat:dt7skk3advhnfiaesklye2aoq4

The tumour suppressor gene l(2)giant discs is required to restrictthe activity of Notch to the dorsoventral boundaryduring Drosophila wing development

Thomas Klein
2003 Developmental Biology  
In the absence of lgd function, the activity of Notch expands from its initial domain at the D/V boundary.  ...  During the development of the Drosophila wing, the activity of the Notch signalling pathway is required to establish and maintain the organizing activity at the dorsoventral boundary (D/V boundary).  ...  This effect is biased, and the expansion toward the D/V boundary is stronger.  ... 
doi:10.1016/s0012-1606(02)00052-0 pmid:12648493 fatcat:oq74x6k7irhtnps3uvo5th7jt4
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