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The genetics of cortical myelination in young adults and its relationships to cerebral surface area, cortical thickness, and intelligence: A magnetic resonance imaging study of twins and families

J. Eric Schmitt, Armin Raznahan, Siyuan Liu, Michael C. Neale
2019 NeuroImage  
its relationships with cerebral surface area (SA) and cortical thickness (CT).  ...  In this study, we use a genetically-informative neuroimaging sample of 1096 young adult subjects from the Human Connectome Project in order to investigate genetic and environmental variation in CM and  ...  Twin and family studies on cerebral surface area (SA) in children and young adults have found that the posterior cerebrum, particularly the parasagittal occipital lobe and precuneus, are reproducibly the  ... 
doi:10.1016/j.neuroimage.2019.116319 pmid:31678229 pmcid:PMC7871660 fatcat:zdnkpunppbh3vb6leynsiicbbm


Arthur W. Toga, Paul M. Thompson
2005 Annual Review of Neuroscience  
A variety of sophisticated brain-mapping approaches relating genetic influences on brain structure and intelligence establishes a regional distribution for this relationship that is consistent with behavioral  ...  Other factors, such as the environment, obviously play a role, but the predominant determinant appears to genetic.  ...  grant and the International Consortium for Brain Mapping, funded by the National Institute of Mental Health and the National Institute on Drug Abuse (P20 MH/DA52176).  ... 
doi:10.1146/annurev.neuro.28.061604.135655 pmid:15651931 fatcat:6dct5ykmijb57jso5zq2xop774

Changes in Thickness and Surface Area of the Human Cortex and Their Relationship with Intelligence

H. G. Schnack, N. E. M. van Haren, R. M. Brouwer, A. Evans, S. Durston, D. I. Boomsma, R. S. Kahn, H. E. Hulshoff Pol
2014 Cerebral Cortex  
In the more intelligent young adults, this relationship reverses so that by the age of 42 a thicker cortex is associated with higher intelligence.  ...  In contrast, cortical surface is larger in more intelligent children at the age of 10. The cortical surface is still expanding, reaching its maximum area during adolescence.  ...  Conflict of Interest: None declared.  ... 
doi:10.1093/cercor/bht357 pmid:24408955 fatcat:6dm7f6rsxzctdgrahtw4fluiiu

Genetic variation, brain, and intelligence differences

Ian J. Deary, Simon R. Cox, W. David Hill
2021 Molecular Psychiatry  
We address research that combines genetics and brain imaging in studying intelligence differences. There are new, though modest, associations in all these areas, and mechanistic accounts are lacking.  ...  From this solid phenotypic foundation and importance for life, comes an interest in the environmental, social, and genetic aetiologies of intelligence, and in the foundations of intelligence differences  ...  cortical thickness and surface area of the anterior cingulate cortex, the prefrontal cortex, the insula, and the medial temporal cortex [120] .  ... 
doi:10.1038/s41380-021-01027-y pmid:33531661 pmcid:PMC8960418 fatcat:h2hzx6lal5ai3gsndvokusngny

Anatomic Magnetic Resonance Imaging of the Developing Child and Adolescent Brain and Effects of Genetic Variation

Jay N. Giedd, Michael Stockman, Catherine Weddle, Maria Liverpool, Aaron Alexander-Bloch, Gregory L. Wallace, Nancy R. Lee, Francois Lalonde, Rhoshel K. Lenroot
2010 Neuropsychology Review  
Magnetic resonance imaging studies have begun to map effects of genetic variation on trajectories of brain development.  ...  Twin studies have demonstrated that genetic factors are responsible for a significant amount of variation in pediatric brain morphometry.  ...  Acknowledgments This research was supported by the Intramural Program of the National Institute of Mental Health, National Institutes of Health.  ... 
doi:10.1007/s11065-010-9151-9 pmid:21069466 pmcid:PMC3268519 fatcat:w3noqwsarranthqrw6iyalj7nm

Personality and local brain structure: their shared genetic basis and reproducibility

Sofie L. Valk, Felix Hoffstaedter, Julia A. Camilleri, Peter Kochunov, B.T. Thomas Yeo, Simon B. Eickhoff
2020 NeuroImage  
However, associations are weak and only the relation between frontal surface area and Neuroticism was consistently observed across three independent samples of young adults.  ...  Here, we study the genetic correlation between personality traits and local cortical structure in a large-scale twin sample (Human Connectome Project, n=1102, 22-37y) and we evaluated whether observed  ...  Funding for the decompression and augmentation of administrative and phenotypic protocols provided by a grant from the Child Mind Institute (1FDN2012-1).  ... 
doi:10.1016/j.neuroimage.2020.117067 pmid:32574809 fatcat:fn4r7mhmwjew7bzvi65dfaxmie

Neurogenetic basis of personality [article]

Sofie Louise Valk, Felix Hoffstaedter, Julia Camilleri, Peter Kochunov, B.T. Thomas Yeo, Simon B. Eickhoff
2019 bioRxiv   pre-print
Previous neuroimaging studies have reported associations between personality and brain structure, while at the same time, studies on imaging genetics have repeatedly demonstrated heritability of brain  ...  Agreeableness was genetically correlated with the posterior-mid temporal, midcingulate, and dorsolateral frontal cortices, while extraversion showed a genetic relation to temporoparietal junction.  ...  To answer our research question, 105 we studied the relationship between the Big Five personality traits and local cortical 106 thickness and surface area.  ... 
doi:10.1101/645945 fatcat:ucri3ahun5bannmjby3qmzhrbi

Recent advances in the use of MRI to assess early human cortical development

Jeffrey J. Neil, Christopher D. Smyser
2018 Journal of magnetic resonance (San Diego, Calif. 1997 : Print)  
Over the past decade, a number of advanced magnetic resonance-based methods have been brought to bear on questions related to early development of the human cerebral cortex.  ...  Abstract Introduction Since its inception, MRI has undergone an explosion in technical development, leading to a rich array of image contrast types which can be used to investigate early cortical development  ...  He is an intelligent, patient and kind teacher with a unique sense of humor, and also a loyal friend.  ... 
doi:10.1016/j.jmr.2018.05.013 pmid:29894905 pmcid:PMC6047926 fatcat:etx3fqlelfbv7br2rgnhgrp6g4

Brain SCALE: Brain Structure and Cognition: an Adolescent Longitudinal Twin Study into the Genetic Etiology of Individual Differences

Inge L. C. van Soelen, Rachel M. Brouwer, Jiska S. Peper, Marieke van Leeuwen, Marinka M. G. Koenis, Toos C. E. M. van Beijsterveldt, Suzanne C. Swagerman, René S. Kahn, Hilleke E. Hulshoff Pol, Dorret I. Boomsma
2012 Twin Research and Human Genetics  
Brain scans were acquired using 1.5 Tesla Magnetic Resonance Imaging (MRI), which provided volumetric measures and measures of cortical thickness.  ...  Twin studies are of great value to explore to what extent genetic and environmental factors explain individual differences in brain development and cognition.  ...  Acknowledgments and Funding We would like to thank all the participants for making this study possible.  ... 
doi:10.1017/thg.2012.4 pmid:22856378 fatcat:lyjkirabuzbavaq3pm355ehesm

The Parieto-Frontal Integration Theory (P-FIT) of intelligence: Converging neuroimaging evidence

Rex E. Jung, Richard J. Haier
2007 Behavioral and Brain Sciences  
Reviewing studies from functional (i.e., functional magnetic resonance imaging, positron emission tomography) and structural (i.e., magnetic resonance spectroscopy, diffusion tensor imaging, voxel-based  ...  We propose that the P-FIT provides a parsimonious account for many of the empirical observations, to date, which relate individual differences in intelligence test scores to variations in brain structure  ...  amenable to structural localization, including structural magnetic resonance imaging (sMRI) and its recent application of voxel-based morphometry (VBM), activation studies of cerebral blood flow and glucose  ... 
doi:10.1017/s0140525x07001185 pmid:17655784 fatcat:24xus3ep2bbejfxkzgrnm26nxa

Maturation of cortical microstructure and cognitive development in childhood and adolescence: a T1w/T2w ratio MRI study [article]

Linn Bonaventure Norbom, Jaroslav Rokicki, Dag Alnaes, Tobias Kaufmann, Nhat Trung Doan, Ole A Andreassen, Lars Tjelta Westlye, Christian K. Tamnes
2019 bioRxiv   pre-print
In the present study, we computed vertex-wise T1w/T2w ratio across the cortical surface in 621 youths (3-21 years) sampled from the Pediatric Imaging, Neurocognition, and Genetics (PING) study and tested  ...  Our study indicates age-related differences in T1w/T2w ratio throughout childhood, adolescence and young adulthood, in line with the known protracted myelination of the cortex.  ...  Development of the Cerebral Cortex across Adolescence: A 563 Multisample Study of Inter-Related Longitudinal Changes in Cortical Volume, 564 Surface Area, and Thickness.  ... 
doi:10.1101/681221 fatcat:bim33qalkng3ppsdalrdrs4t3q

Genetic and Environmental Influences on Neuroimaging Phenotypes: A Meta-Analytical Perspective on Twin Imaging Studies

Gabriëlla A. M. Blokland, Greig I. de Zubicaray, Katie L. McMahon, Margaret J. Wright
2012 Twin Research and Human Genetics  
and cortical thickness (CT) of the uncus, left parahippocampal gyrus, and insula.  ...  Over the past 15 years, twin studies have found evidence for both genetic and environmental influences on neuroimaging phenotypes, but considerable variation across studies makes it difficult to draw clear  ...  Brain structure and function as assessed by magnetic resonance imaging (MRI) can be measured on a continuous quantitative scale independent of disease state, increasing statistical power to detect genetic  ... 
doi:10.1017/thg.2012.11 pmid:22856370 pmcid:PMC4291185 fatcat:lbwr2mfmxngdzbk5tnhlqq6ojy

Sulcal pits and patterns in developing human brains

Kiho Im, P. Ellen Grant
2018 NeuroImage  
Future studies will be aimed at better understanding a comprehensive map of spatiotemporal dynamics of fetal cortical folding in a large longitudinal cohort in order to examine individual clinical fetal  ...  of cortical functional areas and their white matter connections, compared to later developing sulci.  ...  Acknowledgments This work was supported by the National Institutes of Health [R21HD083956, 5R01EB017337-04, and 1U01 HD087211-01]; and Boston Children's Hospital Faculty Career Development Award.  ... 
doi:10.1016/j.neuroimage.2018.03.057 pmid:29601953 pmcid:PMC6160365 fatcat:v55xfspkz5hzfjtppdkorf2r2m

Brain Neuroplasticity in Healthy, Hyperactive and Psychotic Children: Insights from Neuroimaging

Judith L Rapoport, Nitin Gogtay
2007 Neuropsychopharmacology  
Developmental trajectories vary in relation to gender, intelligence, and overall functioning. Twin studies show high heritability for brain volumes, which varies with region and with age.  ...  Noninvasive brain imaging permits longitudinal studies of anatomic brain development in healthy and psychiatrically ill children.  ...  GENETICS OF NORMAL BRAIN DEVELOPMENT Imaging studies of adult twins have found a strong genetic influence on total cerebral volume and lobar gray and white matter volumes (Baare et al, 2001 ).  ... 
doi:10.1038/sj.npp.1301553 pmid:17851542 fatcat:wktnsgqivbczxbptmaetz3qhou

Cortical Anatomy in Autism Spectrum Disorder: An In Vivo MRI Study on the Effect of Age

Armin Raznahan, Roberto Toro, Eileen Daly, Dene Robertson, Clodagh Murphy, Quinton Deeley, Patrick F. Bolton, Tomáš Paus, Declan G. M. Murphy
2009 Cerebral Cortex  
Hence, we used magnetic resonance imaging to investigate the relationship between age and CV, CT, and SA in 127 males aged 10 through 60 years (76 with ASD and 51 healthy controls).  ...  It is less clear, however, if these persist in adulthood and whether these reflect alterations in cortical thickness (CT) or cortical surface area (SA).  ...  The authors wish to thank the MRC UK AIMS network for infrastructure support and the participants and their families for making this study possible. Conflict of Interest : None declared.  ... 
doi:10.1093/cercor/bhp198 pmid:19819933 fatcat:qpkfrmv4prdv3htomjgkd7geni
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