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Compensatory cerebral adaptations before and evolving changes after surgical decompression in cervical spondylotic myelopathy

Yun Dong, Langston T. Holly, Richard Albistegui-Dubois, Xiaohong Yan, Jonathan Marehbian, Jennifer M. Newton, Bruce H. Dobkin
2008 Journal of Neurosurgery : Spine  
The patients improved after surgery on the modified Japanese Orthopaedic Association score for the upper extremity, which correlated with the changes in task-associated activation in specific sensorimotor  ...  Object-The goal of this study was to compare cortical sensorimotor adaptations associated with neurological deterioration and then recovery following surgical decompression for cervical spondylotic myelopathy  ...  Acknowledgments The authors thank Dr. Tom Rockwell for his generous financial support, and Dr. Allan Wu for his help with customizing the DataWizard software for force data analysis. Disclosure  ... 
doi:10.3171/spi.2008.10.0831 pmid:19035745 pmcid:PMC4090101 fatcat:2jdhiwm4dbbnvhl6bcwd5xgqha

Cortical reorganisation in patients with MS

M Filippi
2004 Journal of Neurology, Neurosurgery and Psychiatry  
This is shown in patients with a previous episode of isolated acute myelitis of probable demyelinating origin and lack of brain damage 35 and in patients with neuromyelitis optica. 36 In both these  ...  or, in case of motor tasks, passive movements have been used as the experimental paradigm. 22 Does fMRI disclose abnormal patterns of cortical activations in patients with MS?  ...  proteins. 3 4 Thus, detection of antineuronal autoantibodies in a patient with a progressive neurological disorder may allow the diagnosis of a paraneoplastic syndrome and also provide information about  ... 
doi:10.1136/jnnp.2004.036020 pmid:15258204 pmcid:PMC1739161 fatcat:vecowp5lofci5b7bfs7mfxnogu

Recommended diagnostic criteria for paraneoplastic neurological syndromes

J E Greenlee
2004 Journal of Neurology, Neurosurgery and Psychiatry  
This is shown in patients with a previous episode of isolated acute myelitis of probable demyelinating origin and lack of brain damage 35 and in patients with neuromyelitis optica. 36 In both these  ...  or, in case of motor tasks, passive movements have been used as the experimental paradigm. 22 Does fMRI disclose abnormal patterns of cortical activations in patients with MS?  ...  proteins. 3 4 Thus, detection of antineuronal autoantibodies in a patient with a progressive neurological disorder may allow the diagnosis of a paraneoplastic syndrome and also provide information about  ... 
doi:10.1136/jnnp.2004.038489 pmid:15258205 pmcid:PMC1739162 fatcat:5z2h5itf55emromqop7hp67jh4

Update on neuromyelitis optica: natural history and management

Panitha Jindahra, Gordon Plant
2012 Eye and Brain  
It can involve the optic nerve, the spinal cord and beyond. Here we review its pathophysiology, clinical features, and therapy.  ...  The results were from a woman who presented with a 4 week history of marked right leg weakness and numbness, followed by burning pain in the same area and urinary incontinence.  ...  Optic nerve and spinal cord involvement Pathophysiology In NMO, the involvement of the spinal cord and optic nerves or chiasm has been commonly reported but there is increasing evidence that isolated or  ... 
doi:10.2147/eb.s8392 pmid:28539779 pmcid:PMC5436187 fatcat:afth4xf2s5eobkv5zfvdv65f7u

Muscle Activation Patterns During Movement Attempts in Children With Acquired Spinal Cord Injury: Neurophysiological Assessment of Residual Motor Function Below the Level of Lesion

Darryn A. Atkinson, Laura Mendez, Natalie Goodrich, Sevda C. Aslan, Beatrice Ugiliweneza, Andrea L. Behrman
2019 Frontiers in Neurology  
Results: Evidence of intentional leg muscle activation below the level of lesion was found in 11/24 children with SCI, and was classified based on activation pattern.  ...  Activation of the erector spinae muscles, recorded at the T10-T12 vertebral level, was observed in all children with SCI, regardless of injury level or severity.  ...  Pediatric Neurorecovery clinic at Frazier Rehab Institute and the Kosair Charities Center for Pediatric NeuroRecovery, and the Kentucky Spinal Cord Injury Research Center.  ... 
doi:10.3389/fneur.2019.01295 pmid:31920919 pmcid:PMC6933608 fatcat:iayxhzyxqrhbjilce4jnv4w2fa

Abnormal intrinsic functional activity in patients with cervical spondylotic myelopathy a resting state fMRI study

Cuili Kuang, Yunfei Zha
2019 Neuropsychiatric Disease and Treatment  
These observed intrinsic functional changes in the patients with CSM may be related to functional reorganization and reflect the innate cortical plasticity in patients with CSM.  ...  Lastly, we computed correlations between the altered zALFF, zReHo, and functional connectivity with Japanese Orthopaedic Association scores, Neck Disability Index score, and the duration of symptoms in  ...  This work was supported by Renmin Hospital of Wuhan University. This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.  ... 
doi:10.2147/ndt.s209952 pmid:31686821 pmcid:PMC6708884 fatcat:maheg4m4vzgupbkghgwmvgbdqy

MRI Prognostic Factors in Multiple Sclerosis, Neuromyelitis Optica Spectrum Disorder, and Myelin Oligodendrocyte Antibody Disease

Rosa Cortese, Antonio Giorgio, Gianmarco Severa, Nicola De Stefano
2021 Frontiers in Neurology  
and monitor patients with MS and other inflammatory demyelinating diseases, in particular, NMOSD and MOGAD.  ...  Moreover, the process of identifying new effective therapies for MS patients has been supported by the use of serial MRI examinations in order to sensitively detect the sub-clinical effects of disease-modifying  ...  In MOGAD patients, volumetric cord measures were lower in those with a relapsing course, even in the case of relapses not involving the spinal cord (57).  ... 
doi:10.3389/fneur.2021.679881 pmid:34867701 pmcid:PMC8636325 fatcat:hktdfscaevfz3pppabwiba7nla

Pactrims Invited Lecture / Ordinary Submission

2015 Multiple Sclerosis  
Although neurological involvement of BD is not uncommon, little is known about involvement of spinal cord. Herein we present three cases of transverse myelitis (TM) with BD.  ...  Furthermore, patients with spinal cord syndrome had a lower level of vitamin D 3 in comparison with patients with optic neuritis [11.30±6.82 ng/ml vs. 14.00±10.27 ng/ml, P=0.03].  ...  Conclusions: We report a case of fulminant onset CNS vasculitis after spinal cord involvement.  ... 
doi:10.1177/1352458514563659 pmid:28080249 fatcat:pil4lerkprbv7hc4qitoqsitgm

The Neurological Manifestations of Sjögren's Syndrome: Diagnosis and Treatment [chapter]

Robert I. Fox, Julius Birnbaum
2011 Sjögren's Syndrome  
This chapter addresses the: (a) clinical neurological presentation, (b) laboratory investigation, and (c) treatment of peripheral and central nervous system disease associated with Sjögren's syndrome.  ...  MR Imaging of the Spinal Cord Spinal cord magnetic resonance imaging may be abnormal in patients with sensory ataxic neuropathy with T2* hyperintensities in the fasciculus cuneatus and gracilis (57, 71  ...  A paradoxical finding was that spinal cord MRI's showing postgadolinium enhancement was seen more frequently in patients with white matter myelitis, despite the tendency of white matter myelitis to occur  ... 
doi:10.1007/978-1-60327-957-4_22 fatcat:ed7ekgm7tjdspoesaryxyzsfh4

Proceedings of the Association of British Neurologists, University of Keele, 15-16 April 1993

1993 Journal of Neurology, Neurosurgery and Psychiatry  
Twenty three (60%) showed abnormalities previously associated with thrombotic tendencies. Twelve (32%) of the 38 had lupus anticoagulants, ten (26%) had abnormally high fibrinogen levels.  ...  Patients were screened with US to exclude those with less than 30% stenosis of the symptomatic carotid artery.  ...  A five year follow up study was performed on 70 white patients presenting with isolated neurological syndromes of the optic nerve, brainstem or spinal cord to assess the risk of progression to multiple  ... 
doi:10.1136/jnnp.56.6.724 fatcat:ohxobea7d5dibhwafodxfaklme

Proprioceptive Facilitation Technics for Treatment of Paralysis*

Herman Kabat, Margaret Knott
1953 Physical Therapy  
in dicates facilitation at the spinal level.  ...  One of the fundamental principles of function ing of the reflex centers in the spinal cord is induction.  ... 
doi:10.1093/ptj/33.2.53 pmid:13026412 fatcat:ta26regm2rdhpmaovxnswd2ouu

Role of MRI in multiple sclerosis I: inflammation and lesions

Robert Zivadinov
2004 Frontiers in Bioscience  
In contrast, non-MS myelitis lesions typically involve multiple contiguous spinal levels and more than one-half of the cord diameter (26). This is seen, for example, in Devic's disease.  ...  The lesion is classic for MS, involving less than one spinal level and less than one-half of the cord diameter.  ... 
doi:10.2741/1251 pmid:14766399 fatcat:be5nm4fsore3llnriijlr67weq

Stem and progenitor cell–based therapy of the human central nervous system

Steve Goldman
2005 Nature Biotechnology  
Diseases of the brain and spinal cord represent especially daunting challenges for cell-based strategies of repair, given the multiplicity of cell types in the adult central nervous system (CNS) and the  ...  This review focuses on the potential utility of neural stem and progenitor cells as substrates for structural repair of the brain and the spinal cord.  ...  Cell-based treatments for spinal cord trauma. Spinal cord injury is associated with the loss of both neurons and glia.  ... 
doi:10.1038/nbt1119 pmid:16003375 fatcat:vv2v22hgjjd5venccfmjvwyh2q

World Federation of Neurology

1960 British Journal of Radiology  
Acknowledgments The authors thank Dr. Phil Anslow for the MR images and Dr. Peggy Frith for the images of Behçet disease. Acknowledgment  ...  Progressive Spinal Cord Syndromes The progressive spinal cord syndromes are described in the section on transverse myelitis.  ...  In clinically isolated syndromes, the prevalence of spinal-cord lesions is lower, especially if no spinal-cord symptoms are present (30%-40%).  ... 
doi:10.1259/0007-1285-33-392-528 fatcat:zalhdznc3reuhexm7y2ulvyz6i

2014 Joint ACTRIMS-ECTRIMS Meeting (MSBoston 2014): Oral Presentations

2014 Multiple Sclerosis  
At T1, thalamo-cortical FC showed significant different patterns in the intervention group when compared with controls.  ...  Clinical variables were entered into a one-sample model to calculate correlations with FC in the patient group (cluster level p< 0.05, FWE corrected).  ...  In MS, many patients exhibit lesions in the brain with minimal involvement of the spinal cord, and a small percentage of patients exhibit lesions predominantly in the spinal cord with less lesion involvement  ... 
doi:10.1177/1352458514546076 pmid:25205047 pmcid:PMC4518813 fatcat:5giyc6lpwrdhzgjat3fhfcfcmi
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