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Neural and psychological mechanisms underlying compulsive drug seeking habits and drug memories - indications for novel treatments of addiction

Barry J. Everitt
2014 European Journal of Neuroscience  
Only some individuals lose control over their drug use, and the importance of behavioural impulsivity as a vulnerability trait predicting stimulant abuse and addiction in animals and humans, together with  ...  and extinction to reduce Pavlovian influences on drug seeking as a means of promoting abstinence and preventing relapse.  ...  The reinforcing effects of many abused drugs, but especially stimulants, depend upon dopaminergic transmission in the NAcb shell and closely related ventral striatal areas such as the olfactory tubercle  ... 
doi:10.1111/ejn.12644 pmid:24935353 pmcid:PMC4145664 fatcat:d3b7ypd4orgexodavzgw7fpz34

Classic Psychedelic Drugs: Update on Biological Mechanisms

Franz X. Vollenweider, John W. Smallridge
2022 Pharmacopsychiatry  
These recent results suggest that changes in self-experience, emotional processing, and social cognition may contribute to the potential therapeutic effects of psychedelics.  ...  AbstractRenewed interest in the effects of psychedelics in the treatment of psychiatric disorders warrants a better understanding of the neurobiological mechanisms underlying the effects of these substances  ...  Acknowledgements This work was supported by a grant from Swiss Neuromatrix Foundation (2021-0104) given to FXV and JS.  ... 
doi:10.1055/a-1721-2914 pmid:35079988 pmcid:PMC9110100 fatcat:s3jsjo4uevhbdafcpezevbdczq

The Nucleus Accumbens: Mechanisms of Addiction across Drug Classes Reflect the Importance of Glutamate Homeostasis

M. D. Scofield, J. A. Heinsbroek, C. D. Gipson, Y. M. Kupchik, S. Spencer, A. C. W. Smith, D. Roberts-Wolfe, P. W. Kalivas
2016 Pharmacological Reviews  
A new RCT, recruiting cocaine-dependent individuals who are abstinent at baseline and examining NAC's effects on time to relapse, would likely yield interesting results.  ...  Both D1-like and D2-like receptors can be found on the soma and dendrites of ACh interneurons ; application of the D1 agonist SKF 82958 (3-allyl-6-chloro-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol  ... 
doi:10.1124/pr.116.012484 pmid:27363441 pmcid:PMC4931870 fatcat:rieodnvktfd4df5s5wwdqhdumq

Panel and Study Groups

2013 Neuropsychopharmacology  
In addition there are 30-76 patients with schizophrenia (depending on the brain region and assay) and 63 patients with affective disorders.  ...  Although the expression in GAD67 expression is probably one of the most replicated findings to date, there have been relatively few studies of this finding with respect to genetic variation or brain development  ...  Methods: Following prior observations of negative correlations between D2-like receptor BPnd and measures of impulsiveness, Study 1 used PET to assess D1-like binding in 20 healthy volunteers who gave  ... 
doi:10.1038/npp.2013.278 fatcat:expu2u3f3reypazj7tt7jhybfa

The neural basis of drug craving: An incentive-sensitization theory of addiction

T Robinson
1993 Brain Research Reviews  
responsible for incentive salience (for 'wanting') can occur independently of changes in neural systems that mediate the subjective pleasurable effects of drugs <drug "Wing') and of neural systems that  ...  Incentive salience is a psychotogicai process that transforms the perception of stimuli, imbuing them with salience, mating them attractive, 'wanted', incentive stimuli. (3) in some individuals the repeated  ...  Preparation of this manuscript and research by the authors was supported by Grants from the National Institute on Drug Atruse (04294) to T.E.R. and from the National Institutes of Heafth to K.C.B.  ... 
doi:10.1016/0165-0173(93)90013-p pmid:8401595 fatcat:fanavracsbcr5a5qqvxkjka26e

Social stress, therapeutics and drug abuse: Preclinical models of escalated and depressed intake

2008 Pharmacology and Therapeutics  
The neural circuit comprising the VTA-accumbens-PFCamygdala is activated by brief episodes of social stress, which is critical for the DA-mediated behavioral sensitization and increased stimulant consumption  ...  stress leads to anhedonia-like effects.  ...  One key determinant for the propensity to self-administer drugs and for the behavioral effects of therapeutic drugs appears to be the intermittency and duration of the social stress in both infants and  ... 
doi:10.1016/j.pharmthera.2008.07.006 pmid:18789966 pmcid:PMC2713609 fatcat:ukkye4j2fvhs3mzee22anwv4v4

Alcoholism and Stress: A Framework for Future Treatment Strategies: Meeting Abstracts

2014 Alcohol  
Dopaminergic inputs to mPFC exert powerful effects on network activity via D1/D2 receptor modulation of the balance between excitatory and inhibitory tone.  ...  neural and behavioral effects of ethanol is unclear.  ...  Besides an up-regulation of CRHR1, D1 receptors are strongly and significantly down-regulated within ITCs of alcohol-dependent animals.  ... 
doi:10.1016/j.alcohol.2014.01.002 fatcat:lf72g5a76bbgherbr2pusluixm

Poster Session I

2014 Neuropsychopharmacology  
Transcripts changes that most correlated with anhedonic-like behaviors were those regulated by HRas (p ¼ 7x10-7), which is a small GTPase that can activate Raf kinase, and subsequently the MAPK/ERK pathway  ...  We examined whether there would be similar variability in the behavioral effects of IFN-a in mice, and then explored associations between behavior and changes in gene transcription.  ...  Results: Depending upon the amount of DNA transfected, the level of basal activity displayed by the V175D mutant receptor was up to 3-fold greater than the WT receptor.  ... 
doi:10.1038/npp.2014.280 fatcat:xunw4pdn75hlnmhvvksgp2lsse

Monitoring Rapid Chemical Communication in the Brain

Donita L. Robinson, Andre Hermans, Andrew T. Seipel, R. Mark Wightman
2008 Chemical Reviews  
In other experiments, the measurements need to be made in the brain of behaving animals so that correlations of neurotransmitter fluctuations and specific behaviors can be made.  ...  These multiple interpretations of dopaminergic function have arisen because, until recently, a realtime view of dopamine and its actions in an awake, behaving animal was unavailable.  ...  Acknowledgments Research in the Wightman laboratory on this topic has been supported by NIH.  ... 
doi:10.1021/cr068081q pmid:18576692 pmcid:PMC3110685 fatcat:dx64gre3wre2rjgkcmb5n6u3a4

Tackling the Behavior of Cancer Cells: Molecular Bases for Repurposing Antipsychotic Drugs in the Treatment of Glioblastoma

Michele Persico, Claudia Abbruzzese, Silvia Matteoni, Paola Matarrese, Anna Maria Campana, Veronica Villani, Andrea Pace, Marco G. Paggi
2022 Cells  
In this review, we analyze the effects of antipsychotics in oncology and how these drugs can interfere with the hallmarks of cancer in GBM.  ...  the standard research process.  ...  These drugs are not devoid of well-characterized side effects, such as sedation and extrapyramidal syndrome, most of them dose-dependent and reversible upon drug withdrawal.  ... 
doi:10.3390/cells11020263 pmid:35053377 pmcid:PMC8773942 fatcat:rxr7ctu4yjehhgszebmza5sycm

ACNP 55th Annual Meeting: Panels, Mini-Panels and Study Groups

2016 Neuropsychopharmacology  
This protective effect of stimulation of the AcbSh -LH pathway was behaviorally specific because optogenetic stimulation had no effect on initial or well established alcohol seeking and had no effect on  ...  In the teen years, on average, the "brain age" across the group has the propensity to look younger in emotional contexts relative to neutral contexts.  ...  Upon secretion in the extracellular matrix, RELN binds to VLDL, APOE2, and a3b2 Integrin receptors located on dendritic shafts and spines of postsynaptic pyramidal neurons.  ... 
doi:10.1038/npp.2016.239 fatcat:wg7pyurlzvhp7bvlmlbxtkunl4

1st Annual Meeting: The Canadian Association for Neuroscience / Association canadienne de neuroscience

2007 Canadian Journal of Neurological Sciences  
, and this effect was replicable in D1-and D2-receptor knockout animals.  ...  Haloperidol is an antipsychotic with anti-dopaminergic (predominantly at the D2 receptor) actions.  ... 
doi:10.1017/s0317167100017066 fatcat:aupmr4ntyjd6xes4gp5epa2epm

A food predictive cue must be attributed with incentive salience for it to induce c-fos mRNA expression in cortico-striatal-thalamic brain regions

S.B. Flagel, C.M. Cameron, K.N. Pickup, S.J. Watson, H. Akil, T.E. Robinson
2011 Neuroscience  
We took advantage of the fact that there are large individual differences in the extent to which reward cues are attributed with incentive salience.  ...  However, only in a subset of rats is the cue attributed with incentive salience, becoming an attractive and desirable incentive stimulus.  ...  Acknowledgments-We would like to thank James  ... 
doi:10.1016/j.neuroscience.2011.09.004 pmid:21945724 pmcid:PMC3206316 fatcat:ul5gmdd3hjbvtfvfpx7s6xhwj4

Abstracts from the 28th CINP World Congress of Neuropsychopharmacology, Stockholm, Sweden, 3–7 June 2012

2012 International Journal of Neuropsychopharmacology  
Vernaleken has served on the speakers' bureau of Bristol-Myers Squibb, Eli Lilly, and GlaxoSmithKline.  ...  He has served on the speakers' bureau of Astra Zeneca, Bristol-Myers Squibb, Eli Lilly, Janssen Cilag, Otsuka, Pfizer, Servier, and Wyeth.  ...  and inhibitory effects on behavior.  ... 
doi:10.1017/s1461145712000508 fatcat:ft6ipgmb45azzjxouthbqdn43i

ACNP 58th Annual Meeting: Panels, Mini-Panels and Study Groups

2019 Neuropsychopharmacology  
Results: Caged dynorphin variants exhibited up nearly 5,000fold reductions in EC50 at the kappa, mu and delta opioid receptors depending on peptide length and caging site (e.g. at KOR: Dyn-8 = 7 nM, CYD8  ...  about NP transmission remain: In what behavioral contexts does neuropeptide release occur?  ...  Effects of inflammatory peptides and cortisol depended upon the sex of the fetal-placental unit.  ... 
doi:10.1038/s41386-019-0544-z pmid:31801977 pmcid:PMC6957922 fatcat:hjyvf7fcpbf2fhxit6rlhsvg2y
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