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The influence of brain iron on myelin water imaging

Christoph Birkl, Anna Maria Birkl-Toeglhofer, Verena Endmayr, Romana Hoftberger, Gregor Kasprian, Claudia Krebs, Johannes Haybaeck, Alexander Rauscher
2019 NeuroImage  
The myelin water imaging (MWI) technique allows to separate the T2 decay into short components, specific to myelin water, and long components reflecting the intra- and extracellular water.  ...  The myelin water fraction (MWF) is the ratio of the short components to all components.  ...  Acknowledgments This study was funded by the Austrian Science Fund (FWF) project number J 4038 and by the National MS Society (RG 1507 05301). The authors thank Prof. Alex L MacKay and Prof.  ... 
doi:10.1016/j.neuroimage.2019.05.042 pmid:31108214 pmcid:PMC7610792 fatcat:petbcbnhe5ekjidu4g4fa25mfu

Combining Quantitative Susceptibility Mapping with Automatic Zero Reference (QSM0) and Myelin Water Fraction Imaging to Quantify Iron-Related Myelin Damage in Chronic Active MS Lesions

Y. Yao, T.D. Nguyen, S. Pandya, Y. Zhang, S. Hurtado Rúa, I. Kovanlikaya, A. Kuceyeski, Z. Liu, Y. Wang, S.A. Gauthier
2017 American Journal of Neuroradiology  
BACKGROUND AND PURPOSE: A hyperintense rim on susceptibility in chronic MS lesions is consistent with iron deposition, and the purpose of this study was to quantify iron-related myelin damage within these  ...  The volume of the rim at the initial quantitative susceptibility mapping scan was negatively associated with follow-up myelin water fraction (P Ͻ .01).  ...  MWF was calculated as the ratio of the myelin water signal and the total water signal within a voxel.  ... 
doi:10.3174/ajnr.a5482 pmid:29242359 pmcid:PMC5812818 fatcat:5ch353vesngsdempjhhivze7wi

Histological Basis of Laminar MRI Patterns in High Resolution Images of Fixed Human Auditory Cortex

Mark N. Wallace, Matthew J. Cronin, Richard W. Bowtell, Ian S. Scott, Alan R. Palmer, Penny A. Gowland
2016 Frontiers in Neuroscience  
ACKNOWLEDGMENTS We wish to thank Zoe Thompson for the histological staining and sectioning of blocks used for the MRI analysis and Prof. D. A. Hall for suggesting we undertake the study.  ...  Influence of Iron on Image Contrast The effect of iron distribution on R * 2 images has already been studied in post-mortem visual and somatosensory cortex (Fukunaga et al., 2010) and we wanted to focus  ...  T 1 values are more heavily influenced by myelination and water binding, and lower T 1 values lead to hyperintensity in T 1 -weighted images.  ... 
doi:10.3389/fnins.2016.00455 pmid:27774049 pmcid:PMC5054214 fatcat:6uphemzpo5bwppniwlqe6jxmly

Dietary Iron Repletion following Early-Life Dietary Iron Deficiency Does Not Correct Regional Volumetric or Diffusion Tensor Changes in the Developing Pig Brain

Austin T. Mudd, Joanne E. Fil, Laura C. Knight, Ryan N. Dilger
2018 Frontiers in Neurology  
Main effects of early-life iron status, regardless of imaging time point, 2 Mudd et al.  ...  However, it remains unclear if dietary iron repletion after a period of iron deficiency can recover structural deficits in the brain.  ...  Lastly, they thank Nancy Dodge, Holly Tracey, and Tracey Henigman from the Beckman Imaging Center for their help in MRI data acquisition.  ... 
doi:10.3389/fneur.2017.00735 pmid:29375469 pmcid:PMC5768607 fatcat:fogzm3j5enefjpsujy3hq6ok24

Early nutrition influences developmental myelination and cognition in infants and young children

Sean Deoni, Douglas Dean, Sarah Joelson, Jonathan O'Regan, Nora Schneider
2018 NeuroImage  
Throughout early neurodevelopment, myelination helps provide the foundation for brain connectivity and supports the emergence of cognitive and behavioral functioning.  ...  However, past cognitive and brain imaging studies comparing breast and formula feeding are often: cross-sectional; performed in older children and adolescents relying on parental recall of infant feeding  ...  Acknowledgements This work was supported by the National Institutes of Health (R01 MH087510) The NIH ECHO program (UG3OD023313) and the Bill and Melinda Gates Foundation (OPP1120016).  ... 
doi:10.1016/j.neuroimage.2017.12.056 pmid:29277402 pmcid:PMC6540800 fatcat:pju5igdle5covlv4fhza4jbhue

Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping

Evgeniya Kirilina, Saskia Helbling, Markus Morawski, Kerrin Pine, Katja Reimann, Steffen Jankuhn, Juliane Dinse, Andreas Deistung, Jürgen R. Reichenbach, Robert Trampel, Stefan Geyer, Larissa Müller (+4 others)
2020 Science Advances  
Despite its importance for brain connectivity, very little is known about SWM in humans, mainly due to the lack of noninvasive imaging methods.  ...  Using biophysical modeling informed by quantitative ion beam microscopy on postmortem brain tissue, we demonstrate that MR contrast in SWM is driven by iron and can be linked to the microscopic iron distribution  ...  The orientationdependent influence of myelin and iron on R2* was estimated and removed using the general linear model (GLM) described in Eq. M8.  ... 
doi:10.1126/sciadv.aaz9281 pmid:33028535 pmcid:PMC7541072 fatcat:o4ijzqpw2bfpjplzyk3ymygqdi

Quantitative magnetic resonance imaging towards clinical application in multiple sclerosis

Cristina Granziera, Jens Wuerfel, Frederik Barkhof, Massimiliano Calabrese, Nicola De Stefano, Christian Enzinger, Nikos Evangelou, Massimo Filippi, Jeroen J G Geurts, Daniel S Reich, Maria A Rocca, Stefan Ropele (+7 others)
2021 Brain  
In patients with multiple sclerosis, quantitative MRI techniques such as relaxometry, myelin imaging, magnetization transfer, diffusion MRI, quantitative susceptibility mapping, and perfusion MRI, complement  ...  Quantitative MRI provides biophysical measures of the microstructural integrity of the CNS, which can be compared across CNS regions, patients, and centres.  ...  The three major determinants of T 1 changes in the CNS of patients with multiple sclerosis are myelin, iron, and water.  ... 
doi:10.1093/brain/awab029 pmid:33970206 fatcat:ymb5zhdvcfgnxgccytqgg37esy

In Vivo Brain MR Imaging at Subnanoliter Resolution: Contrast and Histology

2016 Magnetic Resonance in Medical Sciences  
Taken together, a plethora of observations suggests that the delineation of specific structures in high-resolution MR imaging of mammalian brain and the absence of corresponding contrasts in MR imaging  ...  Comparisons between MR imaging at subnanoliter resolution and histological data indicate that (a) myelin sheaths, (b) nerve cells, and (c) the neuropil are most responsible for observed MR imaging contrasts  ...  As a second mechanism, water proton density may have an even greater influence on WM/GM contrast in T 2 -weighted (T 2 W) MR imaging because it is affected by the myelin sheaths occupying the extracellular  ... 
doi:10.2463/mrms.2015-0048 pmid:26346405 fatcat:yxafoaa5xrcabcav63nygzy3aq

Magnetic Resonance of Myelin Water: An in vivo Marker for Myelin

Alex L. MacKay, Cornelia Laule, Bernard Zalc
2016 Brain Plasticity  
Myelin water imaging is a magnetic resonance imaging method which can be used to visualize myelination in the brain and spinal cord in vivo.  ...  Histological validation studies in animal and human brain and spinal cord tissue demonstrate high specificity of myelin water imaging for myelin.  ...  However, MTR and myelin water appeared to be influenced by different aspects of EAE, as modulating the inflammation strongly influenced MTR but had minimal effect on myelin water.  ... 
doi:10.3233/bpl-160033 pmid:29765849 pmcid:PMC5928546 fatcat:sce5or2unvecxfgzz5cart4dru

Assessment of Iron Deposition and White Matter Maturation in Infant Brains by Using Enhanced T2 Star Weighted Angiography (ESWAN): R2* versus Phase Values

Ning Ning, Lei Zhang, Jie Gao, Yumiao Zhang, Zhuanqin Ren, Gang Niu, Yongming Dai, Ed X. Wu, Youmin Guo, Jian Yang, Jie Tian
2014 PLoS ONE  
The aim of this study was to investigate age-related changes of R2* and phase value, and compare their performances for monitoring iron deposition and WM maturation in infant brains.  ...  It has been reported that the R2* and phase values originating from the gradient-echo sequence could both reflect the iron and myelination.  ...  The increased bound water fractions of myelin and myelinated-axon both caused an increase of the R2* values [12] . Secondly, according to Todorich et al.  ... 
doi:10.1371/journal.pone.0089888 pmid:24587101 pmcid:PMC3934963 fatcat:o4jgqprvwfhdjdq26aqbs2ip7e

Magnetization transfer ratio does not correlate to myelin content in the brain in the MOG-EAE mouse model

Sveinung Fjær, Lars Bø, Kjell-Morten Myhr, Øivind Torkildsen, Stig Wergeland
2015 Neurochemistry International  
Mean MTR values were calculated in five regions of the brain and compared to weight, EAE severity score and myelin content assessed by immunostaining for proteolipid protein and luxol fast blue, lymphocyte  ...  This suggest that MTR measures of brain tissue can give significant differences between control mice and EAE mice not caused by demyelination, inflammation or iron deposition, and may not be useful surrogate  ...  Dehydration is another factor that can influence MTR values, as the pools of water affected by magnetization transfer may change relatively in size.  ... 
doi:10.1016/j.neuint.2015.02.006 pmid:25744931 fatcat:3sgbylq7jbb4vjipyvipmafaea

The separate effects of lipids and proteins on brain MRI contrast revealed through tissue clearing

Christoph Leuze, Markus Aswendt, Emily Ferenczi, Corey W. Liu, Brian Hsueh, Maged Goubran, Qiyuan Tian, Gary Steinberg, Michael M. Zeineh, Karl Deisseroth, Jennifer A. McNab
2017 NeuroImage  
MRI of cleared brain tissue showed: 1) minimal contrast on standard MRI sequences; 2) increased relaxation times; and 3) diffusion rates close to free water.  ...  Despite the widespread use of magnetic resonance imaging (MRI) of the brain, the relative contribution of different biological components (e.g. lipids and proteins) to structural MRI contrasts (e.g., T1  ...  This study was funded by the Stanford Neurosciences Institute, the Gatsby Foundation, the Oxford-Stanford Big Data in Biomedicine Seed Grant, Stanford Radiology Angel Funds, GE Healthcare, the Dana Foundation  ... 
doi:10.1016/j.neuroimage.2017.04.021 pmid:28411157 pmcid:PMC5548623 fatcat:gvu2mhovhndm3nenu6eglwarde

MR susceptibility imaging

Jeff Duyn
2013 Journal of magnetic resonance (San Diego, Calif. 1997 : Print)  
This work reviews recent developments in the use of magnetic susceptibility contrast for human MRI, with a focus on the study of brain anatomy.  ...  In white matter, the myelin sheath introduces an anisotropic susceptibility that has distinct effects on the water compartments inside the axons, between the myelin sheath, and the axonal space, and renders  ...  Summary and outlook The magnetic properties of brain tissue, relevant to susceptibility imaging based on MRI, are dominated by iron, myelin and deoxyhemoglobin, whose distribution in the brain is highly  ... 
doi:10.1016/j.jmr.2012.11.013 pmid:23273840 pmcid:PMC3602381 fatcat:wldbhsew2zcfxadv25hs7yjo6e

Quantitative susceptibility mapping (QSM) of white matter multiple sclerosis lesions: Interpreting positive susceptibility and the presence of iron

Cynthia Wisnieff, Sriram Ramanan, John Olesik, Susan Gauthier, Yi Wang, David Pitt
2014 Magnetic Resonance in Medicine  
Here, we examine contributions of iron and myelin to magnetic susceptibility of lesions on quantitative susceptibility mapping (QSM).  ...  Conclusion-Positive susceptibility values with respect to water indicate the presence of iron in MS lesions, though both demyelination and iron deposition contribute to QSM.  ...  Acknowledgments This investigation was supported in part by a grant from the National Multiple Sclerosis Society (RG4866-A-2) and by grants from NIH R01NS072370, R01EB013443 and S10RR025145.  ... 
doi:10.1002/mrm.25420 pmid:25137340 pmcid:PMC4333139 fatcat:2mhr7iwsqjd2rj7bxmtvbunj3u

Investigation of the association between cerebral iron content and myelin content in normative aging using quantitative magnetic resonance neuroimaging

Nikkita Khattar, Curtis Triebswetter, Matthew Kiely, Luigi Ferrucci, Susan M. Resnick, Richard G. Spencer, Mustapha Bouhrara
2021 NeuroImage  
We measured whole-brain myelin water fraction (MWF), a surrogate of myelin content, using multicomponent relaxometry and whole-brain iron content using susceptibility weighted imaging in all individuals  ...  We assessed associations between iron content and myelin content in critical brain regions using quantitative magnetic resonance imaging (MRI) on a cohort of cognitively unimpaired adults ranging in age  ...  This may also influence the overall interpretability of myelination or iron, as well as their associations, during the process of aging ( Fjell et al., 2010 ) .  ... 
doi:10.1016/j.neuroimage.2021.118267 pmid:34139358 fatcat:mmzcrfnsefaafd7eneaz2o3igm
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