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The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

HuBMAP Consortium
2019 Nature  
Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution  ...  molecular and cellular atlas of the human body, in health and under various disease conditions.  ...  Acknowledgements This research is supported by the NIH Common Fund, through the Office of Strategic Coordination/Office of the NIH Director under awards OT2OD026663, OT2OD026671, OT2OD026673, OT2OD026675  ... 
doi:10.1038/s41586-019-1629-x pmid:31597973 pmcid:PMC6800388 fatcat:xabjivxo7zck3ju726nfcapiaq

Mapping the Human Body at Cellular Resolution -- The NIH Common Fund Human BioMolecular Atlas Program [article]

Michael P Snyder, Shin Lin, Amanda Posgai, Mark Atkinson, Aviv Regev, Jennifer Rood, Orit Rosen, Leslie Gaffney, Anna Hupalowska, Rahul Satija, Nils Gehlenborg, Jay Shendure, Julia Laskin, Pehr Harbury (+10 others)
2019 arXiv   pre-print
Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) aims to develop a widely accessible framework for comprehensively mapping the human body at single-cell resolution  ...  atlas of the human body, in health and various disease settings.  ...  HuBMAP (see https://commonfund.nih.gov/hubmap) is a NIH-sponsored program with the goals of developing an open framework and technologies for mapping the human body at cellular resolution as well as generating  ... 
arXiv:1903.07231v1 fatcat:q22nqjuptvcidmwacn7xe3jcqi

Toward mapping the human body at a cellular resolution

Ananda L. Roy, Richard S. Conroy, Doug Kellogg
2018 Molecular Biology of the Cell  
collaboration toward the broader goal of comprehensively mapping the human body with cellular resolution.  ...  The adult human body is composed of nearly 37 trillion cells, each with potentially unique molecular characteristics.  ...  ACKNOWLEDGMENTS We acknowledge the support of the Office of Strategic Coordination and the Division of Program Coordination, Planning, and Strategic Initiatives, National Institutes of Health.  ... 
doi:10.1091/mbc.e18-04-0260 pmid:30058989 fatcat:77hxamvhzjgd5fzkcgg2jv4v5u

The human body at cellular resolution: the NIH Human Biomolecular Atlas Program

HuBMAP Consortium, Apollo-University Of Cambridge Repository, Apollo-University Of Cambridge Repository
2019
Over the next seven years, the NIH Common Fund Human Biomolecular Atlas Program (HuBMAP) intends to develop a widely accessible framework for comprehensively mapping the human body at singlecell resolution  ...  molecular and cellular atlas of the human body, in health and under various disease conditions. t he human body is an incredible machine.  ...  Acknowledgements This research is supported by the NIH Common Fund, through the Office of Strategic Coordination/Office of the NIH Director under awards OT2OD026663, OT2OD026671, OT2OD026673, OT2OD026675  ... 
doi:10.17863/cam.46527 fatcat:otlhbc2y7jfrbeyhahmnero2ha

The Human Lung Cell Atlas - A high-resolution reference map of the human lung in health and disease

Herbert B Schiller, Daniel T Montoro, Lukas M Simon, Emma L Rawlins, Kerstin B Meyer, Maximilian Strunz, Felipe Vieira Braga, Wim Timens, Gerard H Koppelman, G.R. Scott Budinger, Janette K Burgess, Maarten van den Berge (+7 others)
2019 American Journal of Respiratory Cell and Molecular Biology  
The Human Cell Atlas consortium aims to characterize all cells in the healthy human body and has prioritized lung tissue as one of the flagship projects.  ...  Here, we present the rationale, the approach, and the expected impact of a Human Lung Cell Atlas.  ...  HBS acknowledges funding by the Helmholtz Association and the German  ... 
doi:10.1165/rcmb.2018-0416tr pmid:30995076 pmcid:PMC6604220 fatcat:yqlpkerahzcpne6srj2yqjhawe

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution

Deanne M. Taylor, Bruce J. Aronow, Kai Tan, Kathrin Bernt, Nathan Salomonis, Casey S. Greene, Alina Frolova, Sarah E. Henrickson, Andrew Wells, Liming Pei, Jyoti K. Jaiswal, Jeffrey Whitsett (+61 others)
2019 Developmental Cell  
We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs  ...  human lifespan.  ...  For example, the National Institutes of Health (NIH) supports programs such as the Human Biomolecular Atlas Program (HuBMAP), the Human Tumor Atlas Network (HTAN), and the BRAIN Initiative Cell Census  ... 
doi:10.1016/j.devcel.2019.03.001 pmid:30930166 pmcid:PMC6616346 fatcat:izju65rkrbhjxaigueldvsq6aa

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

Orit Rozenblatt-Rosen, Aviv Regev, Philipp Oberdoerffer, Tal Nawy, Anna Hupalowska, Jennifer E Rood, Orr Ashenberg, Ethan Cerami, Robert J Coffey, Emek Demir, Li Ding, Edward D Esplin (+26 others)
2020 Cell  
The Human Tumor Atlas Network (HTAN), part of the National Cancer Institute (NCI) Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate  ...  Transformative single-cell genomics technologies and spatial multiplex in situ methods now provide an opportunity to interrogate this complexity at unprecedented resolution.  ...  HTAN strives to provide compatibility with other relevant platforms, such as the Human Cell Atlas (HCA) Data Coordination Platform and the Human Biomolecular Atlas Program (HuBMAP) High-Performance Integrated  ... 
doi:10.1016/j.cell.2020.03.053 pmid:32302568 pmcid:PMC7376497 fatcat:jlxyctmcfrewlnjzhxrckim5p4

Accelerating a paradigm shift: The Common Fund Single Cell Analysis Program

Ananda L. Roy, Richard Conroy, Jessica Smith, Yong Yao, Andrea C. Beckel-Mitchener, James M. Anderson, Elizabeth L. Wilder
2018 Science Advances  
In this review, we outline the original program goals and provide a perspective on the impact of the program as a catalyst for exploration of heterogeneity of human tissues at the cellular level.  ...  The National Institutes of Health (NIH) Common Fund-supported Single Cell Analysis Program (SCAP) was designed to address this challenge.  ...  Data and materials availability: All data needed to evaluate the conclusions in the paper are present in the paper and/or the materials cited herein.  ... 
doi:10.1126/sciadv.aat8573 pmid:30083611 pmcid:PMC6070315 fatcat:ghuxkfzywbc5bpatq2tnwkggau

A multiscale atlas of the molecular and cellular architecture of the human kidney [article]

Elizabeth Kathleen Neumann, Nathan Heath Patterson, Leonoor E.M. Tideman, Lukasz G Migas, Madeline E. Colley, Melissa A Farrow, Jamie L Allen, Emilio S Rivera, Carrie E Rmer, Haichun Yang, Maya Brewer, Kavya Sharman (+7 others)
2022 bioRxiv   pre-print
These integrated data provide a valuable reference molecular atlas for kidney researchers and are publicly available through the NIH Human Biomolecular Atlas Program (https://portal.hubmapconsortium.org  ...  Towards this end, we have developed an extensive molecular and cellular atlas of the human kidney consisting of over 3 million cells comprising 75,000 functional units from 13 human patients, using a spatially  ...  Acknowledgements Support was provided by the NIH Common Fund and National Institute of Diabetes and Digestive and Kidney Diseases (U54DK120058 awarded to J.M.S. and R.M.C.), the National Science Foundation  ... 
doi:10.1101/2022.04.07.487155 fatcat:twynvwjprfe6hb7kuk3zcdttaa

DECIPHERING ENDOTHELIAL HETEROGENEITY IN HEALTH AND DISEASE AT SINGLE CELL RESOLUTION: PROGRESS AND PERSPECTIVES

Lisa M Becker, Shiau-Haln Chen, Julie Rodor, Laura P M H de Rooij, Andrew H Baker, Peter Carmeliet
2022 Cardiovascular Research  
Here, we discuss recent landmark studies aimed at teasing apart the heterogeneous nature of ECs.  ...  The rise of the new single cell era has led to an emergence of studies aimed at interrogating transcriptome diversity along the vascular tree, and has revolutionized our understanding of EC heterogeneity  ...  Human Cell Atlas portal for all tissues and cell types of the human body, 181 or the NIH Human Biomolecular Atlas Program (HuBMAP), 182 furthermore provide tempting field-specific opportunities in terms  ... 
doi:10.1093/cvr/cvac018 pmid:35179567 fatcat:6ucj2zs5rrf75lpsxyt4mmm6ke

SOP: Construction of Organ Mapping Antibody Panels for Multiplexed Antibody-Based Imaging of Human Tissues [article]

Andrea J. Radtke
2021 Zenodo  
Optical imaging provides critical spatial data and context for the vast network of different cell types and anatomical structures present in the human body.  ...  Given the wealth of information provided by multiplexed antibody-based imaging, these techniques are foundational to international efforts aimed at building a comprehensive human reference atlas (HRA)  ...  This work was supported, in part, by the Intramural Research Program of the NIH, National Institute of Allergy and Infectious Disease and National Cancer Institute.  ... 
doi:10.5281/zenodo.5749883 fatcat:g25ceyntkzgfpksso33vhicjhy

Molecular neuroanatomy: a generation of progress

Jonathan D. Pollock, Da-Yu Wu, John S. Satterlee
2014 Trends in Neurosciences  
rtn=docs/home Non-human primate brain atlases NIH Blueprint NHP Atlas A suite of gene expression data, neuroanatomical data, and informatics tools for exploring the cellular and molecular architecture  ...  http://brainmap.wisc.edu/monkey.html Human brain atlases Big Brain: An Ultrahigh Resolution 3D Human Brain Model An ultrahigh resolution 3D human brain model https://bigbrain.loris.ca/main.php  ... 
doi:10.1016/j.tins.2013.11.001 pmid:24388609 pmcid:PMC3946666 fatcat:bic7nwic3neujkgrnsinidkzra

Cells in experimental life sciences - challenges and solution to the rapid evolution of knowledge

Sirarat Sarntivijai, Alexander D. Diehl, Yongqun He
2017 BMC Bioinformatics  
, which were discussed in the First International Workshop on CELLS at the the International Conference on Biomedical Ontology (ICBO).  ...  The First International Workshop on CELLS at the International Conference on Biomedical Ontology has brought together experimental biologists and biomedical ontologists to discuss solutions to organizing  ...  The Common Coordinate Framework meeting organized by the National Institute of Health, Chan-Zuckerberg Initiative, and the Human Cell Atlas as part of the Human Biomolecular Atlas Program (HuBMAP) [6]  ... 
doi:10.1186/s12859-017-1976-2 pmid:29322916 pmcid:PMC5763506 fatcat:r7y4wcuw6jezvbxfy2ovo6jfh4

The NIH Common Fund/Roadmap Epigenomics Program: Successes of a comprehensive consortium

John S. Satterlee, Lisa H. Chadwick, Frederick L. Tyson, Kim McAllister, Jill Beaver, Linda Birnbaum, Nora D. Volkow, Elizabeth L. Wilder, James M. Anderson, Ananda L. Roy
2019 Science Advances  
The NIH Roadmap Epigenomics Program was launched to deliver reference epigenomic data from human tissues and cells, develop tools and methods for analyzing the epigenome, discover novel epigenetic marks  ...  , develop methods to manipulate the epigenome, and determine epigenetic contributions to diverse human diseases.  ...  Likewise, the newly minted Common Fund Human Biomolecular Atlas Program, focusing on the ambitious goal of providing the map of the human body at cellular resolution, may also benefit from the Epigenomics  ... 
doi:10.1126/sciadv.aaw6507 pmid:31501771 pmcid:PMC6719411 fatcat:fmm4tsakuzgrrbj3wu3mgp7hbq

New views of old proteins: clarifying the enigmatic proteome [article]

Participants in a NIH Workshop on Functional, Integrative Proteomics: Kristin E. Burnum Johnson
2021 arXiv   pre-print
understanding and interactions with human disease in the coming decade.  ...  All human diseases involve proteins, yet our current tools to characterize and quantify them are limited.  ...  The Human Protein Atlas 7 and the Human BioMolecular Atlas Program (HuBMAP) 8 are examples of such efforts.  ... 
arXiv:2108.07660v1 fatcat:5i5fwukf4fckzp2oeilde7arp4
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