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The dynamic structure underlying subthreshold oscillatory activity and the onset of spikes in a model of medial entorhinal cortex stellate cells

Horacio G. Rotstein, Tim Oppermann, John A. White, Nancy Kopell
2006 Journal of Computational Neuroscience  
Medial entorhinal cortex layer II stellate cells display subthreshold oscillations (STOs). We study a single compartment biophysical model of such cells which qualitatively reproduces these STOs.  ...  We also show that the transition from subthreshold oscillatory activity to spiking ("canard explosion") is controlled in the STI by the same structure.  ...  This work was partially supported by the Burroughs Wellcome Fund (HGR), NIH grant 5 RO1 NS46058 (NK), NSF grant DMS-0211505 (NK) and the graduate program "Dynamics and Evolution of Cellular and Macromolecular  ... 
doi:10.1007/s10827-006-8096-8 pmid:16927211 fatcat:gxy7225eurebzbjf567545fpzm

Stimulus statistics and HCN current mediated resonance sets the scale of input-output mapping in Stellate cells of the Medial Entorhinal Cortex [article]

Nupur Katyare, Sujit Sikdar
2018 bioRxiv   pre-print
The functional significance of the computations performed by Stellate cells of the Medial Entorhinal Cortex, proven time and again, makes them insightful, yet intriguing.  ...  In this light, we analyzed the signal gain of stellate cells in the presence of in-vivo like fluctuating conductance based synaptic inputs injected through the Dynamic clamp, in rat brain slices.  ...  Membrane potential dynamics of grid cells. Nature 495, 199-204 (2013). 4. Tennant, S. A. et al. Stellate Cells in the Medial Entorhinal Cortex Are Required for Spatial Learning.  ... 
doi:10.1101/369025 fatcat:u2g5vvo3crahjaonbe5vmhbq6m

How to build a grid cell

C. Schmidt-Hieber, M. Hausser
2013 Philosophical Transactions of the Royal Society of London. Biological Sciences  
One contribution of 24 to a Theo Murphy Meeting Issue 'Space in the brain:  ...  We are grateful to Caswell Barry, Gabija Toleikyte and Carine Wu for helpful discussions and comments on the manuscript. Funding statement.  ...  This work was supported by grants from the European Research Council, Wellcome Trust and Gatsby Charitable Foundation.  ... 
doi:10.1098/rstb.2012.0520 pmid:24366132 pmcid:PMC3866442 fatcat:ff3a7z7afzhapds5ofpphgysbe

Cellular dynamical mechanisms for encoding the time and place of events along spatiotemporal trajectories in episodic memory

Michael E. Hasselmo, Lisa M. Giocomo, Mark P. Brandon, Motoharu Yoshida
2010 Behavioural Brain Research  
Lesions of the hippocampus, entorhinal cortex and subcortical nuclei impair episodic memory function in humans and animals, and unit recording data from these regions in behaving animals indicate episodic  ...  A model presented here shows how intrinsic dynamical properties of neurons could mediate the encoding of episodic memories as complex spatiotemporal trajectories.  ...  Model of encoding and replay of trajectories. A. During encoding, behavior drives the activity of head direction cells that drive the activity of grid cells in entorhinal cortex layers II and III.  ... 
doi:10.1016/j.bbr.2009.12.010 pmid:20018213 pmcid:PMC2891577 fatcat:3vbx6mpe7ndpfferf6l7j4emci

Degeneracy in the robust expression of spectral selectivity, subthreshold oscillations, and intrinsic excitability of entorhinal stellate cells

Divyansh Mittal, Rishikesh Narayanan
2018 Journal of Neurophysiology  
The h channel mediates location dependence and underlying subthreshold oscillatory activity and the onset of spikes in a plasticity of intrinsic phase response in rat hippocampal neurons  ...  J Neurosci model of medial entorhinal cortex stellate cells.  ... 
doi:10.1152/jn.00136.2018 pmid:29718802 pmcid:PMC6101195 fatcat:yjsev6ak7zahxkj4h5jt5ubvmq

Grid cell firing may arise from interference of theta frequency membrane potential oscillations in single neurons

Michael E. Hasselmo, Lisa M. Giocomo, Eric A. Zilli
2007 Hippocampus  
Intracellular recording and computational modelling suggest that interactions of subthreshold membrane potential oscillation frequency in different dendritic branches of entorhinal cortex stellate cells  ...  This model provides a consistent quantitative link between single cell physiological properties and properties of spiking units in awake behaving animals.  ...  The influence of head direction cells in postsubiculum (dorsal parasubiculum) on grid cells in superficial medial entorhinal cortex may be gated by cells in deep layers of medial entorhinal cortex.  ... 
doi:10.1002/hipo.20374 pmid:17924530 pmcid:PMC2408670 fatcat:yyxrpiqt7za7ra4q7ikqjxkqfq

Frequency Selectivity of Layer II Stellate Cells in the Medial Entorhinal Cortex

Julie S. Haas, John A. White
2002 Journal of Neurophysiology  
Haas, Julie S. and John A. White. Frequency selectivity of layer II stellate cells in the medial entorhinal cortex.  ...  J Neurophysiol 88: 2422-2429, 2002 10.1152/jn.00598.2002 from layer II of the medial entorhinal cortex (MEC) are distinguished by intrinsic 4-to 12-Hz subthreshold oscillations.  ...  Haas, Julie S. and John A. White. Frequency selectivity of layer II stellate cells in the medial entorhinal cortex.  ... 
doi:10.1152/jn.00598.2002 pmid:12424283 fatcat:y7tpz56m7bhofce4hbhquxo7h4

Canard Induced Mixed-Mode Oscillations in a Medial Entorhinal Cortex Layer II Stellate Cell Model

Horacio G. Rotstein, Martin Wechselberger, Nancy Kopell
2008 SIAM Journal on Applied Dynamical Systems  
Stellate cells (SCs) of the medial entorhinal cortex (layer II) display mixed-mode oscillatory activity, subthreshold oscillations (small amplitude) interspersed with spikes (large amplitude), at theta  ...  both components (fast and slow) of a hyperpolarization-activated current in addition to the voltage and a persistent sodium current.  ...  Acknowledgments We thank Tasso Kaper for his useful comments on an earlier draft of this manuscript, and Amit Bose, Morten Brøns, Martin Krupa and John White for discussions.  ... 
doi:10.1137/070699093 fatcat:baewoheglvbtrkts74vq6zbcby

Theta oscillations gate the transmission of reliable sequences in the medial entorhinal cortex

Arun Neru, Collins Assisi
2021 eNeuro  
In a realistic computational model of a medial entorhinal cortex (MEC) microcircuit, we show that intrinsic neuronal properties and network mechanisms interact with theta oscillations to generate reliable  ...  Stability and precision of sequential activity in the entorhinal cortex is crucial for encoding spatially guided behavior and memory.  ...  vary along the dorso-ventral axis of the medial entorhinal cortex (Garden et al., 2008; Beed et al., 2013) .  ... 
doi:10.1523/eneuro.0059-20.2021 pmid:33820802 pmcid:PMC8208650 fatcat:42jsxlv5y5bapalxj2yjz7e7yq

Physiological roles of Kv2 channels in entorhinal cortex layer II stellate cells revealed by Guangxitoxin-1E

Christoph Hönigsperger, Maximiliano J. Nigro, Johan F. Storm
2016 Journal of Physiology  
Abstract 1 The medial entorhinal cortex (mEC) is strongly involved in spatial navigation, memory, 2 dementia and epilepsy.  ...  Virtually nothing is known 4 about Kv2 channel functions in medial entorhinal cortex (mEC) neurons, which 5 are involved in representing space, memory formation, epilepsy and dementia. 6  Stellate cells  ...  Frequency selectivity of layer II stellate cells in the medial 26 entorhinal cortex. J Neurophysiol 88, 2422-2429.  ... 
doi:10.1113/jp273024 pmid:27562026 fatcat:o72perdbtnfzjddkouq3uqfyr4

The Mechanism of Abrupt Transition between Theta and Hyper-Excitable Spiking Activity in Medial Entorhinal Cortex Layer II Stellate Cells

Tilman Kispersky, John A. White, Horacio G. Rotstein, Clayton T. Dickson
2010 PLoS ONE  
Recent studies have shown that stellate cells (SCs) of the medial entorhinal cortex become hyper-excitable in animal models of temporal lobe epilepsy.  ...  of the model.  ...  TK would like to thank the Bioengineering Department at the University of Utah for equipment support. Author Contributions Conceived and designed the experiments: TJK JAW HR.  ... 
doi:10.1371/journal.pone.0013697 pmid:21079802 pmcid:PMC2973955 fatcat:tpb6ruak4bgd5bgkwr26vndmt4

Neurophysiological and Computational Principles of Cortical Rhythms in Cognition

Xiao-Jing Wang
2010 Physiological Reviews  
An H-current dependent mechanism underlies resonance observed in layer II stellate cells of entorhinal cortex, and combined with membrane noise gives rise to subthreshold oscillations in these cells (  ...  Assuming that the frequency f i reflects intrinsic membrane oscillations of stellate cells in layer II of the entorhinal cortex (13, 272, 1047) , the oscillatory interference model predicts a decreasing  ... 
doi:10.1152/physrev.00035.2008 pmid:20664082 pmcid:PMC2923921 fatcat:m5xm2wpx2ne7rhc5iwjg45muca

Editorial: Structure-Related Intrinsic Electrical States and Firing Patterns of Neurons With Active Dendrites

Sergey M. Korogod
2018 Frontiers in Cellular Neuroscience  
Magnani et al. address specific oscillatory and firing properties of stellate cells in layer II of the medial entorhinal cortex.  ...  Iannella and Launey used a biophysically detailed model of a reconstructed neocortical layer 2/3 pyramidal cell to investigate the effect of changes in parameters of the spike timing-dependent plasticity  ...  Conflict of Interest Statement: The author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest  ... 
doi:10.3389/fncel.2018.00229 pmid:30186113 pmcid:PMC6113935 fatcat:nekrlno37fewhlzqzshxiykw64

The Art of Grid Fields: Geometry of Neuronal Time

Andrey L. Shilnikov, Andrew Porter Maurer
2016 Frontiers in Neural Circuits  
The discovery of grid cells in the entorhinal cortex has both elucidated our understanding of spatial representations in the brain, and germinated a large number of theoretical models regarding the mechanisms  ...  In contrast to prior models of gird cells, the current manuscript provides a sketch by which a small network of neurons, each with oscillatory components can operate to form grid cells, perhaps providing  ...  Sara Burke, Leon Glass, Aaron Kelley, and Lynn Nadel for thoughtful comments and discussion. Special thanks to Dan Sheremet who offered artistic talents for many of the figures.  ... 
doi:10.3389/fncir.2016.00012 pmid:27013981 pmcid:PMC4782041 fatcat:ga6quu44mza7dmg5h4ukxt7k44

A simulation of parahippocampal and hippocampal structures guiding spatial navigation of a virtual rat in a virtual environment: a functional framework for theta theory [chapter]

Michael Hasselmo, Robert C. Cannon, Randal Koene
2002 The Parahippocampal RegionOrganization and Role in Cognitive Function  
Alonso, A. and Klink, R. (1993) Differential electroresponsiveness of stellate and pyramidallike cells of medial entorhinal cortex layer II. J. Neurophysiol. 70: 128-143.  ...  Alonso A, Garcia-Austt E Neuronal sources of theta rhythm in the entorhinal cortex of the rat. II. Phase relations between unit discharges and theta field potentials. Exp.  ...  In the model, the pattern of activity in entorhinal cortex layer III causes subthreshold activation of layer II and region CA1.  ... 
doi:10.1093/acprof:oso/9780198509172.003.0008 fatcat:xmh4x5ze35ch7duvjfmyuosmhu
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