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The influence of iron oxidation state on quantitative MRI parameters in post mortem human brain

Christoph Birkl, Anna Maria Birkl-Toeglhofer, Christian Kames, Walter Goessler, Johannes Haybaeck, Franz Fazekas, Stefan Ropele, Alexander Rauscher
2020 NeuroImage  
Therefore, quantitative MRI parameters including R1, R2, R2∗, quantitative susceptibility maps (QSM) and magnetization transfer ratio (MTR) of post mortem human brain tissue were acquired prior and after  ...  The purpose of this study was to investigate the sensitivity of MR relaxation and magnetization transfer parameters to changes in iron oxidation state compared to changes in iron concentration.  ...  in total iron content in post mortem human brain tissue.  ... 
doi:10.1016/j.neuroimage.2020.117080 pmid:32585344 fatcat:shwj67hgibebxapnrwqix2ebwi

Off-resonance saturation as an MRI method to quantify ferritin-bound iron in the post-mortem brain [article]

Lucia Bossoni, Ingrid Hegemann-Kleinn, Sjoerd G. van Duinen, Lena H. P. Vroegindeweij, Janneke G. Langendonk, Lydiane Hirschler, Andrew Webb, Louise van der Weerd
2021 bioRxiv   pre-print
Results In post-mortem tissue, the ferritin-iron contrast strongly co-localizes with histological iron staining, in all the cases.  ...  Ferritin-iron maps were obtained from post-mortem tissue of patients with neurological diseases characterized by brain iron accumulation, i. e.  ...  iron pool in the post-18 mortem brain tissue of three patients affected by neurological diseases associated with increased brain 19 iron.  ... 
doi:10.1101/2021.03.22.436424 fatcat:ajgz7fzfqvavxobvkwhy4najwe

Monitoring therapeutic effects in experimental stroke by serial USPIO-enhanced MRI

Marilena Marinescu, Fabien Chauveau, Anne Durand, Adrien Riou, Tae-Hee Cho, Anne Dencausse, Sébastien Ballet, Norbert Nighoghossian, Yves Berthezène, Marlène Wiart
2012 European Radiology  
. • Minocycline treatment significantly reduced areas of signal abnormalities on USPIO-enhanced MRI. • These areas correlated with the amount of iron in the brain. • Thus USPIO-enhanced MRI might provide  ...  Post-mortem brains were prepared either for immunohistology (n016) or for iron dosage (n08).  ...  We also thank Serge Nataf, Marie Chanal and Chantal Watrin from INSERM U842, Laennec School of Medicine, University of Lyon for helping with the histology analysis.  ... 
doi:10.1007/s00330-012-2567-2 pmid:22833303 fatcat:f5oc7c5ji5eojgvup5p4f2jrs4

High field magnetic resonance microscopy of the human hippocampus in Alzheimer's disease: Quantitative imaging and correlation with iron

Vijay Antharam, Joanna F. Collingwood, John-Paul Bullivant, Mark R. Davidson, Saurav Chandra, Albina Mikhaylova, Mary E. Finnegan, Christopher Batich, John R. Forder, Jon Dobson
2012 NeuroImage  
To our knowledge, these data represent an advance in quantitative imaging of hippocampal subfields in unfixed tissue, and the methods facilitate direct analysis of the relationship between MRI parameters  ...  We report R 2 and R 2 * in human hippocampus from five unfixed post-mortem Alzheimer's disease (AD) and three age-matched control cases.  ...  There are conflicting reports concerning the utility of employing quantitative MR properties to look at molecular changes, including utilising the influence of iron on MRI parameters (Fukunaga et al.,  ... 
doi:10.1016/j.neuroimage.2011.08.019 pmid:21867761 pmcid:PMC3690369 fatcat:qf6sfrttqvggrhwr7dmlphae2i

Visualizing iron in multiple sclerosis

Francesca Bagnato, Simon Hametner, Edward Brian Welch
2013 Magnetic Resonance Imaging  
The present review summarizes currently reported in vivo and post mortem MRI evidence of (1) iron detection in white matter and gray matter of MS brains, (2) pathological and physiological correlates of  ...  Magnetic resonance imaging (MRI) protocols that are designed to be sensitive to iron typically take advantage of (1) iron effects on the relaxation of water protons and/or (2) iron-induced local magnetic  ...  We thank Drs S Pawate and R Zivadinov for permitting the authors to use images of their work and to Dr S. Sriram for valid support with the post-mortem work.  ... 
doi:10.1016/j.mri.2012.11.011 pmid:23347601 pmcid:PMC4776767 fatcat:idn2ymqvi5a3zilycnran322iy

Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases

2019 Brain  
We outline the next steps for in vivo, post-mortem and clinical studies that can lay the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenerative diseases.  ...  Pathological alterations to the locus coeruleus, the major source of noradrenaline in the brain, are histologically evident in early stages of neurodegenerative diseases.  ...  The Max Planck Institute for Human Cognitive and Brain Sciences has an institutional research agreement with Siemens Healthcare.  ... 
doi:10.1093/brain/awz193 pmid:31327002 pmcid:PMC6736046 fatcat:yxdzlopav5aefguycccazxz34a

Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis

Cristina Granziera, Jens Wuerfel, Frederik Barkhof, Massimiliano Calabrese, Nicola De Stefano, Christian Enzinger, Nikos Evangelou, Massimo Filippi, Jeroen J G Geurts, Daniel S Reich, Maria A Rocca, Stefan Ropele (+7 others)
2021 Brain  
Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS, which can be compared across CNS regions, patients, and centres.  ...  This review summarizes recent technical advances in quantitative MRI, existing pathological validation of quantitative MRI techniques, and emerging applications of quantitative MRI to patients with multiple  ...  Post-mortem single-component T 2 relaxometry in the normal-appearing tissue of the cervical spinal cord of patients with multiple sclerosis is highly influenced by demyelination (r = 0.77, P 5 0.001) but  ... 
doi:10.1093/brain/awab029 pmid:33970206 fatcat:ymb5zhdvcfgnxgccytqgg37esy

In Vivo Imaging of Human Neuroinflammation

Daniel S. Albrecht, Cristina Granziera, Jacob M. Hooker, Marco L. Loggia
2016 ACS Chemical Neuroscience  
. identification of MS lesions with gadolinium-enhanced MRI), (3) CNS-infiltration of circulating immune cells (e.g. tracking monocyte infiltration into brain parenchyma with iron oxide nanoparticles and  ...  This Review provides an overview of state-of-the-art techniques for imaging human neuroinflammation which have potential to impact patient care in the foreseeable future.  ...  Eva Ratai for helpful feedback on the manuscript.  ... 
doi:10.1021/acschemneuro.6b00056 pmid:26985861 pmcid:PMC5433433 fatcat:gqhfim2wgnannf4jwg3tvbqvz4

Age-related differences in iron content of subcortical nuclei observed in vivo: A meta-analysis

Ana Daugherty, Naftali Raz
2013 NeuroImage  
Accumulation of non-heme iron in the brain has been proposed as a biomarker of the progressive neuroanatomical and cognitive declines in healthy adult aging.  ...  The magnitude of age differences in estimated iron content of the caudate nucleus and putamen partially depended on the method of estimation, but not on the type of design (continuous age vs. extreme age  ...  Acknowledgments Supported by the National Institutes of Health grants R37 AG-011230 to NR and training grant T32 HS-013819 to the Institute of Gerontology, Wayne State University.  ... 
doi:10.1016/j.neuroimage.2012.12.040 pmid:23277110 pmcid:PMC3580001 fatcat:3s7umbnobbcg3mkyk3yygyp4oq

Quantification of different iron forms in the aceruloplasminemia brain to explore iron-related neurodegeneration

Lena H.P. Vroegindeweij, Lucia Bossoni, Agnita J.W. Boon, J.H. Paul Wilson, Marjolein Bulk, Jacqueline Labra-Muñoz, Martina Huber, Andrew Webb, Louise van der Weerd, Janneke G. Langendonk
2021 NeuroImage: Clinical  
We aimed to quantitatively determine the molecular iron forms in the aceruloplasminemia brain, and to illustrate their influence on iron-sensitive MRI metrics.  ...  The basal ganglia, thalamus, red nucleus, dentate nucleus, superior- and middle temporal gyrus and white matter of a post-mortem aceruloplasminemia brain were studied.  ...  Lefering for access to the SQUID and technical assistance, and S.A. Bonnet and S. Zheng for access to the ICP-MS and measuring the iron concentration of the formalin solution.  ... 
doi:10.1016/j.nicl.2021.102657 pmid:33839643 fatcat:zoqm4bmrlncdrfoitx3ca56w3m

Non-invasive assessment of tissue iron overload

R. Fischer, P. R. Harmatz
2009 Hematology ASH Education Program  
In recent years, there has been increasing interest in non-invasive iron measurement, especially of the liver and heart, in patients with iron overload.  ...  Liver iron measurements can now routinely be performed in clinical applications either by quantitative magnetic resonance imaging (MRI) using the transverse magnetic relaxation rate R 2 or R 2 * (1/T 2  ...  Calibration of MRI-R 2 * by iron quantitation in human heart tissue samples is still in progress.  ... 
doi:10.1182/asheducation-2009.1.215 pmid:20008201 fatcat:rmfoybtegfeixgvedcpj3hmnj4

Quantification of different iron forms in the aceruloplasminemia brain to explore iron-related neurodegeneration [article]

Lena H.P. Vroegindeweij, Lucia Bossoni, Agnita J.W. Boon, Paul J.H. Wilson, Marjolein Bulk, Martina Huber, Jaqueline Labra-Muñoz, Andrew Webb, Louise van der Weerd, Janneke G. Langendonk
2020 biorxiv/medrxiv   pre-print
Interference Device (SQUID) magnetometry to specify and quantify the different iron forms per gram wet weight in a post-mortem aceruloplasminemia brain, focused on the basal ganglia, thalamus, red nucleus  ...  The brain iron pool in aceruloplasminemia consisted of EPR-detectable Fe3+ ions, magnetic Fe3+ embedded in the core of ferritin and hemosiderin (ferrihydrite-iron), and magnetic Fe3+ embedded in oxidized  ...  Lefering for access to the SQUID and technical assistance, and S.A. Bonnet and S. Zheng for access to the ICP-MS and measuring the iron concentration of the formalin solution.  ... 
doi:10.1101/2020.10.15.20206102 fatcat:5qteb47wfrflzolwg2bzd4twzy

Uncovering molecular iron compounds in the living human brain [article]

Shir Filo, Rona Shaharabani, Daniel Bar Hanin, Masha Adam, Eliel Ben-David, Hanan Schoffman, Nevo Margalit, Naomi Habib, Tal Shahar, Aviv Mezer
2022 bioRxiv   pre-print
We present a novel magnetic resonance imaging (MRI) technology for mapping of iron compounds in the living brain (the r1-r2* relaxivity).  ...  Therefore, our approach may allow for non-invasive research and diagnosis of iron homeostasis in living human brains.  ...  The influence of iron oxidation state on quantitative MRI parameters in post mortem human brain. Neuroimage 220, (2020). 40. Heath, F., Hurley, S. A., Johansen-Berg, H. & Sampaio-Baptista, C.  ... 
doi:10.1101/2022.05.02.490254 fatcat:npwquwgztjfnjgxjw5lsi35fti

Age and sex related differences in subcortical brain iron concentrations among healthy adults

Ninni Persson, Jianlin Wu, Qing Zhang, Ting Liu, Jing Shen, Ruyi Bao, Mingfei Ni, Tian Liu, Yi Wang, Pascal Spincemaille
2015 NeuroImage  
Age and sex can influence brain iron levels. We studied the influence of these variables on deep gray matter magnetic susceptibilities.  ...  In 183 healthy volunteers (44.7 ± 14.2 years, range 20-69, ♀ 49%), in vivo Quantitative Susceptibility Mapping (QSM) at 1.5T was performed to estimate brain iron accumulation in the following regions of  ...  Acknowledgments This work was supported in part by a grant: R01EB013443, from the National Institute on Aging to YW, Grants FOA11H-349 & FOA13H-090 from the Royal Swedish Society of Sciences, & Solstickan  ... 
doi:10.1016/j.neuroimage.2015.07.050 pmid:26216277 pmcid:PMC4737643 fatcat:4rkgsewrlbhpjenx3pkkv432g4

Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ)

B. Draganski, J. Ashburner, C. Hutton, F. Kherif, R.S.J. Frackowiak, G. Helms, N. Weiskopf
2011 NeuroImage  
The aim of this study is to explore brain tissue properties in normal ageing using quantitative magnetic resonance imaging (MRI) alongside conventional morphological assessment.  ...  We interpret our findings, based on current biophysical models, as a fingerprint of age-dependent brain atrophy and underlying microstructural changes in myelin, iron deposits and water.  ...  Acknowledgment This study and open access to the publication were supported by the Wellcome Trust.  ... 
doi:10.1016/j.neuroimage.2011.01.052 pmid:21277375 pmcid:PMC3093621 fatcat:ff53tqdqdbhp7a4vuozx77gr3e
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