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The Relationship Between Dopamine Neurotransmitter Dynamics and the Blood-Oxygen-Level-Dependent (BOLD) Signal: A Review of Pharmacological Functional Magnetic Resonance Imaging

Tyler J. Bruinsma, Vidur V. Sarma, Yoonbae Oh, Dong Pyo Jang, Su-Youne Chang, Greg A. Worrell, Val J. Lowe, Hang Joon Jo, Hoon-Ki Min
2018 Frontiers in Neuroscience  
neuropharmacologic agents on the BOLD signal.  ...  Functional magnetic resonance imaging (fMRI) is widely used in investigations of normal cognition and brain disease and in various clinical applications.  ...  ACKNOWLEDGMENTS This work was supported by the National Institutes of Health (NIH R01 NS088260 to S-YC and NIH R01 NS92882 to GW). We thank Dr. Penelope S.  ... 
doi:10.3389/fnins.2018.00238 pmid:29692706 pmcid:PMC5902685 fatcat:tvevbeuqx5h23kruxxnmyonxde

Assessment of the Cerebral Vasomotor Reactivity in Internal Carotid Artery Occlusion Using a Transcranial Doppler Sonography and Functional MRI

Roman Herzig, Petr Hluštík, David Školoudík, Daniel Šaňák, Ivanka Vlachová, Miroslav Heřman, Petr Kaňovský
2008 Journal of Neuroimaging  
The aim was to assess the correlation of TCD and fMRI in the CVR assessment.  ...  However, there is a moderate correlation between TCD and fMRI in the case of congruity of both TCD tests. 38  ...  The article was presented in part as a lecture at the 10th Congress of the  ... 
doi:10.1111/j.1552-6569.2007.00168.x pmid:18190494 fatcat:sw4xwnnw2jfulbh2p4nsqtqaby

Measuring vascular reactivity with breath-holds after stroke: A method to aid interpretation of group-level BOLD signal changes in longitudinal fMRI studies

Fatemeh Geranmayeh, Richard J.S. Wise, Robert Leech, Kevin Murphy
2015 Human Brain Mapping  
) and to determine if alterations in regional CVR over time will adversely affect interpretation of task-related BOLD signal changes.  ...  In this cohort, a lack of CVR differences in healthy tissue between the patients and controls indicates that any group level BOLD signal change observed in these regions over time is unlikely to be related  ...  ACKNOWLEDGMENTS The authors thank all the patients and healthy participants who took part in this study.  ... 
doi:10.1002/hbm.22735 pmid:25727648 pmcid:PMC4413362 fatcat:npztv67xsbeb3oxbbdvnnmtchq

Conference of the Neuroradiological Section of the Polish Medical Radiological Society

2008 Neuroradiology  
Fetal MRI has proven its value in pathologies of the central nervous system.  ...  The author discusses the most common anomalies of CNS discover by fetal MR.  ...  as well as tumor-influenced hemodynamic response and BOLD contrast readout.  ... 
doi:10.1007/s00234-008-0436-0 fatcat:byi7dvle2jg3bnundfdazevgpm

Effects of hypoxia, hyperoxia, and hypercapnia on baseline and stimulus-evoked BOLD, CBF, and CMRO2 in spontaneously breathing animals

Kenneth M. Sicard, Timothy Q. Duong
2005 NeuroImage  
(BOLD) signals, cerebral blood flow (CBF), and the cerebral metabolic rate of oxygen (CMRO 2 ) in spontaneously breathing rats under isoflurane anesthesia.  ...  Functional magnetic resonance imaging (fMRI) was used to investigate the effects of inspired hypoxic, hyperoxic, and hypercapnic gases on baseline and stimulus-evoked changes in blood oxygenation leveldependent  ...  This work was supported by grants from the American Heart Association (SDG-0430020N) and the National Institute of Health (NEI R01-EY014211, NINDS R01-NS45879).  ... 
doi:10.1016/j.neuroimage.2004.12.010 pmid:15808985 pmcid:PMC2962945 fatcat:m45yvzrvlvbv5mqfvd2z3c646y

Chapter 14 Cerebral vascular dysregulation in the ischemic brain [chapter]

Alexander Kunz, Costantino Iadecola
2008 Handbook of Clinical Neurology  
In this chapter, we will briefly review the effects of cerebral ischemia on the regulation of CBF, focusing on the potential mechanisms involved in the cerebrovascular dysfunction and on the implications  ...  The brain has limited fuel reserves and is highly dependent on a constant supply of oxygen and energy substrates delivered through blood flow (Hossmann, 1994) .  ...  involving both extra-and intracranial arteries (Schmidt-Kastner et al., 1987) .  ... 
doi:10.1016/s0072-9752(08)01914-3 pmid:18790280 pmcid:PMC3982865 fatcat:gqah4rjs7bduda6av2fu5gdq7q

Diffuse gliomas exhibit whole brain impaired cerebrovascular reactivity

Jorn Fierstra, Christiaan van Niftrik, Marco Piccirelli, Oliver Bozinov, Athina Pangalu, Niklaus Krayenbühl, Antonios Valavanis, Michael Weller, Luca Regli
2018 Magnetic Resonance Imaging  
In this particular manuscript we present a new method to calculate delay based on the signal changes induced by the BOLD signal itself.  ...  As was shown by Slessarev et al [REF], this end tidal tracing reflects the arterial partial pressure of CO2 very well. Therefore, we did not apply an extra smoothing to PetCO2 tracing.  ...  This work was supported with the University of Zurich `Filling-the-Gap 2015` and `Forschungskredit: Postdoc 2016` initiative.  ... 
doi:10.1016/j.mri.2017.09.017 pmid:28986176 fatcat:vlzpsbnphzde5chcargc5sx66u

In vivoquantification of hyperoxic arterial blood waterT1

Jeroen C. W. Siero, Megan K. Strother, Carlos C. Faraco, Hans Hoogduin, Jeroen Hendrikse, Manus J. Donahue
2015 NMR in Biomedicine  
The dependence of T 1a on Y a and Y v has been elegantly characterized ex vivo, however the combined influence of pO 2 , Y a and Y v on T 1a in vivo under normal ventilation have not been reported.  ...  The longitudinal arterial blood-water relaxation time (T 1a ) change with hyperoxia will influence signal quantification through mechanisms relating to elevated partial pressure of plasma-dissolved O 2  ...  However, the BOLD signal is nonspecific, influenced by CBF, CBV and cerebral metabolic rate of oxygen consumption (CMRO 2 ), and deciphering the contributions of each is non-trivial.  ... 
doi:10.1002/nbm.3411 pmid:26419505 pmcid:PMC4618707 fatcat:qk3n5ofxhfggbbsnvnbouccava

Imaging Techniques in Brain Tumor [chapter]

Mingkun Yu, Wei Ye, Xiangqian Qi, Jun Qian, Zhenyang Liu, Wenfeng Fang
2011 Diagnostic Techniques and Surgical Management of Brain Tumors  
The diffusion of the water in central nervous system is depended on the integrity of the cell membrane and the osmotic balance.  ...  MRS can show the fineness and further, the metabolic characters of intracranial tumor.  ...  Bold-fMRI and brain tumor BOLD-fMRI image is got by using endogenous hemoglobin as contrast agents through blood oxygen saturation alteration which reflects the changes of blood flow, blood volume and  ... 
doi:10.5772/20970 fatcat:nkkriqqp2vgjfdjr2h7fs4oquu

Quantifying the Microvascular Origin of BOLD-fMRI from First Principles with Two-Photon Microscopy and an Oxygen-Sensitive Nanoprobe

L. Gagnon, S. Sakad i, F. Lesage, J. J. Musacchia, J. Lefebvre, Q. Fang, M. A. Yucel, K. C. Evans, E. T. Mandeville, J. Cohen-Adad, J. R. Polimeni, M. A. Yaseen (+6 others)
2015 Journal of Neuroscience  
However, the BOLD signal reflects changes in blood volume and oxygenation rather than neuronal activity per se.  ...  The predictive power of the approach is illustrated by quantifying variations in the BOLD signal induced by the morphological folding of the human cortex.  ...  The MRF dictionary used in this case was constructed from a Monte Carlo fMRI model with simplified vascular geometry and oxygen content.  ... 
doi:10.1523/jneurosci.3555-14.2015 pmid:25716864 pmcid:PMC4339366 fatcat:js2kiyatrrezndxyodj25k67hq

Investigating Human Neurovascular Coupling Using Functional Neuroimaging: A Critical Review of Dynamic Models

Clément Huneau, Habib Benali, Hugues Chabriat
2015 Frontiers in Neuroscience  
This may be due to the poor understanding of the underlying physiological mechanisms, in addition to the focus of fMRI community on other aspects of the BOLD signal.  ...  Very recently, the same team included the PI model (now termed arterial impulse model) in a global modeling of the BOLD signal (Kim and Ress, 2016) , very different from the so-called Balloon model.  ...  The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with  ... 
doi:10.3389/fnins.2015.00467 pmid:26733782 pmcid:PMC4683196 fatcat:hhfw7bolgvhnpdjz67xyvsae7y

Respiratory challenge MRI: Practical aspects

Fiona C. Moreton, Krishna A. Dani, Colin Goutcher, Kevin O'Hare, Keith W. Muir
2016 NeuroImage: Clinical  
In this paper we review the rationale for respiratory challenge MRI including the effects of oxygen and carbon dioxide on the cerebral circulation.  ...  Respiratory challenge MRI is the modification of arterial oxygen (PaO 2 ) and/or carbon dioxide (PaCO 2 ) concentration to induce a change in cerebral function or metabolism which is then measured by MRI  ...  Acknowledgements Respiratory challenge research undertaken in the Queen Elizabeth University Hospital has been supported by two project grants from the Chief Scientists Office of Scotland (ETM/244 and  ... 
doi:10.1016/j.nicl.2016.05.003 pmid:27330967 pmcid:PMC4901170 fatcat:d2opuiy5uzgajjxwuroe6pwnk4

Negative BOLD Response to Interictal Epileptic Discharges in Focal Epilepsy

Francesca Pittau, Firas Fahoum, Rina Zelmann, François Dubeau, Jean Gotman
2013 Brain Topography  
The IEDs were accompanied by a slow wave in 87 % of patients whose primary BOLD was a deactivation and only in 33 % of patients with activation.  ...  The significance of deactivation in the region of IED generation is uncertain. The aim of this study was to determine if BOLD deactivation was caused by specific IED characteristics.  ...  Acknowledgments The authors thank Natalja Zazubovits for helping to collect and analyze the data. Pittau F. thanks Dr. Gaetano Cantalupo for the thoughtful comments during the manuscript preparation.  ... 
doi:10.1007/s10548-013-0302-1 pmid:23793553 pmcid:PMC4490905 fatcat:f7akvefvuzbp7n5ifu33665yhu

Imaging techniques for presurgical evaluation of temporal lobe epilepsy

Andrea Bartoli, Serge Vulliemoz, Sven Haller, Karl Schaller, Margitta Seeck
2012 Imaging in Medicine  
The surgical treatment of pharmaco-resistant focal epilepsy has increased dramatically in recent years.  ...  Our aim is to review the current literature and summarize all available data on these validated imaging techniques for the assessment of focal temporal lobe epilepsy.  ...  concordant [98, 99] and can provide further information on intracranial electrode placement [100, 101] ; sometimes EEG-fMRI studies of spike-correlated BOLD changes are inconclusive because of the  ... 
doi:10.2217/iim.12.28 fatcat:pe3iauocj5c4zchrjfti7fibpi

Autonomic arousals contribute to brain fluid pulsations during sleep [article]

Dante Picchioni, Pinar S. Özbay, Hendrik Mandelkow, Jacco A. de Zwart, Yicun Wang, Peter van Gelderen, Jeff H. Duyn
2021 bioRxiv   pre-print
AbstractDuring sleep, slow waves of neuro-electrical activity engulf the human brain and aid in the consolidation of memories.  ...  Therefore, the role of CSF pulsations in brain waste clearance may, in part, depend on proper autoregulatory control of cerebral blood flow.One-Sentence SummaryAutonomic regulation of cerebral vascular  ...  Acknowledgments: Susie Fulton, Steve Newman and, Jiaen Liu are acknowledged for advice and  ... 
doi:10.1101/2021.05.04.442672 fatcat:bxpbfbxotbgm5pjem22uvawfhi
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