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The contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain
2012
NeuroImage
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T 2 *-weighted gradient-echo MRI images at high field (≥ 7 Tesla) have shown rich image contrast within and between brain regions. ...
In this study, the contribution of myelin to both T 2 * and frequency contrasts is investigated using a mouse model of demyelination based on a cuprizone diet. ...
Acknowledgments This research was supported (in part) by the Intramural Research Program of the NIH, NINDS. The authors appreciate useful comments from Dr. Hang Joon Jo at NIH. ...
doi:10.1016/j.neuroimage.2011.10.076
pmid:22056461
pmcid:PMC3288572
fatcat:bvunqeu4lvfytkth6e33pdny4y
Studying brain microstructure with magnetic susceptibility contrast at high-field
2018
NeuroImage
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A rapidly developing application of high field MRI is the study of brain anatomy and function with contrast based on the magnetic susceptibility of tissues. ...
To study the subtle variations in susceptibility contrast between tissues and with changes in brain activity, dedicated scan techniques such as susceptibility-weighted MRI and blood-oxygen level dependent ...
Acknowledgments This work was supported by the Intramural program of NINDS. ...
doi:10.1016/j.neuroimage.2017.02.046
pmid:28242317
pmcid:PMC5569005
fatcat:iksaoydklbdwzik2qfuq47iacy
Study of brain anatomy with high-field MRI: recent progress
2010
Magnetic Resonance Imaging
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Recent developments in high field MRI technology have led to improved contrast and resolution and are opening up new possibilities for the study of human brain anatomy. ...
In particular, techniques sensitized to magnetic susceptibility contrast provide particular advantages at high field that have allowed visualization of brain structures that have been difficult to detect ...
Acknowledgments Members of LFMI are gratefully acknowledged for their contribution to this research. ...
doi:10.1016/j.mri.2010.02.007
pmid:20392587
pmcid:PMC2905498
fatcat:ptrqwxnhrfejdemryn7jhylcpq
MR susceptibility imaging
2013
Journal of magnetic resonance (San Diego, Calif. 1997 : Print)
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The increase in susceptibility contrast with modern high field scanners has led to novel applications and insights into the sources and mechanism contributing to this contrast in brain tissues. ...
This work reviews recent developments in the use of magnetic susceptibility contrast for human MRI, with a focus on the study of brain anatomy. ...
Introduction One area of MRI that has seen rapid development in recent years is that of contrast based on magnetic susceptibility, which relates to the tendency of tissue to become magnetized by a magnetic ...
doi:10.1016/j.jmr.2012.11.013
pmid:23273840
pmcid:PMC3602381
fatcat:wldbhsew2zcfxadv25hs7yjo6e
Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast
2010
Proceedings of the National Academy of Sciences of the United States of America
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Recent advances in high-field MRI have dramatically improved the visualization of human brain anatomy in vivo. ...
Recent developments in high-field MRI (≥7 T) have increased spatial resolution to less than 300 μm (16-18), and improved the ability to detect subtle variations in the magnetic susceptibility of tissue ...
Recent advances in high-field MRI have dramatically improved the visualization of human brain anatomy in vivo. ...
doi:10.1073/pnas.0911177107
pmid:20133720
pmcid:PMC2840419
fatcat:bo5yhmahc5d3jkxclgefvmltva
Micro-compartment specific T2⁎ relaxation in the brain
2013
NeuroImage
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MRI at high field can be sensitized to the magnetic properties of tissues, which introduces a signal dependence on the orientation of white matter (WM) fiber bundles relative to the magnetic field. ...
By comparing MRI measurements of human and marmoset brain at 7 T with magnetic field modeling, we show that: (1) water between the myelin lipid bilayers, in the axonal, and in the interstitial space each ...
We acknowledge the Intramural Research Program of the National Institute of Neurological Disorders and Stroke (NINDS) for support. ...
doi:10.1016/j.neuroimage.2013.03.005
pmid:23528924
pmcid:PMC3816634
fatcat:io6otyy5drhlljujwtk6sa5pue
Contributions to magnetic susceptibility of brain tissue
2016
NMR in Biomedicine
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With the increased availability of high field scanners, the use of magnetic susceptibility contrast for the study of human brain anatomy and function has increased dramatically. ...
This review discusses the major contributors to the subtle magnetic properties of brain tissue and how they affect MRI contrast. ...
JH Duyn also acknowledges the Intramural Research Program of the National Institute of Neurological Disorders and Stroke for support. ...
doi:10.1002/nbm.3546
pmid:27240118
pmcid:PMC5131875
fatcat:3tktfokpfrax3eevydkin5u3cy
Iron in Multiple Sclerosis and Its Noninvasive Imaging with Quantitative Susceptibility Mapping
2016
International Journal of Molecular Sciences
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In recent years, an advanced MRI method, quantitative susceptibility mapping (QSM), has made it possible to study brain iron through in vivo imaging. ...
Magnetic resonance imaging (MRI) is a well-established tool for the non-invasive study of MS. ...
Conflicts of Interest: Yi Wang is named one of the inventors for QSM technology. ...
doi:10.3390/ijms17010100
pmid:26784172
pmcid:PMC4730342
fatcat:4747e3zpbbauhdlcga6durtd4m
Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping
2020
Science Advances
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Despite its importance for brain connectivity, very little is known about SWM in humans, mainly due to the lack of noninvasive imaging methods. ...
Using biophysical modeling informed by quantitative ion beam microscopy on postmortem brain tissue, we demonstrate that MR contrast in SWM is driven by iron and can be linked to the microscopic iron distribution ...
Myelin The myelin contribution to R2* depends on the fiber orientation with respect to the static magnetic field. ...
doi:10.1126/sciadv.aaz9281
pmid:33028535
pmcid:PMC7541072
fatcat:o4ijzqpw2bfpjplzyk3ymygqdi
Biophysical mechanisms of MRI signal frequency contrast in multiple sclerosis
2012
Proceedings of the National Academy of Sciences of the United States of America
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It is commonly assumed that the local contribution to MRI signal phase directly relates to local bulk tissue magnetic susceptibility. ...
Here, we use Maxwell's equations and Monte Carlo simulations to provide theoretical background to the hypothesis that the local contribution to MRI signal phase does not depend on tissue bulk magnetic ...
Naismith for review of the article. This work was supported by National Institutes of Health Grants ...
doi:10.1073/pnas.1206037109
pmid:22891307
pmcid:PMC3435153
fatcat:uicyf6rwvba23czmdu6p4mnqnq
Magnetic susceptibility anisotropy of human brain in vivo and its molecular underpinnings
2012
NeuroImage
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The source of susceptibility anisotropy in white matter is likely to be myelin as evidenced by the loss of anisotropy in the dysmyelinating shiverer mouse brain. ...
A biophysical model is developed to investigate the effect of the molecular susceptibility anisotropy of myelin components, especially myelin lipids, on the bulk anisotropy observed by MRI. ...
The imaging of mouse brains was carried out at the Center of In Vivo Microscopy of Duke University. In vivo human imaging was conducted at the Brain Imaging and Analysis Center of Duke University. ...
doi:10.1016/j.neuroimage.2011.10.038
pmid:22036681
pmcid:PMC3254777
fatcat:ga6ittd2pzhgfo26imjpythvxa
Research Highlights: Highlights from the latest articles in imaging
2012
Imaging in Medicine
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Evaluation of: Gregory A, Lodygensky GA, Marques JP et al. In vivo assessment of myelination by phase imaging at high magnetic field. Neuroimage 59(and susceptibility maps. ...
Secondly, local phase is the result of nonlocal magnetic susceptibility and is highly dependent on the direction of the main magnetic field. ...
doi:10.2217/iim.12.8
fatcat:ix2it43yn5glrcifknkonk66xq
In vivo quantification of T2⁎ anisotropy in white matter fibers in marmoset monkeys
2012
NeuroImage
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T 2 * -weighted MRI at high field is a promising approach for studying noninvasively the tissue structure and composition of the brain. ...
in the magnetic properties of brain tissue. ...
We also thank the Intramural Research Program of NINDS for support. ...
doi:10.1016/j.neuroimage.2011.08.064
pmid:21906687
pmcid:PMC3230780
fatcat:mp2ep44pzbfsxkuc3z6rtzt56a
High-field (9.4T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility
2011
NeuroImage
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The present work demonstrated that loss of myelin in the central nervous system of the shiverer mouse results in a dramatic reduction of magnetic susceptibility in white matter axons. ...
The reduction resulted in a near extinction of susceptibility contrast between gray and white matter. ...
Our results indicate that myelin is the primary source of the phase contrast between gray and white matter in the deep brain regions observed at high field strength. ...
doi:10.1016/j.neuroimage.2011.02.024
pmid:21320606
pmcid:PMC3085608
fatcat:prvuxb5dxfhxje7dkjqrxdmsai
Advances in noninvasive myelin imaging
2017
Developmental Neurobiology
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This allows for specific monitoring of myelination longitudinally and noninvasively in the healthy brain as well as assessment of treatment and intervention efficacy. ...
Here, we offer a nontechnical review of MRI techniques developed to specifically monitor myelin such as magnetization transfer (MT) and myelin water imaging (MWI). ...
This work was supported by Wellcome Principal Research Fellowship to HJB (WT110027/Z/15/Z). ...
doi:10.1002/dneu.22552
pmid:29082667
pmcid:PMC5813152
fatcat:twua2vnmnbfkdlkbvim7kcxbgu
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