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Development of a Biomarker Panel to Distinguish Risk of Progressive Chronic Kidney Disease

Evan Owens, Ken-Soon Tan, Robert Ellis, Sharon Del Vecchio, Tyrone Humphries, Erica Lennan, David Vesey, Helen Healy, Wendy Hoy, Glenda Gobe
2020 Biomedicines  
This investigation develops a model for predicting progressive CKD based on a panel of biomarkers representing the pathophysiological processes of CKD, kidney function, and common CKD comorbidities.  ...  This model has an accuracy of 84.3% when predicting future progressive CKD at baseline, greater than eGFR (66.1%), sCr (67.7%), albuminuria (53.2%), or albumin-creatinine ratio (53.2%).  ...  The DROP CKD models were created to predict future progression events based on the expression of a selected biomarker panel at baseline.  ... 
doi:10.3390/biomedicines8120606 pmid:33327377 fatcat:a42lzoa4bvaaznm4jrnqw4l7ja

Development of a minimal KASP marker panel for distinguishing genotypes in apple collections

Mark Winfield, Amanda Burridge, Matthew Ordidge, Helen Harper, Paul Wilkinson, Danny Thorogood, Liz Copas, Keith Edwards, Gary Barker, Tzen-Yuh Chiang
2020 PLoS ONE  
We show that SNP genotyping with a small set of well selected markers is equally efficient as microsatellites for the identification of apple cultivars and has the added advantage of automation and reduced  ...  Here, we have identified a minimum set of SNP markers sufficient to distinguish apple cultivars held in the English and Welsh national collections providing a cheaper and automatable alternative to the  ...  Acknowledgments We are grateful for contribution of samples from the following orchards: National  ... 
doi:10.1371/journal.pone.0242940 pmid:33253289 fatcat:y2k7brjvyjcftis7mprvqkltee

Idiopathic granulomatous and necrotising inflammatory disorders of the canine central nervous system: a review and future perspectives

Lauren R. Talarico, Scott J. Schatzberg
2010 Journal of Small Animal Practice  
Granulomatous meningoencephalomyelitis, necrotizing meningoencephalitis, and necrotizing leukoencephalitis are common infl ammatory conditions of the canine central nervous system.  ...  Left panel -lymphoid and histiocytoid cells cuffi ng a vessel. Right panel -large reactive astrocytes (gemistocytes)  ...  Acknowledgements We would like to thank Drs Clive Huxtable, Brian Summers, and Alexander de Lahunta for sharing many of the neuropathology slides that can be found on the online veterinary neuropathology  ... 
doi:10.1111/j.1748-5827.2009.00823.x pmid:19814766 fatcat:xqveulpoyfawrdowrign7v5wnq

Current and Future Perspectives on the Structural Identification of Small Molecules in Biological Systems

Daniel Dias, Oliver Jones, David Beale, Berin Boughton, Devin Benheim, Konstantinos Kouremenos, Jean-Luc Wolfender, David Wishart
2016 Metabolites  
This in turn, facilitates downstream metabolite pathway analysis, and a better understanding of the underlying biology of the system under investigation.  ...  Although significant advances have been made in recent years, the structural elucidation of small molecules continues to remain a challenging issue for metabolite profiling.  ...  Conflicts of Interest: The authors declare no conflict of interest.  ... 
doi:10.3390/metabo6040046 pmid:27983674 pmcid:PMC5192452 fatcat:rriyq37ipjdq3ogihk4nxf6z2q

Distinguishing between heterogeneity and inefficiency: stochastic frontier analysis of the World Health Organization's panel data on national health care systems

William Greene
2004 Health Economics  
The most commonly used approaches to parametric (stochastic frontier) analysis of efficiency in panel data, notably the fixed and random effects models, fail to distinguish between cross individual heterogeneity  ...  This blending of effects is particularly problematic in the World Health Organization's (WHO) panel data set on health care delivery, which is a 191 country, five year panel.  ...  Surprisingly, this has hardly been used previously 10 in spite of the fact that most of the received panel data applications involved fairly small panels. 11 The true fixed effects model places the unmeasured  ... 
doi:10.1002/hec.938 pmid:15455464 fatcat:psmalb5bprhgjmc3o4kxx3uk6y

Distinguishing Between Nile Tilapia Strains Using a Low-Density Single-Nucleotide Polymorphism Panel

Matthew G. Hamilton, Curtis E. Lind, Benoy K. Barman, Ravelina R. Velasco, Ma. Jodecel C. Danting, John A. H. Benzie
2020 Frontiers in Genetics  
A tool was developed using a low-density panel of single-nucleotide polymorphisms (SNPs), genotyping-by-sequencing and discriminant analysis of principal components (DAPC).  ...  Numerous genetically improved strains of Nile tilapia have been developed and disseminated through formal and informal channels to hatcheries, many of which operate at a relatively small scale in developing  ...  ACKNOWLEDGMENTS In-country partners that assisted in sample collection in the Philippines included the Bureau of Fisheries and Aquatic Resources (BFAR) regional offices in Cagayan Valley, Central Luzon  ... 
doi:10.3389/fgene.2020.594722 pmid:33335540 pmcid:PMC7736061 fatcat:p6ew7wyj4zbddnkq5vwqg2hw24

A Panel of 3 Markers Including p16, ProExC, or HPV ISH is Optimal for Distinguishing Between Primary Endometrial and Endocervical Adenocarcinomas

Christina S. Kong, Andrew H. Beck, Teri A. Longacre
2010 American Journal of Surgical Pathology  
As the distinction is significant and cannot always be made on the basis of clinical findings, various immunohistochemical panels have been proposed to aid in determining site of origin.  ...  Using a script written in R, the diagnostic accuracy of all possible combinations of markers was evaluated and it was shown that a 3 marker panel including vimentin, ER, or PR, and an HPV marker (p16,  ...  Overall, the 3 marker panels showed a very small but statistically significant improved accuracy compared with the 2 marker panels (4113/4580, 89% of all possible 3 marker panels vs. 3034/3435, 88% of  ... 
doi:10.1097/pas.0b013e3181e3291e pmid:20534993 pmcid:PMC4847142 fatcat:ww26pbhr2fdofdp4x7acprpay4

A Panel of CpG Methylation Sites Distinguishes Human Embryonic Stem Cells and Induced Pluripotent Stem Cells

Kevin Huang, Yin Shen, Zhigang Xue, Marina Bibikova, Craig April, Zhenshan Liu, Linzhao Cheng, Andras Nagy, Matteo Pellegrini, Jian-Bing Fan, Guoping Fan
2014 Stem Cell Reports  
In this study, we analyzed DNA methylation patterns in a large number of hiPSCs (n = 114) and hESCs (n = 155), and identified a panel of 82 CpG methylation sites that can distinguish hiPSCs from hESCs  ...  We show that 12 out of the 82 CpG sites were subject to hypermethylation in part by DNMT3B.  ...  Kevin Huang is supported by the Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.  ... 
doi:10.1016/j.stemcr.2013.11.003 pmid:24511466 pmcid:PMC3916755 fatcat:q3v4su34hvfn7d5opgugjrmoju

An HTM based cortical algorithm for detection of seismic waves [article]

Ruggero Micheletto, Ahyi Kim
2017 arXiv   pre-print
We describe the methodology used and give the first qualitative assessments of the recognition ability of the system.  ...  Main goal of this study is test the ability of the HTM algorithm to be used to signal earthquakes automatically in a feasible disaster prevention system.  ...  Acknowledgments We thank Kahoko Takahashi for the help with citations and for reading this manuscript.  ... 
arXiv:1707.01642v1 fatcat:2zseoaqgvfbtncsyo7qxxt6mlq

Guest Editor's Introduction: The Ultimate Display--What Will It Be?

O. Bimber
2005 Computer  
Acknowledgments The featured articles on future display technologies presented in this issue of Computer are the outcome of a panel held at ACM Siggraph 05.  ...  We thank Jill Smolin, ACM Siggraph 2005 panel chair, for supporting this cooperation with Computer.  ...  Furthermore, most of us routinely carry around small displays as part of mobile phones, personal digital assistants, navigation systems, or laptops. What will come next?  ... 
doi:10.1109/mc.2005.262 fatcat:uxbkoqi4ifhs5jopcmdbiceoxm

Table of Contents

2021 IEEE Aerospace and Electronic Systems Magazine  
Associate Editors and Areas of Specialty How to Reach Us We welcome letters to the editor; but, we reserve the right to edit for space, style, and clarity.  ...  Buonanno . . . . . 34 On-Chip-Antennas: Next Milestone in the Big World of Small Satellites-A Survey of Potentials, Challenges, and Future Directions R. Karim, P.  ...  Griffiths . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 61 2021 Aerospace & Electronics Systems Society Distinguished Lecturers  ... 
doi:10.1109/maes.2020.3040640 fatcat:px3olz2c5fgxhksrvube2ox3uq

A Device for Proximal Anastomosis of Autologous Coronary Vein Grafts: Report from the Meeting of the Circulatory System Devices Panel of the Food and Drug Administration Center for Devices and Radiologic Health

W. H. Maisel
2005 Circulation  
by the challenge of suturing small vessels.  ...  Disclaimer Dr Maisel is the chairperson of the Circulatory System Devices Advisory Panel.  ... 
doi:10.1161/circulationaha.105.569301 pmid:16145015 fatcat:jyzykjoxtbfbxjahm36jjs54be

Evaluating the performance of a deep learning‐based computer‐aided diagnosis (DL‐CAD) system for detecting and characterizing lung nodules: Comparison with the performance of double reading by radiologists

Li Li, Zhou Liu, Hua Huang, Meng Lin, Dehong Luo
2018 Thoracic Cancer  
The study was conducted to evaluate the performance of a state-of-the-art commercial deep learning-based computer-aided diagnosis (DL-CAD) system for detecting and characterizing pulmonary nodules.  ...  scans. 34 Thus, the first priority of lung cancer screening is to ensure detection of all small nodules and record them as the baseline for future surveillance.  ...  Performance of the DL-CAD system for nodule detection Based on the results of the expert panel and the DL-CAD system, a total of 812 true nodules were detected.  ... 
doi:10.1111/1759-7714.12931 pmid:30536611 pmcid:PMC6360226 fatcat:rj7i7hdojzbqvi2jkhh2v3t7ie

Page 2 of Science Trends Vol. 51, Issue 23 [page]

1984 Science Trends  
The most promising systems cited for future development include solid state micro- sensors incorporating membranes that selectively interact with toxic compounds, and miniaturized mass spectrometers that  ...  US Army equipment “appears superior" to that of Soviet and Warsaw Pact forces, the panel said, but none of the sensors currently available or under development can detect possible biological agents such  ... 

3-Form Cosmology: Phantom Behaviour, Singularities and Interactions

João Morais, Mariam Bouhmadi-López, João Marto
2017 Universe  
Sibling of the Big Rip singular event into the future.  ...  We show how the latter happens for a fairly general class of positive-valued potentials, and through a dynamical system approach, we find that in such cases the 3-form field leads the Universe into a Little  ...  Acknowledgments: The Authors are grateful to Juan M. Aguirregabiria and César Silva for enlightening  ... 
doi:10.3390/universe3010021 fatcat:hcklkc4htrao7j4u234hgkwsxa
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