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The faithful copy neuron

Lawrence Sirovich
2012 Journal of Computational Neuroscience  
This results in an unusual mechanism for neuronal firing that uses background noise to achieve the desired firing rate.  ...  This optimal performance is likely accomplished by use of local circuitry that adjusts conductances to match input currents so that the neuron operates near the threshold for firing.  ...  I also thank Ellen Paley for her careful help in the preparation of this paper and for her great patience with the many drafts that preceded this one.  ... 
doi:10.1007/s10827-011-0356-6 pmid:22234837 fatcat:o4ojrfeclfcbdb5vbjatfp5ety

Constructive neural-network learning algorithms for pattern classification

R. Parekh, J. Yang, V. Honavar
2000 IEEE Transactions on Neural Networks  
Additionally, we show how the incorporation of a local pruning step can eliminate several redundant neurons from MTiling-real networks.  ...  We prove the convergence of these algorithms and empirically demonstrate their applicability to practical pattern classification problems.  ...  The input layer neurons are designed to allow the patterns to be input to the network and thus simply copy their input to their output. III.  ... 
doi:10.1109/72.839013 pmid:18249773 fatcat:fedajwlxc5ellcmf3mbq5rprlq

Single-cell whole genome sequencing reveals no evidence for common aneuploidy in normal and Alzheimer's disease neurons

Hilda van den Bos, Diana C. J. Spierings, Aaron Taudt, Bjorn Bakker, David Porubský, Ester Falconer, Carolina Novoa, Nancy Halsema, Hinke G. Kazemier, Karina Hoekstra-Wakker, Victor Guryev, Wilfred F. A. den Dunnen (+4 others)
2016 Genome Biology  
The sensitivity and specificity of our method was shown by the presence of three copies of chromosome 21 in all analyzed neuronal nuclei of a Down's syndrome sample (n = 36).  ...  Results: In the current study, we used a novel single-cell whole genome sequencing (scWGS) approach to assess aneuploidy in isolated neurons from the frontal cortex of normal control individuals (n = 6  ...  Acknowledgements We thank members of the Lansdorp lab for their helpful discussions and the operators at the Central Flow Cytometry Unit of the University Medical Center Groningen, Geert Mesander, Henk  ... 
doi:10.1186/s13059-016-0976-2 pmid:27246599 pmcid:PMC4888403 fatcat:6uhbkgrwqrdjrh5rhy3jjym4ji

DNA Homeostasis and Senescence: Lessons from the Naked Mole Rat

Harvey Boughey, Mateusz Jurga, Sherif F. El-Khamisy
2021 International Journal of Molecular Sciences  
Therefore, limiting the accumulation of DNA damage is essential for healthy neuronal populations.  ...  The build-up of senescent cells negatively affects the local cellular micro-environment and drives ageing associated disease, including neurodegeneration.  ...  The NMR's exceptional neuronal preservation is the culmination of various mechanisms, namely improved antioxidant response, higher fidelity translation, stringent DNA repair, faithful proteome function  ... 
doi:10.3390/ijms22116011 pmid:34199458 pmcid:PMC8199619 fatcat:d7yjc4gubfhmpbmexfqfv7zi6e

Page 28 of Neurology Vol. 8, Issue SUPPLEMENT [page]

1958 Neurology  
The staff of the photostat unit of the N.I.H. photo- graphic section for prompt and careful copying of source material. The Rev. S. X.  ...  And the author’s secretary, Mrs. Virginia L. Gray, for her capable bibiliographic researches and many hours of overtime in faithful manuscript preparation.  ... 

Early Intervention with High‐Dose Acyclovir Treatment during Primary Herpes Simplex Virus Infection Reduces Latency and Subsequent Reactivation in the Nervous System In Vivo

N. M. Sawtell, R. L. Thompson, L. R. Stanberry, D. I. Bernstein
2001 Journal of Infectious Diseases  
During primary infection, herpes simplex virus (HSV) enters the nervous system where the viral genome can be maintained in a state of transcriptional repression, or "latency," in neuronal nuclei (reviewed  ...  Treatment with 50 mg/kg of acyclovir every 8 h reduced the number of latently infected neurons by 190% when treatment was begun before 24 h after infection and by 80% and 70% when begun at 48 or 72 h after  ...  In contrast, surface replication was not a faithful indicator of the level of establishment of latency. However, this parameter did appear to correlate with the copy number profile.  ... 
doi:10.1086/323551 pmid:11574910 fatcat:gpnjqiodtnbedh7jqo3pgldj4u

Defending the structural concept of representation

Andreas BARTELS
2010 THEORIA : an International Journal for Theory, History and Fundations of Science  
, the objection from failing necessity, and the copy theory objection.  ...  Homomorphic representations are not necessarily 'copies' of their representanda, and thus can convey scientific insight.  ...  to the central neuron.  ... 
doi:10.1387/theoria.550 doaj:366e3705799c4e038aaf5197f3ae8d52 fatcat:l5zjva2ksjgr3kzaso4w3pg56q

Does Aneuploidy in the Brain Play a Role in Neurodegenerative Disease? [chapter]

Hilda van den Bos, Diana C.J. Spierings, Floris Foijer, Peter M. Lansdorp
2017 Chromosomal Abnormalities - A Hallmark Manifestation of Genomic Instability  
In addition to these well-known roles of aneuploidy, chromosome copy number changes have also been reported in some studies to occur in neurons in healthy human brain and possibly even more in Alzheimer's  ...  We discuss possible mechanisms for the origin of aneuploidy and the pros and cons of different techniques used to study aneuploidy in the brain, and we provide a future perspective.  ...  Since neurons are postmitotic, methods requiring dividing cells to determine chromosome copy numbers cannot be used when studying aneuploidy in neurons.  ... 
doi:10.5772/67886 fatcat:n6nmjhb4xzhv5cpdzrk4lichoq

A Neural System for Faithful Color Reproduction in Industrial Printing Processes

Beatrice Lazzerini, Francesco Pistolesi
2018 2018 International Joint Conference on Neural Networks (IJCNN)  
The system considers a master color, then compares it to a copy, and returns an objective degree of color fidelity of the copy to the master.  ...  The strengths of the system are that it can measure the difference of colors in a way that is incredibly close to that perceived by the human eye, and the fact that it can do that canceling the color distortion  ...  ACKNOWKEDGMENT The authors would like to thank Roberto Ciardi, Alessandro Degiovanni and Giovanni Falzone for developing the system.  ... 
doi:10.1109/ijcnn.2018.8489306 dblp:conf/ijcnn/LazzeriniP18 fatcat:gqwst4i6sbhcrkzhxols4g6hq4

A Regulatory Code for Neuron-Specific Odor Receptor Expression

Anandasankar Ray, Wynand van der Goes van Naters, John R Carlson, Michael B Eisen
2008 PLoS Biology  
Olfactory receptor neurons (ORNs) must select-from a large repertoire-which odor receptors to express.  ...  of the maxillary palp.  ...  AR and JRC conceived and designed the experiments. AR and WvdGvN performed the experiments. AR and WvdGvN analyzed the data. AR contributed reagents/materials/ analysis tools.  ... 
doi:10.1371/journal.pbio.0060125 pmid:18846726 pmcid:PMC2430909 fatcat:3scua6p7lbentfeuslwwlqeyxa

Techniques for Interpretable Machine Learning [article]

Mengnan Du, Ninghao Liu, Xia Hu
2019 arXiv   pre-print
Interpretable machine learning tackles the important problem that humans cannot understand the behaviors of complex machine learning models and how these models arrive at a particular decision.  ...  We also discuss crucial issues that the community should consider in future work such as designing user-friendly explanations and developing comprehensive evaluation metrics to further push forward the  ...  that copies bear this notice and the full citation on the first page.  ... 
arXiv:1808.00033v3 fatcat:bjyceekmfbf6bjuqolq5jkogjy

Retrotransposon-induced mosaicism in the neural genome

Gabriela O. Bodea, Eleanor G. Z. McKelvey, Geoffrey J. Faulkner
2018 Open Biology  
In particular, the retrotransposon LINE-1 (L1) has been shown to be transcribed and mobilized in the brain.  ...  Over the past decade, major discoveries in retrotransposon biology have depicted the neural genome as a dynamic structure during life.  ...  We thank Dr Sandra Richardson and Dr Francisco Jose Sanchez-Luque for constructive comments on the figures.  ... 
doi:10.1098/rsob.180074 pmid:30021882 pmcid:PMC6070720 fatcat:f62no6wd7zh6vm4mh4ntdtrrrm

The hTH-GFP Reporter Rat Model for the Study of Parkinson's Disease

Lorraine Iacovitti, Xiaotao Wei, Jingli Cai, Eric W. Kostuk, Ruihe Lin, Alexander Gorodinsky, Philip Roman, Gretchen Kusek, Sonal S. Das, Audrey Dufour, Terina N. Martinez, Kuldip D. Dave (+1 others)
2014 PLoS ONE  
In PD, one of the most profoundly affected neuronal populations is the tyrosine hydroxylase (TH)-expressing dopaminergic (DA) neurons of the substantia nigra pars compacta (SNpc).  ...  These DA-producing neurons undergo degeneration while neighboring DA-producing cells of the ventral tegmental area (VTA) are largely spared. To aid in these studies, The Michael J.  ...  Acknowledgments MJFF would like to thank all of the PD patients and donors whose endless optimism continues to inspire us and supports our mission to find a cure for those with PD.  ... 
doi:10.1371/journal.pone.0113151 pmid:25462571 pmcid:PMC4251919 fatcat:crnowjf4f5fobmyunz3bwzegsy

Towards Faithful Model Explanation in NLP: A Survey [article]

Qing Lyu, Marianna Apidianaki, Chris Callison-Burch
2022 arXiv   pre-print
An essential principle of model explanation is Faithfulness, i.e., an explanation should accurately represent the reasoning process behind the model's prediction.  ...  This survey first discusses the definition and evaluation of Faithfulness, as well as its significance for explainability.  ...  Therefore, SmoothGrad proposes to create a few noisy copies of the original input, compute relevance maps for each copy with any existing method, and finally average all maps to obtain a less noisy map  ... 
arXiv:2209.11326v1 fatcat:6yji44dqv5arbimzgph2h2mgua

Torgny Svensson, a superb mind and an inspiring colleague

Siegfried Kasper, Hans-Jürgen Möller, Göran Engberg, Elias Eriksson, Tomas Hökfelt
2020 International Journal of Neuropsychopharmacology  
We still remember the 2012 CINP World Congress in Stockholm where Torgny hosted a gala dinner in the Grand Hotel with a menu copied from the first the Nobel Prize Dinner in 1901 held in the same hotel.  ...  noradrenergic neurons obtained with clonidine.  ... 
doi:10.1093/ijnp/pyaa057 fatcat:w6dzphher5e6fd36zkby6izybe
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