Filters








30 Hits in 3.6 sec

The complex portal - an encyclopaedia of macromolecular complexes

Birgit H.M. Meldal, Oscar Forner-Martinez, Maria C. Costanzo, Jose Dana, Janos Demeter, Marine Dumousseau, Selina S. Dwight, Anna Gaulton, Luana Licata, Anna N. Melidoni, Sylvie Ricard-Blum, Bernd Roechert (+6 others)
2014 Nucleic Acids Research  
The IntAct molecular interaction database has created a new, free, open-source, manually curated resource, the Complex Portal (www.ebi.ac.uk/intact/ complex), through which protein complexes from major  ...  This reference resource will be maintained and grow to encompass an increasing number of organisms. In-put from groups and individuals with specific areas of expertise is welcome.  ...  of information for stable, macromolecular complexes.  ... 
doi:10.1093/nar/gku975 pmid:25313161 pmcid:PMC4384031 fatcat:afmhddxkfbg7rm2rp5yjgj4fyi

ComplexViewer: visualization of curated macromolecular complexes

Colin W Combe, Marine (Dumousseau) Sivade, Henning Hermjakob, Joshua Heimbach, Birgit H M Meldal, Gos Micklem, Sandra Orchard, Juri Rappsilber, Jonathan Wren
2017 Bioinformatics  
Furthermore, if binding regions between molecules are known then these can be displayed in the context of the larger complex.  ...  Availability and implementation: freely available under Apache version 2 license; EMBL-EBI Complex Portal  ...  The European Bioinformatics Institute (EMBL-EBI) has developed the Complex Portal (http://www.ebi.ac.uk/complexportal), an encyclopaedia of manually curated macromolecular complexes that captures the biologically  ... 
doi:10.1093/bioinformatics/btx497 pmid:29036573 pmcid:PMC5870653 fatcat:kpee5g2y4zcy5c5vpcjjuz6doq

Towards an Encyclopaedia of Sequence Biology

Alexander Bolshoy
2018 Linguistic Frontiers  
In this review, I discussed three concepts: a concept of SB, a concept of encyclopaedia of genetic codes, and a concept of a corpus DNA linguistics.  ...  At the heart of SB lies a concept of a sequence code.  ...  ), and is worth the read if only as a portal in to the minds of those luminary workers" [19] .)  ... 
doi:10.2478/lf-2018-0003 fatcat:ewn3njfqdjhtxog3hpmmcvzll4

Molecular modelling techniques in environmental research

Rafał D. Urniaż, Ewelina Rutkowska, Jan P. Jastrzębski, Paweł Książek, Katarzyna Rudnicka
2014 Environmental Biotechnology  
ACKNOWLEDGEMENTS The manuscript was written through contributions of all authors. All authors have given approval to the final version of the manuscript. Authors are grateful to Dr.  ...  The most the Protein Information Resource (PIR). The UniPort databases are accessible by the Bioinformatics Resource Portal -ExPASy.  ...  The latter approach uses resolved ligand-target complexes to illustrate the complementarity of the receptor to the ligand.  ... 
doi:10.14799/ebms198 fatcat:llm4e7jce5hsli7lyw2babzwvm

Unlocking Big Data for better health

Steven Munevar
2017 Nature Biotechnology  
Nucl Acids Res 43:D382-D386 Meldal BHM, Forner-Martinez O, Costanzo MC, et al. (2014) The complex portal -an encyclopaedia of macromolecular complexes.  ...  J Cheminform 6:45 Venkata C, Forster MJ, Howe PW, Steinbeck C. ( Meldal BH, Forner-Martinez O, Costanzo MC, et al. (2014) The complex portal -an encyclopaedia of macromolecular complexes.  ... 
doi:10.1038/nbt.3918 pmid:28700551 fatcat:oqiurm5cgzec7lfenvjvlemxoy

A sample copy of the textbook Principles of Cell and Tissue Biology

George N. Chaldakov
2020 Biomedical Reviews  
Macromolecular crowding The interior of cells is a crowded environment.  ...  The teaching maneuver of the textbook reminds that of teaching new foreign language Definitions of language (according to Encyclopaedia Britannica) "Henry Sweet, an English language scholar, stated: Language  ...  DECALOGUE FOR STUDENTS General Information Organization of the Manuscript Text of manuscripts must include an abstract, an introduction, followed by the body of manuscript, a conclusion, acknowledgments  ... 
doi:10.14748/bmr.v31.7716 fatcat:7tgzg72st5gl5kpmk3qhzimfha

Natural product drug discovery in the artificial intelligence era

Fernanda I Saldivar-Gonzalez, Victor Daniel Aldas-Bulos, José Luis Medina-Franco, Fabien Plisson
2022 Chemical Science  
. 249 These tools represent an opportunity to "de-orphanize" NPs by predicting their macromolecular (protein) targets.  ...  They identified common treatments, and they eased the discovery of NPs in both Zhong Hua Yi Dian (ZHYD; Encyclopaedia of Traditional Chinese Medicine), the most comprehensive encyclopedia of TCM books,  ...  Conflicts of interest There are no conflicts to declare.  ... 
doi:10.1039/d1sc04471k pmid:35282622 pmcid:PMC8827052 fatcat:jyfupubc2bgb7p4v6b62apgtfq

Masthead

2007 Chemistry International  
Zare of Stanford University for the advice and suggestions he gave for improving the questions for this interview and for assistance during the interview.  ...  The MMC Symposium brings together leading scientists and engineers to discuss the latest advances in macromolecular complexes, which include macromolecule-metal complexes, polynuclear complexes, capped  ...  The book also makes an excellent encyclopaedia (partly due to its very good index) for professionals in the field of biobased raw materials, technologies, and products.  ... 
doi:10.1515/ci.2007.29.3.i.masthead fatcat:a45ipy3uvfebxnrgzbe2mnoleu

Pharmaceutical information: A 30-year perspective on the literature

David Bawden, Lyn Robinson
2011 Annual Review of Information Science and Technology  
The review shows the pharmaceutical subject domain to be particularly information intensive, with a complex communication chain, involving a notably varied set of producers and users of information, and  ...  The very problem of defining what constitutes the literature is difficult... It is also increasingly complex, i.e. interdisciplinary and interprofessional in nature.  ...  Pharmaceutical information producers and users It will be clear from what has been written above that the communication chain for pharmaceutical information is complex, and involves an unusually large  ... 
doi:10.1002/aris.2011.1440450109 fatcat:qirsfglp35f3xpiyz6hf6f2ude

Hierarchical Biological Pathway Data Integration and Mining [chapter]

Shubhalaxmi Kher, Jianling Peng, Eve Syrkin, Julie Dickerso
2012 Bioinformatics  
by complex interaction networks.  ...  of images of biological pathways, macromolecular structures, gene families, and cellular relationships BioCarta Several signalling pathways BIND The bio molecular interaction network database  ... 
doi:10.5772/49974 fatcat:wo3ris5q5vfdjjdloan7phhche

Bioinformatics Accelerates the Major Tetrad: A Real Boost for the Pharmaceutical Industry

Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Saurabh Bhatia, Ahmed Al-Harrasi, Gokhan Zengin, Elena Emilia Babes, Ciprian Brisc, Manuela Stoicescu, Mirela Marioara Toma, Cristian Sava (+1 others)
2021 International Journal of Molecular Sciences  
Our analysis aims to provide optimal data in the field by stratification of the information related to the published data in key sectors and to capture the attention of researchers interested in bioinformatics  ...  With advanced technology and its development, bioinformatics is one of the avant-garde fields that has managed to make amazing progress in the pharmaceutical–medical field by modeling the infrastructural  ...  Acknowledgments: The authors would like to thank Chitkara College of Pharmacy, Chitkara University, Punjab, India for providing the various resources for completion of the article and University of Oradea  ... 
doi:10.3390/ijms22126184 pmid:34201152 pmcid:PMC8227524 fatcat:foyvjk4asjfozhj2khewmnwf5q

Representing COVID-19 information in collaborative knowledge graphs: a study of Wikidata

Houcemeddine Turki, Mohamed Ali Hadj Taieb, Thomas Shafee, Tiago Lubiana, Dariusz Jemielniak, Mohamed Ben Aouicha, Jose Emilio Labra Gayo, Mus'ab Banat, Diptanshu Das, Daniel Mietchen
2020 Zenodo  
The structure of the raw data is highly complex, so converting it to meaningful insight requires extraction and visualization, the global crowdsourcing of which adds both additional challenges and opportunities  ...  Here, we introduce four aspects of Wikidata that make it an ideal knowledge base for information on the COVID-19 pandemic: its flexible data model, its multilingual features, its alignment to multiple  ...  Headings (MeSH) codes are an index and thesaurus for the life sciences (≠ MeSH ID, P486) P1417 Encyclopaedia Britannica Online ID identifier for an article in the online version of Encyclopaedia  ... 
doi:10.5281/zenodo.4028482 fatcat:3rmvcbij3jdxjdkfpnilewkwgu

Representing COVID-19 information in collaborative knowledge graphs: a study of Wikidata

Houcemeddine Turki, Mohamed Ali Hadj Taieb, Thomas Shafee, Tiago Lubiana, Dariusz Jemielniak, Mohamed Ben Aouicha, Jose Emilio Labra Gayo, Mus'ab Banat, Diptanshu Das, Daniel Mietchen
2020 Zenodo  
The structure of the raw data is highly complex, so converting it to meaningful insight requires extraction and visualization, the global crowdsourcing of which adds both additional challenges and opportunities  ...  Here, we introduce four aspects of Wikidata that make it an ideal knowledge base for information on the COVID-19 pandemic: its flexible data model, its multilingual features, its alignment to multiple  ...  for the life sciences (≠ MeSH ID, P486) P1417 Encyclopaedia Britannica Online ID identifier for an article in the online version of Encyclopaedia Table 2 : 2 Languages ranked according to various  ... 
doi:10.5281/zenodo.4028483 fatcat:v4fmicaakfhfjoqcrgjkaartsm

GSTCD and INTS12 Regulation and Expression in the Human Lung

Ma'en Obeidat, Suzanne Miller, Kelly Probert, Charlotte K. Billington, Amanda P. Henry, Emily Hodge, Carl P. Nelson, Ceri E. Stewart, Caroline Swan, Louise V. Wain, María Soler Artigas, Erik Melén (+9 others)
2013 PLoS ONE  
positively correlate with percent predicted FEV 1 , and (iv) FEV 1 GWAS associated SNPs in 4q24 were found to act as an eQTL for INTS12 in a number of tissues.  ...  Knowledge of the transcriptional and translational regulation and expression of GSTCD and INTS12 provides important insights into the potential role of these genes in determining lung function.  ...  Acknowledgements We are extremely grateful to Professor James Lowe (University of Nottingham) for assistance in the use of human tissues under the HTA and in assistance with the interpretation of immunohistochemistry  ... 
doi:10.1371/journal.pone.0074630 pmid:24058608 pmcid:PMC3776747 fatcat:43izlywyfbc5xh5gfbrh3m7yfm

State of the Art Review on Genetics and Precision Medicine in Arrhythmogenic Cardiomyopathy

Viraj Patel, Babken Asatryan, Bhurint Siripanthong, Patricia B. Munroe, Anjali Tiku-Owens, Luis R. Lopes, Mohammed Y. Khanji, Alexandros Protonotarios, Pasquale Santangeli, Daniele Muser, Francis E. Marchlinski, Peter A. Brady (+1 others)
2020 International Journal of Molecular Sciences  
Arrhythmogenic cardiomyopathy (ACM) is an inherited cardiomyopathy characterised by ventricular arrhythmia and an increased risk of sudden cardiac death (SCD).  ...  This review details the genetic basis of ACM with specific genotype-phenotype associations, providing the reader with a nuanced perspective of this condition; whilst also proposing a future roadmap to  ...  Alongside the desmosome, the ID contains several macromolecular complexes with distinct properties: the adherens junction, the gap junction and ion channel.  ... 
doi:10.3390/ijms21186615 pmid:32927679 pmcid:PMC7554944 fatcat:yc3i42vfhzawne7tgrnqla774u
« Previous Showing results 1 — 15 out of 30 results