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The coupling of global brain activity and cerebrospinal fluid inflow is correlated with Alzheimer's disease related pathology [article]

Feng Han, Jing Chen, Aaron E. Belkin-Rosen, Yameng Gu, Liying Luo, Orfeu M Buxton, Xiao Liu
2020 bioRxiv   pre-print
Recent studies have reported that widespread, high-amplitude spontaneous brain activations in the drowsy state and during sleep, which are shown as large global signal peaks in resting-state fMRI, is coupled  ...  These results provide critical initial evidence for involvement of sleep-dependent global brain activity, as well as the associated physiological modulations, in the clearance of AD-related brain waste  ...  Acknowledgments: We thank the ADNI for data collection and sharing through generous  ... 
doi:10.1101/2020.06.04.134726 fatcat:6nzjkfus6ved5oyj3qabc4khbq

Consciousness in humans and non-human animals: recent advances and future directions

Melanie Boly, Anil K. Seth, Melanie Wilke, Paul Ingmundson, Bernard Baars, Steven Laureys, David B. Edelman, Naotsugu Tsuchiya
2013 Frontiers in Psychology  
An important role for fronto-parietal networks in consciousness is, however, consistent with evidence describing a range of metabolic activity patterns during different tasks (and rest) since what may  ...  Several intracranial recordings in humans have also shown that temporal and parietal lobe seizure-induced LOC is associated with a widespread increase in neural synchrony (Arthuis et al., 2009; Lambert  ...  Conflict of Interest Statement: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest  ... 
doi:10.3389/fpsyg.2013.00625 pmid:24198791 pmcid:PMC3814086 fatcat:fq4o5x72ijcr5jsu2gxlh32eja

Sex differences and the neurobiology of affective disorders

David R. Rubinow, Peter J. Schmidt
2018 Neuropsychopharmacology  
We next review sex differences in the brain at the structural, cellular, and network levels.  ...  As a disclaimer, the studies cited in this review are not intended to be comprehensive but rather serve as examples of the multitude of levels at which sex and reproductive hormones regulate brain structure  ...  The views expressed in this article do not necessarily represent the views of the NIMH, NIH, HHS, or the US Government.  ... 
doi:10.1038/s41386-018-0148-z pmid:30061743 pmcid:PMC6235863 fatcat:m5ega6a3qjeqdegdv7n4pkrqdq

Brain activity fluctuations propagate as waves traversing the cortical hierarchy [article]

Yameng Gu, Lucas E Sainburg, Sizhe Kuang, Feng Han, Jack W Williams, Yikang Liu, Nanyin Zhang, Xiang Zhang, David A Leopold, Xiao Liu
2020 bioRxiv   pre-print
The brain exhibits highly organized patterns of spontaneous activity as measured by resting-state fMRI fluctuations that are being widely used to assess the brain functional connectivity.  ...  the temporal constraints of the hemodynamic signal.  ...  Licata SC, et al. (2013) The hypnotic zolpidem increases the synchrony of BOLD signal fluctuations in widespread brain networks during a resting paradigm.  ... 
doi:10.1101/2020.08.18.256610 fatcat:k4vtedfphreg3l6deu7gzuj7rq

About Sleep's Role in Memory

Björn Rasch, Jan Born
2013 Physiological Reviews  
Specifically, newer findings characterize sleep as a brain state optimizing memory consolidation, in opposition to the waking brain being optimized for encoding of memories.  ...  In this review we aim to comprehensively cover the field of "sleep and memory" research by providing a historical perspective on concepts and a discussion of more recent key findings.  ...  in preparing the manuscript and Sandra Ackermann-Wohlgemuth, Luciana Besedovsky, Susanne Diekelmann, and Ines Wilhelm for helpful comments  ... 
doi:10.1152/physrev.00032.2012 pmid:23589831 pmcid:PMC3768102 fatcat:hwyquoixznaofmhcrp2ipgixie

Panel, Mini-panel and Study Group

2014 Neuropsychopharmacology  
For ventral striatal activation during reward processing our data provide the first evidence for a systems-level intermediate phenotype signaling increased genetic risk for schizophrenia, which demonstrates  ...  Schizophrenia is a highly debilitating brain disorder with a heritability of up to 80% and a complex genetic architecture.  ...  In women and using fMRI, we examined how the dynamic fluctuations of estradiol across the menstrual cycle and the use of hormonal contraceptives may influence the BOLD signal during fear conditioning and  ... 
doi:10.1038/npp.2014.279 pmid:25466712 pmcid:PMC4261146 fatcat:v6fgkukh6zgtdmswrjpk46dvhi

Top-down and bottom-up control of drug-induced sleep and anaesthesia

David Uygun, William Wisden, Nick Franks, Biotechnology And Biological Sciences Research Council (Great Britain)
But, zolpidem-sensitivity can be restored selectively in brain regions, enabling dissection of the circuitry involved in zolpidem's effect.  ...  Zolpidem is a positive allosteric modulator (PAM) of the GABAA receptor which binds to the benzodiazepine (BZ) site.  ...  The potential fluctuates relative to other groups of neurons and provides a degree of synchrony. LFPs are the units of the EEG signal. Drawn by D.S.  ... 
doi:10.25560/43958 fatcat:wksdls2rmbawjndl7fkjxxbawm


2012 Journal of clinical rheumatology  
Pharmacological inhibition of cAMP production in the caudal, oral pontine reticular formation (PnOc) of the rat results in a long-lasting increase in the expression of REM sleep (1).  ...  In those neurons which exhibited spontaneous discharge, hypocretin increase the frequency of discharge. The typical effects of hypocretin on a NPO neuron are shown in Figure 1 .  ...  However, the use of zolpidem by climbers can be limited by a too long duration (about 6 h) of its hypnotic effects.  ... 
doi:10.1097/rhu.0b013e3182557a66 fatcat:wtmtrd3kpfbyjoysmb6qrgxcua