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The final outcome of such research is affected by many factors, the choice of template being a crucial one. ... This study comprised of homology modelling of 5-HT 6 R based on seven available GPCR templates (A2A, beta1, beta2, CXCR4, D3, H1, rhodopsin), and further verification of created models by means of ligand ... Acknowledgements This study was supported by project UDA-POIG.01.03.01-12-100/08-00 cofinanced by European Union from the European Fund of Regional Development (EFRD); http://www.prokog.pl. ...doi:10.1186/1758-2946-5-s1-p8 pmcid:PMC3606257 fatcat:mtqlsfkprjhlvco4b7govlmouy
The results suggest combination therapies for a wide range of neurodegenerative disorders may be needed to ensure maximal therapeutic benefits. ... Extensive studies demonstrate glutamate and adenosine receptors afford neuroprotection in Alzheimer's disease. ... UODC2 was also docked into an A3R homology model (using the A1R crystal structure, PDB: 5UEN, as a template) using a covalent linkage to Y265 7.36 . ...doi:10.26180/15001146.v1 fatcat:45qkdff3bjfplngwxxpb52s7ry