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The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
2019
Nature
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Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution ...
molecular and cellular atlas of the human body, in health and under various disease conditions. ...
Acknowledgements This research is supported by the NIH Common Fund, through the Office of Strategic Coordination/Office of the NIH Director under awards OT2OD026663, OT2OD026671, OT2OD026673, OT2OD026675 ...
doi:10.1038/s41586-019-1629-x
pmid:31597973
pmcid:PMC6800388
fatcat:xabjivxo7zck3ju726nfcapiaq
Mapping the Human Body at Cellular Resolution -- The NIH Common Fund Human BioMolecular Atlas Program
[article]
2019
arXiv
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Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) aims to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution ...
atlas of the human body, in health and various disease settings. ...
HuBMAP (see https://commonfund.nih.gov/hubmap) is a NIH-sponsored program with the goals of developing an open framework and technologies for mapping the human body at cellular resolution as well as generating ...
arXiv:1903.07231v1
fatcat:q22nqjuptvcidmwacn7xe3jcqi
Toward mapping the human body at a cellular resolution
2018
Molecular Biology of the Cell
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collaboration toward the broader goal of comprehensively mapping the human body with cellular resolution. ...
The adult human body is composed of nearly 37 trillion cells, each with potentially unique molecular characteristics. ...
ACKNOWLEDGMENTS We acknowledge the support of the Office of Strategic Coordination and the Division of Program Coordination, Planning, and Strategic Initiatives, National Institutes of Health. ...
doi:10.1091/mbc.e18-04-0260
pmid:30058989
fatcat:77hxamvhzjgd5fzkcgg2jv4v5u
The human body at cellular resolution: the NIH Human Biomolecular Atlas Program
2019
Preserved Fulltext
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Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at singlecell resolution ...
molecular and cellular atlas of the human body, in health and under various disease conditions. t he human body is an incredible machine. ...
Acknowledgements This research is supported by the NIH Common Fund, through the Office of Strategic Coordination/Office of the NIH Director under awards OT2OD026663, OT2OD026671, OT2OD026673, OT2OD026675 ...
doi:10.17863/cam.46527
fatcat:otlhbc2y7jfrbeyhahmnero2ha
The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease
2019
American Journal of Respiratory Cell and Molecular Biology
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The Human Cell Atlas consortium aims to characterize all cells in the healthy human body and has prioritized lung tissue as one of the flagship projects. ...
Here, we present the rationale, the approach, and the expected impact of a Human Lung Cell Atlas. ...
HBS acknowledges funding by the Helmholtz Association and the German ...
doi:10.1165/rcmb.2018-0416tr
pmid:30995076
pmcid:PMC6604220
fatcat:yqlpkerahzcpne6srj2yqjhawe
The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution
2019
Developmental Cell
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We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs ...
human lifespan. ...
For example, the National Institutes of Health (NIH) supports programs such as the Human Biomolecular Atlas Program (HuBMAP), the Human Tumor Atlas Network (HTAN), and the BRAIN Initiative Cell Census ...
doi:10.1016/j.devcel.2019.03.001
pmid:30930166
pmcid:PMC6616346
fatcat:izju65rkrbhjxaigueldvsq6aa
The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution
2020
Cell
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The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate ...
Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution. ...
HTAN strives to provide compatibility with other relevant platforms, such as the Human Cell Atlas (HCA) Data Coordination Platform and the Human Biomolecular Atlas Program (HuBMAP) High-Performance Integrated ...
doi:10.1016/j.cell.2020.03.053
pmid:32302568
pmcid:PMC7376497
fatcat:jlxyctmcfrewlnjzhxrckim5p4
Accelerating a paradigm shift: The Common Fund Single Cell Analysis Program
2018
Science Advances
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In this review, we outline the original program goals and provide a perspective on the impact of the program as a catalyst for exploration of heterogeneity of human tissues at the cellular level. ...
The National Institutes of Health (NIH) Common Fund-supported Single Cell Analysis Program (SCAP) was designed to address this challenge. ...
Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the materials cited herein. ...
doi:10.1126/sciadv.aat8573
pmid:30083611
pmcid:PMC6070315
fatcat:ghuxkfzywbc5bpatq2tnwkggau
A multiscale atlas of the molecular and cellular architecture of the human kidney
[article]
2022
bioRxiv
pre-print
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These integrated data provide a valuable reference molecular atlas for kidney researchers and are publicly available through the NIH Human Biomolecular Atlas Program (https://portal.hubmapconsortium.org ...
Towards this end, we have developed an extensive molecular and cellular atlas of the human kidney consisting of over 3 million cells comprising 75,000 functional units from 13 human patients, using a spatially ...
Acknowledgements Support was provided by the NIH Common Fund and National Institute of Diabetes and Digestive and Kidney Diseases (U54DK120058 awarded to J.M.S. and R.M.C.), the National Science Foundation ...
doi:10.1101/2022.04.07.487155
fatcat:twynvwjprfe6hb7kuk3zcdttaa
DECIPHERING ENDOTHELIAL HETEROGENEITY IN HEALTH AND DISEASE AT SINGLE CELL RESOLUTION: PROGRESS AND PERSPECTIVES
2022
Cardiovascular Research
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Here, we discuss recent landmark studies aimed at teasing apart the heterogeneous nature of ECs. ...
The rise of the new single cell era has led to an emergence of studies aimed at interrogating transcriptome diversity along the vascular tree, and has revolutionized our understanding of EC heterogeneity ...
Human Cell Atlas portal for all tissues and cell types of the human body, 181 or the NIH Human Biomolecular Atlas Program (HuBMAP), 182 furthermore provide tempting field-specific opportunities in terms ...
doi:10.1093/cvr/cvac018
pmid:35179567
fatcat:6ucj2zs5rrf75lpsxyt4mmm6ke
SOP: Construction of Organ Mapping Antibody Panels for Multiplexed Antibody-Based Imaging of Human Tissues
[article]
2021
Zenodo
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Optical imaging provides critical spatial data and context for the vast network of different cell types and anatomical structures present in the human body. ...
Given the wealth of information provided by multiplexed antibody-based imaging, these techniques are foundational to international efforts aimed at building a comprehensive human reference atlas (HRA) ...
This work was supported, in part, by the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Disease and National Cancer Institute. ...
doi:10.5281/zenodo.5749883
fatcat:g25ceyntkzgfpksso33vhicjhy
Molecular neuroanatomy: a generation of progress
2014
Trends in Neurosciences
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rtn=docs/home
Non-human primate brain atlases
NIH Blueprint NHP Atlas
A suite of gene expression data, neuroanatomical data,
and informatics tools for exploring the cellular and
molecular architecture ...
http://brainmap.wisc.edu/monkey.html
Human brain atlases
Big Brain: An Ultrahigh Resolution
3D Human Brain Model
An ultrahigh resolution 3D human brain model
https://bigbrain.loris.ca/main.php ...
doi:10.1016/j.tins.2013.11.001
pmid:24388609
pmcid:PMC3946666
fatcat:bic7nwic3neujkgrnsinidkzra
Cells in experimental life sciences - challenges and solution to the rapid evolution of knowledge
2017
BMC Bioinformatics
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, which were discussed in the First International Workshop on CELLS at the the International Conference on Biomedical Ontology (ICBO). ...
The First International Workshop on CELLS at the International Conference on Biomedical Ontology has brought together experimental biologists and biomedical ontologists to discuss solutions to organizing ...
The Common Coordinate Framework meeting organized by the National Institute of Health, Chan-Zuckerberg Initiative, and the Human Cell Atlas as part of the Human Biomolecular Atlas Program (HuBMAP) [6] ...
doi:10.1186/s12859-017-1976-2
pmid:29322916
pmcid:PMC5763506
fatcat:r7y4wcuw6jezvbxfy2ovo6jfh4
The NIH Common Fund/Roadmap Epigenomics Program: Successes of a comprehensive consortium
2019
Science Advances
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The NIH Roadmap Epigenomics Program was launched to deliver reference epigenomic data from human tissues and cells, develop tools and methods for analyzing the epigenome, discover novel epigenetic marks ...
, develop methods to manipulate the epigenome, and determine epigenetic contributions to diverse human diseases. ...
Likewise, the newly minted Common Fund Human Biomolecular Atlas Program, focusing on the ambitious goal of providing the map of the human body at cellular resolution, may also benefit from the Epigenomics ...
doi:10.1126/sciadv.aaw6507
pmid:31501771
pmcid:PMC6719411
fatcat:fmm4tsakuzgrrbj3wu3mgp7hbq
New views of old proteins: clarifying the enigmatic proteome
[article]
2021
arXiv
pre-print
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understanding and interactions with human disease in the coming decade. ...
All human diseases involve proteins, yet our current tools to characterize and quantify them are limited. ...
The Human Protein Atlas 7 and the Human BioMolecular Atlas Program (HuBMAP) 8 are examples of such efforts. ...
arXiv:2108.07660v1
fatcat:5i5fwukf4fckzp2oeilde7arp4
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