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Circular RNAs Are Regulators of Diverse Animal Transcriptomes: One Health Perspective

Dora Zucko, Kathleen Boris-Lawrie
2020 Frontiers in Genetics  
- to improve the health and productivity of food animals and generate translational knowledge in animal species.  ...  By titrating microRNAs and RNA binding proteins, circRNA interconnect networks of competing endogenous RNAs.  ...  Linear polymers of DNA and RNA convey the flow of genetic information, whereas circularized forms of DNA and RNA serve regulatory roles in all domains of life.  ... 
doi:10.3389/fgene.2020.00999 pmid:33193584 pmcid:PMC7531264 fatcat:cb7sldufjvf3zg3ldyqpgua3iq

Protein-Related Circular RNAs in Human Pathologies

Olga Wawrzyniak, Żaneta Zarębska, Konrad Kuczyński, Anna Gotz-Więckowska, Katarzyna Rolle
2020 Cells  
Circular RNAs (circRNAs) are a distinct family of RNAs derived from alternative splicing which play a crucial role in regulating gene expression by acting as microRNA (miRNA) and RNA binding protein (RBP  ...  We present the properties and functions of circRNAs, the possible mechanisms of their translation abilities, and the emerging functions of circRNA-derived peptides in human pathologies.  ...  Acknowledgments: We would like to thank Mateusz Starosta for creating and adjusting the illustrations. Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/cells9081841 pmid:32781555 fatcat:dd3kimgrwjcstdwdmtuu3iw6nm

Circular RNA: metabolism, functions and interactions with proteins

Wei-Yi Zhou, Ze-Rong Cai, Jia Liu, De-Shen Wang, Huai-Qiang Ju, Rui-Hua Xu
2020 Molecular Cancer  
Hence, in this review, we briefly summarize recent progress in the metabolism and functions of circRNAs and elaborately discuss the patterns of circRNA-protein interactions, including altering interactions  ...  AbstractCircular RNAs (CircRNAs) are single-stranded, covalently closed RNA molecules that are ubiquitous across species ranging from viruses to mammals.  ...  Later, more studies found or synthesized circular forms of RNAs in various species, including viruses [3] , prokaryotes [4] , unicellular eukaryotes [4, 5] and mammals [6] .  ... 
doi:10.1186/s12943-020-01286-3 pmid:33317550 fatcat:bvejso46hrcybnt7byz6lvpuea

Genome-wide profiling of Sus scrofa circular RNAs across nine organs and three developmental stages

Guoming Liang, Yalan Yang, Guanglin Niu, Zhonglin Tang, Kui Li
2017 DNA Research  
The spatio-temporal expression patterns of Circular RNA (circRNA) across organs and developmental stages are critical for its function and evolution analysis.  ...  , and ATP hydrolysis-coupled proton transport; moreover, this set of genes was markedly enriched in genes involved in tight junctions and the calcium signalling pathway.  ...  Acknowledgements This work was supported by National Key Basic Research Program of China (2014CB138504, 2015CB943101), National Natural Science Foundation of China (31171192, 31330074), the Agricultural  ... 
doi:10.1093/dnares/dsx022 pmid:28575165 pmcid:PMC5737845 fatcat:pverbdr2rncjdpud6onrwwhcee

Colorectal Cancer: From the Genetic Model to Posttranscriptional Regulation by Noncoding RNAs

María Antonia Lizarbe, Jorge Calle-Espinosa, Eva Fernández-Lizarbe, Sara Fernández-Lizarbe, Miguel Ángel Robles, Nieves Olmo, Javier Turnay
2017 BioMed Research International  
We present a general overview of what is known about these molecules and their role and dysregulation in cancer, with a special focus on the biogenesis, characteristics, and function of microRNAs.  ...  In addition, noncoding RNAs have been shown to be important regulators of gene expression.  ...  Acknowledgments This work was supported by Ministerio de Ciencia e Innovación (MICINN) with Grant BFU2008-04758 and by Santander-UCM with Grant PR26/16-20323.  ... 
doi:10.1155/2017/7354260 pmid:28573140 pmcid:PMC5442347 fatcat:wippa63y6zfhfj4ycmdbgpg26y

Fast detection of Southern tomato virus by one-step transcription loop-mediated isothermal amplification (RT-LAMP)

L. Elvira-González, A.V. Puchades, C. Carpino, A. Alfaro-Fernandez, M.I. Font-San-Ambrosio, L. Rubio, L Galipienso
2017 Journal of Virological Methods  
Geminiviruses are plant viruses with circular, single-stranded DNA genomes that infect a wide range of plant species and cause extensive losses in crop production worldwide.  ...  In addition, some of geminiviruses proteins act as silencing suppressors that interfere with plant small interfering RNA (siRNA) production and alter plant DNA methylation and microRNA (miRNA) pathways  ...  The number of copies HIV-1 RNA was relativised from the sample with virus in the absence of compounds.  ... 
doi:10.1016/j.jviromet.2016.12.004 pmid:27965036 fatcat:5vqbhusk7vajhkvtl7wkufo2na

Epigenetics: New Insights into Mammary Gland Biology

Elitsa Ivanova, Sandrine Le Le Guillou, Cathy Hue-Beauvais, Fabienne Le Le Provost
2021 Genes  
This review aims to summarize the available knowledge regarding the involvement of the four main molecular mechanisms in epigenetics: DNA methylation, histone modifications, polycomb protein activity and  ...  This has led to the establishment of a role for epigenetic marks in milk component biosynthesis.  ...  Several long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs) are involved in epigenetic regulation.  ... 
doi:10.3390/genes12020231 pmid:33562534 pmcid:PMC7914701 fatcat:kvtn5bfdwrecxh4iuyyprwsqae

The Fifth International Meeting of ISEV, ISEV2016, Rotterdam, The Netherlands, 4 – 7 May, 2016

2016 Journal of Extracellular Vesicles  
Acknowledgements: This work was funded by the Medical Re-  ...  Interestingly, we observed a selective sorting of circular and linear RNA species into exosomes.  ...  They are generated by a special mode of alternative splicing from pre-mRNAs, whereby single or multiple adjacent and spliced exons are released in circular form.  ... 
doi:10.3402/jev.v5.31552 pmid:27247029 pmcid:PMC4887520 fatcat:gh3lfxdcmjfblnll6opf3p44t4

Challenges for Experimentation on Living Beings at the Dawn of the 21st Century [chapter]

Pierre V. Vignais, Paulette M. Vignais
2010 Discovering Life, Manufacturing Life  
This sudden avalanche was triggered mainly by technological advances that were used profitably in the structural and functional study of genomes and proteomes.  ...  One of the important parameters that has helped to modify the landscape of traditional biological research is related to the 241 ceutical and agronomic industries in the economic development of discoveries  ...  between neighboring animal, plant or microbial species.  ... 
doi:10.1007/978-90-481-3767-1_5 fatcat:o2ns7d3hsbffllocrvhv77y52i

South African Association of Botanists (SAAB) – Annual Meeting 2012

2012 South African Journal of Botany  
Carotenoid pigments are essential components of the photosynthetic apparatus and thus are present in all green tissues of plants.  ...  Plant biotechnology offers an efficient tool for the production and modification of important plant secondary metabolites.  ...  In order to investigate the role of microRNAs in maize development, we employed Exiqon miRCURY LNA arrays (www. exiqon.com) and profiled micro RNA expression in leaves and male and female flowers.  ... 
doi:10.1016/j.sajb.2012.02.002 fatcat:qspiytq66jh33l75n2fcabzvjy

Abstracts of Presentations at the 2016 APS Annual Meeting

2016 Phytopathology  
Expression of a GFP-RDR in construct carrying a TYLCTHV IR (IRhp), tomato intron and GFP led to nuclear localization of IRhp RNAs in plant cells after intron was spliced out and induced TGS.  ...  The relationship among GDD on WCM infestation and WSMV infection across alternative hosts was non-linear.  ...  Recent studies have indicated that microRNA genes play key roles in shaping the compatibility of the interaction between plant-parasitic cyst nematodes and host plants.  ... 
doi:10.1094/phyto-106-12-s4.1 pmid:27922801 fatcat:vztse3dj7rhkdkcokeku2sbqrq

Abstracts from the Human Genome Meeting 2018

2018 Human Genomics  
by GSDC and KREONET in KISTI.  ...  by GSDC and KREONET in KISTI.  ...  Herein We used RNA sequencing (RNA-Seq) to evaluate the role played by alternative exon usage and splicing events in the MPTP mouse model of PD. 2 Materials and methods: MPTP and saline were administered  ... 
doi:10.1186/s40246-018-0138-6 fatcat:nl6xhsuchzgbxik4pjwjvbbkie

1 Keynote address by Nobel Laureate Phillip A. Sharp the 21st century opened with a revolution in RNA biology

Phillip A. Sharp
2015 Journal of Biomolecular Structure and Dynamics  
The discoveries of RNA interference and the evolutionary conservation of microRNAs at the turn of the century heralded a revolution in RNA Biology and the development of important innovations.  ...  Long non-coding RNAs regulate the expression of genes through both cis and trans mechanisms and provide organization to the nucleus.  ...  This research was supported by the Intramural Research Programs of the National Library of Medicine and the National Cancer Institute, NIH.  ... 
doi:10.1080/07391102.2015.1032624 fatcat:w7iil7k3ize77bjkthcyi52ohy

AASLD Abstracts 1-219

2008 Hepatology  
Materials and Methods: Experiments are in accordance with Guiding Principles in the Care and Use of Animals. 16 female pigs, 18-64 kgs, received liver grafts of 20% liver LV, G1 (n=7); G2 animals received  ...  The aim of the study is to demonstrate that abnormal HABR seen in the SFS liver graft is reversed by adenosine infusion with reversal of the SFS liver injury.  ...  Conclusion: A SNP in the AzI gene that correlates with fibrosis progression in HCV patients leads to altered generation of novel alternative splice forms.  ... 
doi:10.1002/hep.22615 fatcat:ecxqlp6dnjgktisryr4qqndvku

Abstracts from the 51st European Society of Human Genetics Conference: Oral Presentations

2019 European Journal of Human Genetics  
We tested associations of established lipid-associated SNPs identified through European samples and of polygenic scores based on these variants using linear mixed models.  ...  Few of the 140 loci displayed nominally significant associations with their target biomarker in the Greek and Ugandan samples. The polygenic scores were associated I. D'Atri 1 , L. Li 2 , X.  ...  of plants and crops.  ... 
doi:10.1038/s41431-019-0407-4 fatcat:3d23n3msz5fulchpvpfipze6pq
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