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The influence of iron oxidation state on quantitative MRI parameters in post mortem human brain
2020
NeuroImage
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Therefore, quantitative MRI parameters including R1, R2, R2∗, quantitative susceptibility maps (QSM) and magnetization transfer ratio (MTR) of post mortem human brain tissue were acquired prior and after ...
The purpose of this study was to investigate the sensitivity of MR relaxation and magnetization transfer parameters to changes in iron oxidation state compared to changes in iron concentration. ...
in total iron content in post mortem human brain tissue. ...
doi:10.1016/j.neuroimage.2020.117080
pmid:32585344
fatcat:shwj67hgibebxapnrwqix2ebwi
Off-resonance saturation as an MRI method to quantify ferritin-bound iron in the post-mortem brain
[article]
2021
bioRxiv
pre-print
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Results In post-mortem tissue, the ferritin-iron contrast strongly co-localizes with histological iron staining, in all the cases. ...
Ferritin-iron maps were obtained from post-mortem tissue of patients with neurological diseases characterized by brain iron accumulation, i. e. ...
iron pool in the post-18 mortem brain tissue of three patients affected by neurological diseases associated with increased brain 19 iron. ...
doi:10.1101/2021.03.22.436424
fatcat:ajgz7fzfqvavxobvkwhy4najwe
Monitoring therapeutic effects in experimental stroke by serial USPIO-enhanced MRI
2012
European Radiology
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. • Minocycline treatment significantly reduced areas of signal abnormalities on USPIO-enhanced MRI. • These areas correlated with the amount of iron in the brain. • Thus USPIO-enhanced MRI might provide ...
Post-mortem brains were prepared either for immunohistology (n016) or for iron dosage (n08). ...
We also thank Serge Nataf, Marie Chanal and Chantal Watrin from INSERM U842, Laennec School of Medicine, University of Lyon for helping with the histology analysis. ...
doi:10.1007/s00330-012-2567-2
pmid:22833303
fatcat:f5oc7c5ji5eojgvup5p4f2jrs4
High field magnetic resonance microscopy of the human hippocampus in Alzheimer's disease: Quantitative imaging and correlation with iron
2012
NeuroImage
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To our knowledge, these data represent an advance in quantitative imaging of hippocampal subfields in unfixed tissue, and the methods facilitate direct analysis of the relationship between MRI parameters ...
We report R 2 and R 2 * in human hippocampus from five unfixed post-mortem Alzheimer's disease (AD) and three age-matched control cases. ...
There are conflicting reports concerning the utility of employing quantitative MR properties to look at molecular changes, including utilising the influence of iron on MRI parameters (Fukunaga et al., ...
doi:10.1016/j.neuroimage.2011.08.019
pmid:21867761
pmcid:PMC3690369
fatcat:qf6sfrttqvggrhwr7dmlphae2i
Visualizing iron in multiple sclerosis
2013
Magnetic Resonance Imaging
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The present review summarizes currently reported in vivo and post mortem MRI evidence of (1) iron detection in white matter and gray matter of MS brains, (2) pathological and physiological correlates of ...
Magnetic resonance imaging (MRI) protocols that are designed to be sensitive to iron typically take advantage of (1) iron effects on the relaxation of water protons and/or (2) iron-induced local magnetic ...
We thank Drs S Pawate and R Zivadinov for permitting the authors to use images of their work and to Dr S. Sriram for valid support with the post-mortem work. ...
doi:10.1016/j.mri.2012.11.011
pmid:23347601
pmcid:PMC4776767
fatcat:idn2ymqvi5a3zilycnran322iy
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
2019
Brain
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We outline the next steps for in vivo, post-mortem and clinical studies that can lay the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenerative diseases. ...
Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases. ...
The Max Planck Institute for Human Cognitive and Brain Sciences has an institutional research agreement with Siemens Healthcare. ...
doi:10.1093/brain/awz193
pmid:31327002
pmcid:PMC6736046
fatcat:yxdzlopav5aefguycccazxz34a
Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis
2021
Brain
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Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS, which can be compared across CNS regions, patients, and centres. ...
This review summarizes recent technical advances in quantitative MRI, existing pathological validation of quantitative MRI techniques, and emerging applications of quantitative MRI to patients with multiple ...
Post-mortem single-component T 2 relaxometry in the normal-appearing tissue of the cervical spinal cord of patients with multiple sclerosis is highly influenced by demyelination (r = 0.77, P 5 0.001) but ...
doi:10.1093/brain/awab029
pmid:33970206
fatcat:ymb5zhdvcfgnxgccytqgg37esy
In Vivo Imaging of Human Neuroinflammation
2016
ACS Chemical Neuroscience
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. identification of MS lesions with gadolinium-enhanced MRI), (3) CNS-infiltration of circulating immune cells (e.g. tracking monocyte infiltration into brain parenchyma with iron oxide nanoparticles and ...
This Review provides an overview of state-of-the-art techniques for imaging human neuroinflammation which have potential to impact patient care in the foreseeable future. ...
Eva Ratai for helpful feedback on the manuscript. ...
doi:10.1021/acschemneuro.6b00056
pmid:26985861
pmcid:PMC5433433
fatcat:gqhfim2wgnannf4jwg3tvbqvz4
Age-related differences in iron content of subcortical nuclei observed in vivo: A meta-analysis
2013
NeuroImage
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Accumulation of non-heme iron in the brain has been proposed as a biomarker of the progressive neuroanatomical and cognitive declines in healthy adult aging. ...
The magnitude of age differences in estimated iron content of the caudate nucleus and putamen partially depended on the method of estimation, but not on the type of design (continuous age vs. extreme age ...
Acknowledgments Supported by the National Institutes of Health grants R37 AG-011230 to NR and training grant T32 HS-013819 to the Institute of Gerontology, Wayne State University. ...
doi:10.1016/j.neuroimage.2012.12.040
pmid:23277110
pmcid:PMC3580001
fatcat:3s7umbnobbcg3mkyk3yygyp4oq
Quantification of different iron forms in the aceruloplasminemia brain to explore iron-related neurodegeneration
2021
NeuroImage: Clinical
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We aimed to quantitatively determine the molecular iron forms in the aceruloplasminemia brain, and to illustrate their influence on iron-sensitive MRI metrics. ...
The basal ganglia, thalamus, red nucleus, dentate nucleus, superior- and middle temporal gyrus and white matter of a post-mortem aceruloplasminemia brain were studied. ...
Lefering for access to the SQUID and technical assistance, and S.A. Bonnet and S. Zheng for access to the ICP-MS and measuring the iron concentration of the formalin solution. ...
doi:10.1016/j.nicl.2021.102657
pmid:33839643
fatcat:zoqm4bmrlncdrfoitx3ca56w3m
Non-invasive assessment of tissue iron overload
2009
Hematology ASH Education Program
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In recent years, there has been increasing interest in non-invasive iron measurement, especially of the liver and heart, in patients with iron overload. ...
Liver iron measurements can now routinely be performed in clinical applications either by quantitative magnetic resonance imaging (MRI) using the transverse magnetic relaxation rate R 2 or R 2 * (1/T 2 ...
Calibration of MRI-R 2 * by iron quantitation in human heart tissue samples is still in progress. ...
doi:10.1182/asheducation-2009.1.215
pmid:20008201
fatcat:rmfoybtegfeixgvedcpj3hmnj4
Quantification of different iron forms in the aceruloplasminemia brain to explore iron-related neurodegeneration
[article]
2020
biorxiv/medrxiv
pre-print
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Interference Device (SQUID) magnetometry to specify and quantify the different iron forms per gram wet weight in a post-mortem aceruloplasminemia brain, focused on the basal ganglia, thalamus, red nucleus ...
The brain iron pool in aceruloplasminemia consisted of EPR-detectable Fe3+ ions, magnetic Fe3+ embedded in the core of ferritin and hemosiderin (ferrihydrite-iron), and magnetic Fe3+ embedded in oxidized ...
Lefering for access to the SQUID and technical assistance, and S.A. Bonnet and S. Zheng for access to the ICP-MS and measuring the iron concentration of the formalin solution. ...
doi:10.1101/2020.10.15.20206102
fatcat:5qteb47wfrflzolwg2bzd4twzy
Uncovering molecular iron compounds in the living human brain
[article]
2022
bioRxiv
pre-print
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We present a novel magnetic resonance imaging (MRI) technology for mapping of iron compounds in the living brain (the r1-r2* relaxivity). ...
Therefore, our approach may allow for non-invasive research and diagnosis of iron homeostasis in living human brains. ...
The influence of iron oxidation state on quantitative MRI parameters in post mortem human brain. Neuroimage 220, (2020). 40. Heath, F., Hurley, S. A., Johansen-Berg, H. & Sampaio-Baptista, C. ...
doi:10.1101/2022.05.02.490254
fatcat:npwquwgztjfnjgxjw5lsi35fti
Age and sex related differences in subcortical brain iron concentrations among healthy adults
2015
NeuroImage
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Age and sex can influence brain iron levels. We studied the influence of these variables on deep gray matter magnetic susceptibilities. ...
In 183 healthy volunteers (44.7 ± 14.2 years, range 20-69, ♀ 49%), in vivo Quantitative Susceptibility Mapping (QSM) at 1.5T was performed to estimate brain iron accumulation in the following regions of ...
Acknowledgments This work was supported in part by a grant: R01EB013443, from the National Institute on Aging to YW, Grants FOA11H-349 & FOA13H-090 from the Royal Swedish Society of Sciences, & Solstickan ...
doi:10.1016/j.neuroimage.2015.07.050
pmid:26216277
pmcid:PMC4737643
fatcat:4rkgsewrlbhpjenx3pkkv432g4
Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ)
2011
NeuroImage
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The aim of this study is to explore brain tissue properties in normal ageing using quantitative magnetic resonance imaging (MRI) alongside conventional morphological assessment. ...
We interpret our findings, based on current biophysical models, as a fingerprint of age-dependent brain atrophy and underlying microstructural changes in myelin, iron deposits and water. ...
Acknowledgment This study and open access to the publication were supported by the Wellcome Trust. ...
doi:10.1016/j.neuroimage.2011.01.052
pmid:21277375
pmcid:PMC3093621
fatcat:ff53tqdqdbhp7a4vuozx77gr3e
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