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The contribution of myelin to magnetic susceptibility-weighted contrasts in high-field MRI of the brain

Jongho Lee, Karin Shmueli, Byeong-Teck Kang, Bing Yao, Masaki Fukunaga, Peter van Gelderen, Sara Palumbo, Francesca Bosetti, Afonso C. Silva, Jeff H. Duyn
2012 NeuroImage  
T 2 *-weighted gradient-echo MRI images at high field (≥ 7 Tesla) have shown rich image contrast within and between brain regions.  ...  In this study, the contribution of myelin to both T 2 * and frequency contrasts is investigated using a mouse model of demyelination based on a cuprizone diet.  ...  Acknowledgments This research was supported (in part) by the Intramural Research Program of the NIH, NINDS. The authors appreciate useful comments from Dr. Hang Joon Jo at NIH.  ... 
doi:10.1016/j.neuroimage.2011.10.076 pmid:22056461 pmcid:PMC3288572 fatcat:bvunqeu4lvfytkth6e33pdny4y

Studying brain microstructure with magnetic susceptibility contrast at high-field

Jeff H. Duyn
2018 NeuroImage  
A rapidly developing application of high field MRI is the study of brain anatomy and function with contrast based on the magnetic susceptibility of tissues.  ...  To study the subtle variations in susceptibility contrast between tissues and with changes in brain activity, dedicated scan techniques such as susceptibility-weighted MRI and blood-oxygen level dependent  ...  Acknowledgments This work was supported by the Intramural program of NINDS.  ... 
doi:10.1016/j.neuroimage.2017.02.046 pmid:28242317 pmcid:PMC5569005 fatcat:iksaoydklbdwzik2qfuq47iacy

Study of brain anatomy with high-field MRI: recent progress

Jozef H. Duyn
2010 Magnetic Resonance Imaging  
Recent developments in high field MRI technology have led to improved contrast and resolution and are opening up new possibilities for the study of human brain anatomy.  ...  In particular, techniques sensitized to magnetic susceptibility contrast provide particular advantages at high field that have allowed visualization of brain structures that have been difficult to detect  ...  Acknowledgments Members of LFMI are gratefully acknowledged for their contribution to this research.  ... 
doi:10.1016/j.mri.2010.02.007 pmid:20392587 pmcid:PMC2905498 fatcat:ptrqwxnhrfejdemryn7jhylcpq

MR susceptibility imaging

Jeff Duyn
2013 Journal of magnetic resonance (San Diego, Calif. 1997 : Print)  
The increase in susceptibility contrast with modern high field scanners has led to novel applications and insights into the sources and mechanism contributing to this contrast in brain tissues.  ...  This work reviews recent developments in the use of magnetic susceptibility contrast for human MRI, with a focus on the study of brain anatomy.  ...  Introduction One area of MRI that has seen rapid development in recent years is that of contrast based on magnetic susceptibility, which relates to the tendency of tissue to become magnetized by a magnetic  ... 
doi:10.1016/j.jmr.2012.11.013 pmid:23273840 pmcid:PMC3602381 fatcat:wldbhsew2zcfxadv25hs7yjo6e

Layer-specific variation of iron content in cerebral cortex as a source of MRI contrast

Masaki Fukunaga, Tie-Qiang Li, Peter van Gelderen, Jacco A. de Zwart, Karin Shmueli, Bing Yao, Jongho Lee, Dragan Maric, Maria A. Aronova, Guofeng Zhang, Richard D. Leapman, John F. Schenck (+2 others)
2010 Proceedings of the National Academy of Sciences of the United States of America  
Recent advances in high-field MRI have dramatically improved the visualization of human brain anatomy in vivo.  ...  Recent developments in high-field MRI (≥7 T) have increased spatial resolution to less than 300 μm (16-18), and improved the ability to detect subtle variations in the magnetic susceptibility of tissue  ...  Recent advances in high-field MRI have dramatically improved the visualization of human brain anatomy in vivo.  ... 
doi:10.1073/pnas.0911177107 pmid:20133720 pmcid:PMC2840419 fatcat:bo5yhmahc5d3jkxclgefvmltva

Micro-compartment specific T2⁎ relaxation in the brain

Pascal Sati, Peter van Gelderen, Afonso C. Silva, Daniel S. Reich, Hellmut Merkle, Jacco A. de Zwart, Jeff H. Duyn
2013 NeuroImage  
MRI at high field can be sensitized to the magnetic properties of tissues, which introduces a signal dependence on the orientation of white matter (WM) fiber bundles relative to the magnetic field.  ...  By comparing MRI measurements of human and marmoset brain at 7 T with magnetic field modeling, we show that: (1) water between the myelin lipid bilayers, in the axonal, and in the interstitial space each  ...  We acknowledge the Intramural Research Program of the National Institute of Neurological Disorders and Stroke (NINDS) for support.  ... 
doi:10.1016/j.neuroimage.2013.03.005 pmid:23528924 pmcid:PMC3816634 fatcat:io6otyy5drhlljujwtk6sa5pue

Contributions to magnetic susceptibility of brain tissue

Jeff H. Duyn, John Schenck
2016 NMR in Biomedicine  
With the increased availability of high field scanners, the use of magnetic susceptibility contrast for the study of human brain anatomy and function has increased dramatically.  ...  This review discusses the major contributors to the subtle magnetic properties of brain tissue and how they affect MRI contrast.  ...  JH Duyn also acknowledges the Intramural Research Program of the National Institute of Neurological Disorders and Stroke for support.  ... 
doi:10.1002/nbm.3546 pmid:27240118 pmcid:PMC5131875 fatcat:3tktfokpfrax3eevydkin5u3cy

Iron in Multiple Sclerosis and Its Noninvasive Imaging with Quantitative Susceptibility Mapping

Carsten Stüber, David Pitt, Yi Wang
2016 International Journal of Molecular Sciences  
In recent years, an advanced MRI method, quantitative susceptibility mapping (QSM), has made it possible to study brain iron through in vivo imaging.  ...  Magnetic resonance imaging (MRI) is a well-established tool for the non-invasive study of MS.  ...  Conflicts of Interest: Yi Wang is named one of the inventors for QSM technology.  ... 
doi:10.3390/ijms17010100 pmid:26784172 pmcid:PMC4730342 fatcat:4747e3zpbbauhdlcga6durtd4m

Superficial white matter imaging: Contrast mechanisms and whole-brain in vivo mapping

Evgeniya Kirilina, Saskia Helbling, Markus Morawski, Kerrin Pine, Katja Reimann, Steffen Jankuhn, Juliane Dinse, Andreas Deistung, Jürgen R. Reichenbach, Robert Trampel, Stefan Geyer, Larissa Müller (+4 others)
2020 Science Advances  
Despite its importance for brain connectivity, very little is known about SWM in humans, mainly due to the lack of noninvasive imaging methods.  ...  Using biophysical modeling informed by quantitative ion beam microscopy on postmortem brain tissue, we demonstrate that MR contrast in SWM is driven by iron and can be linked to the microscopic iron distribution  ...  Myelin The myelin contribution to R2* depends on the fiber orientation with respect to the static magnetic field.  ... 
doi:10.1126/sciadv.aaz9281 pmid:33028535 pmcid:PMC7541072 fatcat:o4ijzqpw2bfpjplzyk3ymygqdi

Biophysical mechanisms of MRI signal frequency contrast in multiple sclerosis

D. A. Yablonskiy, J. Luo, A. L. Sukstanskii, A. Iyer, A. H. Cross
2012 Proceedings of the National Academy of Sciences of the United States of America  
It is commonly assumed that the local contribution to MRI signal phase directly relates to local bulk tissue magnetic susceptibility.  ...  Here, we use Maxwell's equations and Monte Carlo simulations to provide theoretical background to the hypothesis that the local contribution to MRI signal phase does not depend on tissue bulk magnetic  ...  Naismith for review of the article. This work was supported by National Institutes of Health Grants  ... 
doi:10.1073/pnas.1206037109 pmid:22891307 pmcid:PMC3435153 fatcat:uicyf6rwvba23czmdu6p4mnqnq

Magnetic susceptibility anisotropy of human brain in vivo and its molecular underpinnings

Wei Li, Bing Wu, Alexandru V. Avram, Chunlei Liu
2012 NeuroImage  
The source of susceptibility anisotropy in white matter is likely to be myelin as evidenced by the loss of anisotropy in the dysmyelinating shiverer mouse brain.  ...  A biophysical model is developed to investigate the effect of the molecular susceptibility anisotropy of myelin components, especially myelin lipids, on the bulk anisotropy observed by MRI.  ...  The imaging of mouse brains was carried out at the Center of In Vivo Microscopy of Duke University. In vivo human imaging was conducted at the Brain Imaging and Analysis Center of Duke University.  ... 
doi:10.1016/j.neuroimage.2011.10.038 pmid:22036681 pmcid:PMC3254777 fatcat:ga6ittd2pzhgfo26imjpythvxa

Research Highlights: Highlights from the latest articles in imaging

R Marc Lebel
2012 Imaging in Medicine  
Evaluation of: Gregory A, Lodygensky GA, Marques JP et al. In vivo assessment of myelination by phase imaging at high magnetic field. Neuroimage 59(and susceptibility maps.  ...  Secondly, local phase is the result of nonlocal magnetic susceptibility and is highly dependent on the direction of the main magnetic field.  ... 
doi:10.2217/iim.12.8 fatcat:ix2it43yn5glrcifknkonk66xq

In vivo quantification of T2⁎ anisotropy in white matter fibers in marmoset monkeys

Pascal Sati, Afonso C. Silva, Peter van Gelderen, Maria I. Gaitan, Jillian E. Wohler, Steven Jacobson, Jeff H. Duyn, Daniel S. Reich
2012 NeuroImage  
T 2 * -weighted MRI at high field is a promising approach for studying noninvasively the tissue structure and composition of the brain.  ...  in the magnetic properties of brain tissue.  ...  We also thank the Intramural Research Program of NINDS for support.  ... 
doi:10.1016/j.neuroimage.2011.08.064 pmid:21906687 pmcid:PMC3230780 fatcat:mp2ep44pzbfsxkuc3z6rtzt56a

High-field (9.4T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility

Chunlei Liu, Wei Li, G. Allan Johnson, Bing Wu
2011 NeuroImage  
The present work demonstrated that loss of myelin in the central nervous system of the shiverer mouse results in a dramatic reduction of magnetic susceptibility in white matter axons.  ...  The reduction resulted in a near extinction of susceptibility contrast between gray and white matter.  ...  Our results indicate that myelin is the primary source of the phase contrast between gray and white matter in the deep brain regions observed at high field strength.  ... 
doi:10.1016/j.neuroimage.2011.02.024 pmid:21320606 pmcid:PMC3085608 fatcat:prvuxb5dxfhxje7dkjqrxdmsai

Advances in noninvasive myelin imaging

Florence Heath, Samuel A. Hurley, Heidi Johansen-Berg, Cassandra Sampaio-Baptista
2017 Developmental Neurobiology  
This allows for specific monitoring of myelination longitudinally and noninvasively in the healthy brain as well as assessment of treatment and intervention efficacy.  ...  Here, we offer a nontechnical review of MRI techniques developed to specifically monitor myelin such as magnetization transfer (MT) and myelin water imaging (MWI).  ...  This work was supported by Wellcome Principal Research Fellowship to HJB (WT110027/Z/15/Z).  ... 
doi:10.1002/dneu.22552 pmid:29082667 pmcid:PMC5813152 fatcat:twua2vnmnbfkdlkbvim7kcxbgu
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