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Myelination- and immune-mediated MR-based brain network correlates

Manuela Cerina, Muthuraman Muthuraman, Marco Gallus, Nabin Koirala, Andre Dik, Lydia Wachsmuth, Petra Hundehege, Patrick Schiffler, Jan-Gerd Tenberge, Vinzenz Fleischer, Gabriel Gonzalez-Escamilla, Venu Narayanan (+5 others)
2020 Journal of Neuroinflammation  
took advantage of the cuprizone model of general demyelination in mice and performed longitudinal histological and imaging analyses with behavioral tests.  ...  MRI-derived modularization of the brain network and FA reduction in key anatomical regions, including the hippocampus, thalamus, and analyzed cortical areas, were closely related to impaired memory function  ...  Acknowledgements We would like to thank Monika Wart, Jana Pravemann, and Frank Kurth for the excellent technical assistance. Moreover, we would also like to thank Dr.  ... 
doi:10.1186/s12974-020-01827-z pmid:32532336 pmcid:PMC7293122 fatcat:hzh2dgqokjhbtlpufce4thwpwm

Long-Term Connectome Analysis Reveals Reshaping of Visual, Spatial Networks in a Model With Vascular Dementia Features

Gerard R. Hall, Philipp Boehm-Sturm, Ulrich Dirnagl, Carsten Finke, Marco Foddis, Christoph Harms, Stefan Paul Koch, Joseph Kuchling, Christopher R. Madan, Susanne Mueller, Celeste Sassi, Stamatios N. Sotiropoulos (+4 others)
2022 Stroke  
Methods: We present a pipeline adapted for structural and functional connectivity analysis of the mouse brain, and we tested it in a mouse model of vascular dementia.  ...  For the first time, we report that default mode network activity is disrupted in the mouse model.  ...  Acknowledgments Sources of Funding  ... 
doi:10.1161/strokeaha.121.036997 pmid:35105183 pmcid:PMC9022688 fatcat:2anhrq6xrvfppngfdekps7krwa

Current developments in MRI for assessing rodent models of multiple sclerosis

Othman I Alomair, Maree T Smith, Ian M Brereton, Graham J Galloway, Nyoman D Kurniawan
2014 Future Neurology  
to determine the severity of MS pathology, including demyelination/remyelination and brain connectivity impairment from axonal loss.  ...  The broad spectrum of MS pathology manifests in diverse patient MRI presentations and affects the accuracy of patient diagnosis.  ...  In a cuprizone-induced demyelination/remyelination mouse model [54] , T 2 hyperintensity, a reduction in AD and an increase in RD were specifically observed in the caudal segment of the corpus callosum  ... 
doi:10.2217/fnl.14.33 fatcat:byc5bkk565dnpkiqum3sp4sxva

Current and Future Applications of Transcriptomics for Discovery in CNS Disease and Injury

Kathryn M. Munro, Victoria M. Perreau
2009 Neurosignals  
In this review we discuss the current and emerging application of transcriptomics for the study of neural function in health, disease and injury.  ...  In vitro models of neural injury are also proving useful, and transcriptomics is enhancing our understanding of the properties of neural stem cells with a view to their therapeutic application in neural  ...  Importantly, the demyelinating effect of cuprizone is reversible and withdrawal of cuprizone treatment results in spontaneous, progressive remyelination.  ... 
doi:10.1159/000231897 pmid:19816067 fatcat:jui62iuxp5atrekq7j5s3val7u

Vascular cognitive impairment in the mouse reshapes visual, spatial network functional connectivity [article]

Gerard R Hall, Philipp Boehm-Sturm, Ulrich Dirnagl, Carsten Finke, Marco Foddis, Christoph Harms, Stefan Paul Koch, Joseph Kuchling, Christopher R Madan, Susanne Mueller, Celeste Sassi, Stamatios Sotiropoulos (+4 others)
2020 biorxiv/medrxiv   pre-print
To dissect the biological underpinning of these changes, animal models are required. We tested whether the structural connectome is altered in a mouse model of vascular cognitive impairment.  ...  Resting state functional MRI connectivity analysis revealed diminished default mode network activity in the mouse model compared to shams.  ...  The authors declare that they have competing interests.  ... 
doi:10.1101/2020.11.04.366294 fatcat:335ztw5zdbbzjlcuuucetjt2yu

Novel Tools and Investigative Approaches for the Study of Oligodendrocyte Precursor Cells (NG2-Glia) in CNS Development and Disease

Christophe Galichet, Richard W. Clayton, Robin Lovell-Badge
2021 Frontiers in Cellular Neuroscience  
In this review article, we discuss the state-of-the-art tools and investigative approaches being used to characterize the biology and function of OPCs.  ...  Finally, we review the use of in vitro assay to assess OPC functions.  ...  The first study to focus exclusively on gene expression in OPCs was conducted in a mouse model of demyelination (Moyon et al., 2015) .  ... 
doi:10.3389/fncel.2021.673132 pmid:33994951 pmcid:PMC8116629 fatcat:k5jdu5s36jgydpgzrls6yy2umq

A systematic review on the quantitative relationship between structural and functional network connectivity strength in mammalian brains

Milou Straathof, Michel RT Sinke, Rick M Dijkhuizen, Willem M Otte
2018 Journal of Cerebral Blood Flow and Metabolism  
An improved understanding of the structure-function relation is crucial to understand the structural underpinnings of brain function and brain plasticity after injury.  ...  The mammalian brain is composed of densely connected and interacting regions, which form structural and functional networks.  ...  The Declaration of conflicting interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.  ... 
doi:10.1177/0271678x18809547 pmid:30375267 pmcid:PMC6360487 fatcat:rl42rz4by5exfmdj7piiv5jlaq

A Novel Approach for Studying the Physiology and Pathophysiology of Myelinated and Non-Myelinated Axons in the CNS White Matter

Lijun Li, Alexander A. Velumian, Marina Samoilova, Michael G. Fehlings, Peter Wenner
2016 PLoS ONE  
Advances in brain connectomics set the need for detailed knowledge of functional properties of myelinated and non-myelinated (if present) axons in specific white matter pathways.  ...  The corpus callosum (CC), a major white matter structure interconnecting brain hemispheres, is extensively used for studying CNS axonal function.  ...  Acknowledgments The authors thank Mr. Jian Wang and Mr. Behzad Azad for technical assistance and animal care.  ... 
doi:10.1371/journal.pone.0165637 pmid:27829055 pmcid:PMC5102346 fatcat:o3zowwyfpnglxdajntwa75jaae

Delineation of early brain development from fetuses to infants with diffusion MRI and beyond

Minhui Ouyang, Jessica Dubois, Qinlin Yu, Pratik Mukherjee, Hao Huang
2018 NeuroImage  
Decades of histological studies have identified strong spatial and functional maturation gradients in human brain gray and white matter.  ...  Here, we review the recent advances in understanding early brain structural development during the second half of gestation and the first two postnatal years using modern MR techniques.  ...  Jeffrey Neil for the comments and suggestions. We thank the lab member, Michelle Slinger, for contribution to writing.  ... 
doi:10.1016/j.neuroimage.2018.04.017 pmid:29655938 pmcid:PMC6185831 fatcat:h2qkou7sxjhe5hw4fksh6luqum

Challenges for biophysical modeling of microstructure

Ileana O. Jelescu, Marco Palombo, Francesca Bagnato, Kurt G. Schilling
2020 Journal of Neuroscience Methods  
techniques, the development of a generalized standard model for any brain region and pathology, and the seamless communication between different parties involved in the development and application of  ...  Secondly, the model performance and validity should be explored in pathological conditions, and, if appropriate, dedicated models for pathology should be developed.  ...  Acknowledgments The authors acknowledge support from the Center for Biomedical Imaging of the EPFL, Unil, CHUV, UniGE and HUG and the Swiss National Science Foundation grant no.  ... 
doi:10.1016/j.jneumeth.2020.108861 pmid:32692999 fatcat:bapfiafyqvcbtky3qggqibefsu

MRI and M/EEG studies of the White Matter Development in Human Fetuses and Infants: Review and Opinion

Jessica Dubois, Parvaneh Adibpour, Cyril Poupon, Lucie Hertz-Pannier, Ghislaine Dehaene-Lambertz, Bernard Zalc
2016 Brain Plasticity  
At the structural level, the early architecture and myelination of bundles have been assessed with diffusion and relaxometry MRI, recently integrated in multi-compartment models and multi-parametric approaches  ...  brain maturation and skills development in vivo.  ...  A recent study in a cuprizone mouse model of demyelination has shown that among MRI parameters (T1/T2, DTI, MTI), the bound pool fraction (ƒ) from MTI is the best indicator of the myelin sheath fraction  ... 
doi:10.3233/bpl-160031 pmid:29765848 pmcid:PMC5928537 fatcat:6if7kwm3ejc5riwqzh7bjzgtgi

A roadmap of brain recovery in a mouse model of concussion: insights from neuroimaging

Xuan Vinh To, Fatima A. Nasrallah
2021 Acta Neuropathologica Communications  
Overall, a mismatch in the temporal onsets and durations of the behavioural symptoms and structural/functional changes in the brain was seen.  ...  This study conducted a cross-sectional multi-modal examination investigation of the temporal changes in behavioural and brain changes in a mouse model of concussion using magnetic resonance imaging.  ...  We acknowledge the support from the Queensland NMR Network and the National Imaging Facility (a National Collaborative Research Infrastructure Strategy capability) for the operation of 9.4T MRI and utilisation  ... 
doi:10.1186/s40478-020-01098-y pmid:33407949 pmcid:PMC7789702 fatcat:bhkt6y4afbazpiazxtz3a76wvi

Oral Abstracts

2021 Glia  
The development of the most complex biological organ, the Central Nervous System (CNS) comprising the brain and the spinal cord, is one of the most fascinating endeavors undertaken by evolution, and one  ...  oligodendroglia and astrocytes, the role of radial glia as the neural stem cells, and the mechanisms leading to the generation of different neural subtypes, such as cell-cell interaction, patterning,  ...  We are grateful to our outstanding collaborators: Acknowledgement This was was supported by the Agence Nationale de la Recherche (ANR-17-CE16-0008-0), and the Fondation pour la Recherche sur le Cerveau  ... 
doi:10.1002/glia.24035 pmid:34173981 fatcat:q2h3ttvpxnfcxds4p6jy6h7mcq

Recommendations and guidelines from the ISMRM Diffusion Study Group for preclinical diffusion MRI: Part 1 – In vivo small-animal imaging [article]

Ileana O Jelescu, Francesco Grussu, Andrada Ianus, Brian Hansen, Manisha Aggarwal, Stijn Michielse, Fatima Nasrallah, Warda Syeda, Nian Wang, Jelle Veraart, Alard Roebroeck, Andrew F Bagdaserian (+38 others)
2022 arXiv   pre-print
The value of in vivo preclinical diffusion MRI (dMRI) is substantial.  ...  Many of the influential works in this field were first performed in small animals or ex vivo samples.  ...  Common models include cuprizone-induced demyelination and spontaneous remyelination, experimental autoimmune encephalomyelitis or transgenic mouse models of hypomyelination (Ileana O.  ... 
arXiv:2209.12994v1 fatcat:hbgcylc6onectdeqgeyhyvpcgi

Design and Validation of Diffusion MRI Models of White Matter

Ileana O. Jelescu, Matthew D. Budde
2017 Frontiers in Physics  
Frontiers in Physics | www.frontiersin.org  ...  AUTHOR CONTRIBUTIONS All authors listed have made a substantial, direct, and intellectual contribution to the work, and approved it for publication.  ...  A chemical model of demyelination induced through cuprizone toxicity has been used by many groups to validate diffusion and other MRI markers related to specific pathologies.  ... 
doi:10.3389/fphy.2017.00061 pmid:29755979 pmcid:PMC5947881 fatcat:ai6ejv6rzfe55i4tl64l5dihem
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