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Heterogeneity and Individuality: microRNAs in Mental Disorders

Leif G. Hommers, Katharina Domschke, Jürgen Deckert
2014 Journal of neural transmission  
These studies will aid in disentangling the complex genetic nature of these disorders and possibly contribute to the development of novel, individualized diagnostic and therapeutic approaches.  ...  Their molecular mode of action is reminiscent of findings of genome-wide association studies in mental disorders, unable to attribute the risk of disease to a specific gene, but rather to multiple genes  ...  No impact of rs1625579 on the variability of white matter structure was observed using diffusion tensor imaging (DTI) in healthy Irish participants .  ... 
doi:10.1007/s00702-014-1338-4 pmid:25395183 fatcat:fxp3n7wenjcmdov55ijzva2eqe

A Common CACNA1C Gene Risk Variant has Sex-Dependent Effects on Behavioral Traits and Brain Functional Activity

Hikaru Takeuchi, Hiroaki Tomita, Yasuyuki Taki, Yoshie Kikuchi, Chiaki Ono, Zhiqian Yu, Rui Nouchi, Ryoichi Yokoyama, Yuka Kotozaki, Seishu Nakagawa, Atsushi Sekiguchi, Kunio Iizuka (+10 others)
2018 Cerebral Cortex  
Genome-wide association studies have suggested that allelic variations in the CACNA1C gene confer susceptibility to schizophrenia and bipolar disorder only in women.  ...  Imaging analyses revealed significant interaction effects between sex and the minor allele on fractional amplitude of low-frequency fluctuations in the right dorsolateral prefrontal cortex and on brain  ...  Notes We thank Yuki Yamada for operating the MRI scanner, Haruka Nouchi for conducting the psychological tests, all other assistants for helping with the experiments and the study, and the study participants  ... 
doi:10.1093/cercor/bhy189 pmid:30124797 fatcat:5y2cy72xerdhjo6tildjvbvqky

CACNA1C polymorphisms Impact Cognitive Recovery in Patients with Bipolar Disorder in a Six-week Open-label Trial

Kangguang Lin, Guiyun Xu, Lingling Shi, Weicong Lu, Lijie Guan, Huiyi Ouyang, Kun Chen, Yamei Dang, Libing Zhou, Kwok-Fai So
2017 Scientific Reports  
In this six-week open-label trial, we shed light on the impacts of six single nucleotide polymorphisms (SNPs) in the calcium voltage-gated channel subunit alpha1 C (CACNA1C) gene on cognitive recovery  ...  Genome-wide association studies (GWAS) have repeatedly reported multiple single nucleotide polymorphisms (SNPs) in the alpha 1 C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene linked  ...  -E0611), China, which had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.  ... 
doi:10.1038/s41598-017-07368-5 pmid:28765577 pmcid:PMC5539285 fatcat:qheusqvjmbdxththxo47wo5gdm

Neuroimaging biomarkers in bipolar disorder

Josselin Houenou
2012 Frontiers in Bioscience (Elite Edition)  
The impact of susceptibility gene factors on brain structure and function can also be assessed by studying the healthy relatives of patients with BD.  ...  The impact of CACNA1C allelic variation was largely unknown until recent neuroimaging studies revealed that carriers of the CACNA1C risk allele in a group of healthy controls displayed stronger limbic  ... 
doi:10.2741/e402 fatcat:idokvr2ajfburpmvoji3mq2lie

Neuroimaging genomics in psychiatry—a translational approach

Mary S. Mufford, Dan J. Stein, Shareefa Dalvie, Nynke A. Groenewold, Paul M. Thompson, Neda Jahanshad
2017 Genome Medicine  
Notably, genomewide association studies (GWAS) of brain imaging in thousands of individuals around the world have led to a range of promising findings.  ...  Neuroimaging genomics is a relatively new field focused on integrating genomic and imaging data in order to investigate the mechanisms underlying brain phenotypes and neuropsychiatric disorders.  ...  Longitudinal and transgenerational studies of both healthy and at-risk individuals might also prove useful for understanding the impact of the environment on the epigenome [101] .  ... 
doi:10.1186/s13073-017-0496-z pmid:29179742 pmcid:PMC5704437 fatcat:dkp4b47r7za73owbdcbplfwe2e

Integrated Neurobiology of Bipolar Disorder

Vladimir Maletic, Charles Raison
2014 Frontiers in Psychiatry  
Importantly, two recent reviews addressing the impact of medication on imaging outcomes jointly indicate that medications have a fairly discrete impact in functional and diffusion tensor imaging studies  ...  Decreases of hippocampal volume in the adulthood of bipolar individuals may be driven by a polymorphism of genes regulating BDNF function and may be localized to certain hippocampal substructures (9,  ... 
doi:10.3389/fpsyt.2014.00098 pmid:25202283 pmcid:PMC4142322 fatcat:eemet5r5arfelecpwfxl5uf4r4

Functional neuroimaging and schizophrenia: a view towards effective connectivity modeling and polygenic risk

Rebecca Birnbaum, Daniel R Weinberger
2013 Dialogues in Clinical Neuroscience  
A plethora of imaging genetics studies have investigated the impact of genetic variation on brain function, since the paradigm of a neuroimaging intermediate phenotype for schizophrenia first emerged.  ...  We review critical trends in imaging genetics as applied to schizophrenia research, and then discuss some future directions of the field.  ...  of the striatum and prefrontal cortex. 52 An RGS4 variant was found to impact frontoparietal and frontotemporal coupling. 53 A CACNA1C risk SNP was associated with decreased prefrontal-hippocampal  ... 
pmid:24174900 pmcid:PMC3811100 fatcat:hfacbcma3fap7jrjg6utcevtgq

Neurodevelopment in Schizophrenia: The Role of the Wnt Pathways

Isabella Panaccione, Flavia Napoletano, Alberto Forte, Giorgio Kotzalidis, Antonio Casale, Chiara Rapinesi, Chiara Brugnoli, Daniele Serata, Federica Caccia, Ilaria Cuomo, Elisa Ambrosi, Alessio Simonetti (+9 others)
2013 Current Neuropharmacology  
There were no timeframe limitations in our searches. ROLE OF INDIVIDUAL WNT SIGNALLING MOLECULES IN DEVELOPMENT AND NEURO-DEVELOPMENT 3.  ...  Conclusions: The study of the involvement of Wnt pathway abnormalities in schizophrenia may help in understanding this multifaceted clinical entity; the development of Wnt-related pharmacological targets  ...  In fact, using prenatal ultrasound scans, as well as neonatal structural magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI), differences in cerebrospinal fluid (CSF)-occupied spaces were  ... 
doi:10.2174/1570159x113119990037 pmid:24403877 pmcid:PMC3763761 fatcat:6hfvhvwx4nbszpok4s4h6oszem

Panel, Mini-panel and Study Group

2014 Neuropsychopharmacology  
Methods: In a series of studies in healthy individuals and unaffected first-degree relatives of schizophrenia patients we have established and confirmed the link of these phenotypes to the genetic liability  ...  A popular research strategy for the dissection of schizophrenia pathophysiology is imaging genetics, an approach founded on the idea that some neuroimaging phenotypes may bear a closer relationship to  ...  In this study, we investigated the effect of DAT gene polymorphism on fMRI measures of striatal activation in a group of unmedicated BD subjects as well as healthy controls.  ... 
doi:10.1038/npp.2014.279 pmid:25466712 pmcid:PMC4261146 fatcat:v6fgkukh6zgtdmswrjpk46dvhi

Selected rapporteur summaries from the XX world congress of psychiatric genetics, Hamburg, Germany, october 14-18, 2012

Heike Anderson-Schmidt, Olga Beltcheva, Mariko D. Brandon, Enda M. Byrne, Eric J. Diehl, Laramie Duncan, Suzanne D. Gonzalez, Eilis Hannon, Katri Kantojärvi, Iordanis Karagiannidis, Mark Z. Kos, Eszter Kotyuk (+14 others)
2013 American Journal of Medical Genetics Part B: Neuropsychiatric Genetics  
However, the speakers are not responsible for any of the information contained in this report.  ...  The data reported on are as heard during the presentation and where possible, all statements have been checked with the speaker for accuracy.  ...  The findings suggest a neurodegenerative role of the A-alleles of the TNF SNPs rs1800629 (-308G/A) and rs361525 (-238G/A) on hippocampal volumes in healthy individuals.  ... 
doi:10.1002/ajmg.b.32132 pmid:23341144 pmcid:PMC4090768 fatcat:j27eevlpvnf75fqqli5ojamec4

2014 Update of the Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception

Michael W. Weiner, Dallas P. Veitch, Paul S. Aisen, Laurel A. Beckett, Nigel J. Cairns, Jesse Cedarbaum, Robert C. Green, Danielle Harvey, Clifford R. Jack, William Jagust, Johan Luthman, John C. Morris (+7 others)
2015 Alzheimer's & Dementia  
fluid (CSF) biomarkers in a multicenter setting; (2) elucidation of the patterns and rates of change of imaging and CSF biomarker measurements in control subjects, MCI patients, and AD patients.  ...  imaging and biomarker phenotypes, including longitudinal data, to confirm recently identified loci, CR1, CLU, and PICALM and to identify novel AD risk loci; (8) worldwide impact through the establishment  ...  Weiner has served on the scientific advisory boards for Lilly, Araclon and Institut Catala de Neurociencies Aplicades, Gulf War Veterans Illnesses Advisory Committee, VACO, Biogen Idec, and Pfizer; has  ... 
doi:10.1016/j.jalz.2014.11.001 pmid:26073027 pmcid:PMC5469297 fatcat:2k7ag6astffy5gphqxf5lodkdq

The emerging spectrum of allelic variation in schizophrenia: current evidence and strategies for the identification and functional characterization of common and rare variants

B J Mowry, J Gratten
2012 Molecular Psychiatry  
After decades of halting progress, recent large genome-wide association studies (GWAS) are finally shining light on the genetic architecture of schizophrenia.  ...  A further aim is to consider the challenges and opportunities involved in determining the functional basis of genetic associations, for instance using functional genomics, cellular models, animal models  ...  We thank the anonymous referees for their helpful comments and Dee McGrath for help with the figures.  ... 
doi:10.1038/mp.2012.34 pmid:22547114 fatcat:tj3sinccmng2dg4uoqdd47mf6u

Poster Session II

2010 Neuropsychopharmacology  
Diffusion tensor imaging results are to follow.  ...  A linear genotype effect on connectivity in DLPFC and hippocampal formation during a memory task was found in healthy control subjects in an fMRI study.  ...  novel insights into the impact of CNS-acting drug treatments on brain activity and function.  ... 
doi:10.1038/npp.2010.217 fatcat:gbcgyi35jbdndlwhlgwio7ts7y

Brain imaging genetics in ADHD and beyond – Mapping pathways from gene to disorder at different levels of complexity

Marieke Klein, Marten Onnink, Marjolein van Donkelaar, Thomas Wolfers, Benjamin Harich, Yan Shi, Janneke Dammers, Alejandro Arias-Vásquez, Martine Hoogman, Barbara Franke
2017 Neuroscience and Biobehavioral Reviews  
We performed a systematic review of brain imaging genetics studies involving 62 ADHD candidate genes in childhood and adult ADHD cohorts.  ...  Beyond reviewing imaging genetics studies, we also discuss the need for complementary approaches at multiple levels of biological complexity and emphasize the importance of combining and integrating findings  ...  The work was also supported by grants for the ENIGMA Consortium (grant number U54 EB020403) from the BD2K Initiative of a cross-NIH partnership, and by the ECNP Network ADHD across the Lifespan.  ... 
doi:10.1016/j.neubiorev.2017.01.013 pmid:28159610 pmcid:PMC6947924 fatcat:ckrkxgzl5zaqpngbdia3dpdwse

ACNP 55th Annual Meeting: Poster Session III

2016 Neuropsychopharmacology  
evaluation of these two radioligands in a healthy rhesus monkey brain.  ...  The purpose of this study was to determine whether a model on neuroinflammation (i.e., intracerebral injection of lipopolysaccharide (LPS)) would upregulate expression of COX-2 but not COX-1.  ...  brain functional (resting-state) and anatomical (diffusion tensor imaging) networks.  ... 
doi:10.1038/npp.2016.242 fatcat:4efd43swjbboranfrcs3pp32h4
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